1NUK
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CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE EPHB2 RECEPTOR TYROSINE KINASE
Descriptor:PROTEIN (TYROSINE-PROTEIN KINASE RECEPTOR EPH) (2.7.1.112)
Authors:Himanen, J.-P., Henkemeyer, M., Nikolov, D.B.
Deposit date:1998-10-13
Release date:1999-10-13
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2.
Nature, 396, 1998
2LW8
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NMR SOLUTION STRUCTURE OF EPH RECEPTOR
Descriptor:Ephrin type-A receptor 4
Authors:Qin, H., Song, J.
Deposit date:2012-07-24
Release date:2013-07-24
Method:SOLUTION NMR
Cite:NMR solution structure of Eph receptor
To be Published
3C8X
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CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE
Descriptor:Ephrin type-A receptor 2 (E.C.2.7.10.1)
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Butler-Cole, C., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-02-14
Release date:2008-03-25
Last modified:2010-06-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
3CKH
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CRYSTAL STRUCTURE OF EPH A4 RECEPTOR
Descriptor:Ephrin type-A receptor 4 (E.C.2.7.10.1)
Authors:Shi, J.H., Song, J.X.
Deposit date:2008-03-15
Release date:2008-09-23
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor
J.Biol.Chem., 283, 2008
3ETP
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THE CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE EPHB2 RECEPTOR AT 2.0 A RESOLUTION
Descriptor:Ephrin type-B receptor 2 (E.C.2.7.10.1)
Authors:Goldgur, Y., Paavilainen, S., Nikolov, D.B, Himanen, J.P.
Deposit date:2008-10-08
Release date:2008-10-21
Last modified:2009-06-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the ligand-binding domain of the EphB2 receptor at 2 A resolution.
Acta Crystallogr.,Sect.F, 65, 2009
3HPN
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LIGAND RECOGNITION BY A-CLASS EPH RECEPTORS: CRYSTAL STRUCTURES OF THE EPHA2 LIGAND-BINDING DOMAIN AND THE EPHA2/EPHRIN-A1 COMPLEX
Descriptor:Ephrin type-A receptor 2 (E.C.2.7.10.1)
Authors:Himanen, J.P., Goldgur, Y., Miao, H., Myshkin, E., Guo, H., Buck, M., Nguyen, M., Rajashankar, K.R., Wang, B., Nikolov, D.B.
Deposit date:2009-06-04
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
3SKJ
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STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF AN AGONISTIC ANTI-HUMAN EPHA2 MONOCLONAL ANTIBODY
Descriptor:Antibody, light chain, Antibody, heavy chain, Ephrin type-A receptor 2 (E.C.2.7.10.1)
Authors:Oganesyan, V.Y., Wu, H., Dall'Acqua, W.F.
Deposit date:2011-06-22
Release date:2011-08-31
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody.
J.Mol.Biol., 413, 2011
4ET7
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CRYSTAL STRUCTURE OF EPH RECEPTOR 5
Descriptor:Ephrin type-A receptor 5 (E.C.2.7.10.1)
Authors:Shi, J.H., Zhu, W.L., Song, J.X.
Deposit date:2012-04-24
Release date:2013-05-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of Eph receptor 5
To be Published
4W4Z
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STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH PEPTIDE
Descriptor:Ephrin type-A receptor 4 (E.C.2.7.10.1), APY-bAla8.am peptide
Authors:Lechtenberg, B.C., Mace, P.D., Riedl, S.J.
Deposit date:2014-08-15
Release date:2014-10-08
Last modified:2015-01-07
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
4W50
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STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH PEPTIDE
Descriptor:Ephrin type-A receptor 4 (E.C.2.7.10.1), APY peptide
Authors:Lechtenberg, B.C., Mace, P.D., Riedl, S.J.
Deposit date:2014-08-16
Release date:2014-10-08
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Development and Structural Analysis of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor.
