1W9H
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THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS.
Descriptor:HYPOTHETICAL PROTEIN AF1318, CADMIUM ION, NICKEL (II) ION, ...
Authors:Parker, J.S., Roe, S.M., Barford, D.
Deposit date:2004-10-13
Release date:2005-01-13
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of a Piwi Protein Suggests Mechanisms for Sirna Recognition and Slicer Activity
Embo J., 23, 2004
1YTU
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STRUCTURAL BASIS FOR 5'-END-SPECIFIC RECOGNITION OF THE GUIDE RNA STRAND BY THE A. FULGIDUS PIWI PROTEIN
Descriptor:5'-R(P*AP*GP*AP*CP*AP*G)-3', 5'-R(P*UP*GP*UP*C)-3', hypothetical protein AF1318, ...
Authors:Ma, J.B., Yuan, Y.R., Meister, G., Pei, Y., Tuschl, T., Patel, D.J.
Deposit date:2005-02-11
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.
Nature, 434, 2005
2BGG
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THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT SIRNA DUPLEX.
Descriptor:PROTEIN AF1318, 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP)-3', 5'-R(*GP*UP*CP*GP*AP*AP*UP*UP)-3', ...
Authors:Parker, J.S., Roe, S.M., Barford, D.
Deposit date:2004-12-22
Release date:2005-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights Into Mrna Recognition from a Piwi Domain-Sirna Guide Complex
Nature, 434, 2005
2W42
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THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT DNA DUPLEX.
Descriptor:PUTATIVE UNCHARACTERIZED PROTEIN, 5'-D(*TP*TP*CP*GP*AP*CP*GP*CP)-3', 5'-D(*GP*TP*CP*GP*AP*AP*TP*TP)-3', ...
Authors:Parker, J.S., Roe, S.M., Barford, D.
Deposit date:2008-11-19
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Enhancement of the Seed-Target Recognition Step in RNA Silencing by a Piwi-Mid Domain Protein
Mol.Cell, 33, 2009
2YHA
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CRYSTAL STRUCTURE OF THE N. CRASSA QDE-2 AGO MID-PIWI DOMAINS
Descriptor:POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION, GLYCEROL
Authors:Boland, A., Weichenrieder, O.
Deposit date:2011-04-27
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of the Mid-Piwi Lobe of a Eukaryotic Argonaute Protein
Proc.Natl.Acad.Sci.USA, 108, 2011
2YHB
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CRYSTAL STRUCTURE OF THE N. CRASSA QDE-2 AGO MID-PIWI DOMAINS
Descriptor:POST-TRANSCRIPTIONAL GENE SILENCING PROTEIN QDE-2, SULFATE ION, GLYCEROL
Authors:Boland, A., Weichenrieder, O.
Deposit date:2011-04-27
Release date:2011-06-15
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Crystal Structure of the Mid-Piwi Lobe of a Eukaryotic Argonaute Protein
Proc.Natl.Acad.Sci.USA, 108, 2011
5AWH
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RHODOBACTER SPHAEROIDES ARGONAUTE IN COMPLEX WITH GUIDE RNA/TARGET DNA HETERODUPLEX
Descriptor:Uncharacterized protein, RNA (5'-D(P*UP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3'), DNA (5'-D(*CP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*A)-3'), ...
Authors:Miyoshi, T., Ito, K., Murakami, R., Uchiumi, T.
Deposit date:2015-07-03
Release date:2016-07-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute.
Nat Commun, 7, 2016
5G5S
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STRUCTURE OF THE ARGONAUTE PROTEIN FROM METHANOCALDCOCCUS JANASCHII
Descriptor:ARGONAUTE, MAGNESIUM ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Schneider, S., Oellig, C.A., Keegan, R., Grohmann, D., Zander, A., Willkomm, S.
Deposit date:2016-06-03
Release date:2017-02-08
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.
Nat Microbiol, 2, 2017
5G5T
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STRUCTURE OF THE ARGONAUTE PROTEIN FROM METHANOCALDCOCCUS JANASCHII IN COMPLEX WITH GUIDE DNA
Descriptor:ARGONAUTE, GUIDE DNA, MAGNESIUM ION, ...
Authors:Schneider, S., Oellig, C.A., Keegan, R., Grohmann, D., Zander, A., Willkomm, S.
Deposit date:2016-06-03
Release date:2017-02-08
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.
Nat Microbiol, 2, 2017
5THE
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CRYSTAL STRUCTURE OF THE C-TERMINAL LOBE OF A BUDDING YEAST ARGONAUTE
Descriptor:Uncharacterized protein, RNA (5'-R(P*UP*AP*AP*AP*AP*AP*AP*A)-3')
Authors:Dayeh, D.M., Nakanishi, K.
Deposit date:2016-09-29
Release date:2018-03-14
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Structural and functional analyses reveal the contributions of the C- and N-lobes of Argonaute protein to selectivity of RNA target cleavage.
J. Biol. Chem., 293, 2018
6D8A
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RSAGO TERNARY COMPLEX WITH GUIDE RNA AND TARGET DNA CONTAINING A-A BULGE WITHIN THE SEED SEGMENT OF THE TARGET STRAND
Descriptor:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*AP*AP*TP*AP*AP*C)-3'), ...
