PDB: 103 resultsInfo pagesStatus searchChemie searchBIRD

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7YFQ	Cryo-EM structure of the EfPiwi (N959K)-piRNA-target ternary complex Descriptor: MAGNESIUM ION, Piwi, RNA (5'-R(*UP*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*AP*A)-3'), ... Authors: Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. Deposit date: 2022-07-08 Release date: 2024-02-14 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure basis of mammalian Piwi-piRNA silencing machinery To Be Published
8WD8	Cryo-EM structure of TtdAgo-guide DNA-target DNA complex Descriptor: Argonaute family protein, Guide DNA, MAGNESIUM ION, ... Authors: Zhuang, L. Deposit date: 2023-09-14 Release date: 2024-01-31 Last modified: 2024-02-28 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute. Mol.Cell, 84, 2024
8JPX	Cryo-EM structure of PfAgo-guide DNA-target DNA complex Descriptor: Excess DNA, Guide DNA, MAGNESIUM ION, ... Authors: Zhuang, L. Deposit date: 2023-06-13 Release date: 2024-01-31 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonautre Mol.Cell, 84, 2024
8PVV	Archaeoglobus fulgidus AfAgo complex with AfAgo-N protein (fAfAgo) bound with 30 nt RNA guide and 51 nt DNA target Descriptor: Archaeoglobus fulgidus AfAgo-N protein, DNA (51-MER), MAGNESIUM ION, ... Authors: Manakova, E.N, Zaremba, M, Pocevicuite, R, Golovinas, E, Sasnauskas, G, Zagorskaite, E, Silanskas, A. Deposit date: 2023-07-18 Release date: 2024-01-24 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.81 Å) Cite: The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein. Nucleic Acids Res., 52, 2024
8QG0	Archaeoglobus fulgidus AfAgo complex with AfAgo-N protein (fAfAgo) bound with 17 nt RNA guide and 17 nt DNA target Descriptor: AfAgo-N protein, DNA target 17 nt, Piwi protein, ... Authors: Manakova, E.N, Zaremba, M, Pocevicuite, R, Golovinas, E, Zagorskaite, E, Silanskas, A. Deposit date: 2023-09-05 Release date: 2024-01-24 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein. Nucleic Acids Res., 52, 2024
8OK9	Heterodimeric complex of Archaeoglobus fulgidus Argonaute protein Af1318 (AfAgo) with DNA and AfAgo-N protein containing N-L1-L2 domains Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, Archaeoglobus fulgidus AfAgo-N protein, ... Authors: Manakova, E.N, Zaremba, M. Deposit date: 2023-03-27 Release date: 2024-01-24 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein. Nucleic Acids Res., 52, 2024
7YG6	Cryo-EM structure of the EfPiwi(N959K) in complex with piRNA Descriptor: MAGNESIUM ION, Piwi, piRNA Authors: Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. Deposit date: 2022-07-11 Release date: 2024-01-24 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structure basis of mammalian Piwi-piRNA silencing machinery To Be Published
7YGN	Cryo-EM structure of the Mili in complex with piRNA Descriptor: MAGNESIUM ION, Piwi-like protein 2, piRNA Authors: Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. Deposit date: 2022-07-11 Release date: 2024-01-24 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structure basis of mammalian Piwi-piRNA silencing machinery To Be Published
7YFY	Cryo-EM structure of the Mili-piRNA- target ternary complex Descriptor: MAGNESIUM ION, Piwi-like protein 2, RNA (5'-R(P*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*AP*A)-3'), ... Authors: Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. Deposit date: 2022-07-09 Release date: 2024-01-24 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure basis of mammalian Piwi-piRNA silencing machinery To Be Published
7YFX	Cryo-EM structure of Hili in complex with piRNA Descriptor: MAGNESIUM ION, Piwi-like protein 2, piRNA Authors: Li, Z.Q, Liu, H.B, Wu, J.P, Shen, E.Z. Deposit date: 2022-07-09 Release date: 2024-01-24 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure basis of mammalian Piwi-piRNA silencing machinery To Be Published
8D71	Human Ago2 bound to miR122(21nt) Descriptor: MAGNESIUM ION, Protein argonaute-2, miR-122-21nt Authors: Xiao, Y, MacRae, I. Deposit date: 2022-06-07 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength. Embo Rep., 24, 2023
8D6J	Human Ago2 bound to miR122(21nt) with PIWI loop swapped to AtAgo10 sequence Descriptor: MAGNESIUM ION, Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') Authors: Xiao, Y, MacRae, I. Deposit date: 2022-06-06 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength. Embo Rep., 24, 2023
7SVA	Cryo-EM structure of Arabidopsis Ago10-guide RNA complex Descriptor: MAGNESIUM ION, Protein argonaute 10, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') Authors: Xiao, Y, MacRae, I.J. Deposit date: 2021-11-18 Release date: 2022-11-23 Last modified: 2023-07-05 Method: ELECTRON MICROSCOPY (3.26 Å) Cite: Structural basis for RNA slicing by a plant Argonaute. Nat.Struct.Mol.Biol., 30, 2023
