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7CQT
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BU of 7cqt by Molmil
Crystal structure of Brassica juncea HMG-CoA synthase 1 mutant - S359A in complex with acetyl-CoA
Descriptor: 3-hydroxy-3-methylglutaryl coenzyme A synthase, ACETYL COENZYME *A, ADENOSINE-3'-5'-DIPHOSPHATE
Authors:Liao, P, Hu, M, Kong, G.K.W, Hao, Q, Chye, M.L.
Deposit date:2020-08-11
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Overexpression and Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA Synthase Affect Central Metabolic Pathways in Tobacco.
Plant Cell.Physiol., 62, 2021
6ET9
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BU of 6et9 by Molmil
Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Acetyl-CoA acetyltransferase thiolase, CHLORIDE ION, ...
Authors:Engilberge, S, Voegeli, B, Girard, E, Riobe, F, Maury, O, Erb, T.J, Shima, S, Wagner, T.
Deposit date:2017-10-25
Release date:2018-03-14
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6ESQ
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BU of 6esq by Molmil
Structure of the acetoacetyl-CoA thiolase/HMG-CoA synthase complex from Methanothermococcus thermolithotrophicus soaked with acetyl-CoA
Descriptor: CHLORIDE ION, COENZYME A, HydroxyMethylGlutaryl-CoA synthase, ...
Authors:Voegeli, B, Engilberge, S, Girard, E, Riobe, F, Maury, O, Erb, J.T, Shima, S, Wagner, T.
Deposit date:2017-10-24
Release date:2018-03-14
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5KP8
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BU of 5kp8 by Molmil
Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Acetyl Donor-ACP
Descriptor: 4'-PHOSPHOPANTETHEINE, CurB, CurD, ...
Authors:Maloney, F.P, Smith, J.L.
Deposit date:2016-07-02
Release date:2016-08-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KP5
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BU of 5kp5 by Molmil
Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase
Descriptor: CurD, SULFATE ION
Authors:Maloney, F.P, Smith, J.L.
Deposit date:2016-07-02
Release date:2016-08-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KP7
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BU of 5kp7 by Molmil
Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Holo Donor-ACP
Descriptor: 4'-PHOSPHOPANTETHEINE, CurB, CurD, ...
Authors:Maloney, F.P, Smith, J.L.
Deposit date:2016-07-02
Release date:2016-08-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Proc.Natl.Acad.Sci.USA, 113, 2016
5KP6
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Crystal Structure of the Curacin Biosynthetic Pathway HMG Synthase in Complex with Apo Donor-ACP
Descriptor: CurB, CurD
Authors:Maloney, F.P, Smith, J.L.
Deposit date:2016-07-02
Release date:2016-08-31
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Anatomy of the beta-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.
Proc.Natl.Acad.Sci.USA, 113, 2016
5HWO
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BU of 5hwo by Molmil
MvaS in complex with 3-hydroxy-3-methylglutaryl coenzyme A
Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ...
Authors:Bock, T, Kasten, J, Blankenfeldt, W.
Deposit date:2016-01-29
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5HWP
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MvaS with acetylated Cys115 in complex with coenzyme A
Descriptor: COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ...
Authors:Bock, T, Kasten, J, Blankenfeldt, W.
Deposit date:2016-01-29
Release date:2016-05-11
Last modified:2016-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5HWR
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MvaS in complex with coenzyme A
Descriptor: COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ...
Authors:Bock, T, Kasten, J, Blankenfeldt, W.
Deposit date:2016-01-29
Release date:2016-05-11
Last modified:2016-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
5HWQ
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MvaS in complex with acetoacetyl coenzyme A
Descriptor: ACETOACETYL-COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ...
Authors:Bock, T, Kasten, J, Blankenfeldt, W.
Deposit date:2016-01-29
Release date:2016-05-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of the HMG-CoA Synthase MvaS from the Gram-Negative Bacterium Myxococcus xanthus.
Chembiochem, 17, 2016
4YXT
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BU of 4yxt by Molmil
PksG, a HMG-CoA Synthase from Bacillus subtilus
Descriptor: Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
Authors:Till, M, Nair, A.V, Robson, A, Race, P.R.
Deposit date:2015-03-23
Release date:2016-06-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:PksG, a HMG-CoA Synthase from Bacillus subtilus
To Be Published
4YXQ
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BU of 4yxq by Molmil
PksG, a HMG-CoA Synthase from Bacillus subtilis
Descriptor: DI(HYDROXYETHYL)ETHER, Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
Authors:Nair, A.V, Race, P.R, Till, M.
Deposit date:2015-03-23
Release date:2016-06-29
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:PksG, a HMG-CoA Synthase from Bacillus subtilis
To Be Published
4YXV
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BU of 4yxv by Molmil
PksG, a HMG-CoA Synthase from Bacillus subtilus
Descriptor: Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG
Authors:Till, M, Nair, A.V, Robson, A, Race, P.R.
