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1QK9
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The solution structure of the domain from MeCP2 that binds to methylated DNA
Descriptor: METHYL-CPG-BINDING PROTEIN 2
Authors:Wakefield, R.I.D, Smith, B.O, Nan, X, Free, A, Soteriou, A, Uhrin, D, Bird, A.P, Barlow, P.N.
Deposit date:1999-07-12
Release date:1999-10-08
Last modified:2018-04-18
Method:SOLUTION NMR
Cite:The Solution Structure of the Domain from Mecp2 that Binds to Methylated DNA
J.Mol.Biol., 291, 1999
1D9N
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SOLUTION STRUCTURE OF THE METHYL-CPG-BINDING DOMAIN OF THE METHYLATION-DEPENDENT TRANSCRIPTIONAL REPRESSOR MBD1/PCM1
Descriptor: METHYL-CPG-BINDING PROTEIN MBD1
Authors:Ohki, I, Shimotake, N, Fujita, N, Nakao, M, Shirakawa, M.
Deposit date:1999-10-28
Release date:2000-10-28
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1.
EMBO J., 18, 1999
1IG4
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Solution Structure of the Methyl-CpG-Binding Domain of Human MBD1 in Complex with Methylated DNA
Descriptor: 5'-D(*GP*TP*AP*TP*CP*(5CM)P*GP*GP*AP*TP*AP*C)-3', Methyl-CpG Binding Protein
Authors:Ohki, I, Shimotake, N, Fujita, N, Jee, J.-G, Ikegami, T, Nakao, M, Shirakawa, M.
Deposit date:2001-04-17
Release date:2001-05-30
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA.
Cell(Cambridge,Mass.), 105, 2001
1UB1
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Solution structure of the matrix attachment region-binding domain of chicken MeCP2
Descriptor: attachment region binding protein
Authors:Heitmann, B, Maurer, T, Weitzel, J.M, Stratling, W.H, Kalbitzer, H.R, Brunner, E, Structural Proteomics in Europe (SPINE)
Deposit date:2003-03-27
Release date:2003-08-05
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the matrix attachment region-binding domain of chicken MeCP2
EUR.J.BIOCHEM., 270, 2003
3C2I
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The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF
Descriptor: DNA (5'-D(*DAP*DTP*DAP*DGP*DAP*DAP*DGP*DAP*DAP*DTP*DTP*DCP*(5CM)P*DGP*DTP*DTP*DCP*DCP*DAP*DG)-3'), DNA (5'-D(*DTP*DCP*DTP*DGP*DGP*DAP*DAP*(5CM)P*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DTP*DTP*DCP*DTP*DA)-3'), Methyl-CpG-binding protein 2
Authors:Ho, K.L, McNae, I.W, Schmiedeberg, L, Klose, R.J, Bird, A.P, Walkinshaw, M.D.
Deposit date:2008-01-25
Release date:2008-05-13
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:MeCP2 binding to DNA depends upon hydration at methyl-CpG
Mol.Cell, 29, 2008
2KY8
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Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target methylated DNA sequence
Descriptor: DNA (5'-D(*GP*AP*GP*CP*(5CM)P*GP*AP*TP*(TED)P*CP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*TP*(5CM)P*GP*GP*CP*(TED)P*C)-3'), MANGANESE (II) ION, ...
Authors:Williams Jr, D.C, Scarsdale Jr, J.N.
Deposit date:2010-05-18
Release date:2011-05-18
Last modified:2020-02-05
Method:SOLUTION NMR
Cite:Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence.
Nucleic Acids Res., 39, 2011
3VXV
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Crystal structure of methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*GP*TP*CP*AP*CP*TP*AP*CP*(5CM)P*GP*GP*AP*CP*A)-3'), ...
Authors:Otani, J, Arita, K, Kato, T, Kinoshita, M, Ariyoshi, M, Shirakawa, M.
Deposit date:2012-09-21
Release date:2013-01-16
Last modified:2013-08-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4
J.Biol.Chem., 288, 2013
3VYB
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Crystal structure of methyl CpG binding domain of MBD4 in complex with the 5mCG/hmCG sequence
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*GP*TP*CP*(5HC)P*GP*GP*TP*AP*GP*TP*GP*AP*CP*T)-3'), ...
Authors:Otani, J, Arita, K, Kato, T, Kinoshita, M, Ariyoshi, M, Shirakawa, M.
Deposit date:2012-09-22
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4
J.Biol.Chem., 288, 2013
3VXX
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Crystal structure of methyl CpG binding domain of MBD4 in complex with the 5mCG/5mCG sequence
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DNA (5'-D(*GP*TP*CP*(5CM)P*GP*GP*TP*AP*GP*TP*GP*AP*CP*T)-3'), ...
Authors:Otani, J, Arita, K, Kato, T, Kinoshita, M, Ariyoshi, M, Shirakawa, M.
Deposit date:2012-09-21
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4
J.Biol.Chem., 288, 2013
3VYQ
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Crystal structure of the methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence in space group P1
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*AP*CP*AP*TP*CP*(5CM)P*GP*GP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*AP*TP*GP*T)-3'), ...
Authors:Otani, J, Arita, K, Kato, T, Kinoshita, M, Ariyoshi, M, Shirakawa, M.
