1QK9
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THE SOLUTION STRUCTURE OF THE DOMAIN FROM MECP2 THAT BINDS TO METHYLATED DNA
Descriptor:METHYL-CPG-BINDING PROTEIN 2
Authors:Wakefield, R.I.D., Smith, B.O., Nan, X., Free, A., Soteriou, A., Uhrin, D., Bird, A.P., Barlow, P.N.
Deposit date:1999-07-12
Release date:1999-10-08
Last modified:2018-04-18
Method:SOLUTION NMR
Cite:The Solution Structure of the Domain from Mecp2 that Binds to Methylated DNA
J.Mol.Biol., 291, 1999
1UB1
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SOLUTION STRUCTURE OF THE MATRIX ATTACHMENT REGION-BINDING DOMAIN OF CHICKEN MECP2
Descriptor:attachment region binding protein
Authors:Heitmann, B., Maurer, T., Weitzel, J.M., Stratling, W.H., Kalbitzer, H.R., Brunner, E., Structural Proteomics in Europe (SPINE)
Deposit date:2003-03-27
Release date:2003-08-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the matrix attachment region-binding domain of chicken MeCP2
EUR.J.BIOCHEM., 270, 2003
3C2I
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THE CRYSTAL STRUCTURE OF METHYL-CPG BINDING DOMAIN OF HUMAN MECP2 IN COMPLEX WITH A METHYLATED DNA SEQUENCE FROM BDNF
Descriptor:Methyl-CpG-binding protein 2, DNA (5'-D(*DTP*DCP*DTP*DGP*DGP*DAP*DAP*(5CM)P*DGP*DGP*DAP*DAP*DTP*DTP*DCP*DTP*DTP*DCP*DTP*DA)-3'), DNA (5'-D(*DAP*DTP*DAP*DGP*DAP*DAP*DGP*DAP*DAP*DTP*DTP*DCP*(5CM)P*DGP*DTP*DTP*DCP*DCP*DAP*DG)-3')
Authors:Ho, K.L., McNae, I.W., Schmiedeberg, L., Klose, R.J., Bird, A.P., Walkinshaw, M.D.
Deposit date:2008-01-25
Release date:2008-05-13
Last modified:2017-01-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:MeCP2 binding to DNA depends upon hydration at methyl-CpG
Mol.Cell, 29, 2008
3VYQ
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CRYSTAL STRUCTURE OF THE METHYL CPG BINDING DOMAIN OF MBD4 IN COMPLEX WITH THE 5MCG/TG SEQUENCE IN SPACE GROUP P1
Descriptor:Methyl-CpG-binding domain protein 4, DNA (5'-D(*AP*CP*AP*TP*CP*(5CM)P*GP*GP*TP*GP*A)-3'), DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*AP*TP*GP*T)-3'), ...
Authors:Otani, J., Arita, K., Kato, T., Kinoshita, M., Ariyoshi, M., Shirakawa, M.
Deposit date:2012-10-02
Release date:2013-01-16
Last modified:2013-08-14
Method:X-RAY DIFFRACTION (2.525 Å)
Cite:Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4
J.Biol.Chem., 288, 2013
5AGQ
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SOLUTION STRUCTURE OF THE TAM DOMAIN OF HUMAN TIP5 BAZ2A INVOLVED IN EPIGENETIC REGULATION OF RRNA GENES
Descriptor:BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2A
Authors:Anosova, I., Melnik, S., Tripsianes, K., Kateb, F., Grummt, I., Sattler, M.
Deposit date:2015-02-03
Release date:2015-05-06
Last modified:2015-06-10
Method:SOLUTION NMR
Cite:A Novel RNA Binding Surface of the Tam Domain of Tip5/Baz2A Mediates Epigenetic Regulation of Rrna Genes.
Nucleic Acids Res., 43, 2015
5BT2
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MECP2 MBD DOMAIN (A140V) IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding protein 2, DNA (5'-D(*TP*CP*TP*GP*GP*AP*AP*(5CM)P*GP*GP*AP*AP*TP*TP*CP*TP*TP*CP*TP*A)-3'), DNA (5'-D(*AP*TP*AP*GP*AP*AP*GP*AP*AP*TP*TP*CP*(5CM)P*GP*TP*TP*CP*CP*AP*G)-3')
Authors:Ho, K.L., Chia, J.Y., Tan, W.S., Ng, C.L., Hu, N.J., Foo, H.L.
Deposit date:2015-06-02
Release date:2016-08-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A/T Run Geometry of B-form DNA Is Independent of Bound Methyl-CpG Binding Domain, Cytosine Methylation and Flanking Sequence
Sci Rep, 6, 2016
6C1A
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MBD2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, dna strand 1, complement to dna strand 1, ...
Authors:Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-04
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1T
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MBD2 IN COMPLEX WITH A PARTIALLY METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, SULFATE ION, ...
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1U
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MBD2 IN COMPLEX WITH A DEOXY-OLIGONUCLEOTIDE
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1V
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MBD2 IN COMPLEX WITH DOUBLE-STRANDED DNA
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1Y
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MBD OF HUMAN MECP2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Liu, K., Bian, C., Tempel, W., Wernimont, A.K., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:mbd of human mecp2 in complex with methylated DNA
to be published
6C2F
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MBD2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Liu, K., Xu, C., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2018-01-08
Release date:2018-02-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:MBD2 in complex with methylated DNA
to be published
6CNP
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CRYSTAL STRUCTURE OF MBD2 COMPLEX WITH METHYLATED CPG ISLAND
Descriptor:Methyl-CpG-binding domain protein 2, DNA (5'-D(*GP*CP*CP*AP*CP*(5CM)P*GP*GP*TP*GP*GP*C)-3'), CALCIUM ION, ...
Authors:Xu, C., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-03-08
Release date:2018-03-28
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6CNQ
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MBD2 IN COMPLEX WITH METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), UNKNOWN ATOM OR ION
Authors:Liu, K., Xu, C., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-03-08
Release date:2018-03-28
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
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