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1BJP	CRYSTAL STRUCTURE OF 4-OXALOCROTONATE TAUTOMERASE INACTIVATED BY 2-OXO-3-PENTYNOATE AT 2.4 ANGSTROMS RESOLUTION Descriptor: 2-OXO-3-PENTENOIC ACID, 4-OXALOCROTONATE TAUTOMERASE Authors: Taylor, A.B, Czerwinski, R.M, Johnson Junior, W.H, Whitman, C.P, Hackert, M.L. Deposit date: 1998-06-26 Release date: 1998-12-02 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2-oxo-3-pentynoate at 2.4 A resolution: analysis and implications for the mechanism of inactivation and catalysis. Biochemistry, 37, 1998
7M59	Crystal structure of N2, a member of 4-oxalocrotonate tautomerase (4-OT) family Descriptor: Tautomerase domain-containing protein Authors: Medellin, B.P, Moreno, R.Y, Zhang, Y.J. Deposit date: 2021-03-23 Release date: 2021-06-02 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications. Biochemistry, 60, 2021
6OGM	Crystal structure of apo unFused 4-OT Descriptor: 4-oxalocrotonate tautomerase, GLYCEROL Authors: Medellin, B.P, Whitman, C.P, Zhang, Y.J. Deposit date: 2019-04-03 Release date: 2020-02-26 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.865 Å) Cite: Structural, Kinetic, and Mechanistic Analysis of an Asymmetric 4-Oxalocrotonate Tautomerase Trimer. Biochemistry, 58, 2019
7PUO	Structure of a fused 4-OT variant engineered for asymmetric Michael addition reactions Descriptor: 2-hydroxymuconate tautomerase,Chains: A,B,C,D,E,F,2-hydroxymuconate tautomerase, CHLORIDE ION, GLYCEROL Authors: Rozeboom, H.J, Thunnissen, A.M.W.H, Poelarends, G.J. Deposit date: 2021-09-30 Release date: 2022-01-26 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Gene Fusion and Directed Evolution to Break Structural Symmetry and Boost Catalysis by an Oligomeric C-C Bond-Forming Enzyme. Angew.Chem.Int.Ed.Engl., 61, 2022
7XUY	Crystal structure of 5-chloro-2-hydroxymuconate tautomerase CnbG Descriptor: Tautomerase Authors: Ma, H.L, Li, D.F. Deposit date: 2022-05-20 Release date: 2023-03-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Structural insights into the substrate specificity of 5-chloro-2-hydroxymuconate tautomerase CnbG. Biochem.Biophys.Res.Commun., 620, 2022
2FM7	Evolution of Enzymatic Activity in the Tautomerase Superfamily: Mechanistic and Structural Consequences of the L8R Mutation in 4-Oxalocrotonate Tautomerase Descriptor: 4-Oxalocrotonate Tautomerase, CHLORIDE ION Authors: Almrud, J.J, Hackert, M.L. Deposit date: 2006-01-08 Release date: 2006-09-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural consequences of the L8R mutation in 4-oxalocrotonate tautomerase Biochemistry, 45, 2006
3RY0	Crystal structure of TomN, a 4-Oxalocrotonate Tautomerase homologue in Tomaymycin biosynthetic pathway Descriptor: Putative tautomerase Authors: Zhang, Y, Yan, W.P, Li, W.Z, Whitman, C.P. Deposit date: 2011-05-10 Release date: 2011-08-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Kinetic, Crystallographic, and Mechanistic Characterization of TomN: Elucidation of a Function for a 4-Oxalocrotonate Tautomerase Homologue in the Tomaymycin Biosynthetic Pathway. Biochemistry, 50, 2011
2X4K	Crystal structure of SAR1376, a putative 4-oxalocrotonate tautomerase from the methicillin-resistant Staphylococcus aureus (MRSA) Descriptor: 4-OXALOCROTONATE TAUTOMERASE, ACETATE ION, PHOSPHATE ION, ... Authors: Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H. Deposit date: 2010-02-01 Release date: 2010-07-21 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.1 Å) Cite: The Scottish Structural Proteomics Facility: Targets, Methods and Outputs. J.Struct.Funct.Genomics, 11, 2010
