1B44
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CRYSTAL STRUCTURE OF THE B SUBUNIT OF HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY
Descriptor:PROTEIN (B-POL SUBUNIT OF HEAT-LABILE ENTEROTOXIN)
Authors:Matkovic-Calogovic, D., Loregian, A., D'Acunto, M.R., Battistutta, R., Tossi, A., Palu, G., Zanotti, G.
Deposit date:1999-01-04
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of the B subunit of Escherichia coli heat-labile enterotoxin carrying peptides with anti-herpes simplex virus type 1 activity.
J.Biol.Chem., 274, 1999
1CHP
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SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:CHOLERA TOXIN B PENTAMER, CHLORIDE ION
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1995-02-15
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants.
Structure, 3, 1995
1CHQ
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SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:CHOLERA TOXIN B PENTAMER
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1995-02-15
Release date:1996-03-08
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants.
Structure, 3, 1995
1CT1
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CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE
Descriptor:CHOLERA TOXIN, BETA-D-GALACTOSE, N-ACETYL-D-GALACTOSAMINE, ...
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1997-06-03
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of receptor binding by cholera toxin mutants.
Protein Sci., 6, 1997
1DJR
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH M-CARBOXYPHENYL-ALPHA-D-GALACTOSE
Descriptor:HEAT-LABILE ENTEROTOXIN, ALPHA D-GALACTOSE, GLYCEROL, ...
Authors:Minke, W.E., Pickens, J., Merritt, E.A., Fan, E., Verlinde, C.L.M.J., Hol, W.G.J.
Deposit date:1999-12-03
Release date:2000-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of m-carboxyphenyl-alpha-D-galactopyranoside complexed to heat-labile enterotoxin at 1.3 A resolution: surprising variations in ligand-binding modes.
Acta Crystallogr.,Sect.D, 56, 2000
1EEF
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH BOUND LIGAND PEPG
Descriptor:PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN), ALPHA D-GALACTOSE, 2-PHENETHYL-2,3-DIHYDRO-PHTHALAZINE-1,4-DIONE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:2000-01-31
Release date:2000-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta Crystallogr.,Sect.D, 57, 2001
1EEI
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CHOLERA TOXIN B-PENTAMER COMPLEXED WITH METANITROPHENYL-ALPHA-D-GALACTOSE
Descriptor:PROTEIN (CHOLERA TOXIN B), METANITROPHENYL-ALPHA-D-GALACTOSIDE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:2000-01-31
Release date:2000-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta Crystallogr.,Sect.D, 57, 2001
1EFI
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH PARA-AMINOPHENYL-ALPHA-D-GALACTOPYRANOSIDE
Descriptor:PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN), 4'-AMINOPHENYL-ALPHA-D-GALACTOPYRANOSIDE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:2000-02-08
Release date:2000-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta Crystallogr.,Sect.D, 57, 2001
1FD7
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HEAT-LABILE ENTEROTOXIN B-PENTAMER WITH BOUND LIGAND BMSC001
Descriptor:HEAT-LABILE ENTEROTOXIN B CHAIN, N-BENZYL-3-(ALPHA-D-GALACTOS-1-YL)-BENZAMIDE
Authors:Fan, E., Merritt, E.A., Pickens, J., Ahn, M., Hol, W.G.J.
Deposit date:2000-07-19
Release date:2000-08-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives.
Acta Crystallogr.,Sect.D, 57, 2001
1FGB
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TOXIN
Descriptor:CHOLERA TOXIN B SUBUNIT PENTAMER
Authors:Zhang, R.-G., Westbrook, E.
Deposit date:1996-02-21
Release date:1996-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid.
J.Mol.Biol., 251, 1995
1G8Z
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HIS57ALA MUTANT OF CHOLERA TOXIN B-PENATMER
Descriptor:CHOLERA TOXIN B PROTEIN, BETA-D-GALACTOSE
Authors:Aman, A.T., Fraser, S., Merritt, E.A., Rodigherio, C., Kenny, M.
Deposit date:2000-11-21
Release date:2001-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity.
Proc.Natl.Acad.Sci.USA, 98, 2001
1HTL
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MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS
Descriptor:HEAT-LABILE ENTEROTOXIN, SUBUNIT B, SUBUNIT A
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1995-02-15
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli.
Nat.Struct.Biol., 2, 1995
1JQY
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HEAT-LABILE ENTEROTOXIN B-PENTAMER WITH LIGAND BMSC-0010
Descriptor:HEAT-LABILE ENTEROTOXIN B CHAIN, (3-NITRO-5-(3-MORPHOLIN-4-YL-PROPYLAMINOCARBONYL)PHENYL)-GALACTOPYRANOSIDE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:2001-08-09
Release date:2002-05-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.
Chem.Biol., 9, 2002
1JR0
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CHOLERA TOXIN B-PENTAMER WITH LIGAND BMSC-0011
Descriptor:cholera toxin B subunit, (3-NITRO-5-(2-MORPHOLIN-4-YL-ETHYLAMINOCARBONYL)PHENYL)-GALACTOPYRANOSIDE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:2001-08-09
Release date:2002-05-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.
