5XT3
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THE CATALYTIC DOMAIN OF GDPP WITH C-DI-GMP
Descriptor:Phosphodiesterase acting on cyclic dinucleotides, MANGANESE (II) ION, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)
Authors:Wang, F., Gu, L.
Deposit date:2017-06-16
Release date:2018-01-31
Method:X-RAY DIFFRACTION (2.591 Å)
Cite:Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase
Biochem. J., 475, 2018
5XSP
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THE CATALYTIC DOMAIN OF GDPP WITH 5'-PAPA
Descriptor:Phosphodiesterase acting on cyclic dinucleotides, MANGANESE (II) ION, ADENOSINE-5'-MONOPHOSPHATE
Authors:Wang, F., Gu, L.
Deposit date:2017-06-15
Release date:2018-01-31
Method:X-RAY DIFFRACTION (2.146 Å)
Cite:Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase
Biochem. J., 475, 2018
5XSN
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THE CATALYTIC DOMAIN OF GDPP WITH C-DI-AMP
Descriptor:Phosphodiesterase acting on cyclic dinucleotides, MANGANESE (II) ION, (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide
Authors:Wang, F., Gu, L.
Deposit date:2017-06-14
Release date:2018-01-31
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase
Biochem. J., 475, 2018
5XSI
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THE CATALYTIC DOMAIN OF GDPP
Descriptor:Phosphodiesterase acting on cyclic dinucleotides, MANGANESE (II) ION
Authors:Wang, F., Gu, L.
Deposit date:2017-06-14
Release date:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase
Biochem. J., 475, 2018
5O7F
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STRUCTURE OF THE INACTIVE T.MARITIMA PDE (TM1595) D80N D154N MUTANT WITH GMP AND MN2+
Descriptor:phosphodiesterase, GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ...
Authors:Witte, G., Drexler, D., Mueller, M.
Deposit date:2017-06-08
Release date:2017-10-25
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima.
Structure, 25, 2017
5O70
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STRUCTURE OF THE INACTIVE T.MARITIMA PDE (TM1595) D80N D154N MUTANT WITH REACTION PRODUCTS 2 AMP
Descriptor:phosphodiesterase, ADENOSINE MONOPHOSPHATE, SULFATE ION, ...
Authors:Witte, G., Drexler, D.
Deposit date:2017-06-07
Release date:2017-10-25
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima.
Structure, 25, 2017
5O58
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STRUCTURE OF THE INACTIVE T.MARITIMA PDE (TM1595) D80N D154N MUTANT WITH SUBSTRATE 5'-PAPG
Descriptor:phosphodiesterase TM1595, RNA (5'-R(P*AP*G)-3'), 1,2-ETHANEDIOL, ...
Authors:Witte, G., Drexler, D., Mueller, M.
Deposit date:2017-06-01
Release date:2017-10-25
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima.
Structure, 25, 2017
5O4Z
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STRUCTURE OF THE INACTIVE T.MARITIMA PDE (TM1595) D80N D154N MUTANT WITH SUBSTRATE 5'-PAPA
Descriptor:DHH/DHHA1-type phosphodiesterase TM1595, ADENOSINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Witte, G., Drexler, D., Mueller, M.
Deposit date:2017-05-31
Release date:2017-10-25
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima.
Structure, 25, 2017
5O25
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STRUCTURE OF WILDTYPE T.MARITIMA PDE (TM1595) IN LIGAND-FREE STATE
Descriptor:TmPDE, MANGANESE (II) ION, TETRAETHYLENE GLYCOL, ...
Authors:Witte, G., Drexler, D., Mueller, M.
Deposit date:2017-05-19
Release date:2017-10-25
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima.
Structure, 25, 2017
5O1U
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STRUCTURE OF WILDTYPE T.MARITIMA PDE (TM1595) WITH AMP AND MN2+
Descriptor:Phosphodiesterase, MANGANESE (II) ION, ADENOSINE MONOPHOSPHATE, ...
Authors:Witte, G., Drexler, D., Mueller, M.
