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1ZHT
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BU of 1zht by Molmil
Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol
Descriptor: 7-HYDROXYCHOLESTEROL, KES1 protein
Authors:Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H.
Deposit date:2005-04-26
Release date:2005-09-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural mechanism for sterol sensing and transport by OSBP-related proteins
Nature, 437, 2005
1ZHW
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BU of 1zhw by Molmil
Structure of yeast oxysterol binding protein Osh4 in complex with 20-hydroxycholesterol
Descriptor: 20-HYDROXYCHOLESTEROL, KES1 protein, LEAD (II) ION
Authors:Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H.
Deposit date:2005-04-26
Release date:2005-09-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural mechanism for sterol sensing and transport by OSBP-related proteins
Nature, 437, 2005
1ZHX
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BU of 1zhx by Molmil
Structure of yeast oxysterol binding protein Osh4 in complex with 25-hydroxycholesterol
Descriptor: 25-HYDROXYCHOLESTEROL, KES1 protein
Authors:Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H.
Deposit date:2005-04-26
Release date:2005-09-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural mechanism for sterol sensing and transport by OSBP-related proteins
Nature, 437, 2005
1ZHY
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BU of 1zhy by Molmil
Structure of yeast oxysterol binding protein Osh4 in complex with cholesterol
Descriptor: CHOLESTEROL, KES1 protein, LEAD (II) ION
Authors:Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H.
Deposit date:2005-04-26
Release date:2005-09-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural mechanism for sterol sensing and transport by OSBP-related proteins
Nature, 437, 2005
1ZHZ
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BU of 1zhz by Molmil
Structure of yeast oxysterol binding protein Osh4 in complex with ergosterol
Descriptor: ERGOSTEROL, KES1 protein, LEAD (II) ION
Authors:Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H.
Deposit date:2005-04-26
Release date:2005-09-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural mechanism for sterol sensing and transport by OSBP-related proteins
Nature, 437, 2005
1ZI7
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BU of 1zi7 by Molmil
Structure of truncated yeast oxysterol binding protein Osh4
Descriptor: KES1 protein, SULFATE ION
Authors:Im, Y.J, Raychaudhuri, S, Prinz, W.A, Hurley, J.H.
Deposit date:2005-04-27
Release date:2005-09-06
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural mechanism for sterol sensing and transport by OSBP-related proteins
Nature, 437, 2005
3SPW
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BU of 3spw by Molmil
Structure of Osh4p/Kes1p in complex with phosphatidylinositol 4-phosphate
Descriptor: (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, Protein KES1
Authors:Delfosse, V, de Saint-Jean, M, Douguet, D, Antonny, B, Drin, G, Bourguet, W.
Deposit date:2011-07-04
Release date:2011-11-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers.
J.Cell Biol., 195, 2011
4B2Z
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BU of 4b2z by Molmil
Structure of Osh6 in complex with phosphatidylserine
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, ...
Authors:Maeda, K, Anand, K, Chiapparino, A, Kumar, A, Poletto, M, Kaksonen, M, Gavin, A.C.
Deposit date:2012-07-19
Release date:2013-06-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Interactome Map Uncovers Phosphatidylserine Transport by Oxysterol-Binding Proteins
Nature, 501, 2013
4F4B
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BU of 4f4b by Molmil
Structure of OSH4 with a cholesterol analog
Descriptor: (3beta,9beta,25R)-3-hydroxy-26-iodocholest-5-ene-16,22-dione, Protein KES1
Authors:Koag, M.C, Monzingo, A.F, Cheun, Y, Lee, S.
Deposit date:2012-05-10
Release date:2013-05-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.
Steroids, 78, 2013
4FES
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BU of 4fes by Molmil
Structure of OSH4 in complex with cholesterol analogs
Descriptor: (3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2S,6S)-6-methyl-3-oxooctan-2-yl]-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-16H-cyclopenta[a]phenanthren-16-one, Protein KES1
Authors:Koag, M.C, Monzingo, A.F, Cheun, Y, Lee, S.
Deposit date:2012-05-30
Release date:2013-06-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.
Steroids, 78, 2013
4IC4
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BU of 4ic4 by Molmil
Crystal structure of Osh3 ORD from Saccharomyces cerevisiae
Descriptor: Oxysterol-binding protein homolog 3
Authors:Tong, J, Im, Y.J.
Deposit date:2012-12-09
Release date:2013-07-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins
Structure, 21, 2013
4INQ
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Crystal structure of Osh3 ORD in complex with PI(4)P from Saccharomyces cerevisiae
Descriptor: (2R)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Oxysterol-binding protein homolog 3
Authors:Tong, J, Im, Y.J.
Deposit date:2013-01-05
Release date:2013-07-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins
Structure, 21, 2013
4JCH
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BU of 4jch by Molmil
OSH4 bound to an electrophilic oxysterol
Descriptor: (3beta,9beta,22R,25R)-3-hydroxyfurost-5-en-27-yl propanoate, Protein KES1
Authors:Koag, M.C, Kou, Y.I, Monzingo, A.F, Lee, S.
