6MRG
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FAAH BOUND TO NON COVALENT INHIBITOR
Descriptor:Fatty-acid amide hydrolase 1, (1R)-2-{[6-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-4-yl]amino}-1-phenylethan-1-ol
Authors:Saha, A., Shih, A., Mirzadegan, T., Seierstad, M.
Deposit date:2018-10-12
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Predicting the Binding of Fatty Acid Amide Hydrolase Inhibitors by Free Energy Perturbation.
J Chem Theory Comput, 2018
6C6G
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AN UNEXPECTED VESTIGIAL PROTEIN COMPLEX REVEALS THE EVOLUTIONARY ORIGINS OF AN S-TRIAZINE CATABOLIC ENZYME. INHIBITOR BOUND COMPLEX.
Descriptor:Biuret hydrolase, AtzG, CALCIUM ION
Authors:Peat, T.S., Esquirol, L., Wilding, M., Liu, J.W., French, N.G., Hartley, C.J., Hideki, O., Easton, C.J., Newman, J., Scott, C.
Deposit date:2018-01-18
Release date:2018-03-21
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An unexpected vestigial protein complex reveals the evolutionary origins of ans-triazine catabolic enzyme.
J. Biol. Chem., 293, 2018
6C62
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AN UNEXPECTED VESTIGIAL PROTEIN COMPLEX REVEALS THE EVOLUTIONARY ORIGINS OF AN S-TRIAZINE CATABOLIC ENZYME.
Descriptor:Biuret hydrolase, AtzG, MAGNESIUM ION
Authors:Peat, T.S., Esquirol, L., Wilding, M., Liu, J.W., French, N.G., Hartley, C.J., Hideki, O., Easton, C.J., Newman, J., Scott, C.
Deposit date:2018-01-17
Release date:2018-03-21
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An unexpected vestigial protein complex reveals the evolutionary origins of ans-triazine catabolic enzyme.
J. Biol. Chem., 293, 2018
5I8I
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CRYSTAL STRUCTURE OF THE K. LACTIS UREA AMIDOLYASE
Descriptor:Urea Amidolyase
Authors:Zhao, J., Xiang, S.
Deposit date:2016-02-19
Release date:2017-04-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (6.5 Å)
Cite:Structure and function of urea amidolyase.
Biosci. Rep., 38, 2018
5H6T
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CRYSTAL STRUCTURE OF HYDRAZIDASE FROM MICROBACTERIUM SP. STRAIN HM58-2
Descriptor:Amidase
Authors:Akiyama, T., Ishii, M., Takuwa, A., Oinuma, K., Sasaki, Y., Takaya, N., Yajima, S.
Deposit date:2016-11-15
Release date:2017-03-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis of the substrate recognition of hydrazidase isolated from Microbacterium sp. strain HM58-2, which catalyzes acylhydrazide compounds as its sole carbon source
Biochem. Biophys. Res. Commun., 482, 2017
5H6S
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CRYSTAL STRUCTURE OF HYDRAZIDASE S179A MUTANT COMPLEXED WITH A SUBSTRATE
Descriptor:Amidase, 4-oxidanylbenzohydrazide
Authors:Akiyama, T., Ishii, M., Takuwa, A., Oinuma, K., Sasaki, Y., Takaya, N., Yajima, S.
Deposit date:2016-11-15
Release date:2017-02-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of the substrate recognition of hydrazidase isolated from Microbacterium sp. strain HM58-2, which catalyzes acylhydrazide compounds as its sole carbon source
Biochem. Biophys. Res. Commun., 482, 2017
5EWQ
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THE CRYSTAL STRUCTURE OF AN AMIDASE FAMILY PROTEIN FROM BACILLUS ANTHRACIS STR. AMES
Descriptor:Amidase, ACETATE ION
Authors:Tan, K., Zhou, M., Kwon, K., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-11-20
Release date:2015-12-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:The crystal structure of an amidase family protein from Bacillus anthracis str. Ames
To Be Published
5AC3
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CRYSTAL STRUCTURE OF PAM12A
Descriptor:PEPTIDE AMIDASE, CADMIUM ION, ACETIC ACID
Authors:Wu, B., Wijma, H.J., Song, L., Rozeboom, H.J., Poloni, C., Tian, Y., Arif, M.I., Nuijens, T., Quadflieg, P.J.L.M., Szymanski, W., Feringa, B.L., Janssen, D.B.
