1N3K
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SOLUTION STRUCTURE OF PHOSPHOPROTEIN ENRICHED IN ASTROCYTES 15 KDA (PEA-15)
Descriptor:Astrocytic phosphoprotein PEA-15
Authors:Hill, J.M., Vaidyanathan, H., Ramos, J.W., Ginsberg, M.H., Werner, M.H.
Deposit date:2002-10-28
Release date:2003-01-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Recognition of ERK MAP Kinase by PEA-15 Reveals a Common Docking Site Within the Death Domain and Death Effector Domain
Embo J., 21, 2002
2BBR
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CRYSTAL STRUCTURE OF MC159 REVEALS MOLECULAR MECHANISM OF DISC ASSEMBLY AND VFLIP INHIBITION
Descriptor:Viral CASP8 and FADD-like apoptosis regulator, AZIDE ION
Authors:Yang, J.K., Wang, L., Zheng, L., Wan, F., Ahmed, M., Lenardo, M.J., Wu, H.
Deposit date:2005-10-17
Release date:2006-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Mol.Cell, 20, 2005
2BBZ
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CRYSTAL STRUCTURE OF MC159 REVEALS MOLECULAR MECHANISM OF DISC ASSEMBLY AND VFLIP INHIBITION
Descriptor:Viral CASP8 and FADD-like apoptosis regulator
Authors:Yang, J.K., Wang, L., Zheng, L., Wan, F., Ahmed, M., Lenardo, M.J., Wu, H.
Deposit date:2005-10-18
Release date:2006-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.
Mol.Cell, 20, 2005
2F1S
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CRYSTAL STRUCTURE OF A VIRAL FLIP MC159
Descriptor:Viral CASP8 and FADD-like apoptosis regulator
Authors:Li, F.-Y., Jeffrey, P.D., Yu, J.W., Shi, Y.
Deposit date:2005-11-15
Release date:2005-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of a Viral FLIP: INSIGHTS INTO FLIP-MEDIATED INHIBITION OF DEATH RECEPTOR SIGNALING.
J.Biol.Chem., 281, 2006
2LS7
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HIGH DEFINITION SOLUTION STRUCTURE OF PED/PEA-15 DEATH EFFECTOR DOMAIN
Descriptor:Astrocytic phosphoprotein PEA-15
Authors:Twomey, E.C., Wei, Y.
Deposit date:2012-04-20
Release date:2012-08-08
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions.
Biochem.Biophys.Res.Commun., 424, 2012
3CL3
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CRYSTAL STRUCTURE OF A VFLIP-IKKGAMMA COMPLEX: INSIGHTS INTO VIRAL ACTIVATION OF THE IKK SIGNALOSOME
Descriptor:ORF K13, NF-kappa-B essential modulator
Authors:Bagneris, C., Ageichik, A.V., Cronin, N., Boshoff, C., Waksman, G., Barrett, T.
Deposit date:2008-03-18
Release date:2008-06-17
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.
Mol.Cell, 30, 2008
4ZBW
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CRYSTAL STRUCTURE OF DEATH EFFECTOR DOMAIN OF CASPASE8 IN HOMO SAPIENS
Descriptor:Caspase-8
Authors:Shen, C., Wang, T., Quan, J.
Deposit date:2015-04-15
Release date:2015-07-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the death effector domains of caspase-8
Biochem.Biophys.Res.Commun., 463, 2015
5H31
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STRUCTURAL BASIS FOR DIMERIZATION OF THE DEATH EFFECTOR DOMAINS OF CASPASE-8
Descriptor:Caspase-8
Authors:Shen, C., Pei, J., Guo, X., Quan, J.
Deposit date:2016-10-19
Release date:2017-10-25
Method:X-RAY DIFFRACTION (3.169535 Å)
Cite:Structural basis for dimerization of the death effector domains of Caspase-8
To Be Published
5H33
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STRUCTURAL BASIS FOR DIMERIZATION OF THE DEATH EFFECTOR DOMAINS OF CASPASE-8
Descriptor:Caspase-8
Authors:Shen, C., Pei, J., Guo, X., Quan, J.
Deposit date:2016-10-20
Release date:2017-10-25
Method:X-RAY DIFFRACTION (3.600138 Å)
Cite:Structural basis for dimerization of the death effector domains of Caspase-8
To Be Published
5L08
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CRYO-EM STRUCTURE OF CASP-8 TDED FILAMENT
Descriptor:Caspase-8
Authors:Fu, T.M., Li, Y., Lu, A., Wu, H.
Deposit date:2016-07-26
Release date:2016-11-02
Last modified:2016-11-30
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol.Cell, 64, 2016
5LDE
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CRYSTAL STRUCTURE OF A VFLIP-IKKGAMMA STAPLED PEPTIDE DIMER
Descriptor:Immunoglobulin G-binding protein G,Viral FLICE protein, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, ...
Authors:Barrett, T.
Deposit date:2016-06-24
Release date:2017-10-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:IKK gamma-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection.
J. Virol., 91, 2017
2GF5
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STRUCTURE OF INTACT FADD (MORT1)
Descriptor:FADD protein
Authors:Carrington, P.E., Sandu, C., Wei, Y., Hill, J.M., Morisawa, G., Huang, T., Gavathiotis, E., Wei, Y., Werner, M.H.
Deposit date:2006-03-21
Release date:2006-06-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structure of FADD and Its Mode of Interaction with Procaspase-8
Mol.Cell, 22, 2006
4IZ5
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STRUCTURE OF THE COMPLEX BETWEEN ERK2 PHOSPHOMIMETIC MUTANT AND PEA-15
Descriptor:Mitogen-activated protein kinase 1, Astrocytic phosphoprotein PEA-15, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Mace, P.D., Robinson, H., Riedl, S.J.
Deposit date:2013-01-29
Release date:2013-04-10
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Nat Commun, 4, 2013
4IZ7
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STRUCTURE OF NON-PHOSPHORYLATED ERK2 BOUND TO THE PEA-15 DEATH EFFECTOR DOMAIN
Descriptor:Mitogen-activated protein kinase 1, Astrocytic phosphoprotein PEA-15, SODIUM ION
Authors:Mace, P.D., Robinson, H., Riedl, S.J.
Deposit date:2013-01-29
Release date:2013-04-10
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Nat Commun, 4, 2013
4IZA
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STRUCTURE OF DUALLY PHOSPHORYLATED ERK2 BOUND TO THE PEA-15 DEATH EFFECTOR DOMAIN
Descriptor:Mitogen-activated protein kinase 1, Astrocytic phosphoprotein PEA-15
Authors:Mace, P.D., Robinson, H., Riedl, S.J.
Deposit date:2013-01-29
Release date:2013-04-10
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Nat Commun, 4, 2013
5JQE
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CRYSTAL STRUCTURE OF CASPASE8 TDED
Descriptor:Sugar ABC transporter substrate-binding protein,Caspase-8 chimera
Authors:Fu, T., Li, Y., Lu, A., Wu, H.
Deposit date:2016-05-04
Release date:2016-10-26
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (3.157 Å)
Cite:Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
Mol. Cell, 64, 2016
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