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1FIM
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MACROPHAGE MIGRATION INHIBITORY FACTOR
Descriptor: MACROPHAGE MIGRATION INHIBITORY FACTOR
Authors:Suzuki, M, Sugimoto, H, Nakagawa, A, Tanaka, I.
Deposit date:1996-01-31
Release date:1996-07-11
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the macrophage migration inhibitory factor from rat liver.
Nat.Struct.Biol., 3, 1996
1MIF
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)
Descriptor: MACROPHAGE MIGRATION INHIBITORY FACTOR
Authors:Sun, H.-W, Lolis, E.
Deposit date:1996-01-26
Release date:1996-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.
Proc.Natl.Acad.Sci.USA, 93, 1996
1GIF
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HUMAN GLYCOSYLATION-INHIBITING FACTOR
Descriptor: GLYCOSYLATION-INHIBITING FACTOR
Authors:Kato, Y, Kuroki, R.
Deposit date:1996-02-27
Release date:1997-03-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets.
Proc.Natl.Acad.Sci.USA, 93, 1996
1DPT
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D-DOPACHROME TAUTOMERASE
Descriptor: D-DOPACHROME TAUTOMERASE
Authors:Sugimoto, H, Taniguchi, M, Nakagawa, A, Tanaka, I.
Deposit date:1998-05-11
Release date:1999-03-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54 A resolution.
Biochemistry, 38, 1999
1CGQ
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH ALANINE INSERTED BETWEEN PRO-1 AND MET-2
Descriptor: PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
Authors:Lubetsky, J.B, Lolis, E.
Deposit date:1999-03-25
Release date:1999-06-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.
Biochemistry, 38, 1999
1P1G
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH PRO-1 MUTATED TO GLY-1
Descriptor: PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
Authors:Lubetsky, J.B, Lolis, E.
Deposit date:1999-03-24
Release date:1999-06-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.
Biochemistry, 38, 1999
1MFI
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR COMPLEXED WITH (E)-2-FLUORO-P-HYDROXYCINNAMATE
Descriptor: 2-FLUORO-3-(4-HYDROXYPHENYL)-2E-PROPENEOATE, PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
Authors:Taylor, A.B, Johnson Jr, W.H, Czerwinski, R.M, Whitman, C.P, Hackert, M.L.
Deposit date:1998-08-12
Release date:1999-06-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.
Biochemistry, 38, 1999
1CA7
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXPHENYLPYRUVATE
Descriptor: 3-(4-HYDROXY-PHENYL)PYRUVIC ACID, PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
Authors:Lubetsky, J.B, Lolis, E.
Deposit date:1999-02-25
Release date:1999-06-30
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.
Biochemistry, 38, 1999
1MFF
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MACROPHAGE MIGRATION INHIBITORY FACTOR Y95F MUTANT
Descriptor: MACROPHAGE MIGRATION INHIBITORY FACTOR
Authors:Taylor, A.B, Stamps, S.L, Wang, S.C, Hackert, M.L, Whitman, C.P.
Deposit date:1998-10-19
Release date:1999-07-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants.
Biochemistry, 39, 2000
1GCZ
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MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) COMPLEXED WITH INHIBITOR.
Descriptor: 7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER, CITRIC ACID, MACROPHAGE MIGRATION INHIBITORY FACTOR, ...
Authors:Katayama, N, Kurihara, H.
Deposit date:2000-08-24
Release date:2001-02-21
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.
J.Med.Chem., 44, 2001
1GD0
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HUMAN MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)
Descriptor: CITRIC ACID, MACROPHAGE MIGRATION INHIBITORY FACTOR, SULFATE ION
Authors:Kurihara, H, Katayama, N.
Deposit date:2000-08-24
Release date:2001-02-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.
J.Med.Chem., 44, 2001
1HFO
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The Structure of the Macrophage Migration Inhibitory Factor from Trichinella Spiralis.
Descriptor: MIGRATION INHIBITORY FACTOR
Authors:Roe, S.M, Meyer, D.J.
Deposit date:2000-12-07
Release date:2001-08-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Macrophage Migration Inhibitory Factor of the Parasitic Nematode Trichinella Spiralis
Biochem.J., 357, 2001
1LJT
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Crystal Structure of Macrophage Migration Inhibitory Factor complexed with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole-acetic acid methyl ester (ISO-1)
Descriptor: 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER, Macrophage migration inhibitory factor
Authors:Lubetsky, J.B, Dios, A, Han, J, Aljabari, B, Ruzsicska, B, Mitchell, R, Lolis, E, Al-Abed, Y.