Authors:Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
Deposit date:2018-04-26
Release date:2018-07-25
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D8F
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RSAGO TERNARY COMPLEX WITH GUIDE RNA AND TARGET DNA CONTAINING T-T BULGE WITHIN THE SEED SEGMENT
Descriptor:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*TP*TP*TP*AP*AP*C)-3'), ...
Authors:Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
Deposit date:2018-04-26
Release date:2018-07-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D8P
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TERNARY RSAGO COMPLEX CONTAINING GUIDE RNA PAIRED WITH TARGET DNA
Descriptor:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*TP*AP*AP*C)-3'), ...
Authors:Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
Deposit date:2018-04-26
Release date:2018-07-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D92
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TERNARY RSAGO COMPLEX WITH GUIDE RNA AND TARGET DNA CONTAINING A-A NON-CANONICAL PAIR AT POSITION 3
Descriptor:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*AP*AP*AP*C)-3'), ...
Authors:Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
Deposit date:2018-04-27
Release date:2018-07-25
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D95
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TERNARY RSAGO COMPLEX WITH GUIDE RNA PAIRED AND TARGET DNA CONTAINING A8-A8' NON-CANONICAL PAIR
Descriptor:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA 24-Mer, ...
Authors:Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
Deposit date:2018-04-27
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D9K
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TERNARY RSAGO COMPLEX WITH GUIDE RNA AND TARGET DNA CONTAINING A-G NON-CANONICAL PAIR
Descriptor:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*GP*GP*CP*AP*GP*TP*AP*AP*C)-3'), ...
Authors:Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
Deposit date:2018-04-30
Release date:2018-07-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D9L
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TERNARY RSAGO COMPLEX WITH GUIDE RNA AND TARGET DNA CONTAINING G-A NON-CANONICAL PAIR
Descriptor:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*GP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*AP*GP*CP*AP*GP*TP*AP*AP*C)-3'), ...
Authors:Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
Deposit date:2018-04-30
Release date:2018-07-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
1U04
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CRYSTAL STRUCTURE OF FULL LENGTH ARGONAUTE FROM PYROCOCCUS FURIOSUS
Descriptor:hypothetical protein PF0537
Authors:Song, J.J., Smith, S.K., Hannon, G.J., Joshua-Tor, L.
Deposit date:2004-07-12
Release date:2004-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity
Science, 305, 2004
1YVU
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CRYSTAL STRUCTURE OF A. AEOLICUS ARGONAUTE
Descriptor:hypothetical protein aq_1447, CALCIUM ION
Authors:Yuan, Y.R., Pei, Y., Ma, J.B., Kuryavyi, V., Zhadina, M., Meister, G., Chen, H.Y., Dauter, Z., Tuschl, T., Patel, D.J.
Deposit date:2005-02-16
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of A. aeolicus Argonaute provides unique perspectives into the mechanism of guide strand-mediated mRNA cleavage
Mol.Cell, 19, 2005
1Z25
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STRUCTURE OF P.FURIOSUS ARGONAUTE WITH BOUND MN2+
Descriptor:Argonaute, MANGANESE (II) ION
Authors:Rivas, F.V., Tolia, N.H., Song, J.J., Aragon, J.P., Liu, J., Hannon, G.J., Joshua-Tor, L.
Deposit date:2005-03-07
Release date:2005-04-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Purified Argonaute2 and an siRNA form recombinant human RISC.
Nat.Struct.Mol.Biol., 12, 2005
1Z26
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STRUCTURE OF PYROCOCCUS FURIOSUS ARGONAUTE WITH BOUND TUNGSTATE
Descriptor:Argonaute, TUNGSTATE(VI)ION
Authors:Rivas, F.V., Tolia, N.H., Song, J.J., Aragon, J.P., Liu, J., Hannon, G.J., Joshua-Tor, L.
Deposit date:2005-03-07
Release date:2005-04-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Purified Argonaute2 and an siRNA form recombinant human RISC.
Nat.Struct.Mol.Biol., 12, 2005
2F8S
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CRYSTAL STRUCTURE OF AA-AGO WITH EXTERNALLY-BOUND SIRNA
Descriptor:5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*AP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3', Argonaute protein
Authors:Yuan, Y.R., Chen, H.Y., Patel, D.J.
Deposit date:2005-12-03
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
Structure, 14, 2006
2F8T
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CRYSTAL STRUCTURE OF AA-AGO WITH EXTERNALLY-BOUND SIRNA
Descriptor:26-MER, Argonaute protein
Authors:Yuan, Y.R., Chen, H.Y., Patel, D.J.
Deposit date:2005-12-03
Release date:2006-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
Structure, 14, 2006
2NUB
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STRUCTURE OF AQUIFEX AEOLICUS ARGONUATE
Descriptor:Argonaute
Authors:Rashid, U.J., Paterok, D., Koglin, A., Gohlke, H., Piehler, J., Chen, J.C.-H.
Deposit date:2006-11-09
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function.
J.Biol.Chem., 282, 2007
3DLB
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CRYSTAL STRUCTURE OF THE GUIDE-STRAND-CONTAINING ARGONAUTE PROTEIN SILENCING COMPLEX
Descriptor:argonaute, DNA (5'-D(*DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DA)-3')
Authors:Wang, Y., Sheng, G., Patel, D.J.
Deposit date:2008-06-26
Release date:2008-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the guide-strand-containing argonaute silencing complex.
Nature, 456, 2008
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