Acs Chem.Biol., 9, 2014
5JR2
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CRYSTAL STRUCTURE OF THE EPHA4 LBD IN COMPLEX WITH APYD3 PEPTIDE INHIBITOR
Descriptor:Ephrin type-A receptor 4 (E.C.2.7.10.1), APYd3 peptide
Authors:Lechtenberg, B.C., Olson, E.J., Pasquale, E.B., Dawson, P.E., Riedl, S.J.
Deposit date:2016-05-05
Release date:2016-07-06
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability.
Acs Med.Chem.Lett., 7, 2016
1KGY
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CRYSTAL STRUCTURE OF THE EPHB2-EPHRINB2 COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 2 (E.C.2.7.1.112), EPHRIN-B2
Authors:Himanen, J.P., Rajashankar, K.R., Lackmann, M., Cowan, C.A., Henkemeyer, M., Nikolov, D.B.
Deposit date:2001-11-28
Release date:2002-05-28
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of an Eph receptor-ephrin complex.
Nature, 414, 2001
3CZU
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CRYSTAL STRUCTURE OF THE HUMAN EPHRIN A2- EPHRIN A1 COMPLEX
Descriptor:Ephrin type-A receptor 2 (E.C.2.7.10.1), Ephrin-A1
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Butler-Cole, C., Bountra, C., Wikstrom, M., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-04-30
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
3HEI
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LIGAND RECOGNITION BY A-CLASS EPH RECEPTORS: CRYSTAL STRUCTURES OF THE EPHA2 LIGAND-BINDING DOMAIN AND THE EPHA2/EPHRIN-A1 COMPLEX
Descriptor:Ephrin type-A receptor 2 (E.C.2.7.10.1), Ephrin-A1
Authors:Himanen, J.P., Goldgur, Y., Miao, H., Myshkin, E., Guo, H., Buck, M., Nguyen, M., Rajashankar, K.R., Wang, B., Nikolov, D.B.
Deposit date:2009-05-08
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
3MBW
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CRYSTAL STRUCTURE OF THE HUMAN EPHRIN A2 LBD AND CRD DOMAINS IN COMPLEX WITH EPHRIN A1
Descriptor:Crystal structure of the human ephrin A2 LBD and CRD domains complex with ephrin A1
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Butler-Cole, C., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2010-03-26
Release date:2010-06-09
Last modified:2010-06-30
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
1SHW
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EPHB2 / EPHRINA5 COMPLEX STRUCTURE
Descriptor:Ephrin-A5/Ephrin type-B receptor 2
Authors:Himanen, J.P., Chumley, M.J., Lackmann, M., Li, C., Barton, W.A., Jeffrey, P.D., Vearing, C., Geleick, D., Feldheim, D.A., Boyd, A.W.
Deposit date:2004-02-26
Release date:2004-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
Nat.Neurosci., 7, 2004
2X10
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CRYSTAL STRUCTURE OF THE COMPLETE EPHA2 ECTODOMAIN
Descriptor:EPHRIN TYPE-A RECEPTOR 2 (E.C.2.7.10.1)
Authors:Seiradake, E., Harlos, K., Sutton, G., Aricescu, A.R., Jones, E.Y.
Deposit date:2009-12-21
Release date:2010-03-16
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly
Nat.Struct.Mol.Biol., 17, 2010
2X11
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CRYSTAL STRUCTURE OF THE COMPLETE EPHA2 ECTODOMAIN IN COMPLEX WITH EPHRIN A5 RECEPTOR BINDING DOMAIN
Descriptor:EPHRIN TYPE-A RECEPTOR 2 (E.C.2.7.10.1), EPHRIN-A5
Authors:Seiradake, E., Harlos, K., Sutton, G., Aricescu, A.R., Jones, E.Y.
Deposit date:2009-12-21
Release date:2010-03-16
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (4.83 Å)
Cite:An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly
Nat.Struct.Mol.Biol., 17, 2010
3FL7
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CRYSTAL STRUCTURE OF THE HUMAN EPHRIN A2 ECTODOMAIN
Descriptor:Ephrin receptor (E.C.2.7.10.1)
Authors:Walker, J.R., Yermekbayeva, L., Seitova, A., Butler-Cole, C., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2008-12-18
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
3MX0
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CRYSTAL STRUCTURE OF EPHA2 ECTODOMAIN IN COMPLEX WITH EPHRIN-A5
Descriptor:Ephrin type-A receptor 2 (E.C.2.7.10.1), Ephrin-A5
Authors:Himanen, J.P., Yermekbayeva, L., Janes, P.W., Walker, J.R., Xu, K., Atapattu, L., Rajashankar, K.R., Mensinga, A., Lackmann, M., Nikolov, D.B., Dhe-Paganon, S.
Deposit date:2010-05-06
Release date:2010-06-30
Method:X-RAY DIFFRACTION (3.506 Å)
Cite:Architecture of Eph receptor clusters.
Proc.Natl.Acad.Sci.USA, 107, 2010
4BK4
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CRYSTAL STRUCTURE OF THE HUMAN EPHA4 ECTODOMAIN
Descriptor:EPHRIN TYPE-A RECEPTOR 4 (E.C.2.7.10.1)
Authors:Seiradake, E., Schaupp, A., del Toro Ruiz, D., Kaufmann, R., Mitakidis, N., Harlos, K., Aricescu, A.R., Klein, R., Jones, E.Y.
Deposit date:2013-04-22
Release date:2013-07-03
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses
Nat.Struct.Mol.Biol., 20, 2013
4BK5
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CRYSTAL STRUCTURE OF THE HUMAN EPHA4 ECTODOMAIN IN COMPLEX WITH HUMAN EPHRIN A5 (AMINE-METHYLATED SAMPLE)
Descriptor:EPHRIN TYPE-A RECEPTOR 4 (E.C.2.7.10.1), EPHRIN-A5 (E.C.2.7.10.1)
Authors:Seiradake, E., Schaupp, A., del Toro Ruiz, D., Kaufmann, R., Mitakidis, N., Harlos, K., Aricescu, A.R., Klein, R., Jones, E.Y.
Deposit date:2013-04-22
Release date:2013-07-03
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses
Nat.Struct.Mol.Biol., 20, 2013
4BKA
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CRYSTAL STRUCTURE OF THE HUMAN EPHA4 ECTODOMAIN IN COMPLEX WITH HUMAN EPHRIN A5
Descriptor:EPHRIN TYPE-A RECEPTOR 4 (E.C.2.7.10.1), EPHRIN-A5
Authors:Seiradake, E., Schaupp, A., del Toro Ruiz, D., Kaufmann, R., Mitakidis, N., Harlos, K., Aricescu, A.R., Klein, R., Jones, E.Y.
Deposit date:2013-04-23
Release date:2013-07-03
Last modified:2015-10-21
Method:X-RAY DIFFRACTION (5.3 Å)
Cite:Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses
Nat.Struct.Mol.Biol., 20, 2013
4BKF
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CRYSTAL STRUCTURE OF THE HUMAN EPHA4 ECTODOMAIN IN COMPLEX WITH HUMAN EPHRINB3
Descriptor:EPHRIN TYPE-A RECEPTOR 4 (E.C.2.7.10.1), EPHRIN-B3
Authors:Seiradake, E., Schaupp, A., del Toro Ruiz, D., Kaufmann, R., Mitakidis, N., Harlos, K., Aricescu, A.R., Klein, R., Jones, E.Y.
Deposit date:2013-04-24
Release date:2013-07-03
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (4.65 Å)
Cite:Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses
Nat.Struct.Mol.Biol., 20, 2013
4M4P
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CRYSTAL STRUCTURE OF EPHA4 ECTODOMAIN
Descriptor:Ephrin type-A receptor 4 (E.C.2.7.10.1)
Authors:Xu, K., Tsvetkova-Robev, D., Xu, Y., Goldgur, Y., Chan, Y.-P., Himanen, J.P., Nikolov, D.B.
Deposit date:2013-08-07
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.081 Å)
Cite:Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
Proc.Natl.Acad.Sci.USA, 110, 2013
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