1AP8
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TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES
Descriptor:TRANSLATION INITIATION FACTOR EIF4E, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Matsuo, H., Li, H., Mcguire, A.M., Fletcher, M., Gingras, A.C., Sonenberg, N., Wagner, G.
Deposit date:1997-07-25
Release date:1998-01-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein.
Nat.Struct.Biol., 4, 1997
1EJ1
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COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYL-GDP
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Marcotrigiano, J., Gingras, A.-C., Sonenberg, N., Burley, S.K.
Deposit date:2000-02-29
Release date:2000-03-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.
Cell(Cambridge,Mass.), 89, 1997
1EJ4
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COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE
Descriptor:EUKARYOTIC INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E BINDING PROTEIN 1, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Marcotrigiano, J., Gingras, A.-C., Sonenberg, N., Burley, S.K.
Deposit date:2000-02-28
Release date:2000-03-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.
Mol.Cell, 3, 1999
1EJH
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EIF4E/EIF4G PEPTIDE/7-METHYL-GDP
Descriptor:EUKARYOTIC INITIATION FACTOR 4E, EUKARYOTIC INITIATION FACTOR 4GII, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Marcotrigiano, J., Gingras, A.-C., Sonenberg, N., Burley, S.K.
Deposit date:2000-03-02
Release date:2000-03-10
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.
Mol.Cell, 3, 1999
1IPB
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CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GPPPA
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE
Authors:Tomoo, K., Shen, X., Okabe, K., Nozoe, Y., Fukuhara, S., Morino, S., Ishida, T., Taniguchi, T., Hasegawa, H., Terashima, A., Sasaki, M., Katsuya, Y., Kitamura, K., Miyoshi, H., Ishikawa, M., Miura, K.
Deposit date:2001-05-08
Release date:2002-05-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region
BIOCHEM.J., 362, 2002
1IPC
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CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E COMPLEXED WITH 7-METHYL GTP
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
Authors:Tomoo, K., Shen, X., Okabe, K., Nozoe, Y., Fukuhara, S., Morino, S., Ishida, T., Taniguchi, T., Hasegawa, H., Terashima, A., Sasaki, M., Katsuya, Y., Kitamura, K., Miyoshi, H., Ishikawa, M., Miura, K.
Deposit date:2001-05-08
Release date:2002-05-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region
BIOCHEM.J., 362, 2002
1L8B
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COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYLGPPPG
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
Authors:Niedzwiecka, A., Marcotrigiano, J., Stepinski, J., Jankowska-Anyszka, M., Wyslouch-Cieszynska, A., Dadlez, M., Gingras, A.-C., Mak, P., Darzynkiewicz, E., Sonenberg, N.
Deposit date:2002-03-19
Release date:2002-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins.
J.Mol.Biol., 319, 2002
1WKW
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF EIF4E-M7GPPPA-4EBP1 PEPTIDE
Descriptor:Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E binding protein 1, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE
Authors:Tomoo, K., Matsushita, Y., Fujisaki, H., Shen, X., Miyagawa, H., Kitamura, K., Miura, K., Ishida, T.
Deposit date:2004-06-10
Release date:2005-06-10
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods
Biochim.Biophys.Acta, 1753, 2005
2GPQ
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CAP-FREE STRUCTURE OF EIF4E SUGGESTS BASIS FOR ITS ALLOSTERIC REGULATION
Descriptor:Eukaryotic translation initiation factor 4E
Authors:Volpon, L., Osborne, M.J., Borden, K.L.B.
Deposit date:2006-04-18
Release date:2006-11-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.
Embo J., 25, 2006
2IDR
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CRYSTAL STRUCTURE OF TRANSLATION INITIATION FACTOR EIF4E FROM WHEAT
Descriptor:Eukaryotic translation initiation factor 4E-1
Authors:Monzingo, A.F., Sadow, J., Dhaliwal, S., Lyon, A., Hoffman, D.W., Robertus, J.D., Browning, K.S.
Deposit date:2006-09-15
Release date:2007-06-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond.
Plant Physiol., 143, 2007
2IDV
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CRYSTAL STRUCTURE OF WHEAT C113S MUTANT EIF4E BOUND TO 7-METHYL-GDP
Descriptor:Eukaryotic translation initiation factor 4E-1, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Monzingo, A.F., Dutt-Chaudhuri, A., Sadow, J., Dhaliwal, S., Hoffman, D.W., Robertus, J.D., Browning, K.S.
Deposit date:2006-09-15
Release date:2007-06-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond.
Plant Physiol., 143, 2007
2JGB
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STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE
Authors:Cameron, A.D., Rosettani, P., Knapp, S., Vismara, M.G., Rusconi, L.
Deposit date:2007-02-12
Release date:2007-02-27
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
J. Mol. Biol., 368, 2007
2JGC
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STRUCTURE OF THE HUMAN EIF4E HOMOLOGOUS PROTEIN, 4EHP WITHOUT LIGAND BOUND
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 2, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1
Authors:Cameron, A.D., Rosettani, P., Knapp, S., Vismara, M.G., Rusconi, L.
Deposit date:2007-02-12
Release date:2007-02-27
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.