Deposit date:2015-03-23
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:PksG, a HMG-CoA Synthase from Bacillus subtilus
To Be Published
3V4X
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BU of 3v4x by Molmil
The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthase, mvaS, by Hymeglusin
Descriptor: (7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid, HMG-CoA synthase
Authors:Skaff, D.A, Ramyar, K.X, McWhorter, W.J, Geisbrecht, B.V, Miziorko, H.M.
Deposit date:2011-12-15
Release date:2012-04-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.
Biochemistry, 51, 2012
3V4N
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BU of 3v4n by Molmil
The Biochemical and Structural Basis for Inhibition of Enterococcus faecalis HMG-CoA Synthatse, mvaS, by Hymeglusin
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HMG-CoA synthase
Authors:Skaff, D.A, Ramyar, K.X, McWhorter, W.J, Geisbrecht, B.V, Miziorko, H.M.
Deposit date:2011-12-15
Release date:2012-04-25
Last modified:2014-09-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin.
Biochemistry, 51, 2012
2WYA
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BU of 2wya by Molmil
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL- COENZYME A SYNTHASE 2 (HMGCS2)
Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, GLYCEROL, HYDROXYMETHYLGLUTARYL-COA SYNTHASE, ...
Authors:Yue, W.W, Shafqat, N, Savitsky, P, Roos, A.K, Cooper, C, Murray, J.W, von Delft, F, Arrowsmith, C, Wikstrom, M, Edwards, A, Bountra, C, Oppermann, U.
Deposit date:2009-11-13
Release date:2009-11-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structures of Human Hmg-Coa Synthase Isoforms Provide Insights Into Inherited Ketogenesis Disorders and Inhibitor Design.
J.Mol.Biol., 398, 2010
2P8U
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BU of 2p8u by Molmil
Crystal structure of human 3-hydroxy-3-methylglutaryl CoA synthase I
Descriptor: COENZYME A, GLYCEROL, Hydroxymethylglutaryl-CoA synthase, ...
Authors:Turnbull, A, Shafqat, N, Salah, E, Niesen, F.H, Burgess, N, Bunkoczi, G, Debreczeni, J, Pike, A.C.W, Umeano, C, Gorrec, F, von Delft, F, Weigelt, J, Arrowsmith, C.H, Sundstrom, M, Edwards, A, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2007-03-23
Release date:2007-04-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
J.Mol.Biol., 398, 2010
2HDB
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BU of 2hdb by Molmil
HMG-CoA synthase from Enterococcus faecalis. Mutation alanine 110 to glycine
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HMG-CoA synthase, SULFATE ION
Authors:Steussy, C.N, Sutherlin, A, Stauffacher, C.V.
Deposit date:2006-06-20
Release date:2007-03-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A structural limitation on enzyme activity: the case of HMG-CoA synthase.
Biochemistry, 45, 2006
2FA0
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BU of 2fa0 by Molmil
HMG-CoA synthase from Brassica juncea in complex with HMG-CoA and covalently bound to HMG-CoA
Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, HMG-CoA synthase
Authors:Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
Deposit date:2005-12-06
Release date:2006-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FA3
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BU of 2fa3 by Molmil
HMG-CoA synthase from Brassica juncea in complex with acetyl-CoA and acetyl-cys117.
Descriptor: ACETYL COENZYME *A, HMG-CoA synthase
Authors:Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
Deposit date:2005-12-06
Release date:2006-07-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2F9A
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BU of 2f9a by Molmil
HMG-CoA synthase from Brassica juncea in complex with F-244
Descriptor: (7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid, 3-Hydroxy-3-methylglutaryl coenzyme A synthase 1
Authors:Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
Deposit date:2005-12-05
Release date:2006-07-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2F82
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BU of 2f82 by Molmil
HMG-CoA synthase from Brassica juncea in the apo-form
Descriptor: HMG-CoA synthase
Authors:Pojer, F, Ferrer, J.L, Richard, S.B, Noel, J.P.
Deposit date:2005-12-01
Release date:2006-07-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases.
Proc.Natl.Acad.Sci.Usa, 103, 2006
1YSL
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BU of 1ysl by Molmil
Crystal structure of HMG-CoA synthase from Enterococcus faecalis with AcetoAcetyl-CoA ligand.
Descriptor: ACETOACETIC ACID, COENZYME A, GLYCEROL, ...
Authors:Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V.
Deposit date:2005-02-08
Release date:2005-11-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA.
Biochemistry, 44, 2005
1XPL
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BU of 1xpl by Molmil
Crystal Structure of Staphylococcus aureus HMG-COA Synthase with Acetoacetyl-COA and Acetylated Cysteine
Descriptor: 3-hydroxy-3-methylglutaryl CoA synthase, ACETOACETYL-COENZYME A, SULFATE ION
Authors:Theisen, M.J, Misra, I, Saadat, D, Campobasso, N, Miziorko, H.M, Harrison, D.H.T.
Deposit date:2004-10-08
Release date:2004-11-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
Proc.Natl.Acad.Sci.USA, 47, 2004

 

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