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1SQM
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BU of 1sqm by Molmil
STRUCTURE OF [R563A] LEUKOTRIENE A4 HYDROLASE
Descriptor: ACETIC ACID, IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, ...
Authors:Tholander, F.O.T, Rudberg, P.C, Thunnissen, M.M.G.M, Haeggstrom, J.Z.
Deposit date:2004-03-19
Release date:2004-08-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates
J.Biol.Chem., 279, 2004
7ZYF
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Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Mpakali, A, Stratikos, E, Giastas, P, Papakyriakou, A.
Deposit date:2022-05-24
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin.
J.Med.Chem., 65, 2022
7SH0
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CRYSTAL STRUCTURE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 (ERAP2) COMPLEX WITH A HIGHLY SELECTIVE AND POTENT SMALL MOLECULE
Descriptor: (2S)-N-hydroxy-3-(4-methoxyphenyl)-2-[4-({[5-(pyridin-2-yl)thiophene-2-sulfonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Li, L, Bouvier, M.
Deposit date:2021-10-07
Release date:2022-07-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis.
Angew.Chem.Int.Ed.Engl., 61, 2022
6YDX
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Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor
Descriptor: 1,2-ETHANEDIOL, 2-[2-[[[(4~{R},8~{S},11~{S})-11-azanyl-8-[(4-hydroxyphenyl)methyl]-6,10-bis(oxidanylidene)-1,2-dithia-5,9-diazacyclotridec-4-yl]carbonylamino]methyl]phenyl]ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Mpakali, A, Saridakis, E, Giastas, P, Stratikos, E.
Deposit date:2020-03-21
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis of Inhibition of Insulin-Regulated Aminopeptidase by a Macrocyclic Peptidic Inhibitor.
Acs Med.Chem.Lett., 11, 2020
1GW6
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STRUCTURE OF LEUKOTRIENE A4 HYDROLASE D375N MUTANT
Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ...
Authors:Rudberg, P.C, Tholander, F, Thunnissen, M.M.G.M, Samuelsson, B, Haeggstrom, J.Z.
Deposit date:2002-03-07
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Leukotriene A4 Hydrolase: Selective Abrogation of Leukotriene B4 Formation by Mutation of Aspartic Acid 375
Proc.Natl.Acad.Sci.USA, 99, 2002
1H19
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STRUCTURE OF [E271Q]LEUKOTRIENE A4 HYDROLASE
Descriptor: ACETIC ACID, IMIDAZOLE, LEUKOTRIENE A-4 HYDROLASE, ...
Authors:Rudberg, P.C, Tholander, F, Thunnissen, M.M.G.M, Haeggstrom, J.Z.
Deposit date:2002-07-04
Release date:2002-08-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Leukotriene A4 Hydrolase/Aminopeptidase, Glutamate 271 is a Catalyticresidue with Specific Roles in Two Distinct Enzyme Mechanisms
J.Biol.Chem., 277, 2002
8SW1
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Puromycin-sensitive aminopeptidase with bound peptide
Descriptor: Polyglutamine peptide, Puromycin-sensitive aminopeptidase, ZINC ION
Authors:Rodgers, D.W, Madabushi, S.
Deposit date:2023-05-17
Release date:2023-07-26
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Structure of puromycin-sensitive aminopeptidase and polyglutamine binding.
Plos One, 18, 2023
8SW0
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Puromycin sensitive aminopeptidase
Descriptor: 1,4-DIETHYLENE DIOXIDE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Puromycin-sensitive aminopeptidase, ...
Authors:Rodgers, D.W, Sampath, S.
Deposit date:2023-05-17
Release date:2023-07-26
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure of puromycin-sensitive aminopeptidase and polyglutamine binding.
Plos One, 18, 2023
1HS6
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STRUCTURE OF LEUKOTRIENE A4 HYDROLASE COMPLEXED WITH BESTATIN.
Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, ACETATE ION, IMIDAZOLE, ...
Authors:Thunnissen, M.M.G.M, Nordlund, P.N, Haeggstrom, J.Z.
Deposit date:2000-12-24
Release date:2001-06-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.
Nat.Struct.Biol., 8, 2001
7KZE
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Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity
Descriptor: 1-benzyl-4-methoxybenzene, Leukotriene A-4 hydrolase, TRIETHYLENE GLYCOL, ...
Authors:Lee, K.H, Shim, Y, Paige, M, Noble, S.M.
Deposit date:2020-12-10
Release date:2022-06-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Substrate-dependent modulation of the leukotriene A 4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation.
Sci Rep, 12, 2022
7LLQ
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Substrate-dependent divergence of leukotriene A4 hydrolase aminopeptidase activity
Descriptor: 1-benzyl-4-methoxybenzene, 1-{4-oxo-4-[(2S)-pyrrolidin-2-yl]butanoyl}-L-proline, Leukotriene A-4 hydrolase, ...
Authors:Lee, K.H, Lee, S.H, Shim, Y.M, Paige, M, Noble, S.M.
Deposit date:2021-02-04
Release date:2022-06-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Substrate-dependent modulation of the leukotriene A 4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation.
Sci Rep, 12, 2022
5J6S
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Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand
Descriptor: (2S)-N~1~-benzyl-2-[(4-fluorophenyl)methyl]-N~3~-hydroxypropanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Saridakis, E, Giastas, P, Mpakali, A, Deprez-Poulain, R, Stratikos, E.
Deposit date:2016-04-05
Release date:2017-03-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.
ACS Med Chem Lett, 8, 2017
5K1V
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Crystal structure of Endoplasmic Reticulum aminopeptidase 2 (ERAP2) in complex with a diaminobenzoic acid derivative ligand.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 2, ...