7SWQ	Cryo-EM structure of Arabidopsis Ago10-guide-target RNA complex in a bent duplex conformation Descriptor: MAGNESIUM ION, Protein argonaute 10, RNA (5'-R(P*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), ... Authors: Xiao, Y, MacRae, I.J. Deposit date: 2021-11-21 Release date: 2022-11-23 Last modified: 2023-07-05 Method: ELECTRON MICROSCOPY (3.79 Å) Cite: Structural basis for RNA slicing by a plant Argonaute. Nat.Struct.Mol.Biol., 30, 2023
7SWF	Cryo-EM structure of Arabidopsis Ago10-guide-target RNA complex in a central duplex conformation Descriptor: MAGNESIUM ION, Protein argonaute 10, RNA (5'-R(P*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*A)-3'), ... Authors: Xiao, Y, MacRae, I.J. Deposit date: 2021-11-19 Release date: 2022-08-03 Last modified: 2022-10-05 Method: ELECTRON MICROSCOPY (3.79 Å) Cite: The molecular mechanism of microRNA duplex selectivity of Arabidopsis ARGONAUTE10. Nucleic Acids Res., 50, 2022
7KI3	Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA Descriptor: BARIUM ION, HCV genotype 1a miR-122 site-1, Protein argonaute-2, ... Authors: Gebert, L.F.R, MacRae, I.J. Deposit date: 2020-10-22 Release date: 2021-10-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3 Å) Cite: A structured RNA motif locks Argonaute2:miR-122 onto the 5' end of the HCV genome. Nat Commun, 12, 2021
7KX7	Cryo-EM structure of Ephydatia fluviatilis PiwiA-piRNA complex Descriptor: MAGNESIUM ION, Piwi-A, RNA (5'-R(P*UP*CP*UP*CP*AP*GP*(OMC))-3') Authors: Anzelon, T.A, Chowdhury, S, Lander, G.C, MacRae, I.J. Deposit date: 2020-12-03 Release date: 2021-07-14 Last modified: 2021-09-22 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural basis for piRNA targeting. Nature, 597, 2021
7KX9	Cryo-EM structure of Ephydatia fluviatilis PiwiA-piRNA-target complex Descriptor: MAGNESIUM ION, Piwi-A, RNA (5'-R(P*UP*CP*UP*CP*UP*UP*GP*AP*GP*UP*UP*GP*GP*AP*CP*AP*AP*AP*UP*GP*GP*CP*AP*(OMG))-3'), ... Authors: Anzelon, T.A, Chowdhury, S, Lander, G.C, MacRae, I.J. Deposit date: 2020-12-03 Release date: 2021-07-14 Last modified: 2021-09-22 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis for piRNA targeting. Nature, 597, 2021
6XUP	Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT Descriptor: 5'-D(*AP*TP*CP*GP*TP*GP*GP*CP*CP*AP*CP*GP*AP*TP)-3', BETA-MERCAPTOETHANOL, CACODYLATE ION, ... Authors: Grazulis, S, Zaremba, M. Deposit date: 2020-01-20 Release date: 2021-02-03 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT To be published
6XU0	Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, 5'-D(*AP*TP*CP*GP*TP*GP*GP*CP*CP*AP*CP*GP*AP*TP)-3', BETA-MERCAPTOETHANOL, ... Authors: Grazulis, S, Zaremba, M. Deposit date: 2020-01-17 Release date: 2021-01-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Archaeoglobus fulgidus Argonaute protein with DNA oligoduplex 5'-pATCGTGGCCACGAT To be published
6TUO	Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTACGTACAAT Descriptor: 5'-D(*AP*TP*TP*GP*TP*AP*CP*GP*TP*AP*CP*AP*AP*TP)-3', BETA-MERCAPTOETHANOL, CHLORIDE ION, ... Authors: Grazulis, S, Zaremba, M. Deposit date: 2020-01-07 Release date: 2021-01-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTACGTACAAT To be published
6T5T	Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTGGCCACAAT Descriptor: 5'-D(*AP*TP*TP*GP*TP*GP*GP*CP*CP*AP*CP*AP*AP*TP)-3', BETA-MERCAPTOETHANOL, CHLORIDE ION, ... Authors: Grazulis, S, Zaremba, M. Deposit date: 2019-10-17 Release date: 2020-11-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7003 Å) Cite: Crystal structure of Archaeoglobus fulgidus Argonaute protein with cognate DNA oligoduplex 5'-pATTGTGGCCACAAT To be published
6KR6	Crystal structure of Drosophila Piwi Descriptor: MERCURY (II) ION, Protein piwi, ZINC ION, ... Authors: Yamaguchi, S, Oe, A, Yamashita, K, Hirano, S, Mastumoto, N, Ishitani, R, Nishimasu, H, Nureki, O. Deposit date: 2019-08-21 Release date: 2020-02-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structure of Drosophila Piwi. Nat Commun, 11, 2020
6NIT	Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4) Descriptor: Protein argonaute-2, RNA (5'-R(P*AP*AP*CP*AP*CP*CP*AP*UP*CP*CP*AP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') Authors: Sheu-Gruttadauria, J, MacRae, I.J. Deposit date: 2018-12-31 Release date: 2019-08-07 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural Basis for Target-Directed MicroRNA Degradation. Mol.Cell, 75, 2019
6MDZ	Human Argonaute2-miR-122 bound to a target RNA with two central mismatches (bu2) Descriptor: PHENOL, Protein argonaute-2, RNA (5'-R(P*AP*AP*AP*CP*AP*CP*CP*AP*UP*UP*UP*CP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), ... Authors: Sheu-Gruttadauria, J, MacRae, I.J. Deposit date: 2018-09-05 Release date: 2019-08-07 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Structural Basis for Target-Directed MicroRNA Degradation. Mol.Cell, 75, 2019

 

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