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4Z4D
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BU of 4z4d by Molmil
Human Argonaute2 Bound to t1-G Target RNA
Descriptor: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2015-04-02
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.
Elife, 4, 2015
6T5T
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BU of 6t5t by Molmil
Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTGGCCACAAT
Descriptor: 5'-D(*AP*TP*TP*GP*TP*GP*GP*CP*CP*AP*CP*AP*AP*TP)-3', BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Grazulis, S, Zaremba, M.
Deposit date:2019-10-17
Release date:2020-11-18
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7003 Å)
Cite:Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTGGCCACAAT
To be published
4KRE
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BU of 4kre by Molmil
Structure of Human Argonaute-1 bound to endogenous Sf9 RNA
Descriptor: Protein argonaute-1, RNA (5'-R(P*AP*AP*UP*AP*UP*UP*AP*AP*A*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3')
Authors:Faehnle, C.R, Elkayam, E, Joshua-Tor, L.
Deposit date:2013-05-16
Release date:2013-06-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.754 Å)
Cite:The making of a slicer: activation of human argonaute-1.
Cell Rep, 3, 2013
6TUO
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BU of 6tuo by Molmil
Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTACGTACAAT
Descriptor: 5'-D(*AP*TP*TP*GP*TP*AP*CP*GP*TP*AP*CP*AP*AP*TP)-3', BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Grazulis, S, Zaremba, M.
Deposit date:2020-01-07
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTACGTACAAT
To be published
4Z4E
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BU of 4z4e by Molmil
Human Argonaute2 Bound to t1-U Target RNA
Descriptor: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2015-04-02
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.
Elife, 4, 2015
4W5O
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BU of 4w5o by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-9
Descriptor: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2014-08-18
Release date:2014-11-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
6D92
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BU of 6d92 by Molmil
Ternary RsAgo Complex with Guide RNA and Target DNA Containing A-A non-canonical pair at position 3
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*AP*AP*AP*C)-3'), ...
Authors:Liu, Y, Esyunina, D, Olovnikov, I, Teplova, M, Patel, D.J.
Deposit date:2018-04-27
Release date:2018-07-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D95
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BU of 6d95 by Molmil
Ternary RsAgo Complex with Guide RNA Paired and Target DNA containing A8-A8' Non-Canonical Pair
Descriptor: DNA 24-Mer, MAGNESIUM ION, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), ...
Authors:Liu, Y, Esyunina, D, Olovnikov, I, Teplova, M, Patel, D.J.
Deposit date:2018-04-27
Release date:2018-08-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
2YHA
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BU of 2yha by Molmil
Crystal Structure of the N. crassa QDE-2 AGO MID-PIWI Domains
Descriptor: GLYCEROL, POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION
Authors:Boland, A, Weichenrieder, O.
Deposit date:2011-04-27
Release date:2011-06-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of the Mid-Piwi Lobe of a Eukaryotic Argonaute Protein
Proc.Natl.Acad.Sci.USA, 108, 2011
6XUP
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BU of 6xup by Molmil
Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT
Descriptor: 5'-D(*AP*TP*CP*GP*TP*GP*GP*CP*CP*AP*CP*GP*AP*TP)-3', BETA-MERCAPTOETHANOL, CACODYLATE ION, ...
Authors:Grazulis, S, Zaremba, M.
Deposit date:2020-01-20
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT
To be published
2W42
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BU of 2w42 by Molmil
THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT DNA DUPLEX.
Descriptor: 5'-D(*GP*TP*CP*GP*AP*AP*TP*TP)-3', 5'-D(*TP*TP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ...
Authors:Parker, J.S, Roe, S.M, Barford, D.
Deposit date:2008-11-19
Release date:2008-12-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Enhancement of the Seed-Target Recognition Step in RNA Silencing by a Piwi-Mid Domain Protein
Mol.Cell, 33, 2009
6XU0
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BU of 6xu0 by Molmil
Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, 5'-D(*AP*TP*CP*GP*TP*GP*GP*CP*CP*AP*CP*GP*AP*TP)-3', BETA-MERCAPTOETHANOL, ...
Authors:Grazulis, S, Zaremba, M.
Deposit date:2020-01-17
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT
To be published
6OON
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BU of 6oon by Molmil
Human Argonaute4 bound to guide RNA
Descriptor: Protein argonaute-4, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*UP*U)-3')
Authors:Park, M.S, Brackbill, J.A, Nakanishi, K.
Deposit date:2019-04-23
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters.
Mol.Cell, 75, 2019
1W9H
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BU of 1w9h by Molmil
The Structure of a Piwi protein from Archaeoglobus fulgidus.
Descriptor: CADMIUM ION, CHLORIDE ION, HYPOTHETICAL PROTEIN AF1318, ...
Authors:Parker, J.S, Roe, S.M, Barford, D.
