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7YRU
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BU of 7yru by Molmil
ALK2 antibody complex
Descriptor: Activin receptor type-1, antibody heavy chain, antibody light chain
Authors:Kawaguchi, Y, Nakamura, K, Suzuki, M, Tsuji, S, Katagiri, T.
Deposit date:2022-08-10
Release date:2023-05-17
Last modified:2023-06-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A blocking monoclonal antibody reveals dimerization of intracellular domains of ALK2 associated with genetic disorders.
Nat Commun, 14, 2023
7U5O
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BU of 7u5o by Molmil
CRYSTAL STRUCTURE OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE 2 LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-B
Descriptor: Bone morphogenetic protein receptor type-2, Inhibin beta B chain
Authors:Chu, K.Y, Malik, A, Thamilselvan, V, Martinez-Hackert, E.
Deposit date:2022-03-02
Release date:2022-06-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition.
J.Biol.Chem., 298, 2022
7U5P
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BU of 7u5p by Molmil
CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2A, Inhibin beta A chain
Authors:Chu, K.Y, Malik, A, Thamilselvan, V, Martinez-Hackert, E.
Deposit date:2022-03-02
Release date:2022-06-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition.
J.Biol.Chem., 298, 2022
7PPC
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BU of 7ppc by Molmil
Ternary signalling complex of BMP10 bound to ALK1 and BMPRII
Descriptor: Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2, Serine/threonine-protein kinase receptor R3
Authors:Guo, J, Yu, M, Read, R.J, Li, W.
Deposit date:2021-09-13
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.
Nat Commun, 13, 2022
7PPB
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BU of 7ppb by Molmil
2.4 angstrom crystal structure of bone morphogenetic protein receptor type II (BMPRII) extracellular domain in complex with BMP10
Descriptor: Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2
Authors:Guo, J, Yu, M, Li, W.
Deposit date:2021-09-13
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.
Nat Commun, 13, 2022
7PPA
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BU of 7ppa by Molmil
High resolution structure of bone morphogenetic protein receptor type II (BMPRII) extracellular domain in complex with BMP10
Descriptor: Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2, GLYCEROL
Authors:Guo, J, Yu, M, Read, R.J, Li, W.
Deposit date:2021-09-13
Release date:2022-05-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.
Nat Commun, 13, 2022
7OLY
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BU of 7oly by Molmil
Structure of activin A in complex with an ActRIIB-Alk4 fusion reveal insight into activin receptor interactions
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-1B, ...
Authors:Hakansson, M, Rose, N.C, Castonguay, R, Logan, D.T, Krishnan, L.
Deposit date:2021-05-20
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.265 Å)
Cite:Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors.
Iscience, 25, 2022
7MRZ
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BU of 7mrz by Molmil
Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B,Activin receptor type-1B, Fab Heavy Chain, ...
Authors:Goebel, E.J, Kattamuri, C, Gipson, G.R, Thompson, T.B.
Deposit date:2021-05-10
Release date:2022-01-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors.
Iscience, 25, 2022
6MAC
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BU of 6mac by Molmil
Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B, Growth/differentiation factor 11, ...
Authors:Goebel, E.J, Thompson, T.B.
Deposit date:2018-08-27
Release date:2019-07-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
5NHR
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BU of 5nhr by Molmil
CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, CUBIC CRYSTAL FORM
Descriptor: Activin receptor type-2B, Bimagrumab Fv Light-Chain, Bimagrumab Fv heavy-chain
Authors:Rondeau, J.-M.
Deposit date:2017-03-22
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NH3
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BU of 5nh3 by Molmil
CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2A, ...
Authors:Scheufler, C.
Deposit date:2017-03-21
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5NGV
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BU of 5ngv by Molmil
CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM
Descriptor: Activin receptor type-2B, TETRAETHYLENE GLYCOL, anti-human ActRIIB mAb BYM338 heavy-chain, ...
Authors:Rondeau, J.-M, Lehmann, S.
Deposit date:2017-03-20
Release date:2017-11-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4FAO
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BU of 4fao by Molmil
Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B, Growth/differentiation factor 2, ...
Authors:Townson, S.A, Martinez-Hackert, E, Greppi, C, Lowden, P, Sako, D, Liu, J, Ucran, J.A, Liharska, K, Underwood, K.W, Seehra, J, Kumar, R, Grinberg, A.V.