Deposit date:2002-04-22
Release date:2002-11-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Tautomerase Active Site of Macrophage Migration Inhibitory factor is a Potential Target for Discovery of Novel Anti-inflammatory Agents
J.Biol.Chem., 277, 2002
1UIZ
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Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis.
Descriptor: Macrophage Migration Inhibitory Factor
Authors:Suzuki, M, Takamura, Y, Maeno, M, Tochinai, S, Iyaguchi, D, Tanaka, I, Nishihira, J, Ishibashi, T.
Deposit date:2003-07-24
Release date:2004-05-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Xenopus laevis Macrophage Migration Inhibitory Factor Is Essential for Axis Formation and Neural Development.
J.Biol.Chem., 279, 2004
2GDG
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Crystal structure of covalently modified macrophage inhibitory factor
Descriptor: Macrophage migration inhibitory factor
Authors:Golubkov, P.A, Hackert, M.L.
Deposit date:2006-03-16
Release date:2006-07-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate.
Bioorg.Chem., 34, 2006
2OOW
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MIF Bound to a Fluorinated OXIM Derivative
Descriptor: 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Crichlow, G.V, Al-Abed, Y, Lolis, E.
Deposit date:2007-01-26
Release date:2007-06-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.
J.Biol.Chem., 282, 2007
2OOZ
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Macrophage Migration Inhibitory Factor (MIF) Complexed with OXIM6 (an OXIM Derivative Not Containing a Ring in its R-group)
Descriptor: 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Crichlow, G.V, Al-Abed, Y, Lolis, E.
Deposit date:2007-01-26
Release date:2007-06-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.
J.Biol.Chem., 282, 2007
2OOH
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Crystal Structure of MIF bound to a Novel Inhibitor, OXIM-11
Descriptor: 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME, GLYCEROL, Macrophage migration inhibitory factor, ...
Authors:Crichlow, G.V, Al-Abed, Y, Lolis, E.
Deposit date:2007-01-25
Release date:2007-06-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.
J.Biol.Chem., 282, 2007
2OS5
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Macrophage migration inhibitory factor from Ancylostoma ceylanicum
Descriptor: AceMIF, SULFATE ION
Authors:Cho, Y, Lolis, E.
Deposit date:2007-02-05
Release date:2007-06-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74.
J.Biol.Chem., 282, 2007
3B64
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Macrophage Migration Inhibitory Factor (MIF) From /Leishmania Major
Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor-like protein
Authors:Zierow, S, Cho, Y, Lolis, E.
Deposit date:2007-10-27
Release date:2008-06-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:A leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses.
J.Immunol., 180, 2008
3B9S
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Macrophage Migration Inhibitory Factor (MIF) complexed with Inhibitor, 4-IPP.
Descriptor: 4-phenylpyrimidine, GLYCEROL, Macrophage Migration Inhibitory Factor, ...
Authors:Zierow, S, Crichlow, G, Lolis, E.
Deposit date:2007-11-06
Release date:2008-09-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.
Cancer Res., 68, 2008
3DJH
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Macrophage Migration Inhibitory Factor (MIF) at 1.25 A Resolution
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Crichlow, G.V, Lolis, E.
Deposit date:2008-06-23
Release date:2008-12-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.
Biochemistry, 48, 2009
3DJI
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Crystal Structure of Macrophage Migration Inhibitory Factor Bound to an Acetaminophen Dimer Derived from NAPQI
Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor, N,N'-(6,6'-dihydroxybiphenyl-3,3'-diyl)diacetamide
Authors:Crichlow, G.V, Lolis, E.
Deposit date:2008-06-23
Release date:2008-12-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.
Biochemistry, 48, 2009
3CE4
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Structure of Macrophage Migration Inhibitory Factor Covalently Inhibited by PMSF Treatment
Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ...
Authors:Crichlow, G.V, Lolis, E.
Deposit date:2008-02-28
Release date:2008-12-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.
Biochemistry, 48, 2009
3FWT
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Crystal structure of Leishmania major MIF2
Descriptor: Macrophage migration inhibitory factor-like protein
Authors:Walkinshaw, M.D, Richardson, J.M.
Deposit date:2009-01-19
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Leishmania major orthologues of macrophage migration inhibitory factor
Biochem.Biophys.Res.Commun., 380, 2009

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