Deposit date:2017-05-19
Release date:2017-10-25
Last modified:2017-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Biophysical Analysis of the Soluble DHH/DHHA1-Type Phosphodiesterase TM1595 from Thermotoga maritima.
Structure, 25, 2017
5JJU
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CRYSTAL STRUCTURE OF RV2837C COMPLEXED WITH 5'-PAPA AND 5'-AMP
Descriptor:Uncharacterized protein Rv2837c, RNA (5'-R(P*AP*A)-3'), MANGANESE (II) ION, ...
Authors:Wang, F., He, Q., Liu, S., Gu, L.
Deposit date:2016-04-25
Release date:2016-05-04
Last modified:2016-10-12
Method:X-RAY DIFFRACTION (2.312 Å)
Cite:Structural and biochemical insight into the mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP phosphodiesterase
J.Biol.Chem., 291, 2016
5J21
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STRUCTURE OF BACILLUS NANORNASE A (WT)
Descriptor:Bifunctional oligoribonuclease and PAP phosphatase NrnA
Authors:Schmier, B.J., Malhotra, A., Nelersa, C.M.
Deposit date:2016-03-29
Release date:2017-08-02
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bacillus NanoRNase A (H103A) + 2 divalent cations + PO4 at the active site
To Be Published
5IZO
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BACILLUS NANORNASE A (H103A) + 2 DIVALENT CATIONS + PO4 AT THE ACTIVE SITE
Descriptor:Bifunctional oligoribonuclease and PAP phosphatase NrnA, MANGANESE (II) ION, PHOSPHATE ION
Authors:Schmier, B.J., Malhotra, A., Nelersa, C.M.
Deposit date:2016-03-25
Release date:2017-08-02
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Bacillus NanoRNase A (H103A) + 2 divalent cations + PO4 at the active site
To Be Published
5IUF
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BACILLUS NANORNASE A ACTIVE SITE MUTANT BOUND TO PAP
Descriptor:Bifunctional oligoribonuclease and PAP phosphatase NrnA, ADENOSINE-3'-5'-DIPHOSPHATE
Authors:Schmier, B.J., Nelersa, C.M., Malhotra, A.
Deposit date:2016-03-17
Release date:2017-08-02
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Bacillus NanoRNase A active site mutant bound to pAp
To Be Published
5IPP
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STRUCTURE OF BACILLUS NANORNASE A ACTIVE SITE MUTANT BOUND TO A MONONUCLEOTIDE
Descriptor:Bifunctional oligoribonuclease and PAP phosphatase NrnA, ADENOSINE-5'-MONOPHOSPHATE
Authors:Schmier, B.J., Nelersa, C.M., Malhotra, A.
Deposit date:2016-03-09
Release date:2017-08-02
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of Bacillus NanoRNase A active site mutant bound to a mononucleotide
To Be Published
5F56
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STRUCTURE OF RECJ COMPLEXED WITH DNA AND SSB-CT
Descriptor:Single-stranded-DNA-specific exonuclease, DNA (5'-D(*CP*TP*GP*AP*TP*GP*GP*CP*A)-3'), ALA-ASP-LEU-PRO-PHE, ...
Authors:Zhao, Y., Hua, Y., Cheng, K.
Deposit date:2015-12-04
Release date:2016-06-15
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for DNA 5 -end resection by RecJ
Elife, 5, 2016
5F55
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STRUCTURE OF RECJ COMPLEXED WITH DNA
Descriptor:Single-stranded-DNA-specific exonuclease, DNA (5'-D(*GP*AP*TP*GP*TP*AP*CP*GP*CP*TP*AP*GP*GP*C)-3'), SULFATE ION, ...
Authors:Hua, Y., Zhao, Y., Cheng, K.
Deposit date:2015-12-04
Release date:2016-06-15
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for DNA 5 -end resection by RecJ
Elife, 5, 2016
5F54
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STRUCTURE OF RECJ COMPLEXED WITH DTMP
Descriptor:Single-stranded-DNA-specific exonuclease, MANGANESE (II) ION, THYMIDINE-5'-PHOSPHATE
Authors:Hua, Y., Zhao, Y., Cheng, K.
