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8JPW	Crystal Structure of Single-chain L-Glutamate Oxidase Mutant from Streptomyces sp. X-119-6 Descriptor: 2-OXOGLUTARIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, L-glutamate oxidase, ... Authors: Yamaguchi, H, Takahashi, K, Tatsumi, M, Tagami, U, Mizukoshi, T, Miyano, H, Sugiki, M. Deposit date: 2023-06-13 Release date: 2023-08-09 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Development of a novel single-chain l-glutamate oxidase from Streptomyces sp. X-119-6 by inserting flexible linkers Enzyme.Microb.Technol., 170, 2023
8INL	LSD1 in complex with S2172 Descriptor: 3-[3,5-bis(fluoranyl)-2-phenylmethoxy-phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Niwa, H, Sato, S, Umehara, T. Deposit date: 2023-03-10 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.62 Å) Cite: LSD1 in complex with S2172 To Be Published
8DSV	The structure of NicA2 in complex with N-methylmyosmine Descriptor: DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, FAD-dependent oxidoreductase, ... Authors: Wu, K, Dulchavsky, M, Li, J, Bardwell, J.C.A. Deposit date: 2022-07-22 Release date: 2023-07-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme. Nat.Chem.Biol., 19, 2023
8DQ8	The structure of NicA2 variant F104L/A107T/S146I/G317D/H368R/L449V/N462S in complex with N-methylmyosmine Descriptor: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 1,2-ETHANEDIOL, Amine oxidase, ... Authors: Wu, K, Dulchavsky, M, Li, J, Bardwell, J.C.A. Deposit date: 2022-07-18 Release date: 2023-07-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme. Nat.Chem.Biol., 19, 2023
8DQ7	The structure of NicA2 variant F104L/A107T/S146I/G317D/H368R/L449V/N462S from Pseudomonas putida Descriptor: Amine oxidase, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE Authors: Wu, K, Dulchavsky, M, Li, J, Bardwell, J.C.A. Deposit date: 2022-07-18 Release date: 2023-07-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme. Nat.Chem.Biol., 2023
7ZW3	Crystal Structure of human MAO B in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide (inhibitor 19) Descriptor: 1-(8-oxidanylquinolin-2-yl)-N-(phenylmethyl)methanimine oxide, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Binda, C, Gottinger, A. Deposit date: 2022-05-18 Release date: 2023-03-29 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases. Acta Pharm Sin B, 13, 2023
7ZRY	Structure of the 2a splicing variant of the full-length human LSD1 bound to CoREST (delta305) Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Isoform of Lysine-specific histone demethylase 1A, REST corepressor 1 Authors: Caroli, J, Mattevi, A. Deposit date: 2022-05-06 Release date: 2022-08-03 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism. Iscience, 25, 2022
7XW8	Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAK-418 distomer, FAD-adduct Descriptor: GLYCEROL, Lysine-specific histone demethylase 1A, MAGNESIUM ION, ... Authors: Oki, H. Deposit date: 2022-05-26 Release date: 2022-10-12 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects. Eur.J.Med.Chem., 239, 2022
7XE3	Crystal structure of LSD2 in complex with cis-4-Br-2,5-F2-PCPA (S1024) Descriptor: 1,2-ETHANEDIOL, 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal, CITRATE ANION, ... Authors: Niwa, H, Sato, S, Umehara, T. Deposit date: 2022-03-29 Release date: 2022-09-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13, 2022
7XE2	Crystal structure of LSD2 in complex with trans-4-Br-PCPA Descriptor: 3-(4-bromophenyl)propanal, CITRATE ANION, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Niwa, H, Sato, S, Umehara, T. Deposit date: 2022-03-29 Release date: 2022-09-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13, 2022
7XE1	Crystal structure of LSD2 in complex with cis-4-Br-PCPA Descriptor: 3-(4-bromophenyl)propanal, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... Authors: Niwa, H, Sato, S, Umehara, T. Deposit date: 2022-03-29 Release date: 2022-09-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13, 2022
7W3L	Crystal structure of LSD1 in complex with cis-4-Br-2,5-F2-PCPA (S1024) Descriptor: 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Niwa, H, Sato, S, Umehara, T. Deposit date: 2021-11-25 Release date: 2022-09-14 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13, 2022
7VQU	Crystal structure of LSD1 in complex with compound S1427 Descriptor: 3-[3,5-bis(fluoranyl)-2-[(2-fluoranylpyridin-3-yl)methoxy]phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Niwa, H, Koda, Y, Sato, S, Yamamoto, H, Koyama, H, Umehara, T. Deposit date: 2021-10-20 Release date: 2022-06-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. Acs Med.Chem.Lett., 13, 2022
