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7OFV
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BU of 7ofv by Molmil
NMR-guided design of potent and selective EphA4 agonistic ligands
Descriptor: ACETATE ION, EphA4 agonist ligand, Ephrin type-A receptor 4
Authors:Ganichkin, O.M, Craig, T.K, Baggio, C, Pellecchia, M.
Deposit date:2021-05-05
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
J.Med.Chem., 64, 2021
3SKJ
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BU of 3skj by Molmil
Structural And Functional Characterization of an Agonistic Anti-Human EphA2 Monoclonal Antibody
Descriptor: Antibody, heavy chain, light chain, ...
Authors:Oganesyan, V.Y, Wu, H, Dall'Acqua, W.F.
Deposit date:2011-06-22
Release date:2011-08-31
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody.
J.Mol.Biol., 413, 2011
2BBA
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BU of 2bba by Molmil
Crystal Structure and Thermodynamic Characterization of the EphB4 Receptor in Complex with an ephrin-B2 Antagonist Peptide Reveals the Determinants for Receptor Specificity.
Descriptor: Agonist peptide, Ephrin type-B receptor 4, SULFATE ION
Authors:Chrencik, J.E, Kuhn, P, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2005-10-17
Release date:2006-07-18
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity.
Structure, 14, 2006
6RW2
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BU of 6rw2 by Molmil
Bicycle Toxin Conjugate bound to EphA2
Descriptor: 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, ALA-ARG-ASP-CYS-PRO-LEU-VAL-ASN-PRO-LEU-CYS-LEU-HIS-PRO-GLY-TRP-THR-CYS, Ephrin type-A receptor 2, ...
Authors:Brown, D.G, Schroeder, S, Chen, L.
Deposit date:2019-06-03
Release date:2020-04-08
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads.
J.Med.Chem., 63, 2020
5JR2
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BU of 5jr2 by Molmil
Crystal structure of the EphA4 LBD in complex with APYd3 peptide inhibitor
Descriptor: APYd3 peptide, Ephrin type-A receptor 4, GLYCEROL, ...
Authors:Lechtenberg, B.C, Olson, E.J, Pasquale, E.B, Dawson, P.E, Riedl, S.J.
Deposit date:2016-05-05
Release date:2016-07-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability.
Acs Med.Chem.Lett., 7, 2016
6B9L
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BU of 6b9l by Molmil
Crystal structure of EphA2 with peptide 135E2
Descriptor: Ephrin type-A receptor 2, HIS TAG CLEAVED OFF, peptide 135E2, ...
Authors:Song, J, Tan, X.
Deposit date:2017-10-10
Release date:2018-10-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell.
ACS Chem. Biol., 13, 2018
4W50
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BU of 4w50 by Molmil
Structure of the EphA4 LBD in complex with peptide
Descriptor: 1,3-BUTANEDIOL, APY peptide, Ephrin type-A receptor 4, ...
Authors:Lechtenberg, B.C, Mace, P.D, Riedl, S.J.
Deposit date:2014-08-16
Release date:2014-10-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
4W4Z
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BU of 4w4z by Molmil
Structure of the EphA4 LBD in complex with peptide
Descriptor: APY-bAla8.am peptide, Ephrin type-A receptor 4, GLYCEROL, ...
Authors:Lechtenberg, B.C, Mace, P.D, Riedl, S.J.
Deposit date:2014-08-15
Release date:2014-10-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
1NUK
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BU of 1nuk by Molmil
CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE EPHB2 RECEPTOR TYROSINE KINASE
Descriptor: PROTEIN (TYROSINE-PROTEIN KINASE RECEPTOR EPH)
Authors:Himanen, J.-P, Henkemeyer, M, Nikolov, D.B.
Deposit date:1998-10-13
Release date:1999-10-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2.
Nature, 396, 1998
2LW8
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BU of 2lw8 by Molmil
NMR solution structure of Eph receptor
Descriptor: Ephrin type-A receptor 4
Authors:Qin, H, Song, J.
Deposit date:2012-07-24
Release date:2013-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR solution structure of Eph receptor
To be Published
2QBX
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BU of 2qbx by Molmil
EphB2/SNEW Antagonistic Peptide Complex
Descriptor: Ephrin type-B receptor 2, SULFATE ION, antagonistic peptide
Authors:Chrencik, J.E, Brooun, A, Recht, M.I, Nicola, G, Pasquale, E.B, Kuhn, P, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D)
Deposit date:2007-06-18
Release date:2007-11-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition.
