4JKV
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STRUCTURE OF THE HUMAN SMOOTHENED 7TM RECEPTOR IN COMPLEX WITH AN ANTITUMOR AGENT
Descriptor:Soluble cytochrome b562, Smoothened homolog, 4-fluoro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide, ...
Authors:Wang, C., Wu, H., Katritch, V., Han, G.W., Huang, X., Liu, W., Siu, F.Y., Roth, B.L., Cherezov, V., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2013-03-11
Release date:2013-04-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure of the human smoothened receptor bound to an antitumour agent.
Nature, 497, 2013
4N4W
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STRUCTURE OF THE HUMAN SMOOTHENED RECEPTOR IN COMPLEX WITH SANT-1.
Descriptor:Cytochrome b(562),Smoothened homolog, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Wang, C., Wu, H., Han, G.W., Cherezov, V., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2013-10-08
Release date:2014-01-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Nat Commun, 5, 2014
4O9R
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HUMAN SMOOTHENED RECEPTOR STRUCTURE IN COMPLEX WITH CYCLOPAMINE
Descriptor:Smoothened homolog/Soluble cytochrome b562 chimeric protein, Cyclopamine
Authors:Wang, C., Weierstall, U., James, D., White, T.A., Wang, D., Liu, W., Spence, J.C.H., Doak, R.B., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N.A., Liu, H., Basu, S., Wacker, D., Han, G.W., Katritch, V., Boutet, S., Messerschmidt, M., Willams, G.J., Koglin, J.E., Seibert, M.M., Klinker, M., Gati, C., Shoeman, R.L., Barty, A., Chapman, H.N., Kirian, R.A., Beyerlein, K.R., Stevens, R.C., Li, D., Shah, S.T.A., Howe, N., Caffrey, M., Cherezov, V., GPCR Network (GPCR)
Deposit date:2014-01-02
Release date:2014-03-05
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (3.204 Å)
Cite:Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.
Nat Commun, 5, 2014
4QIM
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STRUCTURE OF THE HUMAN SMOOTHENED RECEPTOR IN COMPLEX WITH ANTA XV
Descriptor:Smoothened homolog/Soluble cytochrome b562 chimeric protein, 2-{6-[4-(4-benzylphthalazin-1-yl)piperazin-1-yl]pyridin-3-yl}propan-2-ol, ZINC ION
Authors:Wang, C., Wu, H., Evron, T., Vardy, E., Han, G.W., Huang, X.-P., Hufeisen, S.J., Mangano, T.J., Urban, D.J., Katritch, V., Cherezov, V., Caron, M.G., Roth, B.L., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Nat Commun, 5, 2014
4QIN
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STRUCTURE OF THE HUMAN SMOOTHENED RECEPTOR IN COMPLEX WITH SAG1.5
Descriptor:Smoothened homolog/Soluble cytochrome b562 chimeric protein, 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide
Authors:Wang, C., Wu, H., Evron, T., Vardy, E., Han, G.W., Huang, X.-P., Hufeisen, S.J., Mangano, T.J., Urban, D.J., Katritch, V., Cherezov, V., Caron, M.G., Roth, B.L., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2014-05-31
Release date:2014-07-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.
Nat Commun, 5, 2014
5L7D
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STRUCTURE OF HUMAN SMOOTHENED IN COMPLEX WITH CHOLESTEROL
Descriptor:Smoothened homolog,Soluble cytochrome b562,Smoothened homolog, N-ACETYL-D-GLUCOSAMINE, CHOLESTEROL, ...
Authors:Byrne, E.F.X., Sircar, R., Miller, P.S., Hedger, G., Luchetti, G., Nachtergaele, S., Tully, M.D., Mydock-McGrane, L., Covey, D.F., Rambo, R.P., Sansom, M.S.P., Newstead, S., Rohatgi, R., Siebold, C.
Deposit date:2016-06-03
Release date:2016-07-20
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535, 2016
5L7I
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STRUCTURE OF HUMAN SMOOTHENED IN COMPLEX WITH VISMODEGIB
Descriptor:Smoothened homolog,Soluble cytochrome b562,Smoothened homolog, N-ACETYL-D-GLUCOSAMINE, 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, ...
Authors:Byrne, E.X.B., Sircar, R., Miller, P.S., Hedger, G., Luchetti, G., Nachtergaele, S., Tully, M.D., Mydock-McGrane, L., Covey, D.F., Rambo, R.F., Sansom, M.S.P., Newstead, S., Rohatgi, R., Siebold, C.
Deposit date:2016-06-03
Release date:2016-07-20
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535, 2016
5V56
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2.9A XFEL STRUCTURE OF THE MULTI-DOMAIN HUMAN SMOOTHENED RECEPTOR (WITH E194M MUTATION) IN COMPLEX WITH TC114
Descriptor:Smoothened homolog,Flavodoxin,Smoothened homolog, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., Dharmarajan, V., Griffin, P.R., Gati, C., Nelson, G., Hunter, M.S., Hanson, M.A., Cherezov, V., Stevens, R.C., Tan, W., Tao, H., Xu, F.
Deposit date:2017-03-13
Release date:2017-05-24
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
5V57
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3.0A SYN STRUCTURE OF THE MULTI-DOMAIN HUMAN SMOOTHENED RECEPTOR IN COMPLEX WITH TC114
Descriptor:Smoothened homolog,Flavodoxin,Smoothened homolog, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., Dharmarajan, V., Griffin, P.R., Gati, C., Nelson, G., Hunter, M.S., Hanson, M.A., Cherezov, V., Stevens, R.C., Tan, W., Tao, H., Xu, F.
Deposit date:2017-03-13
Release date:2017-05-24
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
6BD4
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CRYSTAL STRUCTURE OF HUMAN APO-FRIZZLED4 RECEPTOR
Descriptor:Frizzled-4/Rubredoxin chimeric protein, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Yang, S., Wu, Y., Pu, M., Chen, Y., Dong, S., Guo, Y., Han, G.Y., Stevens, R.C., Zhao, S., Xu, F.
Deposit date:2017-10-21
Release date:2018-08-22
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
6D32
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CRYSTAL STRUCTURE OF XENOPUS SMOOTHENED IN COMPLEX WITH CYCLOPAMINE
Descriptor:Smoothened,Soluble cytochrome b562,Smoothened, Cyclopamine
Authors:Huang, P., Zheng, S., Kim, Y., Kruse, A.C., Salic, A.
Deposit date:2018-04-14
Release date:2018-05-23
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.751 Å)
Cite:Structural Basis of Smoothened Activation in Hedgehog Signaling.
Cell, 174, 2018
6D35
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CRYSTAL STRUCTURE OF XENOPUS SMOOTHENED IN COMPLEX WITH CHOLESTEROL
Descriptor:Smoothened,Soluble cytochrome b562,Smoothened, CHOLESTEROL
Authors:Huang, P., Zheng, S., Kim, Y., Kruse, A.C., Salic, A.
Deposit date:2018-04-14
Release date:2018-05-23
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural Basis of Smoothened Activation in Hedgehog Signaling.
Cell, 174, 2018
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