1G8T
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SM ENDONUCLEASE FROM SERATIA MARCENSCENS AT 1.1 A RESOLUTION
Descriptor:NUCLEASE SM2 ISOFORM, SULFATE ION, MAGNESIUM ION
Authors:Lunin, V.V., Perbandt, M., Betzel, C.H., Mikhailov, A.M.
Deposit date:2000-11-21
Release date:2000-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic structure of the Serratia marcescens endonuclease at 1.1 A resolution and the enzyme reaction mechanism.
Acta Crystallogr.,Sect.D, 56, 2000
1QAE
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THE ACTIVE SITE OF SERRATIA ENDONUCLEASE CONTAINS A CONSERVED MAGNESIUM-WATER CLUSTER
Descriptor:PROTEIN (EXTRACELLULAR ENDONUCLEASE), MAGNESIUM ION
Authors:Miller, M.D., Krause, K.L.
Deposit date:1999-03-03
Release date:1999-05-18
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The active site of Serratia endonuclease contains a conserved magnesium-water cluster.
J.Mol.Biol., 288, 1999
1SMN
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IDENTIFICATION OF THE SERRATIA ENDONUCLEASE DIMER: STRUCTURAL BASIS AND IMPLICATIONS FOR CATALYSIS
Descriptor:EXTRACELLULAR ENDONUCLEASE
Authors:Miller, M.D., Krause, K.L.
Deposit date:1995-01-25
Release date:1996-01-29
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Identification of the Serratia endonuclease dimer: structural basis and implications for catalysis.
Protein Sci., 5, 1996
1ZM8
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APO CRYSTAL STRUCTURE OF NUCLEASE A FROM ANABAENA SP.
Descriptor:Nuclease, MANGANESE (II) ION, SULFATE ION, ...
Authors:Ghosh, M., Meiss, G., Pingoud, A., London, R.E., Pedersen, L.C.
Deposit date:2005-05-10
Release date:2005-06-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insights into the Mechanism of Nuclease A, a beta beta alpha Metal Nuclease from Anabaena.
J.Biol.Chem., 280, 2005
3OWV
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STRUCTURAL INSIGHTS INTO CATALYTIC AND SUBSTRATE BINDING MECHANISMS OF THE STRATEGIC ENDA NUCLEASE FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:DNA-entry nuclease, MAGNESIUM ION, CHLORIDE ION
Authors:Moon, A.F., Midon, M., Meiss, G., Pingoud, A.M., London, R.E., Pedersen, L.C.
Deposit date:2010-09-20
Release date:2010-12-22
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae.
Nucleic Acids Res., 39, 2011
3S5B
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CRYSTAL STRUCTURE OF CED-3 PROTEASE SUPPRESSOR-6 (CPS-6) FROM CAENORHABDITIS ELEGANS
Descriptor:Endonuclease G, MAGNESIUM ION
Authors:Yuan, H.S., Lin, J.L.J.
Deposit date:2011-05-23
Release date:2012-01-11
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.796 Å)
Cite:Structural insights into apoptotic DNA degradation by CED-3 protease suppressor-6 (CPS-6) from Caenorhabditis elegans
J.Biol.Chem., 287, 2012
4E3Y
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X-RAY STRUCTURE OF THE SERRATIA MARCESCENS ENDONUCLEASE AT 0.95 A RESOLUTION
Descriptor:Nuclease, MAGNESIUM ION, 1,2-ETHANEDIOL, ...
Authors:Lashkov, A.A., Balaev, V.V., Gabdoulkhakov, A.G., Betzel, C., Mikhailov, A.M.
Deposit date:2012-03-11
Release date:2013-05-08
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:X-ray structure of the Serratia marcescens endonuclease at 0.95 A resolution
To be Published
4QN0
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CRYSTAL STRUCTURE OF THE CPS-6 MUTANT Q130K
Descriptor:Endonuclease G, mitochondrial, MAGNESIUM ION
Authors:Lin, J.L.J., Yuan, H.S.
Deposit date:2014-06-17
Release date:2015-06-17
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G
Cell Rep, 16, 2016
5GKC
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THE CRYSTAL STRUCTURE OF THE CPS-6 H148A/F122A
Descriptor:Endonuclease G, mitochondrial
Authors:Lin, J.L., Yuan, H.S.
Deposit date:2016-07-04
Release date:2016-11-23
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer.
Nucleic Acids Res., 44, 2016
5GKP
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CRYSTAL STRUCTURE OF THE ENDOG WORM HOMOLOGUE CPS-6 H148A/F122A IN COMPLEX WITH DNA
Descriptor:Endonuclease G, mitochondrial, DNA (5'-D(*TP*TP*TP*TP*T)-3'), ...
Authors:Lin, J.L., Yuan, H.S.
Deposit date:2016-07-05
Release date:2016-11-23
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer.
