PDB: 130 resultsInfo pagesStatus searchChemie searchBIRD

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8VK4	Structure of mouse RyR1 in complex with S100A1 (high-Ca2+/CFF/ATP dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-08 Release date: 2024-02-07 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Structural insights into the regulation of RyR1 by S100A1. To Be Published
8DVV	Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions Descriptor: CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Iyer, K.A, Hu, Y, Murayama, T, Samso, M. Deposit date: 2022-07-29 Release date: 2024-01-31 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions To Be Published
8DTZ	Recombinant mouse RyR2 triple phosphonull mutant S2807A/S2813A/S2030A in complex with FKBP12.6 and nanodisc under closed-state conditions Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION Authors: Iyer, K.A, Hu, Y, Murayama, T, Samso, M. Deposit date: 2022-07-26 Release date: 2024-01-31 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Recombinant mouse RyR2 triple phosphonull mutant S2807A/S2813A/S2030A in complex with FKBP12.6 and nanodisc under closed-state conditions To Be Published
8DTY	Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under closed-state conditions Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION Authors: Iyer, K.A, Hu, Y, Murayama, T, Samso, M. Deposit date: 2022-07-26 Release date: 2024-01-31 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under closed-state conditions To Be Published
8VK3	Structure of mouse RyR1 in complex with S100A1 (EGTA-only dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Peptidyl-prolyl cis-trans isomerase FKBP1A, Protein S100A1, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-08 Release date: 2024-01-24 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Structural insights into the regulation of RyR1 by S100A1 To Be Published
8VJJ	Structure of mouse RyR1 (EGTA-only dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-07 Release date: 2024-01-17 Method: ELECTRON MICROSCOPY (2.53 Å) Cite: Structural insights into the regulation of RyR1 by S100A1. To Be Published
8VJK	Structure of mouse RyR1 (high-Ca2+/CFF/ATP dataset) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, ... Authors: Weninger, G, Marks, A.R. Deposit date: 2024-01-07 Release date: 2024-01-17 Method: ELECTRON MICROSCOPY (2.92 Å) Cite: Structural insights into the regulation of RyR1 by S100A1. To Be Published
8UXI	Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.29 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXL	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXG	Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.08 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXC	Structure of PKA phosphorylated human RyR2-R420Q in the primed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXH	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXM	Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXE	Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXF	Structure of PKA phosphorylated human RyR2-R420W in the primed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UQ2	Structure of human RyR2-S2808D in the subprimed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-10-23 Release date: 2023-11-15 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UQ5	Structure of human RyR2-S2808D in the primed state in the presence of Rapamycin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Ryanodine receptor 2, ZINC ION Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-10-23 Release date: 2023-11-15 Method: ELECTRON MICROSCOPY (3.96 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UQ4	Structure of human RyR2-S2808D in the subprimed state in the presence of H2O2/NOC-12/GSH Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-10-23 Release date: 2023-11-15 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UQ3	Structure of human RyR2-S2808D in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-10-23 Release date: 2023-11-15 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8DRP	Focus/local refined map in C4 of signal subtracted RyR1 particles Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, Ryanodine receptor 1, ... Authors: Haji-Ghassemi, O, Van Petegm, F. Deposit date: 2022-07-21 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (2.84 Å) Cite: Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation. Sci Adv, 9, 2023
8DVE	RyR1 in presence of IpCa-T26E phosphomimetic and activating ligands Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... Authors: Haji-Ghassemi, O, Van Petegm, F. Deposit date: 2022-07-28 Release date: 2023-05-31 Last modified: 2023-07-05 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation. Sci Adv, 9, 2023
8DUJ	Global map in C1 of RyR1 particles in complex with ImperaCalcin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... Authors: Haji-Ghassemi, O, Van Petegm, F. Deposit date: 2022-07-27 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation. Sci Adv, 9, 2023
8DTB	Focus/local refined map in C1 of signal subtracted RyR1 particles in complex with ImperaCalcin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, Imperacalcin, ... Authors: Haji-Ghassemi, O, Van Petegm, F. Deposit date: 2022-07-25 Release date: 2023-05-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: Cryo-EM analysis of scorpion toxin binding to Ryanodine Receptors reveals subconductance that is abolished by PKA phosphorylation. Sci Adv, 9, 2023
8SEN	Cryo-EM Structure of RyR1 Descriptor: Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ZINC ION Authors: Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. Deposit date: 2023-04-10 Release date: 2023-05-24 Last modified: 2023-07-19 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023
8SEW	Cryo-EM Structure of RyR1 + ADP (Local Refinement of TMD) Descriptor: ADENOSINE-5'-DIPHOSPHATE, Ryanodine receptor 1, ZINC ION Authors: Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. Deposit date: 2023-04-10 Release date: 2023-05-24 Last modified: 2023-07-19 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives. Structure, 31, 2023

 

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