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8Y7E
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BU of 8y7e by Molmil
Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U12 snRNP part
Descriptor: PHD finger-like domain-containing protein 5A, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ...
Authors:Bai, R, Yuan, M, Zhang, P, Luo, T, Shi, Y, Wan, R.
Deposit date:2024-02-04
Release date:2024-03-13
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.66 Å)
Cite:Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome.
Science, 383, 2024
8QO9
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BU of 8qo9 by Molmil
Cryo-EM structure of a human spliceosomal B complex protomer
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2023-09-28
Release date:2024-01-24
Method:ELECTRON MICROSCOPY (5.29 Å)
Cite:New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published
8CH6
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BU of 8ch6 by Molmil
Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Cretu, C, Schmitzova, J, Pena, V.
Deposit date:2023-02-07
Release date:2023-05-10
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural basis of catalytic activation in human splicing.
Nature, 617, 2023
8C6J
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BU of 8c6j by Molmil
Human spliceosomal PM5 C* complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ...
Authors:Dybkov, O, Kastner, B, Luehrmann, R.
Deposit date:2023-01-12
Release date:2023-07-12
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins.
Sci Adv, 9, 2023
8HK1
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BU of 8hk1 by Molmil
The cryo-EM structure of human pre-17S U2 snRNP
Descriptor: ATP-dependent RNA helicase DDX42, HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, ...
Authors:Zhang, X, Zhan, X, Shi, Y.
Deposit date:2022-11-24
Release date:2023-03-08
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly.
Nat Commun, 14, 2023
7QTT
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BU of 7qtt by Molmil
Structural organization of a late activated human spliceosome (Baqr, core region)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Cretu, C, Pena, V.
Deposit date:2022-01-15
Release date:2023-05-10
Last modified:2023-06-14
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of catalytic activation in human splicing.
Nature, 617, 2023
7W5A
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BU of 7w5a by Molmil
The cryo-EM structure of human pre-C*-II complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ...
Authors:Zhan, X, Lu, Y, Shi, Y.
Deposit date:2021-11-29
Release date:2022-06-22
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mechanism of exon ligation by human spliceosome.
Mol.Cell, 82, 2022
7W59
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BU of 7w59 by Molmil
The cryo-EM structure of human pre-C*-I complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ...
Authors:Zhan, X, Lu, Y, Shi, Y.
Deposit date:2021-11-29
Release date:2022-06-22
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Mechanism of exon ligation by human spliceosome.
Mol.Cell, 82, 2022
7W5B
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BU of 7w5b by Molmil
The cryo-EM structure of human C* complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ...
Authors:Zhan, X, Lu, Y, Shi, Y.
Deposit date:2021-11-29
Release date:2022-06-22
Last modified:2022-08-17
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Mechanism of exon ligation by human spliceosome.
Mol.Cell, 82, 2022
7VPX
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BU of 7vpx by Molmil
The cryo-EM structure of the human pre-A complex
Descriptor: 5SS, DnaJ homolog subfamily C member 8, PHD finger-like domain-containing protein 5A, ...
Authors:Zhang, X, Zhan, X, Shi, Y.
Deposit date:2021-10-18
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mechanism for Branch Site Recognition and Proofreading During Prespliceosome Assembly
To Be Published
7OQC
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BU of 7oqc by Molmil
The U1 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1)
Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A), Pre-mRNA-processing factor 39, ...
Authors:Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2021-06-03
Release date:2021-08-11
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Nature, 596, 2021
7OQE
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BU of 7oqe by Molmil
Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1)
Descriptor: 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A), Cold sensitive U2 snRNA suppressor 1, ...
Authors:Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2021-06-03
Release date:2021-08-11
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Nature, 596, 2021
7OQB
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BU of 7oqb by Molmil
The U2 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1)
Descriptor: ACT1 pre-mRNA (delta-BS-A), Cold sensitive U2 snRNA suppressor 1, Pre-mRNA-processing ATP-dependent RNA helicase PRP5, ...
Authors:Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2021-06-03
Release date:2021-08-11
Last modified:2021-09-22
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Nature, 596, 2021
7EVO
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BU of 7evo by Molmil
The cryo-EM structure of the human 17S U2 snRNP
Descriptor: HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ...
Authors:Zhang, X, Zhan, X, Shi, Y.