Nucleic Acids Res., 44, 2016
2O3B
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CRYSTAL STRUCTURE COMPLEX OF NUCLEASE A (NUCA) WITH INTRA-CELLULAR INHIBITOR NUIA
Descriptor:Nuclease, Sugar-non-specific nuclease inhibitor, NICKEL (II) ION, ...
Authors:Ghosh, M., Meiss, G., Pingoud, A.M., London, R.E., Pedersen, L.C.
Deposit date:2006-12-01
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The nuclease a-inhibitor complex is characterized by a novel metal ion bridge.
J.Biol.Chem., 282, 2007
3ISM
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CRYSTAL STRUCTURE OF THE ENDOG/ENDOGI COMPLEX: MECHANISM OF ENDOG INHIBITION
Descriptor:CG8862, CG4930, MAGNESIUM ION, ...
Authors:Loll, B., Gebhardt, M., Wahle, E., Meinhart, A.
Deposit date:2009-08-26
Release date:2009-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition.
Nucleic Acids Res., 37, 2009
4A1N
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HUMAN MITOCHONDRIAL ENDO-EXONUCLEASE
Descriptor:NUCLEASE EXOG, MITOCHONDRIAL, MAGNESIUM ION, ...
Authors:Welin, M., Moche, M., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Nyman, T., Persson, C., Schuler, H., Thorsell, A.G., Tresaugues, L., Weigelt, J., Nordlund, P.
Deposit date:2011-09-16
Release date:2012-02-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human Mitochondrial Endo-Exonuclease
To be Published
6F2T
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CRYSTAL STRUCTURE OF ECTONUCLEOTIDE PHOSPHODIESTERASE/PYROPHOSPHATASE-3 (NPP3)
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, PHOSPHATE ION, ZINC ION, ...
Authors:Dohler, C., Zebisch, M., Strater, N.
Deposit date:2017-11-27
Release date:2018-08-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3).
Sci Rep, 8, 2018
6F2V
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CRYSTAL STRUCTURE OF ECTONUCLEOTIDE PHOSPHODIESTERASE/PYROPHOSPHATASE-3 (NPP3) IN COMPLEX WITH AMP
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, ADENOSINE MONOPHOSPHATE, ZINC ION, ...
Authors:Dohler, C., Zebisch, M., Strater, N.
Deposit date:2017-11-27
Release date:2018-08-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3).
Sci Rep, 8, 2018
6F2Y
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CRYSTAL STRUCTURE OF ECTONUCLEOTIDE PHOSPHODIESTERASE/PYROPHOSPHATASE-3 (NPP3) IN COMPLEX WITH AP4A
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, ZINC ION, ...
Authors:Dohler, C., Zebisch, M., Strater, N.
Deposit date:2017-11-27
Release date:2018-08-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3).
Sci Rep, 8, 2018
6F30
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CRYSTAL STRUCTURE OF ECTONUCLEOTIDE PHOSPHODIESTERASE/PYROPHOSPHATASE-3 (NPP3) IN COMPLEX WITH UDPGLCNAC
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ZINC ION, ...
Authors:Dohler, C., Zebisch, M., Strater, N.
Deposit date:2017-11-27
Release date:2018-08-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3).
Sci Rep, 8, 2018
6F33
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CRYSTAL STRUCTURE OF ECTONUCLEOTIDE PHOSPHODIESTERASE/PYROPHOSPHATASE-3 (NPP3) IN COMPLEX WITH AMPNPP
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, ZINC ION, ...
Authors:Dohler, C., Zebisch, M., Strater, N.
Deposit date:2017-11-27
Release date:2018-08-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure and substrate binding mode of ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3).
Sci Rep, 8, 2018
2XR9
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CRYSTAL STRUCTURE OF AUTOTAXIN (ENPP2)
Descriptor:ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Kamtekar, S., Hausmann, J., Day, J.E., Christodoulou, E., Perrakis, A.
Deposit date:2010-09-13
Release date:2011-01-19
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of substrate discrimination and integrin binding by autotaxin.
Nat. Struct. Mol. Biol., 18, 2011
2XRG
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CRYSTAL STRUCTURE OF AUTOTAXIN (ENPP2) IN COMPLEX WITH THE HA155 BORONIC ACID INHIBITOR
Descriptor:ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Hausmann, J., Albers, H.M.H.G., Perrakis, A.
Deposit date:2010-09-14
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis of Substrate Discrimination and Integrin Binding by Autotaxin.
Nat.Struct.Mol.Biol., 18, 2011
3NKM
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKN
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 14:0-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKO
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 16:0-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKP
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 18:1-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
3NKQ
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CRYSTAL STRUCTURE OF MOUSE AUTOTAXIN IN COMPLEX WITH 18:3-LPA
Descriptor:Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Nishimasu, H., Ishitani, R., Mihara, E., Takagi, J., Aoki, J., Nureki, O.
Deposit date:2010-06-20
Release date:2011-01-19
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of autotaxin and insight into GPCR activation by lipid mediators
Nat.Struct.Mol.Biol., 18, 2011
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