Deposit date:2012-05-22
Release date:2012-06-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.357 Å)
Cite:Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex.
J.Biol.Chem., 287, 2012
3QB4
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BU of 3qb4 by Molmil
Crystal structure of a TGF-beta ligand-receptor complex
Descriptor: Bone morphogenetic protein receptor type-1A, Growth/differentiation factor 5
Authors:Mueller, T.D, Nickel, J, Sebald, W.
Deposit date:2011-01-12
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:GDF-5 can act as a context-dependent BMP-2 antagonist.
Bmc Biol., 13, 2015
2L5S
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BU of 2l5s by Molmil
Solution structure of the extracellular domain of the TGF-beta type I receptor
Descriptor: TGF-beta receptor type-1
Authors:Zuniga, J.E, Ilangovan, U, Pardeep, M, Hinck, C, Huang, T.
Deposit date:2010-11-04
Release date:2011-10-26
Method:SOLUTION NMR
Cite:The TbetaR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding
J.Mol.Biol., 412, 2011
3NH7
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BU of 3nh7 by Molmil
Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA
Descriptor: Antibody fragment Fab AbD1556, heavy chain, light chain, ...
Authors:Mueller, T.D, Harth, S, Sebald, W.
Deposit date:2010-06-14
Release date:2010-10-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity
Plos One, 5, 2010
3KFD
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BU of 3kfd by Molmil
Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Descriptor: TGF-beta receptor type-1, TGF-beta receptor type-2, Transforming growth factor beta-1
Authors:Radaev, S, Sun, P.D.
Deposit date:2009-10-27
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.995 Å)
Cite:Ternary complex of transforming growth factor-beta1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily.
J.Biol.Chem., 285, 2010
3EVS
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BU of 3evs by Molmil
Crystal structure of the GDF-5:BMP receptor IB complex.
Descriptor: Bone morphogenetic protein receptor type-1B, Growth/differentiation factor 5
Authors:Kotzsch, A, Mueller, T.D.
Deposit date:2008-10-13
Release date:2009-03-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.
Embo J., 28, 2009
2K3G
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BU of 2k3g by Molmil
NMR structure analysis of a BMP receptor
Descriptor: Bone morphogenetic protein receptor type-1A
Authors:Klages, J, Kotzsch, A, Mueller, T, Kessler, H.
Deposit date:2008-05-07
Release date:2008-12-16
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding.
Biochemistry, 47, 2008
2QJ9
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BU of 2qj9 by Molmil
Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B1
Descriptor: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Kotzsch, A, Mueller, T.D.
Deposit date:2007-07-06
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
2QJA
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BU of 2qja by Molmil
Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12
Descriptor: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Kotzsch, A, Mueller, T.D.
Deposit date:2007-07-06
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
2QJB
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BU of 2qjb by Molmil
Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB
Descriptor: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION
Authors:Kotzsch, A, Mueller, T.D.
Deposit date:2007-07-06
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
2PJY
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BU of 2pjy by Molmil
Structural basis for cooperative assembly of the TGF-beta signaling complex
Descriptor: TGF-beta receptor type-1, TGF-beta receptor type-2, Transforming growth factor beta-3
Authors:Groppe, J, Zubieta, C.
Deposit date:2007-04-16
Release date:2008-02-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.
Mol.Cell, 29, 2008
2HLR
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BU of 2hlr by Molmil
Crystal Structure of the Extracellular Domain of the Type II BMP Receptor
Descriptor: Bone morphogenetic protein receptor type-2
Authors:Mace, P.D, Cutfield, J.F, Cutfield, S.M.
Deposit date:2006-07-10
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: Implications for ligand binding
Biochem.Biophys.Res.Commun., 351, 2006
2HLQ
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BU of 2hlq by Molmil
Crystal Structure of the Extracellular Domain of the Type II BMP Receptor
Descriptor: Bone morphogenetic protein receptor type-2
Authors:Mace, P.D, Cutfield, J.F, Cutfield, S.M.
Deposit date:2006-07-09
Release date:2006-11-28
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: Implications for ligand binding
Biochem.Biophys.Res.Commun., 351, 2006

 

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