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7NL1
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BU of 7nl1 by Molmil
Crystal structure of cystathionine gamma-lyase from Toxoplasma gondii
Descriptor: Cystathione gamma lyase, putative, PYRIDOXAL-5'-PHOSPHATE
Authors:Fernandez-Rodriguez, C, Conter, C, Recio, I, Astegno, A, Martinez-Cruz, L.A.
Deposit date:2021-02-22
Release date:2022-03-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.331 Å)
Cite:Structural basis of the inhibition of cystathionine gamma-lyase from Toxoplasma gondii by propargylglycine and cysteine.
Protein Sci., 32, 2023
4XQ2
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BU of 4xq2 by Molmil
Ensemble refinement of cystathione gamma lyase (CalE6) D7G from Micromonospora echinospora
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, CalE6, ...
Authors:Wang, F, Yennamalli, R.M, Singh, S, Tan, K, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2015-01-18
Release date:2015-04-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
To Be Published
7SWH
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BU of 7swh by Molmil
Crystal Structure of Putative cystathionine gamma-synthase from Burkholderia pseudomallei in Complex with PLP
Descriptor: 1,2-ETHANEDIOL, Putative cystathionine gamma-synthase
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2021-11-19
Release date:2021-12-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Putative cystathionine gamma-synthase from Burkholderia pseudomallei in Complex with PLP
to be published
5M3Z
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BU of 5m3z by Molmil
Crystal structure of Citrobacter freundii methionine gamma-lyase with C115H replacement in the complex with L-norleucine
Descriptor: 2-[O-PHOSPHONOPYRIDOXYL]-AMINO-HEXANOIC ACID, Methionine gamma-lyase, NORLEUCINE, ...
Authors:Revtovich, S.V, Nikulin, A.D, Anufrieva, N.V, Morozova, E.A, Demidkina, T.V.
Deposit date:2016-10-17
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal structure of mutant form Cys115His of Citrobacter freundii methionine gamma-lyase complexed with l-norleucine.
Biochim. Biophys. Acta, 1865, 2017
7YEO
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BU of 7yeo by Molmil
Crystal Structure of cystathionine gamma-synthase-like protein C23A1.14c
Descriptor: MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, Uncharacterized trans-sulfuration enzyme C23A1.14c
Authors:Zhang, S.J.
Deposit date:2022-07-06
Release date:2023-01-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of cystathionine gamma-synthase-like protein C23A1.14c
To Be Published
6OVG
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BU of 6ovg by Molmil
L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism
Descriptor: Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W, Irani, S, Zhang, J.
Deposit date:2019-05-07
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.719 Å)
Cite:Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Proc.Natl.Acad.Sci.USA, 117, 2020
2FQ6
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BU of 2fq6 by Molmil
Cystathionine beta-lyase (cbl) from escherichia coli in complex with n-hydrazinocarbonylmethyl-2-trifluoromethyl-benzamide
Descriptor: Cystathionine beta-lyase, PHOSPHORIC ACID MONO-(5-HYDROXY-6-METHYL-4-{[2-(2-TRIFLUOROMETHYL-BENZOYLAMINO)-ACETYL]-HYDRAZONOMETHYL}-PYRIDIN-3-YLMETHYL)ESTER
Authors:Junop, M.S.
Deposit date:2006-01-17
Release date:2006-12-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function.
J.Med.Chem., 50, 2007
5TSU
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BU of 5tsu by Molmil
Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
Descriptor: CYSTEINE, Cystathionine gamma-lyase, METHIONINE, ...
Authors:Yan, W, Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5TT2
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BU of 5tt2 by Molmil
Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
Descriptor: Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W, Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.949 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5IJG
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BU of 5ijg by Molmil
Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution
Descriptor: Cys/Met metabolism pyridoxal-phosphate-dependent enzyme, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE
Authors:Boyko, K.M, Nikolaeva, A.Y, Koolikova, V.V, Kotlov, M.I, Demidkina, T.V, Popov, V.O.
