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1A1Z
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FADD DEATH EFFECTOR DOMAIN, F25G MUTANT, NMR MINIMIZED AVERAGE STRUCTURE
Descriptor: FADD PROTEIN
Authors:Eberstadt, M, Huang, B, Chen, Z, Meadows, R.P, Ng, C, Fesik, S.W.
Deposit date:1997-12-18
Release date:1998-12-30
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
Nature, 392, 1998
1A1W
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FADD DEATH EFFECTOR DOMAIN, F25Y MUTANT, NMR MINIMIZED AVERAGE STRUCTURE
Descriptor: FADD PROTEIN
Authors:Eberstadt, M, Huang, B, Chen, Z, Meadows, R.P, Ng, C, Fesik, S.W.
Deposit date:1997-12-18
Release date:1998-12-30
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
Nature, 392, 1998
1N3K
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BU of 1n3k by Molmil
Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15)
Descriptor: Astrocytic phosphoprotein PEA-15
Authors:Hill, J.M, Vaidyanathan, H, Ramos, J.W, Ginsberg, M.H, Werner, M.H.
Deposit date:2002-10-28
Release date:2003-01-14
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Recognition of ERK MAP Kinase by PEA-15 Reveals a Common Docking Site Within the Death Domain and Death Effector Domain
Embo J., 21, 2002
2BBR
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BU of 2bbr by Molmil
Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition
Descriptor: AZIDE ION, Viral CASP8 and FADD-like apoptosis regulator
Authors:Yang, J.K, Wang, L, Zheng, L, Wan, F, Ahmed, M, Lenardo, M.J, Wu, H.
Deposit date:2005-10-17
Release date:2006-02-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Mol.Cell, 20, 2005
2BBZ
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Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition
Descriptor: Viral CASP8 and FADD-like apoptosis regulator
Authors:Yang, J.K, Wang, L, Zheng, L, Wan, F, Ahmed, M, Lenardo, M.J, Wu, H.
Deposit date:2005-10-18
Release date:2006-02-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Mol.Cell, 20, 2005
2F1S
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BU of 2f1s by Molmil
Crystal Structure of a Viral FLIP MC159
Descriptor: Viral CASP8 and FADD-like apoptosis regulator
Authors:Li, F.-Y, Jeffrey, P.D, Yu, J.W, Shi, Y.
Deposit date:2005-11-15
Release date:2005-11-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of a Viral FLIP: INSIGHTS INTO FLIP-MEDIATED INHIBITION OF DEATH RECEPTOR SIGNALING.
J.Biol.Chem., 281, 2006
2GF5
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Structure of intact FADD (MORT1)
Descriptor: FADD protein
Authors:Carrington, P.E, Sandu, C, Wei, Y, Hill, J.M, Morisawa, G, Huang, T, Gavathiotis, E, Wei, Y, Werner, M.H.
Deposit date:2006-03-21
Release date:2006-06-27
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:The Structure of FADD and Its Mode of Interaction with Procaspase-8
Mol.Cell, 22, 2006
3CL3
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BU of 3cl3 by Molmil
Crystal Structure of a vFLIP-IKKgamma complex: Insights into viral activation of the IKK signalosome
Descriptor: NF-kappa-B essential modulator, ORF K13
Authors:Bagneris, C, Ageichik, A.V, Cronin, N, Boshoff, C, Waksman, G, Barrett, T.
Deposit date:2008-03-18
Release date:2008-06-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.
Mol.Cell, 30, 2008
2LS7
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BU of 2ls7 by Molmil
High Definition Solution Structure of PED/PEA-15 Death Effector Domain
Descriptor: Astrocytic phosphoprotein PEA-15
Authors:Twomey, E.C, Wei, Y.
Deposit date:2012-04-20
Release date:2012-08-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions.
Biochem.Biophys.Res.Commun., 424, 2012
4IZA
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Structure of Dually Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain
Descriptor: Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1
Authors:Mace, P.D, Robinson, H, Riedl, S.J.
Deposit date:2013-01-29
Release date:2013-04-10
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Nat Commun, 4, 2013
4IZ5
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Structure of the complex between ERK2 phosphomimetic mutant and PEA-15
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1, ...
Authors:Mace, P.D, Robinson, H, Riedl, S.J.
Deposit date:2013-01-29
Release date:2013-04-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Nat Commun, 4, 2013
4IZ7
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BU of 4iz7 by Molmil
Structure of Non-Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain
Descriptor: Astrocytic phosphoprotein PEA-15, Mitogen-activated protein kinase 1, SODIUM ION
Authors:Mace, P.D, Robinson, H, Riedl, S.J.
Deposit date:2013-01-29
Release date:2013-04-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Nat Commun, 4, 2013
4ZBW
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BU of 4zbw by Molmil
Crystal structure of death effector domain of Caspase8 in Homo Sapiens
Descriptor: Caspase-8
Authors:Shen, C, Wang, T, Quan, J.