Deposit date:2015-12-04
Release date:2016-06-15
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for DNA 5 -end resection by RecJ
Elife, 5, 2016
5CET
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CRYSTAL STRUCTURE OF RV2837C
Descriptor:Bifunctional oligoribonuclease and PAP phosphatase NrnA, MANGANESE (II) ION
Authors:Wang, F., He, Q., Zhu, D., Liu, S., Gu, L.
Deposit date:2015-07-07
Release date:2015-12-23
Last modified:2016-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase
J.Biol.Chem., 291, 2016
4RPA
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CRYSTAL STRUCTURE OF INORGANIC PYROPHOSPHATASE FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH MN2+
Descriptor:Probable manganese-dependent inorganic pyrophosphatase, MANGANESE (II) ION
Authors:Gajadeera, C.S., Tsodikov, O.V.
Deposit date:2014-10-30
Release date:2015-01-21
Last modified:2015-04-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of inorganic pyrophosphatase from Staphylococcus aureus reveals conformational flexibility of the active site.
J.Struct.Biol., 189, 2015
4PY9
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CRYSTAL STRUCTURE OF AN EXOPOLYPHOSPHATASE-RELATED PROTEIN FROM BACTEROIDES FRAGILIS. NORTHEAST STRUCTURAL GENOMICS TARGET BFR192
Descriptor:Putative exopolyphosphatase-related protein, PHOSPHATE ION, SODIUM ION
Authors:Seetharaman, J., Abashidze, M., Wang, H., Janjua, H., Foote, E.L., Xiao, R., Nair, R., Everett, J.K., Acton, T.B., Rost, B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2014-03-26
Release date:2014-06-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of an exopolyphosphatase-related protein from Bacteroides Fragilis. Northeast Structural Genomics target BFR192
To be Published
4LS9
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STRUCTURE OF MYCOBACTERIAL NRNA HOMOLOG REVEALS MULTIFUNCTIONAL NUCLEASE ACTIVITIES
Descriptor:DHH family protein, MANGANESE (II) ION, GLYCEROL
Authors:Kumar, D., Srivastav, R., Grover, A., Manjasetty, B.A., Sharma, R., Taneja, B.
Deposit date:2013-07-22
Release date:2014-07-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases
Nucleic Acids Res., 42, 2014
3W5W
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MN2+-GMP COMPLEX OF NANORNASE (NRN) FROM BACTEROIDES FRAGILIS
Descriptor:Putative exopolyphosphatase-related protein, GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION
Authors:Uemura, Y., Nakagawa, N., Wakamatsu, T., Montelione, G.T., Hunt, J.F., Masui, R., Kuramitsu, S.
Deposit date:2013-02-07
Release date:2013-07-10
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of the ligand-binding form of nanoRNase from Bacteroides fragilis, a member of the DHH/DHHA1 phosphoesterase family of proteins
To be Published
3DEV
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CRYSTAL STRUCTURE OF SH1221 PROTEIN FROM STAPHYLOCOCCUS HAEMOLYTICUS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SHR87
Descriptor:SH1221, SULFATE ION, MAGNESIUM ION
Authors:Forouhar, F., Neely, H., Seetharaman, J., Mao, L., Xiao, R., Ciccosanti, C., Foote, E.L., Wang, D., Everett, J.K., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-06-10
Release date:2008-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of SH1221 protein from Staphylococcus haemolyticus, Northeast Structural Genomics Consortium Target ShR87
To be Published
2ZXR
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CRYSTAL STRUCTURE OF RECJ IN COMPLEX WITH MG2+ FROM THERMUS THERMOPHILUS HB8
Descriptor:Single-stranded DNA specific exonuclease RecJ, MAGNESIUM ION
Authors:Wakamatsu, T., Kitamura, Y., Nakagawa, N., Masui, R., Kuramitsu, S.
Deposit date:2009-01-05
Release date:2010-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of RecJ exonuclease defines its specificity for single-stranded DNA
J.Biol.Chem., 285, 2010
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