1CKS
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HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL
Descriptor:CYCLIN-DEPENDENT KINASE SUBUNIT, TYPE 2, SULFATE ION
Authors:Parge, H.E., Arvai, A.S., Tainer, J.A.
Deposit date:1993-09-16
Release date:1995-02-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.
Science, 262, 1993
1DKS
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CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 IN COMPLEX WITH PHOSPHATE
Descriptor:CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1, PHOSPHATE ION
Authors:Bourne, Y., Arvai, A.S., Tainer, J.A.
Deposit date:1995-11-22
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain.
J.Mol.Biol., 249, 1995
1DKT
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CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 COMPLEX WITH METAVANADATE
Descriptor:CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1, META VANADATE
Authors:Bourne, Y., Arvai, A.S., Tainer, J.A.
Deposit date:1995-11-22
Release date:1996-03-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain.
J.Mol.Biol., 249, 1995
1PUC
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P13SUC1 IN A STRAND-EXCHANGED DIMER
Descriptor:P13SUC1, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE
Authors:Khazanovich, N., Bateman, K.S., Chernaia, M., Michalak, M., James, M.N.G.
Deposit date:1995-12-08
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the yeast cell-cycle control protein, p13suc1, in a strand-exchanged dimer.
Structure, 4, 1996
1QB3
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CRYSTAL STRUCTURE OF THE CELL CYCLE REGULATORY PROTEIN CKS1
Descriptor:CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT
Authors:Bourne, Y., Watson, M.H., Arvai, A.S., Bernstein, S.L., Reed, S.I., Tainer, J.A.
Deposit date:1999-04-30
Release date:2000-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure and mutational analysis of the Saccharomyces cerevisiae cell cycle regulatory protein Cks1: implications for domain swapping, anion binding and protein interactions.
Structure Fold.Des., 8, 2000
1SCE
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CRYSTAL STRUCTURE OF THE CELL CYCLE REGULATORY PROTEIN SUC1 REVEALS A NOVEL BETA-HINGE CONFORMATIONAL SWITCH
Descriptor:SUC1, CHLORIDE ION
Authors:Bourne, Y., Tainer, J.A.
Deposit date:1995-05-11
Release date:1996-01-29
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch.
Proc.Natl.Acad.Sci.USA, 92, 1995
3QY2
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CRYSTAL STRUCTURE OF THE P93A MONOMER MUTANT OF S. CEREVISIAE CKS1
Descriptor:Cyclin-dependent kinases regulatory subunit, CITRATE ANION
Authors:Balog, E.R.M., Saetern, O.C., Finch, W., Hoeft, C.O., Thai, V., Harvey, S.L., Kellogg, D.K., Rubin, S.M.
Deposit date:2011-03-02
Release date:2011-06-29
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:The structure of a monomeric mutant cks protein reveals multiple functions for a conserved hinge-region proline.
J.Mol.Biol., 411, 2011
4LPA
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CRYSTAL STRUCTURE OF A CDC6 PHOSPHOPEPTIDE IN COMPLEX WITH CKS1
Descriptor:Cyclin-dependent kinases regulatory subunit
Authors:McGrath, D.A., Balog, E.R.M., Koivomagi, M., Lucena, R., Mai, M.V., Hirschi, A., Kellogg, D.R., Loog, M., Rubin, S.M.
Deposit date:2013-07-15
Release date:2013-11-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Cks confers specificity to phosphorylation-dependent CDK signaling pathways.
Nat.Struct.Mol.Biol., 20, 2013
1BUH
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CRYSTAL STRUCTURE OF THE HUMAN CDK2 KINASE COMPLEX WITH CELL CYCLE-REGULATORY PROTEIN CKSHS1
Descriptor:PROTEIN (CDK2 HUMAN), PROTEIN (CKSHS1 HUMAN)
Authors:Bourne, Y., Tainer, J.A.
Deposit date:1998-09-03
Release date:1998-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.
Cell(Cambridge,Mass.), 84, 1996
2ASS
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CRYSTAL STRUCTURE OF THE SKP1-SKP2-CKS1 COMPLEX
Descriptor:S-phase kinase-associated protein 1A, S-phase kinase-associated protein 2, Cyclin-dependent kinases regulatory subunit 1, ...
Authors:Hao, B., Zhang, N., Schulman, B.A., Wu, G., Pagano, M., Pavletich, N.P.
Deposit date:2005-08-24
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase.
Mol.Cell, 20, 2005
2AST
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CRYSTAL STRUCTURE OF SKP1-SKP2-CKS1 IN COMPLEX WITH A P27 PEPTIDE
Descriptor:S-phase kinase-associated protein 1A, S-phase kinase-associated protein 2, Cyclin-dependent kinases regulatory subunit 1, ...
Authors:Hao, B., Zhang, N., Schulman, B.A., Wu, G., Pagano, M., Pavletich, N.P.
Deposit date:2005-08-24
Release date:2005-10-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of the Cks1-Dependent Recognition of p27(Kip1) by the SCF(Skp2) Ubiquitin Ligase.
Mol.Cell, 20, 2005
4Y72
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HUMAN CDK1/CYCLINB1/CKS2 WITH INHIBITOR
Descriptor:Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ...
Authors:Brown, N.R., Korolchuk, S., Martin, M.P., Stanley, W., Moukhametzianov, R., Noble, M.E.M., Endicott, J.A.
Deposit date:2015-02-13
Release date:2015-08-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
4YC3
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CDK1/CYCLINB1/CKS2 APO
Descriptor:Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ...
Authors:Brown, N.R., Korolchuk, S., Martin, M.P., Stanley, W., Moukhametzianov, R., Noble, M.E.M., Endicott, J.A.
Deposit date:2015-02-19
Release date:2016-04-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
4YC6
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CDK1/CKS1
Descriptor:Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1
Authors:Brown, N.R., Korolchuk, S., Martin, M.P., Stanley, W., Moukhametzianov, R., Noble, M.E.M., Endicott, J.A.
Deposit date:2015-02-19
Release date:2015-05-20
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
5HQ0
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TERNARY COMPLEX OF HUMAN PROTEINS CDK1, CYCLIN B AND CKS2, BOUND TO AN INHIBITOR
Descriptor:Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ...
Authors:Noble, M.E., Martin, M.P., Korolchuk, S., Brown, N.R., Moukhametzianov, R., Stanley, W.A.
Deposit date:2016-01-21
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.
Nat Commun, 6, 2015
5LQF
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CDK1/CYCLINB1/CKS2 IN COMPLEX WITH NU6102
Descriptor:Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ...
Authors:Coxon, C.R., Anscombe, E., Harnor, S.J., Martin, M.P., Carbain, B.J., Hardcastle, I.R., Harlow, L.K., Korolchuk, S., Matheson, C.J., Noble, M.E., Newell, D.R., Turner, D.M., Sivaprakasam, M., Wang, L.Z., Wong, C., Golding, B.T., Griffin, R.J., Endicott, J.A., Cano, C.
Deposit date:2016-08-17
Release date:2017-01-11
Last modified:2017-03-22
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
J. Med. Chem., 60, 2017
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