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8SA9	Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP-Oxamate Adduct (C2 form) Descriptor: CITRATE ANION, Cystathionine beta-lyase, PYRIDOXAL-5'-PHOSPHATE, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-03-31 Release date: 2023-04-12 Method: X-RAY DIFFRACTION (1.1 Å) Cite: Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP-Oxamate Adduct (C2 form) To be published
6LXU	Crystal structure of methionine gamma-lyase from Fusobacterium nucleatum Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, L-methionine gamma-lyase, NITRATE ION Authors: Kezuka, Y, Yoshida, Y, Nonaka, T. Deposit date: 2020-02-12 Release date: 2021-02-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.19 Å) Cite: Crystal structure of methionine gamma-lyase from Fusobacterium nucleatum To Be Published
8SA8	Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, Covalently bound and free PLP (I2 form) Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Cystathionine beta-lyase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-03-31 Release date: 2023-04-12 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes (I2 form) To be published
2RFV	High resolution structure of L-methionine gamma-lyase from Citrobacter freundii Descriptor: CHLORIDE ION, Methionine gamma-lyase Authors: Nikulin, A.D, Revtovich, S.V, Morozova, E.A, Nevskaya, N.A, Nikonov, S.V, Garber, M.B, Demidkina, T.V. Deposit date: 2007-10-02 Release date: 2008-08-19 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.355 Å) Cite: High-resolution structure of methionine gamma-lyase from Citrobacter freundii. Acta Crystallogr.,Sect.D, 64, 2008
8U98	Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes (PLP-Glycine adduct) Descriptor: 1,2-ETHANEDIOL, Cystathionine beta-lyase, GLYCINE, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-09-18 Release date: 2023-09-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes (PLP-Glycine adduct) To be published
8SA7	Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes (C2 form) Descriptor: BROMIDE ION, CHLORIDE ION, Cystathionine beta-lyase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-03-31 Release date: 2023-04-12 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes (C2 form) To be published
8SAD	Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP/Malonate complex (C2 form) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Cystathionine beta-lyase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-03-31 Release date: 2023-04-12 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP/Malonate complex (C2 form) To be published
6EGR	Crystal structure of Citrobacter freundii methionine gamma-lyase with V358Y replacement Descriptor: DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, ... Authors: Revtovich, S.V, Demitri, N, Raboni, S, Nikulin, A.D, Morozova, E.A, Demidkina, T.V, Storici, P, Mozzarelli, A. Deposit date: 2017-09-12 Release date: 2018-10-10 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Engineering methionine gamma-lyase from Citrobacter freundii for anticancer activity. Biochim Biophys Acta Proteins Proteom, 1866, 2018
5M3Z	Crystal structure of Citrobacter freundii methionine gamma-lyase with C115H replacement in the complex with L-norleucine Descriptor: 2-[O-PHOSPHONOPYRIDOXYL]-AMINO-HEXANOIC ACID, Methionine gamma-lyase, NORLEUCINE, ... Authors: Revtovich, S.V, Nikulin, A.D, Anufrieva, N.V, Morozova, E.A, Demidkina, T.V. Deposit date: 2016-10-17 Release date: 2017-06-28 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Crystal structure of mutant form Cys115His of Citrobacter freundii methionine gamma-lyase complexed with l-norleucine. Biochim. Biophys. Acta, 1865, 2017
8SAA	Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP and phosphate bound (C2 form) Descriptor: Cystathionine beta-lyase, MAGNESIUM ION, PHOSPHATE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-03-31 Release date: 2023-04-12 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP and phosphate bound (C2 form) To be published
4MKK	Crystal structure of C115A mutant L-methionine gamma-lyase from Citrobacter freundii modified by allicine Descriptor: CHLORIDE ION, Methionine gamma-lyase, POTASSIUM ION, ... Authors: Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Zakomirdina, L.N, Demidkina, T.V. Deposit date: 2013-09-05 Release date: 2014-11-12 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Alliin is a suicide substrate of Citrobacter freundii methionine gamma-lyase: structural bases of inactivation of the enzyme. Acta Crystallogr.,Sect.D, 70, 2014
3JWA	Crystal structure of L-methionine gamma-lyase from Citrobacter freundii with methionine phosphinate Descriptor: (1-AMINO-3-METHYLSULFANYL-PROPYL)-PHOSPHINIC ACID, DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase Authors: Revtovish, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V. Deposit date: 2009-09-18 Release date: 2010-09-08 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Three-dimensional structures of noncovalent complexes of Citrobacter freundii methionine gamma-lyase with substrates. Biochemistry Mosc., 76, 2011
6S0C	Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by dimethylthiosulfinate Descriptor: Cystathionine gamma-synthase, PYRIDOXAL-5'-PHOSPHATE, TRIETHYLENE GLYCOL Authors: Revtovich, S.V, Morozova, E.A, Nikulin, A.D, Demidkina, T.V. Deposit date: 2019-06-14 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation. Biochimie, 168, 2020