Deposit date:2016-03-02
Release date:2017-04-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of O-acetylhomoserine sulfhydrolase from Brucella melitensis at 2.0 A resolution
To Be Published
1UKJ
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BU of 1ukj by Molmil
Detailed structure of L-Methionine-Lyase from Pseudomonas putida
Descriptor: Methionine gamma-lyase, SULFATE ION
Authors:Misaki, S, Takimoto, A, Takakura, T, Yoshioka, T, Yamashita, M, Tamura, T, Tanaka, H, Inagaki, K.
Deposit date:2003-08-24
Release date:2004-10-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Detailed structure of L-Methionine -Lyase from Pseudomonas putida
To be Published
2GQN
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BU of 2gqn by Molmil
Cystathionine Beta-Lyase (CBL) from Escherichia Coli in complex with N-Hydrazinocarbonylmethyl-2-Nitro-Benzamide
Descriptor: (5-HYDROXY-6-METHYL-4-((2-(2-(2-NITROBENZAMIDO)ACETYL)HYDRAZINYL)METHYL)PYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Cystathionine beta-lyase
Authors:Summerfield, R, Junop, M.S.
Deposit date:2006-04-21
Release date:2007-03-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibitors of Bacterial Cystathionine beta-Lyase: Leads for New Antimicrobial Agents and Probes of Enzyme Structure and Function.
J.Med.Chem., 50, 2007
8J6N
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BU of 8j6n by Molmil
Crystal structure of Cystathionine gamma-lyase in complex with compound 1
Descriptor: 1,2-ETHANEDIOL, Cystathionine gamma-lyase, GLYCEROL, ...
Authors:Hibi, R, Toma-Fukai, S, Shimizu, T, Hanaoka, K.
Deposit date:2023-04-26
Release date:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of a cystathionine gamma-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation.
Sci Rep, 13, 2023
7BQW
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BU of 7bqw by Molmil
Crystal structure of Methionine gamma-lyase from Fusobacterium nucleatum
Descriptor: L-methionine gamma-lyase
Authors:Lan, J, Chen, Y, Liu, W, Xu, Y.
Deposit date:2020-03-25
Release date:2020-04-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of Methionine gamma-lyase from Fusobacterium nucleatum
To Be Published
8OVH
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BU of 8ovh by Molmil
Crystal structure of O-acetyl-L-homoserine sulfhydrolase from Saccharomyces cerevisiae in complex with Pyridoxal-5'-phosphate
Descriptor: DI(HYDROXYETHYL)ETHER, Homocysteine/cysteine synthase, PYRIDOXAL-5'-PHOSPHATE
Authors:Saleem-Batcha, R, Andexer, J.N, Mohr, M.
Deposit date:2023-04-26
Release date:2023-06-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.171 Å)
Cite:Enzymatic Synthesis of l-Methionine Analogues and Application in a Methyltransferase Catalysed Alkylation Cascade.
Chemistry, 29, 2023
7BA4
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BU of 7ba4 by Molmil
Structure of Cystathionine gamma-lyase from Pseudomonas aeruginosa
Descriptor: Cystathionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE
Authors:Fernandez-Rodriguez, C, Oyenarte, I, Gonzalez-Recio, I, Majtan, T, Astegno, A, Martinez-Cruz, L.A.
Deposit date:2020-12-15
Release date:2021-09-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Cystathionine gamma-lyase from Pseudomonas aeruginosa
To Be Published
6S0C
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BU of 6s0c by Molmil
Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by dimethylthiosulfinate
Descriptor: Cystathionine gamma-synthase, PYRIDOXAL-5'-PHOSPHATE, TRIETHYLENE GLYCOL
Authors:Revtovich, S.V, Morozova, E.A, Nikulin, A.D, Demidkina, T.V.