Deposit date:2012-10-02
Release date:2013-01-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.525 Å)
Cite:Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4
J.Biol.Chem., 288, 2013
4LG7
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BU of 4lg7 by Molmil
Crystal structure MBD4 MBD domain in complex with methylated CpG DNA
Descriptor: DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), Methyl-CpG-binding domain protein 4, UNKNOWN ATOM OR ION
Authors:Xu, C, Tempel, W, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-06-27
Release date:2013-07-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure MBD4 MBD domain in complex with methylated CpG DNA
To be Published
2MB7
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Solution structure of MBD3 methylcytosine binding domain
Descriptor: Methyl-CpG-binding domain protein 3
Authors:Williams Jr, D.C, Scarsdale, J.N.
Deposit date:2013-07-26
Release date:2013-12-11
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Probing the Dynamic Distribution of Bound States for Methylcytosine-binding Domains on DNA.
J.Biol.Chem., 289, 2014
2MOE
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Solution structure of MBD4 methyl-cytosine binding domain bound to methylated DNA
Descriptor: DNA (5'-D(*GP*AP*GP*CP*(5CM)P*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*(5CM)P*GP*GP*CP*TP*C)-3'), Methyl-CpG-binding domain protein 4
Authors:Williams, D.C, Walavalkar, N.M.
Deposit date:2014-04-24
Release date:2014-09-10
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches.
Nucleic Acids Res., 42, 2015
5AGQ
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Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes
Descriptor: BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2A
Authors:Anosova, I, Melnik, S, Tripsianes, K, Kateb, F, Grummt, I, Sattler, M.
Deposit date:2015-02-03
Release date:2015-05-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A Novel RNA Binding Surface of the Tam Domain of Tip5/Baz2A Mediates Epigenetic Regulation of Rrna Genes.
Nucleic Acids Res., 43, 2015
5BT2
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BU of 5bt2 by Molmil
MeCP2 MBD domain (A140V) in complex with methylated DNA
Descriptor: DNA (5'-D(*AP*TP*AP*GP*AP*AP*GP*AP*AP*TP*TP*CP*(5CM)P*GP*TP*TP*CP*CP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*GP*GP*AP*AP*(5CM)P*GP*GP*AP*AP*TP*TP*CP*TP*TP*CP*TP*A)-3'), Methyl-CpG-binding protein 2
Authors:Ho, K.L, Chia, J.Y, Tan, W.S, Ng, C.L, Hu, N.J, Foo, H.L.
Deposit date:2015-06-02
Release date:2016-08-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A/T Run Geometry of B-form DNA Is Independent of Bound Methyl-CpG Binding Domain, Cytosine Methylation and Flanking Sequence.
Sci Rep, 6, 2016
6C1A
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BU of 6c1a by Molmil
MBD2 in complex with methylated DNA
Descriptor: Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION, complement to dna strand 1, ...
Authors:Liu, K, Xu, C, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-01-04
Release date:2018-02-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1T
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MBD2 in complex with a partially methylated DNA
Descriptor: 12-mer DNA, GLYCEROL, Methyl-CpG-binding domain protein 2, ...
Authors:Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1Y
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mbd of human mecp2 in complex with methylated DNA
Descriptor: 12-mer DNA, Methyl-CpG-binding protein 2, UNKNOWN ATOM OR ION
Authors:Liu, K, Bian, C, Tempel, W, Wernimont, A.K, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Biochim Biophys Acta Gene Regul Mech, 1862, 2019
6C1V
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MBD2 in complex with double-stranded DNA
Descriptor: 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION
Authors:Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C2F
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MBD2 in complex with methylated DNA
Descriptor: 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION
Authors:Liu, K, Xu, C, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-01-08
Release date:2018-02-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:MBD2 in complex with methylated DNA
to be published
6C1U
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MBD2 in complex with a deoxy-oligonucleotide
Descriptor: 12-mer DNA, Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION
Authors:Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CNQ
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MBD2 in complex with methylated DNA
Descriptor: DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), Methyl-CpG-binding domain protein 2, UNKNOWN ATOM OR ION
Authors:Liu, K, Xu, C, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-03-08
Release date:2018-03-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CNP
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Crystal structure of MBD2 complex with methylated CpG island
Descriptor: CALCIUM ION, DNA (5'-D(*GP*CP*CP*AP*CP*(5CM)P*GP*GP*TP*GP*GP*C)-3'), Methyl-CpG-binding domain protein 2, ...
Authors:Xu, C, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-03-08
Release date:2018-03-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CC8
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Crystal structure MBD3 MBD domain in complex with methylated CpG DNA
Descriptor: Methyl-CpG-binding domain protein 3, UNKNOWN ATOM OR ION, methylated CpG DNA
Authors:Liu, K, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-02-06
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019
6CEV
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MBD3 MBD in complex with methylated, non-palindromic CpG DNA: alternative interpretation of crystallographic data
Descriptor: DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*CP*TP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*AP*GP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), Methyl-CpG-binding domain protein 3, ...
Authors:Liu, K, Tempel, W, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2018-02-12
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Structural analyses reveal that MBD3 is a methylated CG binder.
Febs J., 286, 2019

 

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