1KDX
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KIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES
Descriptor:CBP, CREB
Authors:Radhakrishnan, I., Perez-Alvarado, G.C., Dyson, H.J., Wright, P.E.
Deposit date:1997-09-16
Release date:1998-11-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions.
Cell(Cambridge,Mass.), 91, 1997
1SB0
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SOLUTION STRUCTURE OF THE KIX DOMAIN OF CBP BOUND TO THE TRANSACTIVATION DOMAIN OF C-MYB
Descriptor:protein CBP, protein c-Myb
Authors:Zor, T., De Guzman, R.N., Dyson, H.J., Wright, P.E.
Deposit date:2004-02-09
Release date:2004-04-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of c-Myb
J.Mol.Biol., 337, 2004
2AGH
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STRUCTURAL BASIS FOR COOPERATIVE TRANSCRIPTION FACTOR BINDING TO THE CBP COACTIVATOR
Descriptor:Myb proto-oncogene protein, Crebbp protein, Zinc finger protein HRX
Authors:De Guzman, R.N., Goto, N.K., Dyson, H.J., Wright, P.E.
Deposit date:2005-07-26
Release date:2005-11-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Basis for Cooperative Transcription Factor Binding to the CBP Coactivator
J.Mol.Biol., 355, 2006
2KWF
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THE STRUCTURE OF E-PROTEIN ACTIVATION DOMAIN 1 BOUND TO THE KIX DOMAIN OF CBP/P300 ELUCIDATES LEUKEMIA INDUCTION BY E2A-PBX1
Descriptor:CREB-binding protein, Transcription factor 4
Authors:Denis, C.M., Chitayat, S., Plevin, M.J., Liu, S., Spencer, H.L., Ikura, M., LeBrun, D.P., Smith, S.P.
Deposit date:2010-04-08
Release date:2011-07-20
Method:SOLUTION NMR
Cite:The structure of E-protein activation domain 1 bound to the KIX domain of CBP/p300 elucidates leukemia induction by E2A-PBX1
To be Published
2LQH
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NMR STRUCTURE OF FOXO3A TRANSACTIVATION DOMAINS (CR2C-CR3) IN COMPLEX WITH CBP KIX DOMAIN (2B3L CONFORMATION)
Descriptor:CREB-binding protein, Forkhead box O3
Authors:Wang, F., Marshall, C.B., Yamamoto, K., Li, G.B., Gasmi-Seabrook, G.M.C., Okada, H., Mak, T.W., Ikura, M.
Deposit date:2012-03-06
Release date:2012-05-16
Method:SOLUTION NMR
Cite:Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Proc.Natl.Acad.Sci.USA, 109, 2012
2LQI
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NMR STRUCTURE OF FOXO3A TRANSACTIVATION DOMAINS (CR2C-CR3) IN COMPLEX WITH CBP KIX DOMAIN (2L3B CONFORMATION)
Descriptor:CREB-binding protein, Forkhead box O3
Authors:Wang, F., Marshall, C.B., Yamamoto, K., Li, G.B., Gasmi-Seabrook, G.M.C., Okada, H., Mak, T.W., Ikura, M.
Deposit date:2012-03-06
Release date:2012-05-16
Method:SOLUTION NMR
Cite:Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment.
Proc.Natl.Acad.Sci.USA, 109, 2012
2LXS
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ALLOSTERIC COMMUNICATION IN THE KIX DOMAIN PROCEEDS THROUGH DYNAMIC RE-PACKING OF THE HYDROPHOBIC CORE
Descriptor:CREB-binding protein, Histone-lysine N-methyltransferase MLL
Authors:Bruschweiler, S., Schanda, P., Konrat, R., Tollinger, M.
Deposit date:2012-08-31
Release date:2013-06-12
Method:SOLUTION NMR
Cite:Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core.
Acs Chem.Biol., 2013
2LXT
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ALLOSTERIC COMMUNICATION IN THE KIX DOMAIN PROCEEDS THROUGH DYNAMIC RE-PACKING OF THE HYDROPHOBIC CORE
Descriptor:CREB-binding protein, Histone-lysine N-methyltransferase MLL, Cyclic AMP-responsive element-binding protein 1
Authors:Bruschweiler, S., Schanda, P., Konrat, R., Tollinger, M.
Deposit date:2012-08-31
Release date:2013-06-12
Method:SOLUTION NMR
Cite:Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core.
Acs Chem.Biol., 2013
4I9O
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CRYSTAL STRUCTURE OF GACKIX L664C TETHERED TO 1-10
Descriptor:CREB-binding protein, 1-{4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl}-3-sulfanylpropan-1-one, 1,2-ETHANEDIOL
Authors:Wang, N., Meagher, J.L., Stuckey, J.A., Mapp, A.K.
Deposit date:2012-12-05
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ordering a dynamic protein via a small-molecule stabilizer.
J.Am.Chem.Soc., 135, 2013
5SVH
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CRYSTAL STRUCTURE OF THE KIX DOMAIN OF CBP IN COMPLEX WITH A MLL/C-MYB CHIMERA
Descriptor:CREB-binding protein, MLL/c-Myb chimera, GLYCEROL, ...
Authors:Langelaan, D.N., Smith, S.P., Allingham, J.A.
Deposit date:2016-08-06
Release date:2018-05-09
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Design of a nanomolar affinity ligand to the KIX domain of CBP
To Be Published
5U4K
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NMR STRUCTURE OF THE COMPLEX BETWEEN THE KIX DOMAIN OF CBP AND THE TRANSACTIVATION DOMAIN 1 OF P65
Descriptor:CREB-binding protein, Transcription factor p65
Authors:Lecoq, L., Raiola, L., Chabot, P.R., Cyr, N., Arseneault, G., Omichinski, J.G.
Deposit date:2016-12-05
Release date:2017-03-08
Last modified:2017-05-31
Method:SOLUTION NMR
Cite:Structural characterization of interactions between transactivation domain 1 of the p65 subunit of NF-kappa B and transcription regulatory factors.
Nucleic Acids Res., 45, 2017
6DMX
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HBZ56 IN COMPLEX WITH KIX AND C-MYB
Descriptor:BZIP factor, Transcriptional activator Myb, CREB-binding protein
Authors:Yang, K., Wright, P.E., Stanfield, R.L.
Deposit date:2018-06-05
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DNQ
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HBZ77 IN COMPLEX WITH KIX AND C-MYB
Descriptor:BZIP factor, Transcriptional activator Myb, CREB-binding protein, ...
Authors:Yang, K., Wright, P.E., Stanfield, R.L.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural basis for cooperative regulation of KIX-mediated transcription pathways by the HTLV-1 HBZ activation domain.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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