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1E8C
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Structure of MurE the UDP-N-acetylmuramyl tripeptide synthetase from E. coli
Descriptor: 2,6-DIAMINOPIMELIC ACID, CHLORIDE ION, UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE, ...
Authors:Gordon, E.J, Chantala, L, Dideberg, O.
Deposit date:2000-09-19
Release date:2001-09-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Udp-N-Acetylmuramoyl-L-Alanyl-D-Glutamate: Meso-Diaminopimelate Ligase from Escherichia Coli
J.Biol.Chem., 276, 2001
1GG4
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI UDPMURNAC-TRIPEPTIDE D-ALANYL-D-ALANINE-ADDING ENZYME (MURF) AT 2.3 ANGSTROM RESOLUTION
Descriptor: UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,6-DIAMINOPIMELATE-D-ALANYL-D-ALANYL LIGASE
Authors:Yan, Y, Munshi, S, Chen, Z.
Deposit date:2000-07-12
Release date:2000-12-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution.
J.Mol.Biol., 304, 2000
1GQQ
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MURC - Crystal structure of the apo-enzyme from Haemophilus influenzae
Descriptor: UDP-N-ACETYLMURAMATE-L-ALANINE LIGASE
Authors:Skarzynski, T, Cleasby, A, Domenici, E, Gevi, M, Shaw, J.
Deposit date:2001-12-03
Release date:2003-06-15
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structures of Udp-N-Acetylmuramate-L-Alanine Ligase (Murc) from Haemophilus Influenzae
To be Published
1GQY
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MURC - CRYSTAL STRUCTURE OF THE ENZYME FROM HAEMOPHILUS INFLUENZAE COMPLEXED WITH AMPPCP
Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, UDP-N-ACETYLMURAMATE-L-ALANINE LIGASE
Authors:Skarzynski, T, Cleasby, A, Domenici, E, Gevi, M, Shaw, J.
Deposit date:2001-12-06
Release date:2003-06-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Udp-N-Acetylmuramate-L-Alanine Ligase (Murc) from Haemophilus Influenzae
To be Published
1J6U
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BU of 1j6u by Molmil
Crystal structure of UDP-N-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution
Descriptor: UDP-N-acetylmuramate-alanine ligase MurC
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2002-08-29
Release date:2002-11-06
Last modified:2023-01-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution.
Proteins, 55, 2004
1P31
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BU of 1p31 by Molmil
Crystal Structure of UDP-N-acetylmuramic acid:L-alanine Ligase (MurC) from Haemophilus influenzae
Descriptor: MAGNESIUM ION, UDP-N-acetylmuramate--alanine ligase, URIDINE-DIPHOSPHATE-2(N-ACETYLGLUCOSAMINYL) BUTYRIC ACID
Authors:Mol, C.D, Brooun, A, Dougan, D.R, Hilgers, M.T, Tari, L.W, Wijnands, R.A, Knuth, M.W, McRee, D.E, Swanson, R.V.
Deposit date:2003-04-16
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzae.
J.Bacteriol., 185, 2003
1P3D
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BU of 1p3d by Molmil
Crystal Structure of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) in Complex with UMA and ANP.
Descriptor: MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, UDP-N-acetylmuramate--alanine ligase, ...
Authors:Mol, C.D, Brooun, A, Dougan, D.R, Hilgers, M.T, Tari, L.W, Wijnands, R.A, Knuth, M.W, McRee, D.E, Swanson, R.V.
Deposit date:2003-04-17
Release date:2003-07-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structures of Active Fully Assembled Substrate- and Product-Bound Complexes of UDP-N-Acetylmuramic Acid:L-Alanine Ligase (MurC) from Haemophilus influenzae.
J.Bacteriol., 185, 2003
2AM1
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sp protein ligand 1
Descriptor: 2,4-DICHLORO-N-(3-CYANO-4,5,6,7-TETRAHYDRO-BENZOTHIOPHEN-2YL)-5-(MORPHOLINE-4-SULFONYL)-BENZAMIDE, GLYCEROL, UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase, ...
Authors:Longenecker, K.L, Stamper, G.F, Hajduk, P.J, Fry, E.H, Jakob, C.G, Harlan, J.E, Edalji, R, Bartley, D.M, Walter, K.A, Solomon, L.R.