Deposit date:2015-08-11
Release date:2016-07-20
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Versatile Peptide C-Terminal Functionalization Via a Computationally Peptide Amidase
Acs Catalysis, 2016
4YJI
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THE CRYSTAL STRUCTURE OF A BACTERIAL ARYL ACYLAMIDASE BELONGING TO THE AMIDASE SIGNATURE (AS) ENZYMES FAMILY
Descriptor:Aryl acylamidase, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL)
Authors:Choi, I.-G., Lee, S., Park, E.-H., Ko, H.-J., Bang, W.-G.
Deposit date:2015-03-03
Release date:2015-11-04
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal structure analysis of a bacterial aryl acylamidase belonging to the amidase signature enzyme family
Biochem.Biophys.Res.Commun., 467, 2015
4YJ6
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THE CRYSTAL STRUCTURE OF A BACTERIAL ARYL ACYLAMIDASE BELONGING TO THE AMIDASE SIGNATURE (AS) ENZYMES FAMILY
Descriptor:Aryl acylamidase, PHOSPHATE ION
Authors:Lee, S., Park, E.-H., Ko, H.-J., Bang, W.-G., Choi, I.-G.
Deposit date:2015-03-03
Release date:2015-11-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure analysis of a bacterial aryl acylamidase belonging to the amidase signature enzyme family
Biochem.Biophys.Res.Commun., 467, 2015
4WJ3
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CRYSTAL STRUCTURE OF THE ASPARAGINE TRANSAMIDOSOME FROM PSEUDOMONAS AERUGINOSA
Descriptor:Glutamyl-tRNA(Gln) amidotransferase subunit A, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Glutamyl-tRNA(Gln) amidotransferase subunit C, ...
Authors:Suzuki, T., Nakamura, A., Kato, K., Tanaka, I., Yao, M.
Deposit date:2014-09-29
Release date:2014-12-31
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (3.705 Å)
Cite:Structure of the Pseudomonas aeruginosa transamidosome reveals unique aspects of bacterial tRNA-dependent asparagine biosynthesis
Proc.Natl.Acad.Sci.USA, 112, 2015
4N0I
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CRYSTAL STRUCTURE OF S. CEREVISIAE MITOCHONDRIAL GATFAB IN COMPLEX WITH GLUTAMINE
Descriptor:Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial, Glutamyl-tRNA(Gln) amidotransferase subunit B, ...
Authors:Araiso, Y., Ishitani, R., Nureki, O.
Deposit date:2013-10-02
Release date:2014-04-16
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases
Nucleic Acids Res., 42, 2014
4N0H
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CRYSTAL STRUCTURE OF S. CEREVISIAE MITOCHONDRIAL GATFAB
Descriptor:Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial, Glutamyl-tRNA(Gln) amidotransferase subunit B, ...
Authors:Araiso, Y., Ishitani, R., Nureki, O.
Deposit date:2013-10-02
Release date:2014-04-16
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Crystal structure of Saccharomyces cerevisiae mitochondrial GatFAB reveals a novel subunit assembly in tRNA-dependent amidotransferases
Nucleic Acids Res., 42, 2014
4J5P
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CRYSTAL STRUCTURE OF A COVALENTLY BOUND ALPHA-KETOHETEROCYCLE INHIBITOR (PHENHEXYL/OXADIAZOLE/PYRIDINE) TO A HUMANIZED VARIANT OF FATTY ACID AMIDE HYDROLASE
Descriptor:Fatty-acid amide hydrolase 1, (1S)-1-{5-[5-(bromomethyl)pyridin-2-yl]-1,3-oxazol-2-yl}-7-phenylheptan-1-ol, DI(HYDROXYETHYL)ETHER, ...
Authors:Otrubova, K., Brown, M., McCormick, M.S., Han, G.W., O'Neal, S.T., Cravatt, B.F., Stevens, R.C., Lichtman, A.H., Boger, D.L.
Deposit date:2013-02-08
Release date:2013-05-01
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Rational design of Fatty Acid amide hydrolase inhibitors that act by covalently bonding to two active site residues.
