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8AB5	Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl] Descriptor: Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl], Rhomboid protease GlpG Authors: Skerlova, J, Polovinkin, V, Bach, K, Borshchevskiy, V, Strisovsky, K. Deposit date: 2022-07-04 Release date: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl] To Be Published
6XRO	Crystal structure of GlpG in complex with peptide boronate inhibitor, Ac-KRFRSMQYSA-B(OH)2 Descriptor: ALANINE BORONIC ACID, CHLORIDE ION, Rhomboid protease GlpG, ... Authors: Urban, S, Cho, S. Deposit date: 2020-07-13 Release date: 2020-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
6XRP	Crystal structure of GlpG in complex with peptide ketoamide inhibitor, Ac-RVWHA-ketoamide-phenylbutyl Descriptor: N-(4-phenylbutyl)formamide, Rhomboid protease GlpG, peptide ketoamide inhibitor Authors: Urban, S, Cho, S. Deposit date: 2020-07-13 Release date: 2020-09-16 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
6VJ8	Crystal structure of GlpG in complex with peptide chloromethylketone inhibitor Descriptor: Peptide chloromethylketone inhibitor, Rhomboid family intramembrane serine protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2020-01-15 Release date: 2020-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
6VJ9	Crystal structure of GlpG in complex with peptide boronate inhibitor Descriptor: ACE-VAL-ARG-MET-B2A, Rhomboid family intramembrane serine protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2020-01-15 Release date: 2020-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chem Biol, 27, 2020
6PJU	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-11-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJR	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: CHLORIDE ION, Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJA	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ9	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ7	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJQ	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-11-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ8	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJP	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-28 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ5	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-27 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
6PJ4	Time-resolved structural snapshot of proteolysis by GlpG inside the membrane Descriptor: Peptide aldehyde inhibitor, Rhomboid protease GlpG Authors: Urban, S, Cho, S. Deposit date: 2019-06-27 Release date: 2019-10-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Ten catalytic snapshots of rhomboid intramembrane proteolysis from gate opening to peptide release. Nat.Struct.Mol.Biol., 26, 2019
5MTF	A modular route to novel potent and selective inhibitors of rhomboid intramembrane proteases Descriptor: CHLORIDE ION, Rhomboid protease GlpG, inhibitor, ... Authors: Ticha, A, Stanchev, S, Vinothkumar, K.R, Mikles, D.C, Pachl, P, Svehlova, K, Nguyen, M.T.N, Verhelst, S.H.L, Johnson, D, Bachovchin, D, Lepsik, M, Majer, P, Strisovsky, K. Deposit date: 2017-01-09 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.79 Å) Cite: General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
5MT7	Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-VRHA-cmk Descriptor: ACE-VAL-ARG-HIS-ALA-0QE, Rhomboid protease GlpG Authors: Vinothkumar, K.R. Deposit date: 2017-01-06 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.05 Å) Cite: General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
5MT6	Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-phenylethyl-ketoamide Descriptor: ACE-ARG-VAL-ARG-HIS-ALA-V9C, Rhomboid protease GlpG, nonyl beta-D-glucopyranoside Authors: Vinothkumar, K.R. Deposit date: 2017-01-06 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.16 Å) Cite: General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
5MT8	Structure of E.coli GlpG in complex with peptide derived inhibitor Ac-RVRHA-cmk Descriptor: ACE-ARG-VAL-ARG-HIS-ALA-0QE, CHLORIDE ION, Rhomboid protease GlpG, ... Authors: Vinothkumar, K.R. Deposit date: 2017-01-06 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.95 Å) Cite: General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases. Cell Chem Biol, 24, 2017
5F5B	Structure of E.Coli GlpG complexed with peptidic inhibitor Ac-VRMA-CHO Descriptor: Rhomboid protease GlpG, peptidic derivative of Gurken: ACE-VAL-ARG-MET-ALA-aldehyde Authors: Urban, S, Cho, S, Dickey, S.W. Deposit date: 2015-12-04 Release date: 2016-02-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
5F5D	Crystal structures and Inhibition kinetics reveal a two-state catalytic mechanism with drug design implications for rhomboid proteolysis Descriptor: Rhomboid protease GlpG Authors: Urban, S, Cho, S, Dickey, S.W. Deposit date: 2015-12-04 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
5F5G	Structure of E.Coli GlpG Y205F mutant complexed with peptidic inhibitor Ac-RMA-CHO in the DMPC/CHAPSO bicelle Descriptor: ACE-ARG-MET-ALA-aldehyde, Rhomboid protease GlpG Authors: Urban, S, Cho, S, Dickey, S.W. Deposit date: 2015-12-04 Release date: 2016-04-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
5F5K	E.Coli GlpG Y205F mutant complexed with aldehyde inhibitor in DMPC/CHAPSO bicelle Descriptor: Peptidic derivative of Gurken: ACE-ARG-LYS-VAL-ARG-MET-ALA-aldehyde, Rhomboid protease GlpG Authors: Urban, S, Cho, S, Dickey, S.W. Deposit date: 2015-12-04 Release date: 2016-02-10 Last modified: 2016-02-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
5F5J	E.coli GlpG Y205F mutant complexed with aldehyde inhibitor in DMPC/CHAPSO bicelle Descriptor: Rhomboid protease GlpG, peptidic derivative of Gurken: ACE-VAL-ARG-MET-ALA-aldehyde Authors: Urban, S, Cho, S, Dickey, S. Deposit date: 2015-12-04 Release date: 2016-02-10 Last modified: 2016-02-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis. Mol.Cell, 61, 2016
4NJN	Crystal Structure of E.coli GlpG at pH 4.5 Descriptor: Rhomboid protease GlpG Authors: Dickey, S.W, Baker, R.P, Cho, S, Urban, S. Deposit date: 2013-11-11 Release date: 2013-12-25 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity. Cell(Cambridge,Mass.), 155, 2013

 

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