Deposit date:2019-06-14
Release date:2020-04-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation.
Biochimie, 168, 2020
5K30
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BU of 5k30 by Molmil
Crystal structure of methionine gamma-lyase from Citrobacter freundii modified by S-Ethyl-L-cysteine sulfoxide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, ...
Authors:Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V.
Deposit date:2016-05-19
Release date:2017-07-12
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Sulfoxides of sulfur-containing amino acids are suicide substrates of Citrobacter freundii methionine gamma-lyase. Structural bases of the enzyme inactivation.
Biochimie, 168, 2020
2CB1
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BU of 2cb1 by Molmil
Crystal Structure of O-actetyl Homoserine Sulfhydrylase From Thermus Thermophilus HB8,OAH2.
Descriptor: O-ACETYL HOMOSERINE SULFHYDRYLASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Imagawa, T, Utsunomiya, H, Tsuge, H, Ebihara, A, Kanagawa, M, Nakagawa, N, Kuroishi, C, Agari, Y, Kuramitsu, S, Yokoyama, S.
Deposit date:2005-12-28
Release date:2007-01-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Crystal Structure of O-Acetyl Homoserine Sulfhydrylase
To be Published
2CTZ
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BU of 2ctz by Molmil
Crystal structure of o-acetyl homoserine sulfhydrylase from Thermus thermophilus HB8
Descriptor: O-acetyl-L-homoserine sulfhydrylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Imagawa, T, Kousumi, Y, Tsuge, H, Utsunomiya, H, Ebihara, A, Nakagawa, N, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-05-24
Release date:2005-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of o-acetyl homoserine sulfhydrylase from Thermus thermophilus HB8
To be Published
1Y4I
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BU of 1y4i by Molmil
Crystal structure of Citrobacter Freundii L-methionine-lyase
Descriptor: SULFATE ION, methionine gamma-lyase
Authors:Revtovich, S.V, Mamaeva, D.V, Morozova, E.A, Nikulin, A.D, Nikonov, S.V, Garber, M.B, Demidkina, T.V.
Deposit date:2004-12-01
Release date:2005-06-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of Citrobacter freundii L-methionine gamma-lyase.
Acta Crystallogr.,Sect.F, 61, 2005
4Q31
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BU of 4q31 by Molmil
The crystal structure of cystathione gamma lyase (CalE6) from Micromonospora echinospora
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, FORMIC ACID, ...
Authors:Tan, K, Bigelow, L, Jedrzejczak, R, Babnigg, G, Bingman, C.A, Yennamalli, R.M, Singh, S, Kharel, M.K, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2014-04-10
Release date:2014-05-07
Last modified:2017-03-08
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Structural dynamics of a methionine gamma-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.
Struct Dyn, 3, 2016
6CJA
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BU of 6cja by Molmil
Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 in complex with Alanyl-PLP and Serine
Descriptor: (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-alanine, Cystathionine beta-lyase, GLYCEROL, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2018-02-26
Release date:2018-03-21
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 in complex with Alanyl-PLP and Serine
to be published
6CJB
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BU of 6cjb by Molmil
Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 covalently bound to Pyridoxal phosphate
Descriptor: Cystathionine beta-lyase, FORMIC ACID, GLYCEROL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2018-02-26
Release date:2018-03-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of Cystathionine beta-lyase from Legionella pneumophila Philadelphia 1 covalently bound to Pyridoxal phosphate
to be published
8ERB
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BU of 8erb by Molmil
Crystal structure of Fub7 in complex with vinylglycine ketimine
Descriptor: (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid, Sulfhydrylase FUB7
Authors:Hai, Y.
Deposit date:2022-10-11
Release date:2023-10-18
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Molecular and Structural Basis for C gamma-C Bond Formation by PLP-Dependent Enzyme Fub7.
Angew.Chem.Int.Ed.Engl., 63, 2024

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PDB entries from 2024-03-27

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