Deposit date:2004-10-13
Release date:2005-01-13
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of a Piwi Protein Suggests Mechanisms for Sirna Recognition and Slicer Activity
Embo J., 23, 2004
5AWH
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BU of 5awh by Molmil
Rhodobacter sphaeroides Argonaute in complex with guide RNA/target DNA heteroduplex
Descriptor: DNA (5'-D(*CP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*A)-3'), MAGNESIUM ION, RNA (5'-D(P*UP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3'), ...
Authors:Miyoshi, T, Ito, K, Murakami, R, Uchiumi, T.
Deposit date:2015-07-03
Release date:2016-07-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute.
Nat Commun, 7, 2016
6D9K
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BU of 6d9k by Molmil
Ternary RsAgo Complex with Guide RNA and Target DNA Containing A-G Non-canonical Pair
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*GP*GP*CP*AP*GP*TP*AP*AP*C)-3'), ...
Authors:Liu, Y, Esyunina, D, Olovnikov, I, Teplova, M, Patel, D.J.
Deposit date:2018-04-30
Release date:2018-07-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
5THE
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BU of 5the by Molmil
Crystal structure of the C-terminal lobe of a budding yeast Argonaute
Descriptor: RNA (5'-R(P*UP*AP*AP*AP*AP*AP*AP*A)-3'), Uncharacterized protein
Authors:Dayeh, D.M, Nakanishi, K.
Deposit date:2016-09-29
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Structural and functional analyses reveal the contributions of the C- and N-lobes of Argonaute protein to selectivity of RNA target cleavage.
J. Biol. Chem., 293, 2018
6D8P
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BU of 6d8p by Molmil
Ternary RsAgo Complex Containing Guide RNA Paired with Target DNA
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CACODYLATE ION, ...
Authors:Liu, Y, Esyunina, D, Olovnikov, I, Teplova, M, Patel, D.J.
Deposit date:2018-04-26
Release date:2018-07-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
4KRF
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BU of 4krf by Molmil
Structure of Human Argonaute-1 let-7 complex
Descriptor: Protein argonaute-1, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*UP*U)-3')
Authors:Faehnle, C.R, Elkayam, E, Joshua-Tor, L.
Deposit date:2013-05-16
Release date:2013-06-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:The making of a slicer: activation of human argonaute-1.
Cell Rep, 3, 2013
6D8F
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BU of 6d8f by Molmil
RsAgo Ternary Complex with Guide RNA and Target DNA Containing T-T Bulge Within the Seed Segment
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*TP*TP*TP*AP*AP*C)-3'), ...
Authors:Liu, Y, Esyunina, D, Olovnikov, I, Teplova, M, Patel, D.J.
Deposit date:2018-04-26
Release date:2018-07-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
5KI6
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BU of 5ki6 by Molmil
Human Argonaute-2 bound to a guide RNA with a nucleobase modification at position 1
Descriptor: PHENOL, Protein argonaute-2, miR-122
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2016-06-16
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.153 Å)
Cite:Structure-Guided Control of siRNA Off-Target Effects.
J.Am.Chem.Soc., 138, 2016
4NCB
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BU of 4ncb by Molmil
Structure of Thermus thermophilus Argonaute bound to guide DNA and 19-mer target DNA with Mg2+
Descriptor: 5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*C)-3', 5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', ...
Authors:Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y.
Deposit date:2013-10-24
Release date:2014-01-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.189 Å)
Cite:Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
2BGG
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BU of 2bgg by Molmil
The structure of a Piwi protein from Archaeoglobus fulgidus complexed with a 16nt siRNA duplex.
Descriptor: 5'-R(*GP*UP*CP*GP*AP*AP*UP*UP)-3', 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ...
Authors:Parker, J.S, Roe, S.M, Barford, D.
Deposit date:2004-12-22
Release date:2005-03-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights Into Mrna Recognition from a Piwi Domain-Sirna Guide Complex
Nature, 434, 2005
6CBD
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BU of 6cbd by Molmil
Crystal Structure of Human Argonaute2 Bound to Three Tryptophans
Descriptor: Guide RNA, ISOPROPYL ALCOHOL, MAGNESIUM ION, ...
Authors:Sheu-Gruttadauria, J, MacRae, I.J.
Deposit date:2018-02-02
Release date:2018-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Phase Transitions in the Assembly and Function of Human miRISC.
Cell, 173, 2018
4N41
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BU of 4n41 by Molmil
Structure of Thermus thermophilus Argonaute bound to guide DNA and 15-mer target DNA
Descriptor: 5'-D(*AP*AP*CP*CP*TP*AP*CP*TP*GP*CP*CP*TP*CP*G)-3', 5'-D(P*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*T*GP*TP*AP*TP*AP*GP*T)-3', ...
Authors:Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y.
Deposit date:2013-10-08
Release date:2014-01-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.248 Å)
Cite:Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014

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