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2XOV	Crystal Structure of E.coli rhomboid protease GlpG, native enzyme Descriptor: GLYCEROL, RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside Authors: Vinothkumar, K.R, Strisovsky, K, Andreeva, A, Christova, Y, Verhelst, S, Freeman, M. Deposit date: 2010-08-24 Release date: 2010-10-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.65 Å) Cite: The structural basis for catalysis and substrate specificity of a rhomboid protease. EMBO J., 29, 2010
2XTV	Structure of E.coli rhomboid protease GlpG, active site mutant, S201T, orthorhombic crystal form Descriptor: 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, RHOMBOID PROTEASE GLPG Authors: Vinothkumar, K.R. Deposit date: 2010-10-12 Release date: 2011-02-02 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure of rhomboid protease in a lipid environment. J. Mol. Biol., 407, 2011
3B44	Crystal structure of GlpG W136A mutant Descriptor: glpG, nonyl beta-D-glucopyranoside Authors: Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. Deposit date: 2007-10-23 Release date: 2008-01-22 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol., 374, 2007
5MTF	A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases Descriptor: CHLORIDE ION, Rhomboid protease GlpG, inhibitor, ... Authors: Ticha, A, Stanchev, S, Vinothkumar, K.R, Mikles, D.C, Pachl, P, Svehlova, K, Nguyen, M.T.N, Verhelst, S.H.L, Johnson, D, Bachovchin, D, Lepsik, M, Majer, P, Strisovsky, K. Deposit date: 2017-01-09 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.79 Å) Cite: General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
2XTU	Structure of E.coli rhomboid protease GlpG active site mutant, S201T in trigonal crystal form Descriptor: RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside Authors: Vinothkumar, K.R. Deposit date: 2010-10-12 Release date: 2011-02-02 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure of Rhomboid Protease in a Lipid Environment J.Mol.Biol., 407, 2011
3B45	Crystal structure of GlpG at 1.9A resolution Descriptor: glpG, nonyl beta-D-glucopyranoside Authors: Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y. Deposit date: 2007-10-23 Release date: 2008-01-22 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG. J.Mol.Biol., 374, 2007
5MT8	Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-cmk Descriptor: ACE-ARG-VAL-ARG-HIS-ALA-0QE, CHLORIDE ION, Rhomboid protease GlpG, ... Authors: Vinothkumar, K.R. Deposit date: 2017-01-06 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.95 Å) Cite: General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
5MT7	Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-VRHA-cmk Descriptor: ACE-VAL-ARG-HIS-ALA-0QE, Rhomboid protease GlpG Authors: Vinothkumar, K.R. Deposit date: 2017-01-06 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.05 Å) Cite: General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
2XOW	Structure of GlpG in complex with a mechanism-based isocoumarin inhibitor Descriptor: 5-AMINO-2-(2-METHOXY-2-OXOETHYL)BENZOIC ACID, RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside Authors: Vinothkumar, K.R, Strisovsky, K, Andreeva, A, Christova, Y, Verhelst, S, Freeman, M. Deposit date: 2010-08-24 Release date: 2010-10-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.09 Å) Cite: The Structural Basis for Catalysis and Substrate Specificity of a Rhomboid Protease Embo J., 29, 2010
2IC8	Crystal structure of GlpG Descriptor: Protein glpG, nonyl beta-D-glucopyranoside Authors: Ha, Y. Deposit date: 2006-09-12 Release date: 2006-10-17 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of a rhomboid family intramembrane protease. Nature, 444, 2006
5MT6	Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-phenylethyl-ketoamide Descriptor: ACE-ARG-VAL-ARG-HIS-ALA-V9C, Rhomboid protease GlpG, nonyl beta-D-glucopyranoside Authors: Vinothkumar, K.R. Deposit date: 2017-01-06 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.16 Å) Cite: General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
2NR9	Crystal structure of GlpG, Rhomboid Peptidase from Haemophilus influenzae Descriptor: (R)-2-(FORMYLOXY)-3-(PHOSPHONOOXY)PROPYL PENTANOATE, 3,6,12,15,18,21,24-HEPTAOXAHEXATRIACONTAN-1-OL, Protein glpG homolog Authors: Lemieux, M.J, Fischer, S.J, Cherney, M.M, Bateman, K.S, James, M.N.G. Deposit date: 2006-11-01 Release date: 2006-11-14 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis. Proc.Natl.Acad.Sci.USA, 104, 2007