J.Biol.Chem., 282, 2007
3HPN
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BU of 3hpn by Molmil
Ligand recognition by A-class EPH receptors: crystal structures of the EPHA2 ligand-binding domain and the EPHA2/EPHRIN-A1 complex
Descriptor: Ephrin type-A receptor 2
Authors:Himanen, J.P, Goldgur, Y, Miao, H, Myshkin, E, Guo, H, Buck, M, Nguyen, M, Rajashankar, K.R, Wang, B, Nikolov, D.B.
Deposit date:2009-06-04
Release date:2009-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
3NRU
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BU of 3nru by Molmil
Ligand binding domain of EPHA7
Descriptor: CHLORIDE ION, Ephrin receptor, SULFATE ION
Authors:Walker, J.R, Yermekbayeva, L, Seitova, A, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S.
Deposit date:2010-06-30
Release date:2010-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ephrin A7 ligand binding domain
To be Published
3P1I
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BU of 3p1i by Molmil
Ligand binding domain of human ephrin type-B receptor 3
Descriptor: CHLORIDE ION, Ephrin type-B receptor 3, SULFATE ION
Authors:Walker, J.R, Yermekbayeva, L, Seitova, A, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2010-09-30
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Ligand Binding Domain of Human Ephb3
To be Published
3C8X
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BU of 3c8x by Molmil
Crystal structure of the ligand binding domain of human Ephrin A2 (Epha2) receptor protein kinase
Descriptor: Ephrin type-A receptor 2
Authors:Walker, J.R, Yermekbayeva, L, Seitova, A, Butler-Cole, C, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2008-02-14
Release date:2008-03-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
2WO1
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BU of 2wo1 by Molmil
Crystal Structure of the EphA4 Ligand Binding Domain
Descriptor: EPHRIN TYPE-A RECEPTOR, N-PROPANOL
Authors:Bowden, T.A, Aricescu, A.R, Nettleship, J.E, Siebold, C, Rahman-Huq, N, Owens, R.J, Stuart, D.I, Jones, E.Y.
Deposit date:2009-07-21
Release date:2009-10-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Plasticity of Eph-Receptor A4 Facilitates Cross-Class Ephrin Signalling
Structure, 17, 2009
3CKH
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BU of 3ckh by Molmil
Crystal structure of Eph A4 receptor
Descriptor: Ephrin type-A receptor 4
Authors:Shi, J.H, Song, J.X.
Deposit date:2008-03-15
Release date:2008-09-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor.
J.Biol.Chem., 283, 2008
6NK0
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BU of 6nk0 by Molmil
EphA2 LBD in complex with bA-WLA-Yam peptide
Descriptor: 1,2-ETHANEDIOL, 6-AMINOHEXANOIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NKP
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BU of 6nkp by Molmil
EphA2 LBD in complex with bA-WLA-YSKbio peptide
Descriptor: BIOTIN, Ephrin type-A receptor 2, bA-WLA-YSKbio peptide
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-07
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.033 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NJZ
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BU of 6njz by Molmil
EphA2 LBD in complex with YSA-GSGSK-bio peptide
Descriptor: BIOTIN, Ephrin type-A receptor 2, GLYCEROL, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NK1
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BU of 6nk1 by Molmil
EphA2 LBD in complex with bA-WLA-YRPKbio peptide
Descriptor: ACETATE ION, Ephrin type-A receptor 2, GLYCEROL, ...
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
6NK2
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BU of 6nk2 by Molmil
EphA2 LBD in complex with bA-WLA-YRPK bio peptide
Descriptor: DI(HYDROXYETHYL)ETHER, Ephrin type-A receptor 2, bA-WLA-YPRKbio peptide
Authors:Lechtenberg, B.C, Pasquale, E.B.
Deposit date:2019-01-04
Release date:2019-05-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
J.Biol.Chem., 294, 2019
3ETP
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BU of 3etp by Molmil
The crystal structure of the ligand-binding domain of the EphB2 receptor at 2.0 A resolution
Descriptor: Ephrin type-B receptor 2
Authors:Goldgur, Y, Paavilainen, S, Nikolov, D.B, Himanen, J.P.
Deposit date:2008-10-08
Release date:2008-10-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the ligand-binding domain of the EphB2 receptor at 2 A resolution.
Acta Crystallogr.,Sect.F, 65, 2009
4ET7
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BU of 4et7 by Molmil
Crystal structure of Eph receptor 5
Descriptor: Ephrin type-A receptor 5
Authors:Shi, J.H, Zhu, W.L, Song, J.X.
Deposit date:2012-04-24
Release date:2013-05-22
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of Eph receptor 5
To be Published
7B7N
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BU of 7b7n by Molmil
Human herpesvirus-8 gH/gL in complex with EphA2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Pederzoli, R, Guardado-Calvo, P, Rey, F.A, Backovic, M.
Deposit date:2020-12-11
Release date:2020-12-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling.
Plos Biol., 19, 2021

 

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