7VQT	Crystal structure of LSD1 in complex with compound 5 Descriptor: 3-[3,5-bis(fluoranyl)-2-[(2-fluoranylpyridin-4-yl)methoxy]phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Niwa, H, Koda, Y, Sato, S, Yamamoto, H, Koyama, H, Umehara, T. Deposit date: 2021-10-20 Release date: 2022-06-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. Acs Med.Chem.Lett., 13, 2022
7VQS	Crystal structure of LSD1 in complex with compound 4 Descriptor: 3-[3,5-bis(fluoranyl)-2-[(2-fluoranylpyridin-3-yl)methoxy]phenyl]propanal, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... Authors: Niwa, H, Koda, Y, Sato, S, Yamamoto, H, Koyama, H, Umehara, T. Deposit date: 2021-10-20 Release date: 2022-06-01 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. Acs Med.Chem.Lett., 13, 2022
7U6L	Pseudooxynicotine amine oxidase Descriptor: Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE Authors: Choudhary, V, Stull, F, Wu, K. Deposit date: 2022-03-04 Release date: 2022-07-20 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase. J.Biol.Chem., 298, 2022
7RT0	1.80 A resolution structure of MAO from P. nicotinovorans in complex with FAD Descriptor: 4-methylaminobutanoate oxidase (methylamine-forming), FLAVIN-ADENINE DINUCLEOTIDE, TETRAETHYLENE GLYCOL Authors: Lovell, S, Bowman, A, Battaile, K.P, Deay, D.O. Deposit date: 2021-08-12 Release date: 2021-08-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: To be determined To be published
7P4H	Crystal Structure of Monoamine Oxidase B in complex with inhibitor (+)-2 Descriptor: 3,4-dimethyl-7-[[(3~{S})-piperidin-3-yl]methoxy]chromen-2-one, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Iacovino, L.G, Binda, C, Pisani, L. Deposit date: 2021-07-11 Release date: 2022-05-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures. Acs Med.Chem.Lett., 13, 2022
7P4F	Crystal Structure of Monoamine Oxidase B in complex with inhibitor 1 Descriptor: 4-(hydroxymethyl)-7-[[4-[[methyl-(phenylmethyl)amino]methyl]phenyl]methoxy]chromen-2-one, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Iacovino, L.G, Binda, C, Pisani, L. Deposit date: 2021-07-11 Release date: 2022-05-18 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures. Acs Med.Chem.Lett., 13, 2022
7OY0	Structure of human Spermine Oxidase in complex with a highly selective allosteric inhibitor Descriptor: 4-[(4-imidazo[1,2-a]pyridin-3-yl-1,3-thiazol-2-yl)amino]phenol, CHLORIDE ION, FAD-MDL72527 adduct, ... Authors: Impagliazzo, A, Thomsen, M, Johannsson, S, Krapp, S. Deposit date: 2021-06-23 Release date: 2022-07-13 Last modified: 2022-08-17 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Commun Biol, 5, 2022
7OXL	Crystal structure of human Spermine Oxidase Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, FAD-MDL72527 adduct, ... Authors: Impagliazzo, A, Johannsson, S, Thomsen, M, Krapp, S. Deposit date: 2021-06-22 Release date: 2022-07-13 Last modified: 2022-08-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Commun Biol, 5, 2022
7OG2	Crystal structure of Pseudoalteromonas luteoviolacea L-amino acid oxidase Descriptor: Amine oxidoreductase, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Rozeboom, H.J, Savino, S, Fraaije, M.W. Deposit date: 2021-05-06 Release date: 2021-11-10 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Kinetic and Structural Properties of a Robust Bacterial L-Amino Acid Oxidase Catalysts, 2021
7KHO	NicA2 variant N462V in complex with (S)-nicotine Descriptor: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE Authors: Tararina, M.A, Allen, K.N. Deposit date: 2020-10-21 Release date: 2021-02-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2. Biochemistry, 60, 2021
7KHN	NicA2 variant N462Y/W427Y in complex with (S)-nicotine Descriptor: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE Authors: Tararina, M.A, Allen, K.N. Deposit date: 2020-10-21 Release date: 2021-02-03 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2. Biochemistry, 60, 2021
7EME	Putative Leptospira interrogans recombinant L-amino acid oxidase Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, NAD(P)/FAD-dependent oxidoreductase Authors: Vaigundan, D, Yuvaraj, I, Krishnaswamy, P.R, Sekar, K, Murthy, M.R.N, Sunita, P. Deposit date: 2021-04-13 Release date: 2021-08-18 Last modified: 2023-03-01 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Structural characterization of a putative recombinant L-amino acid oxidase from Leptospira interrogans Curr.Sci., 123, 2022

 

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