1BTE
 
 | | CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE TYPE II ACTIVIN RECEPTOR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (ACTIVIN RECEPTOR TYPE II) | | Authors: | Greenwald, J, Fischer, W, Vale, W, Choe, S. | | Deposit date: | 1998-09-01 | | Release date: | 1999-02-09 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase.
Nat.Struct.Biol., 6, 1999
|
|
1ES7
 | |
1LX5
 | | Crystal Structure of the BMP7/ActRII Extracellular Domain Complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin Type II Receptor, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-4)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Greenwald, J, Groppe, J, Kwiatkowski, W, Choe, S. | | Deposit date: | 2002-06-04 | | Release date: | 2003-04-01 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | The BMP7/ActRII Extracellular Domain Complex Provides New Insights into
the Cooperative Nature of Receptor Assembly
Mol.Cell, 11, 2003
|
|
1NYS
 | |
1NYU
 | |
1REW
 | | Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor | | Descriptor: | bone morphogenetic protein 2, bone morphogenetic protein receptor type IA | | Authors: | Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D. | | Deposit date: | 2003-11-07 | | Release date: | 2004-05-04 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.863 Å) | | Cite: | Molecular recognition of BMP-2 and BMP receptor IA.
Nat.Struct.Mol.Biol., 11, 2004
|
|
1S4Y
 | | Crystal structure of the activin/actrIIb extracellular domain | | Descriptor: | Activin receptor type IIB precursor, Inhibin beta A chain | | Authors: | Greenwald, J, Vega, M.E, Allendorph, G.P, Fischer, W.H, Vale, W, Choe, S, Joint Center for Structural Genomics (JCSG) | | Deposit date: | 2004-01-19 | | Release date: | 2004-08-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A Flexible Activin Explains the Membrane-Dependent Cooperative Assembly of TGF-beta Family Receptors.
Mol.Cell, 15, 2004
|
|
2GOO
 | | Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, Activin receptor type 2A, Bone morphogenetic protein 2, ... | | Authors: | Allendorph, G.P, Choe, S. | | Deposit date: | 2006-04-13 | | Release date: | 2006-05-09 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the ternary signaling complex of a TGF-beta superfamily member.
Proc.Natl.Acad.Sci.Usa, 103, 2006
|
|
2H62
 | | Crystal structure of a ternary ligand-receptor complex of BMP-2 | | Descriptor: | Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA | | Authors: | Mueller, T.D. | | Deposit date: | 2006-05-30 | | Release date: | 2007-04-10 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
|
|
2H64
 | |
2HLQ
 | |
2HLR
 | |
2K3G
 | |
2L5S
 | | Solution structure of the extracellular domain of the TGF-beta type I receptor | | Descriptor: | TGF-beta receptor type-1 | | Authors: | Zuniga, J.E, Ilangovan, U, Pardeep, M, Hinck, C, Huang, T. | | Deposit date: | 2010-11-04 | | Release date: | 2011-10-26 | | Method: | SOLUTION NMR | | Cite: | The TbetaR-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding
J.Mol.Biol., 412, 2011
|
|
2PJY
 | |
2QJ9
 | | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B1 | | Descriptor: | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA | | Authors: | Kotzsch, A, Mueller, T.D. | | Deposit date: | 2007-07-06 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
|
|
2QJA
 | | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12 | | Descriptor: | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA | | Authors: | Kotzsch, A, Mueller, T.D. | | Deposit date: | 2007-07-06 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
|
|
2QJB
 | | Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB | | Descriptor: | Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION | | Authors: | Kotzsch, A, Mueller, T.D. | | Deposit date: | 2007-07-06 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
|
|
3EVS
 | | Crystal structure of the GDF-5:BMP receptor IB complex. | | Descriptor: | Bone morphogenetic protein receptor type-1B, Growth/differentiation factor 5 | | Authors: | Kotzsch, A, Mueller, T.D. | | Deposit date: | 2008-10-13 | | Release date: | 2009-03-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.
Embo J., 28, 2009
|
|
3KFD
 | |
3NH7
 | | Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA | | Descriptor: | Antibody fragment Fab AbD1556, heavy chain, light chain, ... | | Authors: | Mueller, T.D, Harth, S, Sebald, W. | | Deposit date: | 2010-06-14 | | Release date: | 2010-10-27 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity
Plos One, 5, 2010
|
|
3QB4
 | |
4FAO
 | | Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B, Growth/differentiation factor 2, ... | | Authors: | Townson, S.A, Martinez-Hackert, E, Greppi, C, Lowden, P, Sako, D, Liu, J, Ucran, J.A, Liharska, K, Underwood, K.W, Seehra, J, Kumar, R, Grinberg, A.V. | | Deposit date: | 2012-05-22 | | Release date: | 2012-06-20 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.357 Å) | | Cite: | Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex.
J.Biol.Chem., 287, 2012
|
|
5NGV
 | |
5NH3
 | | CRYSTAL STRUCTURE OF THE Activin receptor type-2A LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2A, ... | | Authors: | Scheufler, C. | | Deposit date: | 2017-03-21 | | Release date: | 2017-11-15 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
