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1LTS
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REFINED STRUCTURE OF E. COLI HEAT LABILE ENTEROTOXIN, A CLOSE RELATIVE OF CHOLERA TOXIN
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
Authors:Sixma, T.K, Hol, W.G.J.
Deposit date:1992-07-15
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin.
J.Mol.Biol., 230, 1993
1LTT
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LACTOSE BINDING TO HEAT-LABILE ENTEROTOXIN REVEALED BY X-RAY CRYSTALLOGRAPHY
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B, ...
Authors:Sixma, T.K, Hol, W.G.J.
Deposit date:1992-07-15
Release date:1994-01-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography.
Nature, 355, 1992
1LTB
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2.6 ANGSTROMS CRYSTAL STRUCTURE OF PARTIALLY-ACTIVATED E. COLI HEAT-LABILE ENTEROTOXIN (LT)
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
Authors:Merritt, E.A, Sixma, T.K, Hol, W.G.J.
Deposit date:1993-09-15
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolution.
FEBS Lett., 337, 1994
1LTA
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2.2 ANGSTROMS CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN (LT) WITH BOUND GALACTOSE
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B, ...
Authors:Merritt, E.A, Sixma, T.K, Kalk, K.H, Van Zanten, B.A.M, Hol, W.G.J.
Deposit date:1993-09-15
Release date:1994-01-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT).
Mol.Microbiol., 13, 1994
1HTL
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MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS
Descriptor: HEAT-LABILE ENTEROTOXIN, SUBUNIT A, SUBUNIT B
Authors:Merritt, E.A, Hol, W.G.J.
Deposit date:1995-02-15
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli.
Nat.Struct.Biol., 2, 1995
1LTG
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THE ARG7LYS MUTANT OF HEAT-LABILE ENTEROTOXIN EXHIBITS GREAT FLEXIBILITY OF ACTIVE SITE LOOP 47-56 OF THE A SUBUNIT
Descriptor: HEAT-LABILE ENTEROTOXIN
Authors:Van Den Akker, F, Hol, W.G.J.
Deposit date:1995-06-13
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Arg7Lys mutant of heat-labile enterotoxin exhibits great flexibility of active site loop 47-56 of the A subunit.
Biochemistry, 34, 1995
1XTC
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CHOLERA TOXIN
Descriptor: CHOLERA TOXIN
Authors:Zhang, R.-G, Westbrook, E.
Deposit date:1996-01-10
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The three-dimensional crystal structure of cholera toxin.
J.Mol.Biol., 251, 1995
1TII
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ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB
Descriptor: HEAT LABILE ENTEROTOXIN TYPE IIB
Authors:Van Den Akker, F, Hol, W.G.J.
Deposit date:1996-03-20
Release date:1996-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of a new heat-labile enterotoxin, LT-IIb.
Structure, 4, 1996
1LTI
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HEAT-LABILE ENTEROTOXIN (LT-I) COMPLEX WITH T-ANTIGEN
Descriptor: HEAT LABILE ENTEROTOXIN TYPE I, beta-D-galactopyranose, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose
Authors:Van Den Akker, F, Hol, W.G.J.
Deposit date:1996-05-09
Release date:1996-08-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli.
Protein Sci., 5, 1996
1LT3
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HEAT-LABILE ENTEROTOXIN DOUBLE MUTANT N40C/G166C
Descriptor: HEAT-LABILE ENTEROTOXIN, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:Van Den Akker, F, Hol, W.G.J.
Deposit date:1997-04-12
Release date:1997-07-07
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit.
Protein Sci., 6, 1997
1LT4
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HEAT-LABILE ENTEROTOXIN MUTANT S63K
Descriptor: HEAT-LABILE ENTEROTOXIN, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose
Authors:Van Den Akker, F, Hol, W.G.J.
Deposit date:1997-04-14
Release date:1997-06-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a non-toxic mutant of heat-labile enterotoxin, which is a potent mucosal adjuvant.
Protein Sci., 6, 1997
1S5F
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Cholera holotoxin, Crystal form 2
Descriptor: Cholera enterotoxin, A chain, SODIUM ION, ...
Authors:O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G.
Deposit date:2004-01-20
Release date:2004-04-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
Biochemistry, 43, 2004
1S5E
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Cholera holotoxin, Crystal form 1
Descriptor: Cholera enterotoxin, A chain precursor, SODIUM ION, ...
Authors:O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G.
Deposit date:2004-01-20
Release date:2004-04-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
Biochemistry, 43, 2004
1S5C
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Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 1
Descriptor: Cholera enterotoxin, A chain, SODIUM ION, ...
Authors:O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G.
Deposit date:2004-01-20
Release date:2004-04-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
Biochemistry, 43, 2004
1S5D
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Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 2
Descriptor: Cholera enterotoxin, A chain, GLYCEROL, ...
Authors:O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G.
Deposit date:2004-01-20
Release date:2004-04-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
Biochemistry, 43, 2004
1S5B
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Cholera holotoxin with an A-subunit Y30S mutation Form 3
Descriptor: Cholera enterotoxin, A chain precursor, SODIUM ION, ...
Authors:O'Neal, C.J, Amaya, E.I, Jobling, M.G, Holmes, R.K, Hol, W.G.
Deposit date:2004-01-20
Release date:2004-04-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Crystal structures of an intrinsically active cholera toxin mutant yield insight into the toxin activation mechanism
Biochemistry, 43, 2004
2A5F
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Cholera toxin A1 subunit bound to its substrate, NAD+, and its human protein activator, ARF6
Descriptor: ADP-ribosylation factor 6, Cholera enterotoxin, A chain, ...
Authors:O'Neal, C.J, Jobling, M.G, Holmes, R.K, Hol, W.G.J.
Deposit date:2005-06-30
Release date:2005-08-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis for the activation of cholera toxin by human ARF6-GTP.
Science, 309, 2005
2A5D
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Structural basis for the activation of cholera toxin by human ARF6-GTP
Descriptor: ADP-ribosylation factor 6, Cholera enterotoxin, A chain, ...
Authors:O'Neal, C.J, Jobling, M.G, Holmes, R.K, Hol, W.G.J.
Deposit date:2005-06-30
Release date:2005-08-16
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the activation of cholera toxin by human ARF6-GTP.
Science, 309, 2005
2A5G
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Cholera toxin A1 subunit bound to ARF6(Q67L)
Descriptor: ADP-ribosylation factor 6, Cholera enterotoxin, A chain, ...
Authors:O'Neal, C.J, Jobling, M.G, Holmes, R.K, Hol, W.G.J.
Deposit date:2005-06-30
Release date:2005-08-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural basis for the activation of cholera toxin by human ARF6-GTP.
Science, 309, 2005

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