3ZEB	A complex of GlpG with isocoumarin inhibitor covalently bonded to serine 201 and histidine 150 Descriptor: 2-phenylethyl 2-(4-azanyl-2-methanoyl-phenyl)ethanoate, CHLORIDE ION, RHOMBOID PROTEASE GLPG, ... Authors: Vinothkumar, K.R, voskya, O, Kuettler, E.V, Brouwer, A.J, Liskamp, R.M.J, Verhelst, S.H.L. Deposit date: 2012-12-04 Release date: 2013-02-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Activity-Based Probes for Rhomboid Proteases Discovered in a Mass Spectrometry-Based Assay. Proc.Natl.Acad.Sci.USA, 110, 2013
3ZMI	Structure of E.coli rhomboid protease GlpG in complex with monobactam L29 Descriptor: RHOMBOID PROTEASE GLPG, nonyl beta-D-glucopyranoside, phenyl N-[(1R)-3-oxidanylidene-1-phenyl-propyl]carbamate Authors: Vinothkumar, K.R, Pierrat, O.A, Large, J.M, Freeman, M. Deposit date: 2013-02-11 Release date: 2013-05-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of Rhomboid Protease in Complex with Beta-Lactam Inhibitors Defines the S2' Cavity. Structure, 21, 2013
6XRO	Crystal structure of GlpG in complex with peptide boronate inhibitor, Ac-KRFRSMQYSA-B(OH)2 Descriptor: ALANINE BORONIC ACID, CHLORIDE ION, Rhomboid protease GlpG, ... Authors: Urban, S, Cho, S. Deposit date: 2020-07-13 Release date: 2020-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
3TXT	Crystal structure of GlpG in complex with inhibitor DFP Descriptor: DIISOPROPYL PHOSPHONATE, Rhomboid protease glpG Authors: Xue, Y, Ha, Y. Deposit date: 2011-09-23 Release date: 2011-12-07 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The crystal structure of rhomboid protease GlpG in complex with a mechanism-based inhibitor To be Published
5F5B	Structure of E.Coli GlpG complexed with peptidic inhibitor Ac-VRMA-CHO Descriptor: Rhomboid protease GlpG, peptidic derivative of Gurken: ACE-VAL-ARG-MET-ALA-aldehyde Authors: Urban, S, Cho, S, Dickey, S.W. Deposit date: 2015-12-04 Release date: 2016-02-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
5F5G	Structure of E.Coli GlpG Y205F mutant complexed with peptidic inhibitor Ac-RMA-CHO in the DMPC/CHAPSO bicelle Descriptor: ACE-ARG-MET-ALA-aldehyde, Rhomboid protease GlpG Authors: Urban, S, Cho, S, Dickey, S.W. Deposit date: 2015-12-04 Release date: 2016-04-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
6VJ8	Crystal structure of GlpG in complex with peptide chloromethylketone inhibitor Descriptor: Peptide chloromethylketone inhibitor, Rhomboid family intramembrane serine protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2020-01-15 Release date: 2020-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
6VJ9	Crystal structure of GlpG in complex with peptide boronate inhibitor Descriptor: ACE-VAL-ARG-MET-B2A, Rhomboid family intramembrane serine protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2020-01-15 Release date: 2020-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
2IRV	Crystal structure of GlpG, a rhomboid intramembrane serine protease Descriptor: (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, DODECYL-BETA-D-MALTOSIDE, LAURYL DIMETHYLAMINE-N-OXIDE, ... Authors: Bibi, E, Fass, D, Ben-Shem, A. Deposit date: 2006-10-16 Release date: 2006-10-31 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for intramembrane proteolysis by rhomboid serine proteases. Proc.Natl.Acad.Sci.Usa, 104, 2007
6PJ7	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ4	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-27 Release date: 2019-10-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
3ZMH	Structure of E.coli rhomboid protease GlpG in complex with monobactam L62 Descriptor: CHLORIDE ION, CYCLOPENTYL 2-OXO-4-PHENYLAZETIDINE-1-CARBOXYLATE, RHOMBOID PROTEASE GLPG, ... Authors: Vinothkumar, K.R, Pierrat, O.A, Large, J.M, Freeman, M. Deposit date: 2013-02-11 Release date: 2013-05-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of rhomboid protease in complex with beta-lactam inhibitors defines the S2' cavity. Structure, 21, 2013
3ZMJ	Structure of E.coli rhomboid protease GlpG in complex with monobactam L61 Descriptor: 2-methylpropyl N-[(1R)-3-oxidanylidene-1-phenyl-propyl]carbamate, CHLORIDE ION, RHOMBOID PROTEASE GLPG, ... Authors: Vinothkumar, K.R, Pierrat, O, Large, J.M, Freeman, M. Deposit date: 2013-02-11 Release date: 2013-05-22 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of Rhomboid Protease in Complex with Beta-Lactam Inhibitors Defines the S2' Cavity. Structure, 21, 2013

 

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