8SAE	Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP and Hepes bound (C2 form) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cystathionine beta-lyase, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-03-31 Release date: 2023-04-12 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP and Hepes bound (C2 form) To be published
1CS1	CYSTATHIONINE GAMMA-SYNTHASE (CGS) FROM ESCHERICHIA COLI Descriptor: 2,4-DIOXO-PENTANEDIOIC ACID, PROTEIN (CYSTATHIONINE GAMMA-SYNTHASE) Authors: Clausen, T, Messerschmidt, A. Deposit date: 1998-09-23 Release date: 1999-09-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution. EMBO J., 17, 1998
5X5H	Crystal structure of metB from Corynebacterium glutamicum Descriptor: Cystathionine beta-lyases/cystathionine gamma-synthases, GLYCEROL, MAGNESIUM ION, ... Authors: Sagong, H.-Y, Kim, K.-J. Deposit date: 2017-02-16 Release date: 2017-03-01 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Structural Insights into Substrate Specificity of Cystathionine gamma-Synthase from Corynebacterium glutamicum J. Agric. Food Chem., 65, 2017
8BIX	Cystathionine gamma-lyase N360S mutant from Toxoplasma gondii in complex with cystathionine Descriptor: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, Cystathionine beta-lyase, putative, ... Authors: Fernandez-Rodriguez, C, Conter, C, Oyenarte, I, Favretto, F, Quintana, I, Martinez-Chantar, M.L, Astegno, A, Martinez-Cruz, L.A. Deposit date: 2022-11-02 Release date: 2023-04-12 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Structural basis of the inhibition of cystathionine gamma-lyase from Toxoplasma gondii by propargylglycine and cysteine. Protein Sci., 32, 2023
5K30	Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by S-Ethyl-L-cysteine sulfoxide Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, ... Authors: Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V. Deposit date: 2016-05-19 Release date: 2017-07-12 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation. Biochimie, 168, 2020
8SAB	Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP adduct with Alanine (C2 form) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ALANYL-PYRIDOXAL-5'-PHOSPHATE, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-03-31 Release date: 2023-04-12 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of Cystathionine beta lyase from Klebsiella aerogenes, PLP adduct with Alanine (C2 form) To be published
7MCT	Crystal structure of Staphylococcus aureus Cystathionine gamma lyase, Holoenzyme with bound NL1 Descriptor: Bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase, GLYCEROL, N-[(6-bromo-1H-indol-1-yl)acetyl]glycine, ... Authors: Nuthanakanti, A, Serganov, A, Kaushik, A. Deposit date: 2021-04-02 Release date: 2021-06-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Inhibitors of bacterial H 2 S biogenesis targeting antibiotic resistance and tolerance. Science, 372, 2021
4OMA	The crystal structure of methionine gamma-lyase from Citrobacter freundii in complex with L-cycloserine pyridoxal-5'-phosphate Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL, ... Authors: Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V. Deposit date: 2014-01-27 Release date: 2014-11-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Pre-steady-state Kinetic and Structural Analysis of Interaction of Methionine gamma-Lyase from Citrobacter freundii with Inhibitors. J.Biol.Chem., 290, 2015
4ITX	P113S mutant of E. coli Cystathionine beta-lyase MetC inhibited by reaction with L-Ala-P Descriptor: CALCIUM ION, Cystathionine beta-lyase MetC, {1-[(3-HYDROXY-METHYL-5-PHOSPHONOOXY-METHYL-PYRIDIN-4-YLMETHYL)-AMINO]-ETHYL}-PHOSPHONIC ACID Authors: Squire, C.J, Yosaatmadja, Y, Soo, V.W.C, Patrick, W.M. Deposit date: 2013-01-19 Release date: 2014-12-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes. J.Biol.Chem., 291, 2016
3JWB	Crystal structure of L-methionine gamma-lyase from Citrobacter freundii with norleucine Descriptor: DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, NORLEUCINE Authors: Revtovish, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V. Deposit date: 2009-09-18 Release date: 2010-09-08 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Three-dimensional structures of noncovalent complexes of Citrobacter freundii methionine gamma-lyase with substrates. Biochemistry Mosc., 76, 2011
3QHX	Crystal Structure of Cystathionine gamma-synthase MetB (Cgs) from Mycobacterium ulcerans Agy99 bound to HEPES Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Cystathionine gamma-synthase MetB (Cgs), GLYCEROL, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-01-26 Release date: 2011-03-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure of the cystathionine [gamma]-synthase MetB from Mycobacterium ulcerans Acta Crystallogr.,Sect.F, 67, 2011
3MKJ	Methionine gamma-lyase from Citrobacter freundii with pyridoximine-5'-phosphate Descriptor: Methionine gamma-lyase, [5-hydroxy-4-(iminomethyl)-6-methyl-pyridin-3-yl]methyl dihydrogen phosphate Authors: Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V. Deposit date: 2010-04-15 Release date: 2010-08-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Exploring methionine gamma-lyase structure-function relationship via microspectrophotometry and X-ray crystallography Biochim.Biophys.Acta, 1814, 2011

 

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