2H8A
 
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2UUI
 | | Crystal structure of Human Leukotriene C4 Synthase | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, LEUKOTRIENE C4 SYNTHASE, NICKEL (II) ION, ... | | Authors: | Martinez Molina, D, Wetterholm, A, Kohl, A, McCarthy, A.A, Niegowski, D, Ohlson, E, Hammarberg, T, Eshaghi, S, Haeggstrom, J.Z, Nordlund, P. | | Deposit date: | 2007-03-02 | | Release date: | 2007-07-17 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase.
Nature, 448, 2007
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2UUH
 | | Crystal structure of Human Leukotriene C4 Synthase in complex with substrate glutathione | | Descriptor: | DODECYL-ALPHA-D-MALTOSIDE, GLUTATHIONE, LEUKOTRIENE C4 SYNTHASE, ... | | Authors: | Martinez Molina, D, Wetterholm, A, Kohl, A, McCarthy, A.A, Niegowski, D, Ohlson, E, Hammarberg, T, Eshaghi, S, Haeggstrom, J.Z, Nordlund, P. | | Deposit date: | 2007-03-02 | | Release date: | 2007-07-17 | | Last modified: | 2011-12-07 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase.
Nature, 448, 2007
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2PNO
 | | Crystal structure of human leukotriene C4 synthase | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, GLUTATHIONE, Leukotriene C4 synthase | | Authors: | Ago, H, Kanaoka, Y, Irikura, D, Lam, B.K, Shimamura, T, Austen, K.F, Miyano, M. | | Deposit date: | 2007-04-24 | | Release date: | 2007-08-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
Nature, 448, 2007
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2Q7M
 | | Crystal structure of human FLAP with MK-591 | | Descriptor: | 3-[3-(TERT-BUTYLTHIO)-1-(4-CHLOROBENZYL)-5-(QUINOLIN-2-YLMETHOXY)-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID, Arachidonate 5-lipoxygenase-activating protein | | Authors: | Ferguson, A.D. | | Deposit date: | 2007-06-07 | | Release date: | 2007-08-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (4.25 Å) | | Cite: | Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.
Science, 317, 2007
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2Q7R
 | | Crystal structure of human FLAP with an iodinated analog of MK-591 | | Descriptor: | 3-[3-(3,3-DIMETHYLBUTANOYL)-1-(4-IODOBENZYL)-5-(QUINOLIN-2-YLMETHOXY)-1H-INDOL-2-YL]-2,2-DIMETHYLPROPANOIC ACID, Arachidonate 5-lipoxygenase-activating protein | | Authors: | Ferguson, A.D. | | Deposit date: | 2007-06-07 | | Release date: | 2007-08-21 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.
Science, 317, 2007
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3DWW
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3HKK
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3LEO
 | | Structure of human Leukotriene C4 synthase mutant R31Q in complex with glutathione | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, GLUTATHIONE, GLYCEROL, ... | | Authors: | Niegowski, D, Martinez-Molina, D, Rinaldo-Matthis, A, Nordlund, P, Haeggstrom, J. | | Deposit date: | 2010-01-15 | | Release date: | 2010-10-27 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Arginine 104 is a key catalytic residue in leukotriene C4 synthase.