Deposit date:2005-08-08
Release date:2006-01-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure
Protein Sci., 14, 2005
2AM2
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sp protein ligand 2
Descriptor: 2-CHLORO-N-(3-CYANO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHEN-2-YL)-5-DIETHYLSULFAMOYL-BENZAMIDE, UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase, MurF protein
Authors:Longenecker, K.L, Stamper, G.F, Hajduk, P.J, Fry, E.H, Jakob, C.G, Harlan, J.E, Edalji, R, Bartley, D.M, Walter, K.A, Solomon, L.R.
Deposit date:2005-08-08
Release date:2006-01-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure
Protein Sci., 14, 2005
2F00
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Escherichia coli MurC
Descriptor: MAGNESIUM ION, UDP-N-acetylmuramate--L-alanine ligase
Authors:Deva, T, Baker, E.N, Squire, C.J, Smith, C.A.
Deposit date:2005-11-10
Release date:2006-10-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Escherichia coliUDP-N-acetylmuramoyl:L-alanine ligase (MurC).
Acta Crystallogr.,Sect.D, 62, 2006
2WTZ
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MurE ligase of Mycobacterium Tuberculosis
Descriptor: MAGNESIUM ION, UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE, URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE-D-GLUTAMATE
Authors:Basavannacharya, C, Robertson, G, Munshi, T, Keep, N.H, Bhakta, S.
Deposit date:2009-09-25
Release date:2009-12-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:ATP-Dependent Mure Ligase in Mycobacterium Tuberculosis: Biochemical and Structural Characterisation.
Tuberculosis(Edinb.), 90, 2010
2XJA
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Structure of MurE from M.tuberculosis with dipeptide and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE, ...
Authors:Basavannacharya, C, Moody, P.R, Bhakta, S, Keep, N.
Deposit date:2010-07-03
Release date:2010-08-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Essential Residues for the Enzyme Activity of ATP-Dependent Mure Ligase from Mycobacterium Tuberculosis.
Protein Cell, 1, 2010
3EAG
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The crystal structure of UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (MPL) from Neisseria meningitides
Descriptor: GLYCEROL, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
Authors:Chang, C, Hendricks, R, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
Deposit date:2008-08-25
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The crystal structure of UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (MPL) from Neisseria meningitides
To be Published
3HN7
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Crystal structure of a murein peptide ligase mpl (psyc_0032) from psychrobacter arcticus 273-4 at 1.65 A resolution
Descriptor: UDP-N-acetylmuramate-L-alanine ligase
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2009-05-29
Release date:2009-06-16
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and function of the first full-length murein Peptide ligase (mpl) cell wall recycling protein.
Plos One, 6, 2011
3ZL8
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CRYSTAL STRUCTURE OF MURF LIGASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE
Authors:Favini-Stabile, S, Contreras-Martel, C, Thielens, N, Dessen, A.
Deposit date:2013-01-29
Release date:2013-09-11
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mreb and Murg as Scaffolds for the Cytoplasmic Steps of Peptidoglycan Biosynthesis
Environ.Microbiol., 15, 2013
3ZM5
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BU of 3zm5 by Molmil
CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR
Descriptor: 2,4-bis(chloranyl)-N-[3-cyano-6-[(4-hydroxyphenyl)methyl]-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl]-5-morpholin-4-ylsulfonyl-benzamide, UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE
Authors:Hrast, M, Turk, S, Sosic, I, Knez, D, Randall, C.P, Barreteau, H, Contreras-Martel, C, Dessen, A, ONeill, A.J, Mengin-Lecreulx, D, Blanot, D, Gobec, S.
Deposit date:2013-02-05
Release date:2013-07-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Structure-Activity Relationships of New Cyanothiophene Inhibitors of the Essential Peptidoglycan Biosynthesis Enzyme Murf.
Eur.J.Med.Chem., 66C, 2013
3ZM6
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BU of 3zm6 by Molmil
CRYSTAL STRUCTURE OF MURF LIGASE IN COMPLEX WITH CYANOTHIOPHENE INHIBITOR
Descriptor: N-(6-(4-(2h-tetrazol-5-yl)benzyl)-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2,4-dichloro-5-(morpholinosulfonyl)benzamide, UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE
Authors:Hrast, M, Turk, S, Sosic, I, Knez, D, Randall, C.P, Barreteau, H, Contreras-Martel, C, Dessen, A, ONeill, A.J, Mengin-Lecreulx, D, Blanot, D, Gobec, S.
