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8K8E
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BU of 8k8e by Molmil
Human gamma-secretase in complex with a substrate mimetic
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shi, Y.G, Zhou, R, Wolfe, M.S.
Deposit date:2023-07-29
Release date:2024-01-31
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Familial Alzheimer mutations stabilize synaptotoxic gamma-secretase-substrate complexes.
Cell Rep, 43, 2024
8IM7
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BU of 8im7 by Molmil
Human gamma-secretase treated with ganglioside GM1
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhou, R, Yang, G, Shi, Y.
Deposit date:2023-03-06
Release date:2024-01-17
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Preferential Regulation of Gamma-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease.
Adv Sci, 10, 2023
7Y5Z
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BU of 7y5z by Molmil
CryoEM structure of human PS2-containing gamma-secretase
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2022-06-18
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
7Y5X
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BU of 7y5x by Molmil
CryoEM structure of PS2-containing gamma-secretase treated with MRK-560
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2022-06-17
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
7Y5T
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BU of 7y5t by Molmil
CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y.
Deposit date:2022-06-17
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.
Nat Commun, 13, 2022
7D8X
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BU of 7d8x by Molmil
CryoEM structure of human gamma-secretase in complex with E2012 and L685458
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y.
Deposit date:2020-10-11
Release date:2021-01-27
Last modified:2021-02-03
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
7C9I
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BU of 7c9i by Molmil
Human gamma-secretase in complex with small molecule L-685,458
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y.
Deposit date:2020-06-05
Release date:2021-01-27
Last modified:2021-02-03
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
6LR4
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BU of 6lr4 by Molmil
Molecular basis for inhibition of human gamma-secretase by small molecule
Descriptor: (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y.
Deposit date:2020-01-15
Release date:2021-01-27
Last modified:2021-02-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
6LQG
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BU of 6lqg by Molmil
Human gamma-secretase in complex with small molecule Avagacestat
Descriptor: (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoranyl-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-tris(fluoranyl)pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y.
Deposit date:2020-01-13
Release date:2021-01-27
Last modified:2021-02-03
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
6IYC
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BU of 6iyc by Molmil
Recognition of the Amyloid Precursor Protein by Human gamma-secretase
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhou, R, Yang, G, Guo, X, Zhou, Q, Lei, J, Shi, Y.
Deposit date:2018-12-14
Release date:2019-01-23
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Recognition of the amyloid precursor protein by human gamma-secretase.
Science, 363, 2019
6IDF
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BU of 6idf by Molmil
Cryo-EM structure of gamma secretase in complex with a Notch fragment
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yang, G, Zhou, R, Zhou, Q, Guo, X, Yan, C, Ke, M, Lei, J, Shi, Y.
Deposit date:2018-09-09
Release date:2018-12-26
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis of Notch recognition by human gamma-secretase
Nature, 565, 2019
5FN5
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BU of 5fn5 by Molmil
Cryo-EM structure of gamma secretase in class 3 of the apo- state ensemble
Descriptor: Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ...
Authors:Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2019-09-11
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5FN4
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BU of 5fn4 by Molmil
Cryo-EM structure of gamma secretase in class 2 of the apo- state ensemble
Descriptor: Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ...
Authors:Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2019-09-11
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5FN3
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BU of 5fn3 by Molmil
Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble
Descriptor: Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ...
Authors:Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2019-09-11
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5FN2
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BU of 5fn2 by Molmil
Cryo-EM structure of gamma secretase in complex with a drug DAPT
Descriptor: Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Nicastrin, ...
Authors:Bai, X.C, Rajendra, E, Yang, G.H, Shi, Y.G, Scheres, S.H.W.
Deposit date:2015-11-10
Release date:2015-12-16
Last modified:2019-09-04
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Sampling the conformational space of the catalytic subunit of human gamma-secretase.
Elife, 4, 2015
5A63
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BU of 5a63 by Molmil
Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution.
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Bai, X, Yan, C, Yang, G, Lu, P, Ma, D, Sun, L, Zhou, R, Scheres, S.H.W, Shi, Y.
Deposit date:2015-06-24
Release date:2015-08-05
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:An Atomic Structure of Human Gamma-Secretase
Nature, 525, 2015
2KR6
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BU of 2kr6 by Molmil
Solution structure of presenilin-1 CTF subunit
Descriptor: Presenilin-1
Authors:Doetsch, V.
Deposit date:2009-12-04
Release date:2010-04-28
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of presenilin-1 CTF subunit
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PDB entries from 2024-03-27

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