J.Biol.Chem., 285, 2010
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3PCV
 | | Crystal structure analysis of human leukotriene C4 synthase at 1.9 angstrom resolution | | Descriptor: | 1,2-ETHANEDIOL, DODECYL-BETA-D-MALTOSIDE, GLUTATHIONE, ... | | Authors: | Saino, H, Ago, H, Miyano, M. | | Deposit date: | 2010-10-22 | | Release date: | 2011-03-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The catalytic architecture of leukotriene C4 synthase with two arginine residues
J.Biol.Chem., 286, 2011
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3B29
 | | Human leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside | | Descriptor: | GLUTATHIONE, Leukotriene C4 synthase, SULFATE ION, ... | | Authors: | Saino, H, Ago, H, Miyano, M. | | Deposit date: | 2011-07-22 | | Release date: | 2011-12-14 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Seleno-detergent MAD phasing of leukotriene C4 synthase in complex with dodecyl-beta-D-selenomaltoside
Acta Crystallogr.,Sect.F, 67, 2011
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4AL0
 | | Crystal structure of Human PS-1 | | Descriptor: | GLUTATHIONE, PALMITIC ACID, PROSTAGLANDIN E SYNTHASE, ... | | Authors: | Sjogren, T, Nord, J, Ek, M, Johansson, P, Liu, G, Geschwindner, S. | | Deposit date: | 2012-02-29 | | Release date: | 2013-02-06 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.16 Å) | | Cite: | Crystal Structure of Microsomal Prostaglandin E2 Synthase Provides Insight Into Diversity in the Mapeg Superfamily.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4AL1
 | | Crystal structure of Human PS-1 GSH-analog complex | | Descriptor: | L-gamma-glutamyl-S-(2-biphenyl-4-yl-2-oxoethyl)-L-cysteinylglycine, PALMITIC ACID, PROSTAGLANDIN E SYNTHASE, ... | | Authors: | Sjogren, T, Nord, J, Ek, M, Johansson, P, Liu, G, Geschwindner, S. | | Deposit date: | 2012-02-29 | | Release date: | 2013-02-06 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal Structure of Microsomal Prostaglandin E2 Synthase Provides Insight Into Diversity in the Mapeg Superfamily.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4JC7
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | Descriptor: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | | Authors: | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | Deposit date: | 2013-02-21 | | Release date: | 2014-01-01 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
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4JRZ
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | Descriptor: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | | Authors: | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | Deposit date: | 2013-03-22 | | Release date: | 2014-01-01 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
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4JCZ
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | Descriptor: | Leukotriene C4 synthase, NICKEL (II) ION, PALMITIC ACID, ... | | Authors: | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | Deposit date: | 2013-02-22 | | Release date: | 2014-01-01 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
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4J7T
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | Descriptor: | D-gamma-glutamyl-S-(4-phenylbutyl)-L-cysteinylglycine, Leukotriene C4 synthase, NICKEL (II) ION, ... | | Authors: | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | Deposit date: | 2013-02-14 | | Release date: | 2014-01-01 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.203 Å) | | Cite: | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
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4J7Y
 | | Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis | | Descriptor: | D-gamma-glutamyl-(Z)-N-(carboxymethylidene)-S-[(2R)-2-hydroxy-4-phenylbutyl]-L-cysteinamide, Leukotriene C4 synthase, NICKEL (II) ION, ... | | Authors: | Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. | | Deposit date: | 2013-02-14 | | Release date: | 2014-01-01 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.901 Å) | | Cite: | Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM.
J.Biol.Chem., 289, 2014
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4BPM
 | | Crystal structure of a human integral membrane enzyme | | Descriptor: | 2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide, GLUTATHIONE, PROSTAGLANDIN E SYNTHASE, ... | | Authors: | Li, D, Wang, M, Olieric, V, Caffrey, M. | | Deposit date: | 2013-05-27 | | Release date: | 2014-04-16 | | Last modified: | 2019-04-03 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy.
Cryst.Growth Des., 14, 2014
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4WAB
 | | Crystal structure of mPGES1 solved by native-SAD phasing | | Descriptor: | 2-[[2,6-bis(chloranyl)-3-[(2,2-dimethylpropanoylamino)methyl]phenyl]amino]-1-methyl-6-(2-methyl-2-oxidanyl-propoxy)-N-[2,2,2-tris(fluoranyl)ethyl]benzimidazole-5-carboxamide, GLUTATHIONE, Prostaglandin E synthase,Leukotriene C4 synthase | | Authors: | Weinert, T, Li, D, Howe, N, Caffrey, M, Wang, M. | | Deposit date: | 2014-08-29 | | Release date: | 2014-12-10 | | Last modified: | 2015-02-11 | | Method: | X-RAY DIFFRACTION (2.704 Å) | | Cite: | Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
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4NTF
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4NTA
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4NTB
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4YL1
 | | Crystal Structures of mPGES-1 Inhibitor Complexes | | Descriptor: | 5-(4-tert-butylphenyl)-1-[4-(propan-2-yloxy)phenyl]-1H-indole-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLUTATHIONE, ... | | Authors: | Luz, J.G, Antonysamy, S, Kuklish, S.L, Fisher, M.J. | | Deposit date: | 2015-03-04 | | Release date: | 2015-06-10 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.41 Å) | | Cite: | Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem., 58, 2015
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4YL0
 | | Crystal Structures of mPGES-1 Inhibitor Complexes | | Descriptor: | 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile, DI(HYDROXYETHYL)ETHER, GLUTATHIONE, ... | | Authors: | Luz, J.G, Antonysamy, S, Kuklish, S.L, Fisher, M.J. | | Deposit date: | 2015-03-04 | | Release date: | 2015-06-10 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem., 58, 2015
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