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1WB9
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Crystal Structure of E. coli DNA Mismatch Repair enzyme MutS, E38T mutant, in complex with a G.T mismatch
Descriptor: 5'-D(*AP*CP*TP*GP*GP*TP*GP*CP*TP*TP *GP*GP*CP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP *CP*AP*CP*CP*AP*GP*TP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Natrajan, G, Georgijevic, D, Lebbink, J.H.G, Winterwerp, H.H.K, de Wind, N, Sixma, T.K.
Deposit date:2004-10-31
Release date:2006-01-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Dual Role of Muts Glutamate 38 in DNA Mismatch Discrimination and in the Authorization of Repair.
Embo J., 25, 2006
1E3M
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The crystal structure of E. coli MutS binding to DNA with a G:T mismatch
Descriptor: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP*CP*AP*CP*CP*AP* GP*TP*GP*TP*CP*AP*GP*CP*GP*TP*CP*CP*TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP*GP*AP*CP*AP*CP* TP*GP*GP*TP*GP*CP*TP*TP*GP*GP*CP*AP*GP*CP*T)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Lamers, M.H, Perrakis, A, Enzlin, J.H, Winterwerp, H.H.K, De Wind, N, Sixma, T.K.
Deposit date:2000-06-19
Release date:2000-11-01
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Crystal Structure of DNA Mismatch Repair Protein Muts Binding to a G X T Mismatch
Nature, 407, 2000
1EWQ
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CRYSTAL STRUCTURE TAQ MUTS COMPLEXED WITH A HETERODUPLEX DNA AT 2.2 A RESOLUTION
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*GP*AP*CP*GP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*CP*TP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*CP*GP*AP*GP*CP*CP*GP*CP*CP*GP*CP*TP*AP*GP*CP*GP*TP*CP*G)-3'), ...
Authors:Obmolova, G, Ban, C, Hsieh, P, Yang, W.
Deposit date:2000-04-26
Release date:2000-10-23
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA.
Nature, 407, 2000
3K0S
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Crystal structure of E.coli DNA mismatch repair protein MutS, D693N mutant, in complex with GT mismatched DNA
Descriptor: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP*CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP*CP*CP*TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP*GP*AP*C*AP*CP*T*GP*GP*TP*GP*CP*TP*TP*GP*GP*CP*AP*GP*CP*T)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Reumer, G.A, Winterwerp, H.H.K, Sixma, T.K.
Deposit date:2009-09-25
Release date:2010-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Magnesium coordination controls the molecular switch function of DNA mismatch repair protein MutS.
J.Biol.Chem., 285, 2010
1W7A
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ATP bound MutS
Descriptor: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP *CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP*CP*CP*TP* AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP *GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*TP*TP*GP*GP*CP*AP*GP* CP*T)-3', ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Lamers, M.H, Georgijevic, D, Lebbink, J, Winterwerp, H.H.K, Agianian, B, de Wind, N, Sixma, T.K.
Deposit date:2004-08-31
Release date:2004-09-10
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:ATP Increases the Affinity between Muts ATPase Domains: Implications for ATP Hydrolysis and Conformational Changes
J.Biol.Chem., 279, 2004
1OH6
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THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN A:A MISMATCH
Descriptor: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*AP*GP *CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP* CP*CP*TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP *GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*AP*TP*GP*GP* CP*AP*GP*CP*T)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Natrajan, G, Lamers, M.H, Enzlin, J.H, Winterwerp, H.H.K, Perrakis, A, Sixma, T.K.
Deposit date:2003-05-23
Release date:2003-08-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of E. Coli DNA Mismatch Repair Enzyme Muts in Complex with Different Mismatches: A Common Recognition Mode for Diverse Substrates
Nucleic Acids Res., 31, 2003
1WBD
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Crystal structure of E. coli DNA mismatch repair enzyme MutS, E38Q mutant, in complex with a G.T mismatch
Descriptor: 5'-D(*AP*CP*TP*GP*GP*TP*GP*CP*TP*TP *GP*GP*CP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP *CP*AP*CP*CP*AP*GP*TP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Natrajan, G, Georgijevic, D, Lebbink, J.H.G, Winterwerp, H.H.K, de Wind, N, Sixma, T.K.
Deposit date:2004-10-31
Release date:2006-01-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dual Role of Muts Glutamate 38 in DNA Mismatch Discrimination and in the Authorization of Repair.
Embo J., 25, 2006
1OH7
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THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A G:G MISMATCH
Descriptor: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP *CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP *CP*CP*TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP *GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*GP*TP*GP*GP *CP*AP*GP*CP*T)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Natrajan, G, Lamers, M.H, Enzlin, J.H, Winterwerp, H.H.K, Perrakis, A, Sixma, T.K.
