1CSG
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THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
Descriptor:Granulocyte-macrophage colony-stimulating factor
Authors:Walter, M.R., Cook, W.J., Ealick, S.E.
Deposit date:1992-11-23
Release date:1993-10-31
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor.
J.Mol.Biol., 224, 1992
2GMF
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HUMAN GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR
Descriptor:GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
Authors:Rozwarski, D., Diederichs, K., Hecht, R., Boone, T., Karplus, P.A.
Deposit date:1996-04-24
Release date:1996-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Refined crystal structure and mutagenesis of human granulocyte-macrophage colony-stimulating factor.
Proteins, 26, 1996
5C7X
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CRYSTAL STRUCTURE OF MOR04357, A NEUTRALIZING ANTI-HUMAN GM-CSF ANTIBODY FAB FRAGMENT IN COMPLEX WITH HUMAN GM-CSF
Descriptor:Granulocyte-macrophage colony-stimulating factor, Immunglobulin G1 Fab fragment, heavy chain, ...
Authors:Eylenstein, R., Weinfurtner, D., Steidl, S., Boettcher, J., Augustin, M.
Deposit date:2015-06-25
Release date:2015-10-14
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody.
Mabs, 8, 2016
5D22
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STRUCTURE OF OVINE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
Descriptor:Granulocyte-macrophage colony-stimulating factor, ACETATE ION, 1,2-ETHANEDIOL
Authors:Felix, J., Savvides, S.N.
Deposit date:2015-08-05
Release date:2016-11-16
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Nat Commun, 7, 2016
5D28
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COMPLEX OF GM-CSF/IL-2 INHIBITION FACTOR WITH GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
Descriptor:GM-CSF/IL-2 inhibition factor, Granulocyte-macrophage colony-stimulating factor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Felix, J., Savvides, S.N.
Deposit date:2015-08-05
Release date:2016-11-16
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Nat Commun, 7, 2016
5D70
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CRYSTAL STRUCTURE OF MOR03929, A NEUTRALIZING ANTI-HUMAN GM-CSF ANTIBODY FAB FRAGMENT IN COMPLEX WITH HUMAN GM-CSF
Descriptor:Granulocyte-macrophage colony-stimulating factor, Immunglobulin G1 Fab fragment, heavy chain, ...
Authors:Eylenstein, R., Weinfurtner, D., Steidl, S., Boettcher, J., Augustin, M.
Deposit date:2015-08-13
Release date:2015-10-14
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody.
Mabs, 8, 2016
6BFQ
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THE MECHANISM OF GM-CSF INHIBITION BY HUMAN GM-CSF AUTO-ANTIBODIES
Descriptor:Fab Heavy chain, Fab Light Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
6BFS
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THE MECHANISM OF GM-CSF INHIBITION BY HUMAN GM-CSF AUTO-ANTIBODIES
Descriptor:Fab light Chain, Fab Heavy Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
4NKQ
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STRUCTURE OF A CYTOKINE RECEPTOR COMPLEX
Descriptor:Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, ...
Authors:Parker, M.W., Broughton, S.E.
Deposit date:2013-11-13
Release date:2015-09-23
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
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