1FYV
 
 | | CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1 | | Descriptor: | TOLL-LIKE RECEPTOR 1 | | Authors: | Xu, Y, Tao, X, Shen, B, Horng, T, Medzhitov, R, Manley, J.L, Tong, L. | | Deposit date: | 2000-10-03 | | Release date: | 2000-11-22 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Nature, 408, 2000
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1FYW
 | | CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR2 | | Descriptor: | TOLL-LIKE RECEPTOR 2 | | Authors: | Xu, Y, Tao, X, Shen, B, Horng, T, Medzhitov, R, Manley, J.L, Tong, L, Northeast Structural Genomics Consortium (NESG) | | Deposit date: | 2000-10-03 | | Release date: | 2000-11-22 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Nature, 408, 2000
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1FYX
 | | CRYSTAL STRUCTURE OF P681H MUTANT OF TIR DOMAIN OF HUMAN TLR2 | | Descriptor: | TOLL-LIKE RECEPTOR 2 | | Authors: | Xu, Y, Tao, X, Shen, B, Horng, T, Medzhitov, R, Manley, J.L, Tong, L. | | Deposit date: | 2000-10-03 | | Release date: | 2000-11-22 | | Last modified: | 2021-11-03 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Nature, 408, 2000
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1O77
 | | CRYSTAL STRUCTURE OF THE C713S MUTANT OF THE TIR DOMAIN OF HUMAN TLR2 | | Descriptor: | TOLL-LIKE RECEPTOR 2 | | Authors: | Tao, X, Xu, Y, Ye, Z, Beg, A.A, Tong, L. | | Deposit date: | 2002-10-24 | | Release date: | 2002-11-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | An Extensively Associated Dimer in the Structure of the C713S Mutant of the Tir Domain of Human Tlr2
Biochem.Biophys.Res.Commun., 299, 2002
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1T3G
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2J67
 | | The TIR domain of human Toll-Like Receptor 10 (TLR10) | | Descriptor: | TOLL LIKE RECEPTOR 10 | | Authors: | Stenmark, P, Ogg, D, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ericsson, U.B, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Johansson, I, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson, M.E, Nilsson-Ehle, P, Nyman, T, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Wallden, K, Weigelt, J, Welin, M, Nordlund, P. | | Deposit date: | 2006-09-26 | | Release date: | 2006-09-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Crystal Structure of the Human Toll-Like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer.
J.Biol.Chem., 283, 2008
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3J0A
 | | Homology model of human Toll-like receptor 5 fitted into an electron microscopy single particle reconstruction | | Descriptor: | Toll-like receptor 5, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Modis, Y, Zhou, K, Kanai, R, Lee, P, Wang, H.W. | | Deposit date: | 2011-06-02 | | Release date: | 2011-12-28 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (26 Å) | | Cite: | Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.
J.Struct.Biol., 177, 2012
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3JRN
 | | Crystal structure of TIR domain from Arabidopsis Thaliana | | Descriptor: | ARSENIC, AT1G72930 protein | | Authors: | Chan, S.L, Mukasa, T, Santelli, E, Low, L.Y, Pascual, J. | | Deposit date: | 2009-09-08 | | Release date: | 2009-10-20 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of a TIR domain from Arabidopsis thaliana reveals a conserved helical region unique to plants.
Protein Sci., 19, 2009
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3OZI
 | | Crystal structure of the TIR domain from the flax disease resistance protein L6 | | Descriptor: | COBALT (II) ION, L6tr | | Authors: | Ve, T, Bernoux, M, Williams, S, Valkov, E, Warren, C, Hatters, D, Ellis, J.G, Dodds, P.N, Kobe, B. | | Deposit date: | 2010-09-25 | | Release date: | 2011-04-27 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation.
Cell Host Microbe, 9, 2011
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4C6R
 | | Crystal structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RPS4 | | Descriptor: | DISEASE RESISTANCE PROTEIN RPS4 | | Authors: | Williams, S.J, Sohn, K.H, Wan, L, Bernoux, M, Ma, Y, Segonzac, C, Ve, T, Sarris, P, Ericsson, D.J, Saucet, S.B, Zhang, X, Parker, J, Dodds, P.N, Jones, J.D.G, Kobe, B. | | Deposit date: | 2013-09-19 | | Release date: | 2014-05-28 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor.
Science, 344, 2014
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4C6T
 | | Crystal structure of the RPS4 and RRS1 TIR domain heterodimer | | Descriptor: | DISEASE RESISTANCE PROTEIN RPS4, MALONIC ACID, PROBABLE WRKY TRANSCRIPTION FACTOR 52 | | Authors: | Williams, S.J, Sohn, K.H, Wan, L, Bernoux, M, Ma, Y, Segonzac, C, Ve, T, Sarris, P, Ericsson, D.J, Saucet, S.B, Zhang, X, Parker, J, Dodds, P.N, Jones, J.D.G, Kobe, B. | | Deposit date: | 2013-09-19 | | Release date: | 2014-05-28 | | Last modified: | 2015-04-22 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor.
Science, 344, 2014
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4OM7
 | | Crystal structure of TIR domain of TLR6 | | Descriptor: | Toll-like receptor 6 | | Authors: | Park, H.H, Jang, T.H. | | Deposit date: | 2014-01-26 | | Release date: | 2014-08-06 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.204 Å) | | Cite: | Crystal Structure of TIR Domain of TLR6 Reveals Novel Dimeric Interface of TIR-TIR Interaction for Toll-Like Receptor Signaling Pathway.