Deposit date:2003-05-23
Release date:2003-08-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of E. Coli DNA Mismatch Repair Enzyme Muts in Complex with Different Mismatches: A Common Recognition Mode for Diverse Substrates
Nucleic Acids Res., 31, 2003
1WBB
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Crystal structure of E. coli DNA mismatch repair enzyme MutS, E38A mutant, in complex with a G.T mismatch
Descriptor: 5'-D(*AP*CP*TP*GP*GP*TP*GP*CP*TP*TP *GP*GP*CP*AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP *CP*AP*CP*CP*AP*GP*TP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Natrajan, G, Georgijevic, D, Lebbink, J.H.G, Winterwerp, H.H.K, de Wind, N, Sixma, T.K.
Deposit date:2004-10-31
Release date:2006-01-18
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Dual Role of Muts Glutamate 38 in DNA Mismatch Discrimination and in the Authorization of Repair.
Embo J., 25, 2006
6I5F
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Crystal structure of DNA-free E.coli MutS P839E dimer mutant
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein MutS, GLYCEROL, ...
Authors:Bhairosing-Kok, D, Groothuizen, F.S, Fish, A, Dharadhar, S, Winterwerp, H.H.K, Sixma, T.K.
Deposit date:2018-11-13
Release date:2019-08-14
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Sharp kinking of a coiled-coil in MutS allows DNA binding and release.
Nucleic Acids Res., 47, 2019
1NG9
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E.coli MutS R697A: an ATPase-asymmetry mutant
Descriptor: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP*CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP*CP*CP*TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP*GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*TP*TP*GP*GP*CP*AP*GP*CP*T)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Lamers, M.H, Winterwerp, H.H.K, Sixma, T.K.
Deposit date:2002-12-17
Release date:2003-02-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The alternating ATPase domains of MutS control DNA mismatch repair
Embo J., 22, 2003
3THX
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Human MutSbeta complexed with an IDL of 3 bases (Loop3) and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA Loop3 minus strand, DNA Loop3 plus strand, ...
Authors:Yang, W.
Deposit date:2011-08-19
Release date:2011-12-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops
Nat.Struct.Mol.Biol., 19, 2012
1FW6
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CRYSTAL STRUCTURE OF A TAQ MUTS-DNA-ADP TERNARY COMPLEX
Descriptor: 5'-D(*GP*CP*GP*AP*CP*GP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*CP*TP*CP*GP*TP*C)-3', 5'-D(*GP*GP*AP*CP*GP*AP*GP*CP*CP*GP*CP*CP*GP*CP*TP*AP*GP*CP*GP*TP*CP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Junop, M.S, Obmolova, G, Rausch, K, Hsieh, P, Yang, W.
Deposit date:2000-09-21
Release date:2001-02-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair.
Mol.Cell, 7, 2001
2O8B
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human MutSalpha (MSH2/MSH6) bound to ADP and a G T mispair
Descriptor: 5'-D(*CP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*TP*TP*C)-3', 5'-D(*GP*AP*AP*CP*CP*GP*CP*GP*CP*GP*CP*TP*AP*GP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Warren, J.J, Pohlhaus, T.J, Changela, A, Modrich, P.L, Beese, L.S.
Deposit date:2006-12-12
Release date:2007-06-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of the Human MutSalpha DNA Lesion Recognition Complex.
Mol.Cell, 26, 2007
8AG6
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human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (50-MER), DNA mismatch repair protein Msh2, ...
Authors:Bruekner, S.R, Sixma, T.K.
Deposit date:2022-07-19
Release date:2023-01-25
Last modified:2023-03-01
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Unexpected moves: a conformational change in MutS alpha enables high-affinity DNA mismatch binding.
Nucleic Acids Res., 51, 2023
3THY
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Human MutSbeta complexed with an IDL of 2 bases (Loop2) and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA Loop2 minus strand, DNA Loop2 plus strand, ...
Authors:Yang, W.
Deposit date:2011-08-19
Release date:2011-12-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.894 Å)
Cite:Mechanism of mismatch repair revealed by human MutSbeta bound to unpaired DNA loops
Nat.Struct.Mol.Biol., 19, 2012
1OH5
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THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH A C:A MISMATCH
Descriptor: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*CP*GP *CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP *CP*CP*TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP *GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*AP*TP*GP*GP *CP*AP*GP*CP*T)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Natrajan, G, Lamers, M.H, Enzlin, J.H, Winterwerp, H.H.K, Perrakis, A, Sixma, T.K.