Deposit date:2013-02-05
Release date:2013-07-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structure-Activity Relationships of New Cyanothiophene Inhibitors of the Essential Peptidoglycan Biosynthesis Enzyme Murf.
Eur.J.Med.Chem., 66C, 2013
4BUB
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BU of 4bub by Molmil
CRYSTAL STRUCTURE OF MURE LIGASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--LD-LYSINE LIGASE
Authors:Favini-Stabile, S, Contreras-Martel, C, Thielens, N, Dessen, A.
Deposit date:2013-06-20
Release date:2013-07-17
Last modified:2013-12-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Mreb and Murg as Scaffolds for the Cytoplasmic Steps of Peptidoglycan Biosynthesis
Environ.Microbiol., 15, 2013
4C12
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X-ray Crystal Structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Fulop, V, Roper, D.I, Ruane, K.M, Barreteau, H, Boniface, A, Dementin, S, Blanot, D, Mengin-Lecreulx, D, Gobec, S, Dessen, A, Dowson, C.G, Lloyd, A.J.
Deposit date:2013-08-09
Release date:2013-10-02
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Specificity Determinants for Lysine Incorporation in Staphylococcus Aureus Peptidoglycan as Revealed by the Structure of a Mure Enzyme Ternary Complex.
J.Biol.Chem., 288, 2013
4C13
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x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys
Descriptor: CHLORIDE ION, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Ruane, K.M, Roper, D.I, Fulop, V, Barreteau, H, Boniface, A, Dementin, S, Blanot, D, Mengin-Lecreulx, D, Gobec, S, Dessen, A, Dowson, C.G, Lloyd, A.J.
Deposit date:2013-08-09
Release date:2013-10-02
Last modified:2021-03-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy.
Nat.Chem.Biol., 2021
4CVK
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BU of 4cvk by Molmil
PaMurF in complex with UDP-MurNAc-tripeptide (mDAP)
Descriptor: ALA-FGA-API, N-acetyl-alpha-muramic acid, UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase, ...
Authors:Ruane, K.M, Majce, V.
Deposit date:2014-03-28
Release date:2015-04-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Pamurf in Complex with Udp-Murnac-Tripeptide (Mdap)
To be Published
4CVL
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PaMurF in complex with AMP-PNP
Descriptor: MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE
Authors:Ruane, K.M, Majce, V.
Deposit date:2014-03-28
Release date:2015-04-22
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Pamurf in Complex with AMP-Pnp
To be Published
4CVM
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BU of 4cvm by Molmil
PaMurF in complex with AMP-PNP and UDP-MurNAc-tripeptide (mDAP)
Descriptor: ALANINE, GAMMA-D-GLUTAMIC ACID, MAGNESIUM ION, ...
Authors:Ruane, K.M, Majce, V.
Deposit date:2014-03-28
Release date:2015-04-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Pamurf in Complex with AMP-Pnp and Udp-Murnac-Tripeptide
To be Published
4HV4
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2.25 Angstrom resolution crystal structure of UDP-N-acetylmuramate--L-alanine ligase (murC) from Yersinia pestis CO92 in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, BETA-MERCAPTOETHANOL, UDP-N-acetylmuramate--L-alanine ligase
Authors:Halavaty, A.S, Minasov, G, Dubrovska, I, Winsor, J, Shuvalova, L, Peterson, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-11-05
Release date:2012-11-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:2.25 Angstrom resolution crystal structure of UDP-N-acetylmuramate--L-alanine ligase (murC) from Yersinia pestis CO92 in complex with AMP
To be Published
4QDI
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Crystal structure II of MurF from Acinetobacter baumannii
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:An, Y.J, Jeong, C.S, Cha, S.S.
Deposit date:2014-05-13
Release date:2015-04-01
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:ATP-binding mode including a carbamoylated lysine and two Mg(2+) ions, and substrate-binding mode in Acinetobacter baumannii MurF
Biochem.Biophys.Res.Commun., 450, 2014

 

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