Chem.Biol., 9, 2002
1LLR
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CHOLERA TOXIN B-PENTAMER WITH LIGAND BMSC-0012
Descriptor:CHOLERA TOXIN B SUBUNIT, 5-AMINOCARBONYL-3-NITROPHENYL-ALPHA-D-GALACTOPYRANOSE, 3-AMINO-4-{3-[2-(2-PROPOXY-ETHOXY)-ETHOXY]-PROPYLAMINO}-CYCLOBUT-3-ENE-1,2-DIONE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:2002-04-30
Release date:2002-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin.
J.Am.Chem.Soc., 124, 2002
1LT3
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HEAT-LABILE ENTEROTOXIN DOUBLE MUTANT N40C/G166C
Descriptor:HEAT-LABILE ENTEROTOXIN, BETA-D-GALACTOSE, BETA-D-GLUCOSE
Authors:Van Den Akker, F., Hol, W.G.J.
Deposit date:1997-04-12
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit.
Protein Sci., 6, 1997
1LT4
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HEAT-LABILE ENTEROTOXIN MUTANT S63K
Descriptor:HEAT-LABILE ENTEROTOXIN, BETA-D-GALACTOSE, BETA-D-GLUCOSE
Authors:Van Den Akker, F., Hol, W.G.J.
Deposit date:1997-04-14
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a non-toxic mutant of heat-labile enterotoxin, which is a potent mucosal adjuvant.
Protein Sci., 6, 1997
1LT5
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH THIODIGALACTOSIDE
Descriptor:HEAT-LABILE ENTEROTOXIN, THIODIGALACTOSIDE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1997-09-30
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin.
Structure, 5, 1997
1LT6
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH METANITROPHENYLGALACTOSIDE
Descriptor:HEAT-LABILE ENTEROTOXIN, METANITROPHENYL-ALPHA-D-GALACTOSIDE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1997-10-01
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin.
Structure, 5, 1997
1LTA
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2.2 ANGSTROMS CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN (LT) WITH BOUND GALACTOSE
Descriptor:HEAT-LABILE ENTEROTOXIN, SUBUNIT B, SUBUNIT A, ...
Authors:Merritt, E.A., Sixma, T.K., Kalk, K.H., Van Zanten, B.A.M., Hol, W.G.J.
Deposit date:1993-09-15
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT).
Mol.Microbiol., 13, 1994
1LTB
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2.6 ANGSTROMS CRYSTAL STRUCTURE OF PARTIALLY-ACTIVATED E. COLI HEAT-LABILE ENTEROTOXIN (LT)
Descriptor:HEAT-LABILE ENTEROTOXIN, SUBUNIT B, SUBUNIT A
Authors:Merritt, E.A., Sixma, T.K., Hol, W.G.J.
Deposit date:1993-09-15
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolution.
FEBS Lett., 337, 1994
1LTG
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THE ARG7LYS MUTANT OF HEAT-LABILE ENTEROTOXIN EXHIBITS GREAT FLEXIBILITY OF ACTIVE SITE LOOP 47-56 OF THE A SUBUNIT
Descriptor:HEAT-LABILE ENTEROTOXIN
Authors:Van Den Akker, F., Hol, W.G.J.
Deposit date:1995-06-13
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Arg7Lys mutant of heat-labile enterotoxin exhibits great flexibility of active site loop 47-56 of the A subunit.
Biochemistry, 34, 1995
1LTI
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HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN
Descriptor:HEAT LABILE ENTEROTOXIN TYPE I, BETA-D-GALACTOSE, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE
Authors:Van Den Akker, F., Hol, W.G.J.
Deposit date:1996-05-09
Release date:1996-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli.
Protein Sci., 5, 1996
1LTR
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CRYSTAL STRUCTURE OF THE B SUBUNIT OF HUMAN HEAT-LABILE ENTEROTOXIN FROM E. COLI CARRYING A PEPTIDE WITH ANTI-HSV ACTIVITY
Descriptor:HEAT-LABILE ENTEROTOXIN, SULFATE ION
Authors:Matkovic-Calogovic, D., Loreggian, A., Palu, G., Zanotti, G.
Deposit date:1998-07-31
Release date:1999-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Crystal structure of the B subunit of Escherichia coli heat-labile enterotoxin carrying peptides with anti-herpes simplex virus type 1 activity.
J.Biol.Chem., 274, 1999
1LTS
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REFINED STRUCTURE OF E. COLI HEAT LABILE ENTEROTOXIN, A CLOSE RELATIVE OF CHOLERA TOXIN
Descriptor:HEAT-LABILE ENTEROTOXIN, SUBUNIT B, SUBUNIT A
Authors:Sixma, T.K., Hol, W.G.J.
Deposit date:1992-07-15
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin.
J.Mol.Biol., 230, 1993
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