Deposit date:2015-04-15
Release date:2015-07-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the death effector domains of caspase-8
Biochem.Biophys.Res.Commun., 463, 2015
5JQE
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BU of 5jqe by Molmil
Crystal structure of caspase8 tDED
Descriptor: Sugar ABC transporter substrate-binding protein,Caspase-8 chimera
Authors:Fu, T, Li, Y, Lu, A, Wu, H.
Deposit date:2016-05-04
Release date:2016-10-26
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (3.157 Å)
Cite:Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol. Cell, 64, 2016
5LDE
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BU of 5lde by Molmil
Crystal structure of a vFLIP-IKKgamma stapled peptide dimer
Descriptor: Immunoglobulin G-binding protein G,Viral FLICE protein, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, ...
Authors:Barrett, T.
Deposit date:2016-06-24
Release date:2017-10-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:IKK gamma-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection.
J. Virol., 91, 2017
5L08
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BU of 5l08 by Molmil
Cryo-EM structure of Casp-8 tDED filament
Descriptor: Caspase-8
Authors:Fu, T.M, Li, Y, Lu, A, Wu, H.
Deposit date:2016-07-26
Release date:2016-11-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol.Cell, 64, 2016
5H31
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BU of 5h31 by Molmil
Structural basis for dimerization of the death effector domains of Caspase-8
Descriptor: Caspase-8
Authors:Shen, C, Pei, J, Guo, X, Quan, J.
Deposit date:2016-10-19
Release date:2017-10-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.16953516 Å)
Cite:Structural basis for dimerization of the death effector domains of Caspase-8
To Be Published
5H33
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BU of 5h33 by Molmil
Structural basis for dimerization of the death effector domains of Caspase-8
Descriptor: Caspase-8
Authors:Shen, C, Pei, J, Guo, X, Quan, J.
Deposit date:2016-10-20
Release date:2017-10-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.600138 Å)
Cite:Structural basis for dimerization of the death effector domains of Caspase-8
To Be Published
6AGW
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BU of 6agw by Molmil
Pro-domain of Caspase-8
Descriptor: Caspase-8 pro-domain
Authors:Park, H.H.
Deposit date:2018-08-15
Release date:2019-06-26
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:Molecular basis of dimerization of initiator caspase was revealed by crystal structure of caspase-8 pro-domain.
Cell Death Differ., 26, 2019
6P6C
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BU of 6p6c by Molmil
CS-Rosetta Model of PEA-15 Death Effector Domain in the Complex with ERK2
Descriptor: Astrocytic phosphoprotein PEA-15
Authors:Wei, Y, Crespo Flores, S, Cabezas, A, Hassan, S.
Deposit date:2019-06-03
Release date:2019-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions.
Int J Mol Sci, 20, 2019
6P6B
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BU of 6p6b by Molmil
CS-Rosetta Model of PEA-15 Death Effector Domain
Descriptor: Astrocytic phosphoprotein PEA-15
Authors:Wei, Y, Crespo Flores, S, Cabezas, A, Hassan, S.
Deposit date:2019-06-03
Release date:2019-07-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions.
Int J Mol Sci, 20, 2019
6M6O
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BU of 6m6o by Molmil
NMR SOLUTION STRUCTURE OF A C-FLIPs
Descriptor: CASP8 and FADD-like apoptosis regulator
Authors:Bai, Z.Q, Hu, K.F.
Deposit date:2020-03-16
Release date:2021-03-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structure of c-FLIP death effector domains.
Biochem.Biophys.Res.Commun., 617, 2022
7DEE
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BU of 7dee by Molmil
Structural Basis of the regulation of DISC Assembly by the interaction of c-FLIPs with Procaspase-8
Descriptor: C8-H1a, CASP8 and FADD-like apoptosis regulator
Authors:Bai, Z.Q, Hu, K.F.
Deposit date:2020-11-03
Release date:2021-11-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Backbone and side-chain chemical shift assignments of a cellular FLICE-inhibitory protein (c-FLIPS)
Biomol NMR Assign, 14, 2020
7LVM
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BU of 7lvm by Molmil
CASP8 isoform B DED domain
Descriptor: Caspase-8
Authors:Weichert, K, Lu, F, Kodandapani, L, Sauder, J.M.
Deposit date:2021-02-25
Release date:2022-03-02
Last modified:2022-04-20
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.
ACR Open Rheumatol, 4, 2022
7LVJ
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BU of 7lvj by Molmil
CASP8 isoform G DED domain
Descriptor: Isoform 9 of Caspase-8
Authors:Weichert, K, Lu, F, Kodandapani, L, Sauder, J.M.
Deposit date:2021-02-25
Release date:2022-03-02
Last modified:2022-04-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Caspase-8 Variant G Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Aggressive Behavior.
ACR Open Rheumatol, 4, 2022

 

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