Deposit date:2021-05-21
Release date:2022-08-03
Last modified:2024-01-17
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural insights into branch site proofreading by human spliceosome
Nat.Struct.Mol.Biol., 2024
7MX2
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BU of 7mx2 by Molmil
Cryo-EM structure of human ternary NatC complex with a Bisubstrate inhibitor
Descriptor: CARBOXYMETHYL COENZYME *A, N-alpha-acetyltransferase 30, N-alpha-acetyltransferase 35, ...
Authors:Deng, S, Marmorstein, R.
Deposit date:2021-05-18
Release date:2022-12-14
Last modified:2023-06-28
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.
Structure, 31, 2023
7DVQ
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BU of 7dvq by Molmil
Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 5'-O-[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(methoxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]guanosine, Armadillo repeat-containing protein 7, ...
Authors:Bai, R, Wan, R, Wang, L, Xu, K, Zhang, Q, Lei, J, Shi, Y.
Deposit date:2021-01-14
Release date:2021-03-31
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Structure of the activated human minor spliceosome.
Science, 371, 2021
7L1K
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BU of 7l1k by Molmil
Cryo-EM structure of S. Pombe NatC complex with a Bisubstrate inhibitor and inositol hexaphosphate
Descriptor: CARBOXYMETHYL COENZYME *A, INOSITOL HEXAKISPHOSPHATE, MLGP peptide, ...
Authors:Deng, S, Marmorstein, R.
Deposit date:2020-12-14
Release date:2021-05-12
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Molecular mechanism of N-terminal acetylation by the ternary NatC complex.
Structure, 29, 2021
7B9V
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BU of 7b9v by Molmil
Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound
Descriptor: 5' exon of UBC4 mRNA, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0054360.mRNA.1.CDS.1, ...
Authors:Wilkinson, M.E, Fica, S.M, Galej, W.P, Nagai, K.
Deposit date:2020-12-14
Release date:2021-03-10
Last modified:2021-04-14
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for conformational equilibrium of the catalytic spliceosome.
Mol.Cell, 81, 2021
7B0Y
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BU of 7b0y by Molmil
Structure of a transcribing RNA polymerase II-U1 snRNP complex
Descriptor: 145-nt RNA, DNA-directed RNA polymerase II subunit D, DNA-directed RNA polymerase II subunit E, ...
Authors:Zhang, S, Aibara, S, Vos, S.M, Agafonov, D.E, Luehrmann, R, Cramer, P.
Deposit date:2020-11-23
Release date:2021-01-13
Last modified:2021-01-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of a transcribing RNA polymerase II-U1 snRNP complex.
Science, 371, 2021
7DCO
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BU of 7dco by Molmil
Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom
Descriptor: BJ4_G0014900.mRNA.1.CDS.1, BJ4_G0027490.mRNA.1.CDS.1, BJ4_G0037700.mRNA.1.CDS.1, ...
Authors:Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y.
Deposit date:2020-10-26
Release date:2021-03-17
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Science, 371, 2021
7ABG
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BU of 7abg by Molmil
Human pre-Bact-1 spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2020-12-23
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
7ABI
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BU of 7abi by Molmil
Human pre-Bact-2 spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2021-02-10
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
7A5P
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BU of 7a5p by Molmil
Human C Complex Spliceosome - Medium-resolution PERIPHERY
Descriptor: Cell division cycle 5-like protein, Crooked neck-like protein 1, Eukaryotic initiation factor 4A-III, ...
Authors:Bertram, K, Kastner, B.
Deposit date:2020-08-21
Release date:2020-10-14
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.
Mol.Cell, 80, 2020
6YGC
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BU of 6ygc by Molmil
Crystal structure of the NatC complex bound to Arl3 peptide and CoA
Descriptor: ADP-ribosylation factor-like protein 3, CHLORIDE ION, COENZYME A, ...
Authors:Grunwald, S, Hopf, L, Bock-Bierbaum, T, Lally, C.C, Spahn, C.M.T, Daumke, O.
Deposit date:2020-03-27
Release date:2020-10-28
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.994 Å)
Cite:Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Nat Commun, 11, 2020
6YGB
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BU of 6ygb by Molmil
Crystal structure of the NatC complex bound to CoA
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, COENZYME A, ...
Authors:Grunwald, S, Hopf, L, Bock-Bierbaum, T, Lally, C.C, Spahn, C.M.T, Daumke, O.
Deposit date:2020-03-27
Release date:2020-10-28
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.451 Å)
Cite:Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.
Nat Commun, 11, 2020

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PDB entries from 2024-03-27

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