Deposit date:2003-05-23
Release date:2003-08-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of E. Coli DNA Mismatch Repair Enzyme Muts in Complex with Different Mismatches: A Common Recognition Mode for Diverse Substrates
Nucleic Acids Res., 31, 2003
1OH8
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THE CRYSTAL STRUCTURE OF E. COLI MUTS BINDING TO DNA WITH AN UNPAIRED THYMIDINE
Descriptor: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP *CP*AP*CP*CP*AP*GP*TP*GP*TP*CP*AP*GP*CP*GP*TP*CP*CP* TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP *GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*CP*TP*TP*GP*GP*CP* AP*GP*CP*T)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Natrajan, G, Lamers, M.H, Enzlin, J.H, Winterwerp, H.H.K, Perrakis, A, Sixma, T.K.
Deposit date:2003-05-23
Release date:2003-08-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of E. Coli DNA Mismatch Repair Enzyme Muts in Complex with Different Mismatches: A Common Recognition Mode for Diverse Substrates
Nucleic Acids Res., 31, 2003
5YK4
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Mismatch Repair Protein
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein MutS
Authors:Nirwal, S, Nair, D.T.
Deposit date:2017-10-12
Release date:2017-11-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Mechanism of formation of a toroid around DNA by the mismatch sensor protein.
Nucleic Acids Res., 46, 2018
2O8D
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human MutSalpha (MSH2/MSH6) bound to ADP and a G dU mispair
Descriptor: 5'-D(*CP*CP*TP*AP*GP*CP*GP*(DU)P*GP*CP*GP*GP*TP*TP*C)-3', 5'-D(*GP*AP*AP*CP*CP*GP*CP*GP*CP*GP*CP*TP*AP*GP*G)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Warren, J.J, Pohlhaus, T.J, Changela, A, Modrich, P.L, Beese, L.S.
Deposit date:2006-12-12
Release date:2007-06-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Human MutSalpha DNA Lesion Recognition Complex.
Mol.Cell, 26, 2007
3THW
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Human MutSbeta complexed with an IDL of 4 bases (Loop4) and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA Loop4 hairpin, DNA mismatch repair protein Msh2, ...
Authors:Yang, W.
Deposit date:2011-08-19
Release date:2011-12-21
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops
Nat.Struct.Mol.Biol., 19, 2012
8OLX
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MutSbeta bound to (CAG)2 DNA (canonical form)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (25-MER), DNA mismatch repair protein Msh2, ...
Authors:Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C.
Deposit date:2023-03-30
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:MutSbeta bound to (CAG)2 DNA (canonical form)
To Be Published
3ZLJ
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CRYSTAL STRUCTURE OF FULL-LENGTH E.COLI DNA MISMATCH REPAIR PROTEIN MUTS D835R MUTANT IN COMPLEX WITH GT MISMATCHED DNA
Descriptor: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP*CP*AP*CP*CP *AP*GP*TP*GP*TP*CP*AP)-3', 5'-D(*TP*GP*AP*CP*AP*CP*TP*GP*GP*TP*GP*CP*TP*TP *GP*GP*CP*AP*GP*CP*TP)-3', DNA MISMATCH REPAIR PROTEIN MUTS
Authors:Groothuizen, F.S, Fish, A, Petoukhov, M.V, Reumer, A, Manelyte, L, Winterwerp, H.H.K, Marinus, M.G, Lebbink, J.H.G, Svergun, D.I, Friedhoff, P, Sixma, T.K.
Deposit date:2013-02-01
Release date:2013-07-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Using Stable Muts Dimers and Tetramers to Quantitatively Analyze DNA Mismatch Recognition and Sliding Clamp Formation.
Nucleic Acids Res., 41, 2013
1NNE
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Crystal Structure of the MutS-ADPBeF3-DNA complex
Descriptor: 1,2-ETHANEDIOL, 5'-D(*GP*CP*GP*AP*CP*GP*CP*TP*AP*GP*CP*GP*TP*GP*CP*GP*GP*CP*TP*CP*GP*TP*C)-3', 5'-D(P*GP*GP*AP*CP*GP*AP*GP*CP*CP*GP*CP*CP*GP*CP*TP*AP*GP*CP*GP*TP*CP*G)-3', ...
Authors:Alani, E, Lee, J.Y, Schofield, M.J, Kijas, A.W, Hsieh, P, Yang, W.
Deposit date:2003-01-13
Release date:2003-05-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Crystal structure and biochemical analysis of the MutS-ADP-Beryllium Fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair
J.Biol.Chem., 278, 2003
8OMQ
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DNA-unbound MutSbeta-ATP complex (straight clamp form)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ...
Authors:Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C.
Deposit date:2023-03-31
Release date:2023-05-24
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:DNA-unbound MutSbeta-ATP complex (straight clamp form)
To Be Published

 

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