Authors:Saridakis, E, Papakyriakou, A, Giastas, P, Mpakali, A, Mavridis, I.M, Stratikos, E.
Deposit date:2016-05-18
Release date:2017-03-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.897 Å)
Cite:Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.
ACS Med Chem Lett, 8, 2017
4DPR
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BU of 4dpr by Molmil
Structure of human Leukotriene A4 hydrolase in complex with inhibitor captopril
Descriptor: ACETIC ACID, GLYCEROL, L-CAPTOPRIL, ...
Authors:Stsiapanava, A, Haeggstrom, J.Z, Rinaldo-Matthis, A.
Deposit date:2012-02-14
Release date:2013-02-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Capturing LTA4hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4synthesis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4E36
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BU of 4e36 by Molmil
Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2 variant N392K
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Birtley, J.R, Saridakis, E, Pegias, P, Stratikos, E, Mavridis, I.M.
Deposit date:2012-03-09
Release date:2012-08-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing.
J.Immunol., 189, 2012
2R59
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BU of 2r59 by Molmil
Leukotriene A4 hydrolase complexed with inhibitor RB3041
Descriptor: ACETIC ACID, Leukotriene A-4 hydrolase, N-{(2S)-3-[(R)-[(1R)-1-amino-2-phenylethyl](hydroxy)phosphoryl]-2-benzylpropanoyl}-L-phenylalanine, ...
Authors:Tholander, F, Haeggstrom, J.Z, Thunnissen, M, Muroya, A, Roques, B.P, Fournie-Zaluski, M.C.
Deposit date:2007-09-03
Release date:2008-08-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Structure-based dissection of the active site chemistry of leukotriene a4 hydrolase: implications for m1 aminopeptidases and inhibitor design.
Chem.Biol., 15, 2008
2VJ8
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BU of 2vj8 by Molmil
Complex of human leukotriene A4 hydrolase with a hydroxamic acid inhibitor
Descriptor: 6-[{(2S)-2-AMINO-3-[4-(BENZYLOXY)PHENYL]PROPYL}(HYDROXY)AMINO]-6-OXOHEXANOIC ACID), ACETATE ION, IMIDAZOLE, ...
Authors:Thunnissen, M.M.G.M, Andersson, B, Wong, C.-H, Samuelsson, B, Haeggstrom, J.Z.
Deposit date:2007-12-07
Release date:2008-01-15
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Leukotriene A4 Hydrolase in Complex with Captopril and Two Competitive Tight-Binding Inhibitors
Faseb J., 16, 2002
6G8B
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BU of 6g8b by Molmil
E. coli Aminopeptidase N solved by Native SAD from a dataset collected in 60 second with JUNGFRAU detector
Descriptor: Aminopeptidase N, DIMETHYL SULFOXIDE, SODIUM ION, ...
Authors:Leonarski, F, Olieric, V, Redford, S, Wang, M.
Deposit date:2018-04-08
Release date:2018-08-01
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.374 Å)
Cite:Fast and accurate data collection for macromolecular crystallography using the JUNGFRAU detector.
Nat. Methods, 15, 2018
3SE6
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BU of 3se6 by Molmil
Crystal structure of the human Endoplasmic Reticulum Aminopeptidase 2
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Birtley, J.R, Saridakis, E, Stratikos, E, Mavridis, I.M.
Deposit date:2011-06-10
Release date:2011-12-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing.
Biochemistry, 51, 2012
2GTQ
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Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis
Descriptor: SULFATE ION, ZINC ION, aminopeptidase N
Authors:Nocek, B, Mulligan, R, Bargassa, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2006-04-28
Release date:2006-05-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of aminopeptidase N from human pathogen Neisseria meningitidis.
Proteins, 70, 2007
3T8V
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BU of 3t8v by Molmil
A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
Descriptor: M1 family aminopeptidase, MAGNESIUM ION, N-[(2-{2-[(N-{(2S,3R)-3-amino-4-[4-(benzyloxy)phenyl]-2-hydroxybutanoyl}-L-alanyl)amino]ethoxy}ethoxy)acetyl]-4-benzoyl-L-phenylalanyl-N~6~-hex-5-ynoyllysinamide, ...
Authors:McGowan, S, Klemba, M, Greebaum, D.C.
Deposit date:2011-08-01
Release date:2011-09-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases
Proc.Natl.Acad.Sci.USA, 108, 2011
6Q4R
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BU of 6q4r by Molmil
High-resolution crystal structure of ERAP1 with bound phosphinic transition-state analogue inhibitor
Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Giastas, P, Neu, M, Rowland, P, Stratikos, E.
Deposit date:2018-12-06
Release date:2019-04-10
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor.
Acs Med.Chem.Lett., 10, 2019
3U9W
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Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Niegowski, D, Thunnissen, M, Tholander, F, Rinaldo-Matthis, A, Muroya, A, Haeggstrom, J.Z.
Deposit date:2011-10-20
Release date:2012-10-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A
To be Published
2HPT
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Crystal Structure of E. coli PepN (Aminopeptidase N)in complex with Bestatin
Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, Aminopeptidase N, GLYCEROL, ...
Authors:Addlagatta, A, Matthews, B.W, Gay, L.
Deposit date:2006-07-17
Release date:2006-08-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2HPO
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Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site
Descriptor: Aminopeptidase N, GLYCEROL, ZINC ION
Authors:Addlagatta, A, Matthews, B.W, Gay, L.
Deposit date:2006-07-17
Release date:2006-08-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site.
Proc.Natl.Acad.Sci.Usa, 103, 2006

217705

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