J. Mol. Biol., 368, 2007
2V8W
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CRYSTALLOGRAPHIC AND MASS SPECTROMETRIC CHARACTERISATION OF EIF4E WITH N7-CAP DERIVATIVES
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE
Authors:Brown, C.J., Mcnae, I., Fischer, P.M., Walkinshaw, M.D.
Deposit date:2007-08-16
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
2V8X
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CRYSTALLOGRAPHIC AND MASS SPECTROMETRIC CHARACTERISATION OF EIF4E WITH N7-CAP DERIVATIVES
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, 7-BENZYL GUANINE MONOPHOSPHATE
Authors:Brown, C.J., Mcnae, I., Fischer, P.M., Walkinshaw, M.D.
Deposit date:2007-08-16
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
2V8Y
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CRYSTALLOGRAPHIC AND MASS SPECTROMETRIC CHARACTERISATION OF EIF4E WITH N7-CAP DERIVATIVES
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 1, P-FLUORO-7-BENZYL GUANINE MONOPHOSPHATE
Authors:Brown, C.J., Mcnae, I., Fischer, P.M., Walkinshaw, M.D.
Deposit date:2007-08-16
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic and Mass Spectrometric Characterisation of Eif4E with N(7)-Alkylated CAP Derivatives.
J.Mol.Biol., 372, 2007
2W97
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CRYSTAL STRUCTURE OF EIF4E BOUND TO GLYCEROL AND EIF4G1 PEPTIDE
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE, ...
Authors:Brown, C.J., Verma, C.S., Walkinshaw, M.D., Lane, D.P.
Deposit date:2009-01-22
Release date:2010-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystallization of Eif4E Complexed with Eif4Gi Peptide and Glycerol Reveals Distinct Structural Differences Around the CAP-Binding Site.
Cell Cycle, 8, 2009
2WMC
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CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E FROM PISUM SATIVUM
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
Authors:Ashby, J.A., Stevenson, C.E.M., Maule, A.J., Lawson, D.M.
Deposit date:2009-06-30
Release date:2010-09-01
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Based Mutational Analysis of Eif4E in Relation to Sbm1 Resistance to Pea Seed-Borne Mosaic Virus in Pea.
Plos One, 6, 2011
3AM7
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CRYSTAL STRUCTURE OF THE TERNARY COMPLEX OF EIF4E-M7GTP-4EBP2 PEPTIDE
Descriptor:Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 2, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE
Authors:Tomoo, K., Fukuyo, A., In, Y., Ishida, T.
Deposit date:2010-08-17
Release date:2011-08-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the ternary complex of eIF4E-M7GTP-4EBP2 peptide
To be Published
3M93
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COMPLEX CRYSTAL STRUCTURE OF ASCARIS SUUM EIF4E-3 WITH M7G CAP
Descriptor:Translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Liu, W., Berkeley Structural Genomics Center (BSGC)
Deposit date:2010-03-19
Release date:2011-07-20
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation.
Nucleic Acids Res., 39, 2011
3M94
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COMPLEX CRYSTAL STRUCTURE OF ASCARIS SUUM EIF4E-3 WITH M2,2,7G CAP
Descriptor:Translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate), ...
Authors:Liu, W., Berkeley Structural Genomics Center (BSGC)
Deposit date:2010-03-19
Release date:2011-07-20
Last modified:2011-12-14
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation.
Nucleic Acids Res., 39, 2011
3TF2
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CRYSTAL STRUCTURE OF THE CAP FREE HUMAN TRANSLATION INITIATION FACTOR EIF4E
Descriptor:Eukaryotic translation initiation factor 4E, UNKNOWN ATOM OR ION
Authors:Siddiqui, N., Tempel, W., Nedyalkova, L., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Borden, K.L.B., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-08-15
Release date:2011-08-31
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E.
J.Mol.Biol., 415, 2012
3U7X
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CRYSTAL STRUCTURE OF THE HUMAN EIF4E-4EBP1 PEPTIDE COMPLEX WITHOUT CAP
Descriptor:Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, SULFATE ION, ...
Authors:Siddiqui, N., Tempel, W., Nedyalkova, L., Wernimont, A.K., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Borden, K.L.B., Park, H., Structural Genomics Consortium (SGC)
Deposit date:2011-10-14
Release date:2011-11-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E.
J.Mol.Biol., 415, 2012
4AXG
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STRUCTURE OF EIF4E-CUP COMPLEX
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, PROTEIN CUP
Authors:Kinkelin, K., Veith, K., Gruenwald, M., Bono, F.
Deposit date:2012-06-12
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of a Minimal Eif4E-Cup Complex Revelas a General Mechanism of Eif4E Regulation in Translational Repression
RNA, 18, 2012
4AZA
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IMPROVED EIF4E BINDING PEPTIDES BY PHAGE DISPLAY GUIDED DESIGN.
Descriptor:EUKARYOTIC TRANSLATION INITIATION FACTOR 4E, EIF4G1_D5S PEPTIDE, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE
Authors:Chew, W.Z., Quah, S.T., Verma, C.S., Liu, Y., Lane, D.P., Brown, C.J.
Deposit date:2012-06-25
Release date:2012-08-08
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Improved Eif4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects.
Plos One, 7, 2012
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