Deposit date:2013-02-21
Release date:2014-03-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of OSH4 bound to an electrophilic oxysterol
To be Published
4PH7
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BU of 4ph7 by Molmil
Structure of Osh6p in complex with phosphatidylinositol 4-phosphate
Descriptor: (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, Oxysterol-binding protein homolog 6
Authors:Delfosse, V, Moser von Filseck, J, Antonny, B, Bourguet, W, Drin, G.
Deposit date:2014-05-05
Release date:2015-07-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate.
Science, 349, 2015
5H2D
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BU of 5h2d by Molmil
Crystal structure of Osh1 ORD domain in complex with ergosterol
Descriptor: ERGOSTEROL, KLLA0C04147p, SULFATE ION
Authors:Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S.
Deposit date:2016-10-14
Release date:2017-05-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction
Structure, 25, 2017
5WVR
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BU of 5wvr by Molmil
Crystal structure of Osh1 ORD domain in complex with cholesterol
Descriptor: CHOLESTEROL, KLLA0C04147p, SULFATE ION
Authors:Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S.
Deposit date:2016-12-28
Release date:2017-05-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction
Structure, 25, 2017
5ZM5
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BU of 5zm5 by Molmil
Crystal structure of human ORP1-ORD in complex with cholesterol at 2.6 A resolution
Descriptor: CHOLESTEROL, Oxysterol-binding protein-related protein 1
Authors:Dong, J, Wang, J, Wu, J.W.
Deposit date:2018-04-01
Release date:2019-02-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.
Nat Commun, 10, 2019
5ZM6
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BU of 5zm6 by Molmil
Crystal structure of ORP1-ORD in complex with PI(4,5)P2
Descriptor: ACETATE ION, Oxysterol-binding protein-related protein 1, [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate
Authors:Dong, J, Wang, J, Luo, Z, Wu, J.W.
Deposit date:2018-04-01
Release date:2019-02-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.
Nat Commun, 10, 2019
5ZM7
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BU of 5zm7 by Molmil
Crystal structure of ORP1-ORD in complex with cholesterol at 3.4 A resolution
Descriptor: CHOLESTEROL, Oxysterol-binding protein-related protein 1
Authors:Dong, J, Wang, J, Wu, J.W.
Deposit date:2018-04-01
Release date:2019-02-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.401 Å)
Cite:Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.
Nat Commun, 10, 2019
5ZM8
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BU of 5zm8 by Molmil
Crystal structure of ORP2-ORD in complex with PI(4,5)P2
Descriptor: Oxysterol-binding protein-related protein 2, [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate
Authors:Wang, H, Dong, J.Q, Wang, J, Wu, J.W.
Deposit date:2018-04-01
Release date:2019-01-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).
Mol. Cell, 73, 2019
7CYZ
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BU of 7cyz by Molmil
The structure of human ORP3 OSBP-related domain
Descriptor: Oxysterol-binding protein-related protein 3
Authors:Dong, X.
Deposit date:2020-09-05
Release date:2020-10-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of ORP3 reveals the conservative PI4P binding pattern.
Biochem.Biophys.Res.Commun., 529, 2020
7DEI
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BU of 7dei by Molmil
Structure of human ORP3 ORD domain in complex with PI(4)P
Descriptor: (2R)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Oxysterol-binding protein-related protein 3
Authors:Tong, J, Tan, L, Im, Y.J.
Deposit date:2020-11-04
Release date:2021-03-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.
Plos One, 16, 2021
7DEJ
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BU of 7dej by Molmil
Structure of human ORP3 ORD in apo-form
Descriptor: Oxysterol-binding protein-related protein 3
Authors:Tong, J, Tan, L, Im, Y.J.
Deposit date:2020-11-04
Release date:2021-03-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of human ORP3 ORD reveals conservation of a key function and ligand specificity in OSBP-related proteins.
Plos One, 16, 2021
7V62
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BU of 7v62 by Molmil
Crystal structure of human OSBP ORD in complex with cholesterol
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHOLESTEROL, CITRIC ACID, ...
Authors:Kobayashi, J, Kato, R.
Deposit date:2021-08-19
Release date:2022-06-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Ligand Recognition by the Lipid Transfer Domain of Human OSBP Is Important for Enterovirus Replication.
Acs Infect Dis., 8, 2022
8P7A
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BU of 8p7a by Molmil
Crystal structure of the ORD domain of human ORP8
Descriptor: Oxysterol-binding protein-related protein 8
Authors:Eisenreichova, A, Klima, M, Boura, E.
Deposit date:2023-05-30
Release date:2023-08-23
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Crystal Structure of the ORP8 Lipid Transport ORD Domain: Model of Lipid Transport.
Cells, 12, 2023

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