4X1C	Crystal structure of 4-OT from Pseudomonas putida mt-2 with an enamine adduct on the N-terminal proline at 1.7 Angstrom resolution Descriptor: 2-hydroxymuconate tautomerase, COBALT HEXAMMINE(III) Authors: Thunnissen, A.M.W.H, Poddar, H. Deposit date: 2014-11-24 Release date: 2015-03-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Evidence for the Formation of an Enamine Species during Aldol and Michael-type Addition Reactions Promiscuously Catalyzed by 4-Oxalocrotonate Tautomerase. Chembiochem, 16, 2015
1OTF	4-OXALOCROTONATE TAUTOMERASE-TRICLINIC CRYSTAL FORM Descriptor: 4-OXALOCROTONATE TAUTOMERASE Authors: Subramanya, H.S, Roper, D.I, Dauter, Z, Dodson, E.J, Davies, G.J, Wilson, K.S, Wigley, D.B. Deposit date: 1995-11-09 Release date: 1996-04-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases. Biochemistry, 35, 1996
4X19	Crystal structure of native 4-OT from Pseudomonas putida mt-2 at 1.94 Angstrom Descriptor: 2-hydroxymuconate tautomerase, COBALT HEXAMMINE(III) Authors: Thunnissen, A.M.W.H, Poddar, H. Deposit date: 2014-11-24 Release date: 2015-03-11 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.944 Å) Cite: Evidence for the Formation of an Enamine Species during Aldol and Michael-type Addition Reactions Promiscuously Catalyzed by 4-Oxalocrotonate Tautomerase. Chembiochem, 16, 2015
6VVR	Q0 fused 4-OT wild type symmetric trimer Descriptor: Tautomerase Authors: Medellin, B.P, Whitman, C.P, Zhang, Y.J. Deposit date: 2020-02-18 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Basis for the Asymmetry of a 4-Oxalocrotonate Tautomerase Trimer. Biochemistry, 59, 2020
6FPS	Crystal structure of 4-oxalocrotonate tautomerase triple mutant L8Y/M45Y/F50A Descriptor: 2-hydroxymuconate tautomerase, GLYCEROL, PHOSPHATE ION Authors: Pijning, T, Thunnissen, A.M.W.H. Deposit date: 2018-02-12 Release date: 2019-03-06 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Enantioselective Synthesis of Pharmaceutically Active gamma-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions. ACS Catal, 9, 2019
6VVW	W0 fused 4-OT wild type symmetric trimer Descriptor: Tautomerase Authors: Medellin, B.P, Whitman, C.P, Zhang, Y.J. Deposit date: 2020-02-18 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural Basis for the Asymmetry of a 4-Oxalocrotonate Tautomerase Trimer. Biochemistry, 59, 2020
6BLM	Crystal Structure of Native Fused 4-OT Descriptor: 4-oxalocrotonate tautomerase Authors: LeVieux, J, Baas, B.J, Zhang, Y.J, Whitman, C.P. Deposit date: 2017-11-10 Release date: 2017-12-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.488 Å) Cite: A global view of structure-function relationships in the tautomerase superfamily. J. Biol. Chem., 293, 2018
6BGN	Crystal Structure of 4-Oxalocrotonate Tautomerase After Incubation with 5-Fluoro-2-hydroxy-2,4-pentadienoate Descriptor: 2-hydroxymuconate tautomerase, 5-fluoranyl-2-oxidanylidene-pentanoic acid, GLYCEROL, ... Authors: Zhang, Y, Li, W, Stack, T. Deposit date: 2017-10-29 Release date: 2018-02-21 Last modified: 2019-12-25 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates. Biochemistry, 57, 2018
6GHW	Substituting the prolines of 4-oxalocrotonate tautomerase with non-canonical analogue (2S)-3,4-dehydroproline Descriptor: 2-hydroxymuconate tautomerase, CALCIUM ION Authors: Pavkov-Keller, T, Lukesch, M.S, Wiltschi, B, Gruber, K. Deposit date: 2018-05-09 Release date: 2019-03-06 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Substituting the catalytic proline of 4-oxalocrotonate tautomerase with non-canonical analogues reveals a finely tuned catalytic system. Sci Rep, 9, 2019