J.Am.Chem.Soc., 135, 2013
4IST
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S177A KLUYVEROMYCES LACTIS ALLOPHANATE HYDROLASE
Descriptor:Allophanate Hydrolase, D(-)-TARTARIC ACID
Authors:Fan, C., Xiang, S.
Deposit date:2013-01-17
Release date:2013-06-19
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and function of allophanate hydrolase.
J.Biol.Chem., 288, 2013
4ISS
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SEMET-SUBSTITUTED KLUYVEROMYCES LACTIS ALLOPHANATE HYDROLASE
Descriptor:Allophanate Hydrolase, D(-)-TARTARIC ACID, GLYCEROL
Authors:Fan, C., Xiang, S.
Deposit date:2013-01-17
Release date:2013-06-19
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and function of allophanate hydrolase.
J.Biol.Chem., 288, 2013
4HBP
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CRYSTAL STRUCTURE OF FAAH IN COMPLEX WITH INHIBITOR
Descriptor:Fatty-acid amide hydrolase 1, 4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyridin-3-yl)piperazine-1-carboxamide
Authors:Behnke, C., Skene, R.J.
Deposit date:2012-09-28
Release date:2013-02-06
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.
Bioorg.Med.Chem., 21, 2013
4GYS
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GRANULIBACTER BETHESDENSIS ALLOPHANATE HYDROLASE CO-CRYSTALLIZED WITH MALONATE
Descriptor:Allophanate hydrolase, MALONATE ION
Authors:Lin, Y., St Maurice, M.
Deposit date:2012-09-05
Release date:2013-01-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:The Structure of Allophanate Hydrolase from Granulibacter bethesdensis Provides Insights into Substrate Specificity in the Amidase Signature Family.
Biochemistry, 52, 2013
4GYR
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GRANULIBACTER BETHESDENSIS ALLOPHANATE HYDROLASE APO
Descriptor:Allophanate hydrolase
Authors:Lin, Y., St Maurice, M.
Deposit date:2012-09-05
Release date:2013-01-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of Allophanate Hydrolase from Granulibacter bethesdensis Provides Insights into Substrate Specificity in the Amidase Signature Family.
Biochemistry, 52, 2013
4DO3
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STRUCTURE OF FAAH WITH A NON-STEROIDAL ANTI-INFLAMMATORY DRUG
Descriptor:Fatty-acid amide hydrolase 1, CHLORIDE ION, CYCLOHEXANE AMINOCARBOXYLIC ACID, ...
Authors:Garau, G.
Deposit date:2012-02-09
Release date:2013-01-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase.
J.Am.Chem.Soc., 135, 2013
4CP8
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STRUCTURE OF THE AMIDASE DOMAIN OF ALLOPHANATE HYDROLASE FROM PSEUDOMONAS SP STRAIN ADP
Descriptor:ALLOPHANATE HYDROLASE, MALONATE ION
Authors:Balotra, S., Newman, J., French, N., French, L., Peat, T.S., Scott, C.
Deposit date:2014-02-03
Release date:2014-11-26
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-Ray Structure of the Amidase Domain of Atzf, the Allophanate Hydrolase from the Cyanuric Acid-Mineralizing Multienzyme Complex.
Appl.Environ.Microbiol., 81, 2015
3QKV
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE COMPOUND
Descriptor:Fatty-acid amide hydrolase 1, (6-bromo-1'H,4H-spiro[1,3-benzodioxine-2,4'-piperidin]-1'-yl)methanol
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-02-01
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
3QK5
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE INHIBITOR
Descriptor:Fatty-acid amide hydrolase 1, (3-{(3R)-1-[4-(1-benzothiophen-2-yl)pyrimidin-2-yl]piperidin-3-yl}-2-methyl-1H-pyrrolo[2,3-b]pyridin-1-yl)acetonitrile, 1,2-ETHANEDIOL, ...
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-01-31
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3QJ9
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE WITH SMALL MOLECULE INHIBITOR
Descriptor:Fatty-acid amide hydrolase 1, 1-{(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl}-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one, 1,2-ETHANEDIOL, ...
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-01-28
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
3QJ8
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE
Descriptor:Fatty-acid amide hydrolase 1
Authors:Min, X., Walker, N.P.C., Wang, Z.
Deposit date:2011-01-28
Release date:2011-04-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).
Proc.Natl.Acad.Sci.USA, 108, 2011
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