Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8OVB
DownloadVisualize
BU of 8ovb by Molmil
Human Complement C3b in complex with Trypanosoma brucei ISG65.
Descriptor: Complement C3, Complement C3f fragment, ISG65 G
Authors:Cook, A.D, Higgins, M.K.
Deposit date:2023-04-25
Release date:2024-02-14
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular mechanism of complement factor C3b inhibition by the trypanosome ISG65 receptor.
To be published
8OQ3
DownloadVisualize
BU of 8oq3 by Molmil
Structure of methylamine treated human complement C3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gadeberg, T.A.F, Andersen, G.R.
Deposit date:2023-04-11
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of methylamine treated human complement C3
To Be Published
8COE
DownloadVisualize
BU of 8coe by Molmil
complement C5 in complex with the LCP0195 nanobody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, Complement C5 beta chain, ...
Authors:Andersen, G.R, Pedersen, D.V.
Deposit date:2023-02-28
Release date:2024-01-03
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration.
Mol.Immunol., 165, 2023
8CML
DownloadVisualize
BU of 8cml by Molmil
Cryo-EM structure of complement C5 in complex with nanobodies UNbC5-1 and UNbC5-2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, Complement C5 beta chain, ...
Authors:De la O Becerra, K.I, Gros, P.
Deposit date:2023-02-20
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies.
J.Biol.Chem., 299, 2023
8CEM
DownloadVisualize
BU of 8cem by Molmil
Structure of bovine native C3, re-refinement
Descriptor: Complement C3 alpha chain, Complement C3 beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Andersen, G.R, Fredslund, F.
Deposit date:2023-02-02
Release date:2023-04-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of bovine complement component 3 reveals the basis for thioester function.
J Mol Biol, 361, 2006
8EOK
DownloadVisualize
BU of 8eok by Molmil
Structure of the C3bB proconvertase in complex with lufaxin and factor Xa
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activated factor Xa heavy chain, Complement C3 beta chain, ...
Authors:Andersen, J.F, Lei, H.
Deposit date:2022-10-03
Release date:2023-08-30
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
8ENU
DownloadVisualize
BU of 8enu by Molmil
Structure of the C3bB proconvertase in complex with lufaxin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ...
Authors:Andersen, J.F, Lei, H.
Deposit date:2022-09-30
Release date:2023-08-09
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism.
Blood, 141, 2023
8B0H
DownloadVisualize
BU of 8b0h by Molmil
2C9, C5b9-CD59 cryoEM structure
Descriptor: CD59 glycoprotein, Complement C5, Complement component C6, ...
Authors:Couves, E.C, Gardner, S, Bubeck, D.
Deposit date:2022-09-07
Release date:2023-02-22
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
8B0G
DownloadVisualize
BU of 8b0g by Molmil
2C9, C5b9-CD59 structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 glycoprotein, Complement C5, ...
Authors:Couves, E.C, Gardner, S, Bubeck, D.
Deposit date:2022-09-07
Release date:2023-02-22
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
8B0F
DownloadVisualize
BU of 8b0f by Molmil
CryoEM structure of C5b8-CD59
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Bubeck, D, Couves, E.C, Gardner, S.
Deposit date:2022-09-07
Release date:2023-02-22
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for membrane attack complex inhibition by CD59.
Nat Commun, 14, 2023
8AYH
DownloadVisualize
BU of 8ayh by Molmil
Structure of Complement C5 in Complex with small molecule inhibitor and CVF
Descriptor: 5-methoxy-2-[[(1~{S})-1-(2-methoxyphenyl)ethyl]carbamoylamino]-4-(4-methylpentoxy)benzoic acid, Cobra venom factor, Complement C5 alpha chain, ...
Authors:Srinivas, H.
Deposit date:2022-09-02
Release date:2022-12-21
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:A small-molecule inhibitor of C5 complement protein.
Nat.Chem.Biol., 15, 2019
7ZGJ
DownloadVisualize
BU of 7zgj by Molmil
Trypanosoma brucei gambiense ISG65 in complex with human complement component C3
Descriptor: 65 kDa invariant surface glycoprotein, putative, Complement C3, ...
Authors:Suelzen, H, Zoll, S.
Deposit date:2022-04-03
Release date:2023-04-05
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Nat Commun, 14, 2023
7ZGK
DownloadVisualize
BU of 7zgk by Molmil
Trypanosoma brucei gambiense ISG65 in complex with human complement component C3b
Descriptor: 65 kDa invariant surface glycoprotein, putative, Complement C3 beta chain, ...
Authors:Suelzen, H, Zoll, S.