1S0Y	The structure of trans-3-chloroacrylic acid dehalogenase, covalently inactivated by the mechanism-based inhibitor 3-bromopropiolate at 2.3 Angstrom resolution Descriptor: MALONIC ACID, alpha-subunit of trans-3-chloroacrylic acid dehalogenase, beta-subunit of trans-3-chloroacrylic acid dehalogenase Authors: de Jong, R.M, Brugman, W, Poelarends, G.J, Whitman, C.P, Dijkstra, B.W. Deposit date: 2004-01-05 Release date: 2004-02-24 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The X-ray structure of trans-3-chloroacrylic acid dehalogenase reveals a novel hydration mechanism in the tautomerase superfamily J.Biol.Chem., 279, 2004
5CLO	Crystal structure of a 4-oxalocrotonate tautomerase mutant in complex with nitrostyrene at 2.3 Angstrom Descriptor: 2-hydroxymuconate tautomerase, trans beta nitrostyrene Authors: Thunnissen, A.M.W.H, Poddar, H. Deposit date: 2015-07-16 Release date: 2016-03-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases. Nat Commun, 7, 2016
5CLN	Crystal structure of a 4-oxalocrotonate tautomerase mutant at 2.7 Angstrom Descriptor: 2-hydroxymuconate tautomerase Authors: Thunnissen, A.M.W.H, Poddar, H. Deposit date: 2015-07-16 Release date: 2016-03-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases. Nat Commun, 7, 2016
3ABF	Crystal Structure of a 4-Oxalocrotonate Tautomerase Homologue (TTHB242) Descriptor: 4-oxalocrotonate tautomerase, SULFATE ION Authors: Kida, H, Miki, K. Deposit date: 2009-12-10 Release date: 2010-12-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Crystal Structure of a 4-Oxalocrotonate Tautomerase Homologue (TTHB242) from Thermus thermophilus HB8 To be Published
4FAZ	Kinetic and structural characterization of the 4-oxalocrotonate tautomerase isozymes from Methylibium petroleiphilum Descriptor: 4-oxalocrotonate isomerase protein, SULFATE ION Authors: Terrell, C.R, Hoffman, D.W, Whitman, C.P. Deposit date: 2012-05-22 Release date: 2013-06-05 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Structural and kinetic characterization of two 4-oxalocrotonate tautomerases in Methylibium petroleiphilum strain PM1. Arch.Biochem.Biophys., 537, 2013
4FDX	Kinetic and structural characterization of the 4-oxalocrotonate tautomerase isozymes from Methylibium petroleiphilum Descriptor: 4-oxalocrotonase tautomerase isozyme Authors: Terrell, C.R, Hoffman, D.W, Whitman, C.P. Deposit date: 2012-05-29 Release date: 2013-06-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Structural and kinetic characterization of two 4-oxalocrotonate tautomerases in Methylibium petroleiphilum strain PM1. Arch.Biochem.Biophys., 537, 2013
5TIG	CRYSTAL STRUCTURE OF 4-OXALOCROTONATE TAUTOMERASE INACTIVATED BY BrHPD Descriptor: (3E)-5-hydroxy-2-oxopent-3-enoic acid, 2-hydroxymuconate tautomerase Authors: Zhang, Y, Li, W, Stack, T. Deposit date: 2016-10-02 Release date: 2018-02-21 Last modified: 2019-04-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Inactivation of 4-Oxalocrotonate Tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates. Biochemistry, 57, 2018
8T9Q	Crystal structure of fused YR, an asymmetric 4-OT trimer Descriptor: Tautomerase Authors: Moreno, R.Y, Zhang, Y.J. Deposit date: 2023-06-24 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Introduction of Asymmetry in the Fused 4-Oxalocrotonate Tautomerases. Biochemistry, 62, 2023

 

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