J.Mol.Biol., 426, 2014
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5H3C
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5KU7
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5TEB
 | | Crystal Structure of the TIR domain from the Arabidopsis Thaliana disease resistance protein RPP1 | | Descriptor: | Recognition of Peronospora parasitica 1 | | Authors: | Bentham, A.R, Zhang, X, Croll, T, Williams, S, Kobe, B. | | Deposit date: | 2016-09-20 | | Release date: | 2017-02-01 | | Last modified: | 2020-01-01 | | Method: | X-RAY DIFFRACTION (2.796 Å) | | Cite: | Multiple functional self-association interfaces in plant TIR domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5TEC
 | | Crystal structure of the TIR domain from the Arabidopsis thaliana NLR protein SNC1 | | Descriptor: | Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1 | | Authors: | Zhang, X, Bentham, A, Ve, T, Williams, S.J, Kobe, B. | | Deposit date: | 2016-09-20 | | Release date: | 2017-02-01 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Multiple functional self-association interfaces in plant TIR domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6O0W
 | | Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 in complex with NADP+ and Bis-Tris | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE-2'-5'-DIPHOSPHATE, TIR-NB-LRR type resistance protein RUN1 | | Authors: | Horsefield, S, Burdett, H, Zhang, X, Manik, M.K, Shi, Y, Chen, J, Tiancong, Q, Gilley, J, Lai, J, Gu, W, Rank, M, Casey, L, Ericsson, D.J, Foley, G, Hughes, R.O, Bosanac, T, von Itzstein, M, Rathjen, J.P, Nanson, J.D, Boden, M, Dry, I.B, Williams, S.J, Staskawicz, B.J, Coleman, M.P, Ve, T, Dodds, P.N, Kobe, B. | | Deposit date: | 2019-02-17 | | Release date: | 2019-09-04 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
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7C76
 | | Cryo-EM structure of human TLR3 in complex with UNC93B1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ... | | Authors: | Ohto, U, Ishida, H, Shimizu, T. | | Deposit date: | 2020-05-23 | | Release date: | 2021-01-06 | | Last modified: | 2021-02-24 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
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7C77
 | | Cryo-EM structure of mouse TLR3 in complex with UNC93B1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ... | | Authors: | Ohto, U, Ishida, H, Shimizu, T. | | Deposit date: | 2020-05-23 | | Release date: | 2021-01-06 | | Last modified: | 2021-02-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
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7CRB
 | | Cryo-EM structure of plant NLR RPP1 LRR-ID domain in complex with ATR1 | | Descriptor: | Avirulence protein ATR1, NAD+ hydrolase (NADase) | | Authors: | Ma, S.C, Lapin, D, Liu, L, Sun, Y, Song, W, Zhang, X.X, Logemann, E, Yu, D.L, Wang, J, Jirschitzka, J, Han, Z.F, SchulzeLefert, P, Parker, J.E, Chai, J.J. | | Deposit date: | 2020-08-13 | | Release date: | 2020-12-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme.
Science, 370, 2020
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7CRC
 | | Cryo-EM structure of plant NLR RPP1 tetramer in complex with ATR1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Avirulence protein ATR1, ... | | Authors: | Ma, S.C, Lapin, D, Liu, L, Sun, Y, Song, W, Zhang, X.X, Logemann, E, Yu, D.L, Wang, J, Jirschitzka, J, Han, Z.F, SchulzeLefert, P, Parker, J.E, Chai, J.J. | | Deposit date: | 2020-08-13 | | Release date: | 2020-12-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme.
Science, 370, 2020
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7CYN
 | | Cryo-EM structure of human TLR7 in complex with UNC93B1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ... | | Authors: | Ohto, U, Ishida, H, Shimizu, T. | | Deposit date: | 2020-09-03 | | Release date: | 2021-01-06 | | Last modified: | 2021-02-24 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Nat.Struct.Mol.Biol., 28, 2021
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7DFV
 | | Cryo-EM structure of plant NLR RPP1 tetramer core part | | Descriptor: | NAD+ hydrolase (NADase) | | Authors: | Ma, S.C, Lapin, D, Liu, L, Sun, Y, Song, W, Zhang, X.X, Logemann, E, Yu, D.L, Wang, J, Jirschitzka, J, Han, Z.F, SchulzeLefert, P, Parker, J.E, Chai, J.J. | | Deposit date: | 2020-11-10 | | Release date: | 2020-12-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme.
Science, 370, 2020
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7FCC
 | | IL-1RAcPb TIR domain | | Descriptor: | Isoform 4 of Interleukin-1 receptor accessory protein | | Authors: | Wang, X, Zhou, J. | | Deposit date: | 2021-07-14 | | Release date: | 2022-07-20 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.144 Å) | | Cite: | Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling
Iscience, 25, 2022
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7FCH
 | | IL-18Rbeta TIR domain | | Descriptor: | Interleukin-18 receptor accessory protein | | Authors: | Wang, X, Zhou, J. | | Deposit date: | 2021-07-14 | | Release date: | 2022-07-20 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.883 Å) | | Cite: | Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling
Iscience, 25, 2022
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