Deposit date:2022-04-03
Release date:2023-04-05
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Cryo-EM structures of Trypanosoma brucei gambiense ISG65 with human complement C3 and C3b and their roles in alternative pathway restriction.
Nat Commun, 14, 2023
7TV9
DownloadVisualize
BU of 7tv9 by Molmil
HUMAN COMPLEMENT COMPONENT C3B IN COMPLEX WITH APL-1030
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, APL-1030 Nanofitin, Complement C3 beta chain, ...
Authors:Fontano, E, Nadupalli, A, Lakshminarasimhan, D, White, A, Garlish, J, Cinier, M, Chevrel, A, Perrocheau, A, Eyerman, D, Orme, M, Kitten, O, Scheibler, L.
Deposit date:2022-02-04
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation.
Biomolecules, 12, 2022
7QIV
DownloadVisualize
BU of 7qiv by Molmil
Structure of human C3b in complex with the EWE nanobody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ...
Authors:Pedersen, H, Andersen, G.R.
Deposit date:2021-12-16
Release date:2022-02-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.
Front Immunol, 13, 2022
7Q62
DownloadVisualize
BU of 7q62 by Molmil
Structure of TEV cleaved A2ML1 dimer (A2ML1-TT dimer)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1
Authors:Nielsen, N.S, Zarantonello, A, Andersen, G.R.
Deposit date:2021-11-05
Release date:2022-04-20
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q60
DownloadVisualize
BU of 7q60 by Molmil
Structure of TEV cleaved A2ML1 (A2ML1-TE)
Descriptor: Alpha-2-macroglobulin-like protein 1
Authors:Nielsen, N.S, Zarantonello, A, Andersen, G.R.
Deposit date:2021-11-05
Release date:2022-04-20
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q5Z
DownloadVisualize
BU of 7q5z by Molmil
Cryo-EM structure of native human A2ML1
Descriptor: Alpha-2-macroglobulin-like protein 1
Authors:Zarantonello, A, Nielsen, N.S, Andersen, G.R.
Deposit date:2021-11-05
Release date:2022-04-20
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q61
DownloadVisualize
BU of 7q61 by Molmil
Structure of TEV conjugated A2ML1 (A2ML1-TC)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1
Authors:Nielsen, N.S, Zarantonello, A, Andersen, G.R.
Deposit date:2021-11-05
Release date:2022-04-20
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7Q1Y
DownloadVisualize
BU of 7q1y by Molmil
X-ray structure of human A2ML1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1, ...
Authors:Andersen, G.R, Zarantonello, A, Enghild, J.J, Nielsen, N.S.
Deposit date:2021-10-22
Release date:2022-04-20
Last modified:2022-11-02
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family.
Nat Commun, 13, 2022
7VOO
DownloadVisualize
BU of 7voo by Molmil
Induced alpha-2-macroglobulin monomer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ...
Authors:Huang, X, Wang, Y, Ping, Z.
Deposit date:2021-10-14
Release date:2022-10-19
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
7VON
DownloadVisualize
BU of 7von by Molmil
Native alpha-2-macroglobulin monomer
Descriptor: Alpha-2-macroglobulin
Authors:Huang, X, Wang, Y.
Deposit date:2021-10-14
Release date:2022-11-16
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor.
Sci China Life Sci, 65, 2022
7S63
DownloadVisualize
BU of 7s63 by Molmil
Native-form oocyte/egg Alpha-2-Macroglobulin (A2Moo) tetramer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha 2-Macroglobulin
Authors:Arimura, Y, Funabiki, H.
Deposit date:2021-09-13
Release date:2022-01-05
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (4.12 Å)
Cite:Structural Mechanics of the Alpha-2-Macroglobulin Transformation.
J.Mol.Biol., 434, 2021
7S64
DownloadVisualize
BU of 7s64 by Molmil
Intermediate-form oocyte/egg Alpha-2-Macroglobulin (A2Moo) tetramer
Descriptor: Alpha 2-macroglobulin
Authors:Arimura, Y, Funabiki, H.
Deposit date:2021-09-13
Release date:2022-01-05
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (6.43 Å)
Cite:Structural Mechanics of the Alpha-2-Macroglobulin Transformation.
J.Mol.Biol., 434, 2021
7S62
DownloadVisualize
BU of 7s62 by Molmil
Locally refined protomer structure of native-form oocyte/egg Alpha-2-Macroglobulin (A2Moo) tetramer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha 2-macroglobulin
Authors:Arimura, Y, Funabiki, H.
Deposit date:2021-09-12
Release date:2022-01-05
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Structural Mechanics of the Alpha-2-Macroglobulin Transformation.
J.Mol.Biol., 434, 2021

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon