6LQF
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2CXY
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2EH9
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7V8N
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4LJX
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7C4J
| Cryo-EM structure of the yeast Swi/Snf complex in a nucleosome free state | Descriptor: | Actin-like protein ARP9, Actin-related protein 7, Regulator of Ty1 transposition protein 102, ... | Authors: | Wang, C.C, Guo, Z.Y, Zhan, X.C, Zhang, X.F. | Deposit date: | 2020-05-18 | Release date: | 2020-07-15 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structure of the yeast Swi/Snf complex in a nucleosome free state Nat Commun, 2020
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5V9P
| Crystal structure of pyrrolidine amide inhibitor [(3S)-3-(4-bromo-1H-pyrazol-1-yl)pyrrolidin-1-yl][3-(propan-2-yl)-1H-pyrazol-5-yl]methanone (compound 35) in complex with KDM5A | Descriptor: | Lysine-specific demethylase 5A, NICKEL (II) ION, SULFATE ION, ... | Authors: | Kiefer, J.R, Liang, J, Vinogradova, M. | Deposit date: | 2017-03-23 | Release date: | 2017-05-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
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6LTH
| Structure of human BAF Base module | Descriptor: | AT-rich interactive domain-containing protein 1A, SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, ... | Authors: | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | Deposit date: | 2020-01-22 | Release date: | 2020-02-12 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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5V9T
| Crystal structure of selective pyrrolidine amide KDM5a inhibitor N-{(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide (compound 48) | Descriptor: | Lysine-specific demethylase 5A, N-{(3R)-1-[3-(propan-2-yl)-1H-pyrazole-5-carbonyl]pyrrolidin-3-yl}cyclopropanecarboxamide, NICKEL (II) ION, ... | Authors: | Kiefer, J.R, Liang, J, Vinogradova, M. | Deposit date: | 2017-03-23 | Release date: | 2017-05-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
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5CEH
| Structure of histone lysine demethylase KDM5A in complex with selective inhibitor | Descriptor: | 7-oxo-5-phenyl-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile, Lysine-specific demethylase 5A, NICKEL (II) ION, ... | Authors: | Kiefer, J.R, Vinogradova, M. | Deposit date: | 2015-07-06 | Release date: | 2016-05-18 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (3.14 Å) | Cite: | An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat.Chem.Biol., 12, 2016
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5K4L
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8FYH
| G4 RNA-mediated PRC2 dimer | Descriptor: | G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ... | Authors: | Song, J, Kasinath, V. | Deposit date: | 2023-01-26 | Release date: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science, 381, 2023
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7VDV
| The overall structure of human chromatin remodeling PBAF-nucleosome complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2,AT-rich interactive domain-containing protein 2, Actin, ... | Authors: | Chen, Z.C, Chen, K.J, Yuan, J.J. | Deposit date: | 2021-09-07 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of human chromatin-remodelling PBAF complex bound to a nucleosome. Nature, 605, 2022
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7EGM
| The SRM module of SWI/SNF-nucleosome complex | Descriptor: | SWI/SNF chromatin-remodeling complex subunit SNF5, SWI/SNF chromatin-remodeling complex subunit SWI1, SWI/SNF complex subunit SWI3, ... | Authors: | Chen, Z.C, Chen, K.J, He, Z.Y, Ye, Y.P. | Deposit date: | 2021-03-24 | Release date: | 2022-01-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity. Cell Discov, 7, 2021
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6LTJ
| Structure of nucleosome-bound human BAF complex | Descriptor: | AT-rich interactive domain-containing protein 1A, Actin, cytoplasmic 1, ... | Authors: | He, S, Wu, Z, Tian, Y, Yu, Z, Yu, J, Wang, X, Li, J, Liu, B, Xu, Y. | Deposit date: | 2020-01-22 | Release date: | 2020-02-12 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of nucleosome-bound human BAF complex. Science, 367, 2020
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7KSO
| Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 | Descriptor: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | Authors: | Grau, D.J, Armache, K.J. | Deposit date: | 2020-11-23 | Release date: | 2021-02-03 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
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7Y8R
| The nucleosome-bound human PBAF complex | Descriptor: | ACTB protein (Fragment), ADENOSINE-5'-DIPHOSPHATE, AT-rich interactive domain-containing protein 2, ... | Authors: | Wang, L, Yu, J, Yu, Z, Wang, Q, He, S, Xu, Y. | Deposit date: | 2022-06-24 | Release date: | 2022-12-07 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structure of nucleosome-bound human PBAF complex. Nat Commun, 13, 2022
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6UXV
| SWI/SNF Body Module | Descriptor: | SWI/SNF chromatin-remodeling complex subunit SNF5, SWI/SNF chromatin-remodeling complex subunit SWI1, SWI/SNF complex subunit SWI3, ... | Authors: | He, Y, Han, Y. | Deposit date: | 2019-11-08 | Release date: | 2020-03-18 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Cryo-EM structure of SWI/SNF complex bound to a nucleosome. Nature, 579, 2020
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7EGP
| The structure of SWI/SNF-nucleosome complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP9, Actin-related protein 7, ... | Authors: | Chen, Z.C, Chen, K.J, He, Z.Y, Ye, Y.P. | Deposit date: | 2021-03-24 | Release date: | 2022-01-12 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity. Cell Discov, 7, 2021
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6UXW
| SWI/SNF nucleosome complex with ADP-BeFx | Descriptor: | 601 sequence bottom strand, 601 sequence top strand, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | He, Y, Han, Y. | Deposit date: | 2019-11-08 | Release date: | 2020-03-18 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (8.96 Å) | Cite: | Cryo-EM structure of SWI/SNF complex bound to a nucleosome. Nature, 579, 2020
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1IG6
| HUMAN MRF-2 DOMAIN, NMR, 11 STRUCTURES | Descriptor: | MODULATOR RECOGNITION FACTOR 2 | Authors: | Lin, D, Tsui, V, Case, D, Yuan, Y.C, Chen, Y. | Deposit date: | 2001-04-17 | Release date: | 2001-04-25 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | HUMAN MRF-2 DOMAIN, NMR, 11 STRUCTURES To be Published
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2OEH
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1C20
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1KN5
| SOLUTION STRUCTURE OF ARID DOMAIN OF ADR6 FROM SACCHAROMYCES CEREVISIAE | Descriptor: | Transcription regulatory protein ADR6 | Authors: | Tu, X, Wu, J, Xu, Y, Shi, Y. | Deposit date: | 2001-12-18 | Release date: | 2002-07-17 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | 1H, 13C and 15N resonance assignments and secondary structure of ADR6 DNA-binding domain. J.Biomol.Nmr, 21, 2001
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1KQQ
| Solution Structure of the Dead ringer ARID-DNA Complex | Descriptor: | 5'-D(*CP*CP*AP*CP*AP*TP*CP*AP*AP*TP*AP*CP*AP*GP*G)-3', 5'-D(*CP*CP*TP*GP*TP*AP*TP*TP*GP*AP*TP*GP*TP*GP*G)-3', DEAD RINGER PROTEIN | Authors: | Iwahara, J, Iwahara, M, Daughdrill, G.W, Ford, J, Clubb, R.T. | Deposit date: | 2002-01-07 | Release date: | 2002-03-06 | Last modified: | 2021-10-27 | Method: | SOLUTION NMR | Cite: | The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA. EMBO J., 21, 2002
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