6G2I
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FILAMENT OF ACETYL-COA CARBOXYLASE AND BRCT DOMAINS OF BRCA1 (ACC-BRCT) AT 5.9 A RESOLUTION
Descriptor:Acetyl-CoA carboxylase 1, Breast cancer type 1 susceptibility protein
Authors:Hunkeler, M., Hagmann, A., Stuttfeld, E., Chami, M., Stahlberg, H., Maier, T.
Deposit date:2018-03-23
Release date:2018-06-13
Last modified:2018-06-27
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural basis for regulation of human acetyl-CoA carboxylase.
Nature, 558, 2018
6G2H
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FILAMENT OF ACETYL-COA CARBOXYLASE AND BRCT DOMAINS OF BRCA1 (ACC-BRCT) CORE AT 4.6 A RESOLUTION
Descriptor:Acetyl-CoA carboxylase 1
Authors:Hunkeler, M., Hagmann, A., Stuttfeld, E., Chami, M., Stahlberg, H., Maier, T.
Deposit date:2018-03-23
Release date:2018-06-13
Last modified:2018-06-27
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis for regulation of human acetyl-CoA carboxylase.
Nature, 558, 2018
6G2D
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CITRATE-INDUCED ACETYL-COA CARBOXYLASE (ACC-CIT) FILAMENT AT 5.4 A RESOLUTION
Descriptor:Acetyl-CoA carboxylase 1
Authors:Hunkeler, M., Hagmann, A., Stuttfeld, E., Chami, M., Stahlberg, H., Maier, T.
Deposit date:2018-03-23
Release date:2018-06-13
Last modified:2018-06-27
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Structural basis for regulation of human acetyl-CoA carboxylase.
Nature, 558, 2018
5VJ1
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CRYSTAL STRUCTURE OF A PSEUDOMONAS MALONATE DECARBOXYLASE HETERO-TETRAMER IN COMPLEX WITH COENZYME A
Descriptor:MdcA, MdcC, MdcD, ...
Authors:Maderbocus, R., Tong, L.
Deposit date:2017-04-18
Release date:2017-08-16
Method:X-RAY DIFFRACTION (2.995 Å)
Cite:Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer.
Nat Commun, 8, 2017
5VIT
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CRYSTAL STRUCTURE OF A PSEUDOMONAS MALONATE DECARBOXYLASE HETERO-TETRAMER IN COMPLEX WITH MALONATE
Descriptor:MdcA, MdcC, MdcD, ...
Authors:Maderbocus, R., Tong, L.
Deposit date:2017-04-17
Release date:2017-08-16
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer.
Nat Commun, 8, 2017
5VIP
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CRYSTAL STRUCTURE OF PSEUDOMONAS MALONATE DECARBOXYLASE MDCD-MDCE HETERO-DIMER
Descriptor:MdcE, MdcD
Authors:Maderbocus, R., Tong, L.
Deposit date:2017-04-17
Release date:2017-08-16
Method:X-RAY DIFFRACTION (1.857 Å)
Cite:Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer.
Nat Commun, 8, 2017
5KDR
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THE CRYSTAL STRUCTURE OF CARBOXYLTRANSFERASE FROM STAPHYLOCOCCUS AUREUS BOUND TO THE ANTIMICROBIAL AGENT MOIRAMIDE B.
Descriptor:Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha, Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, SULFATE ION, ...
Authors:Silvers, M.A., Pakhomova, S., Neau, D., Silvers, W.C., Anzalone, N., Taylor, C.M., Waldrop, G.L.
Deposit date:2016-06-08
Release date:2016-08-10
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Carboxyltransferase from Staphylococcus aureus Bound to the Antibacterial Agent Moiramide B.
Biochemistry, 55, 2016
5INI
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STRUCTURAL BASIS FOR ACYL-COA CARBOXYLASE-MEDIATED ASSEMBLY OF UNUSUAL POLYKETIDE SYNTHASE EXTENDER UNITS INCORPORATED INTO THE STAMBOMYCIN ANTIBIOTICS
Descriptor:Putative carboxyl transferase, HEXANOYL-COENZYME A
Authors:Valentic, T.R., Ray, L., Miyazawa, T., Withall, D.M., Song, L., Milligan, J.C., Osada, H., Tsai, S.C., Challis, G.L.
Deposit date:2016-03-07
Release date:2016-12-28
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016
5ING
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A CROTONYL-COA REDUCTASE-CARBOXYLASE INDEPENDENT PATHWAY FOR ASSEMBLY OF UNUSUAL ALKYLMALONYL-COA POLYKETIDE SYNTHASE EXTENDER UNIT
Descriptor:Putative carboxyl transferase
Authors:Valentic, T.R., Ray, L., Miyazawa, T., Song, L., Withall, D.M., Milligan, J.C., Takahashi, S., Osada, H., Tsai, S.C., Challis, G.L.
Deposit date:2016-03-07
Release date:2016-12-28
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016
5INF
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STRUCTURAL BASIS FOR ACYL-COA CARBOXYLASE-MEDIATED ASSEMBLY OF UNUSUAL POLYKETIDE SYNTHASE EXTENDER UNITS INCORPORATED INTO THE STAMBOMYCIN ANTIBIOTICS
Descriptor:Carboxyl transferase, HEXANOYL-COENZYME A
Authors:Valentic, T.R., Ray, L., Miyazawa, T., Withall, D.M., Song, L., Osada, H., Tsai, S.C., Challis, G.L.
Deposit date:2016-03-07
Release date:2016-12-28
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016
5IKL
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CRYSTAL STRUCTURE OF P. AERUGINOSA GERANYL-COA CARBOXYLASE (GCC), BETA SUBUNIT
Descriptor:Geranyl-CoA carboxylase, beta-subunit
Authors:Huang, C.S., Jurado, A.R., Tong, L.
Deposit date:2016-03-03
Release date:2016-04-13
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and substrate selectivity of the 750-kDa alpha6beta6 holoenzyme of geranyl-CoA carboxylase
Nat Commun, 6, 2015
5I6I
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CRYSTAL STRUCTURE OF A DBCCP-VARIANT OF CHAETOMIUM THERMOPHILUM ACETYL-COA CARBOXYLASE
Descriptor:Acetyl-CoA carboxylase-like protein,Acetyl-CoA carboxylase-like protein,Acetyl-CoA carboxylase-like protein
Authors:Hunkeler, M., Stuttfeld, E., Hagmann, A., Imseng, S., Maier, T.
Deposit date:2016-02-16
Release date:2016-04-20
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (8.4 Å)
Cite:The dynamic organization of fungal acetyl-CoA carboxylase.
Nat Commun, 7, 2016
5I6H
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CRYSTAL STRUCTURE OF CD-CT DOMAINS OF CHAETOMIUM THERMOPHILUM ACETYL-COA CARBOXYLASE
Descriptor:Acetyl-CoA carboxylase-like protein
Authors:Hunkeler, M., Stuttfeld, E., Hagmann, A., Imseng, S., Maier, T.
Deposit date:2016-02-16
Release date:2016-04-20
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (7.2 Å)
Cite:The dynamic organization of fungal acetyl-CoA carboxylase.
Nat Commun, 7, 2016
5I6G
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CRYSTAL STRUCTURE OF C-TERMINAL VARIANT 2 OF CHAETOMIUM THERMOPHILUM ACETYL-COA CARBOXYLASE
Descriptor:Acetyl-CoA carboxylase-like protein,Acetyl-CoA carboxylase-like protein
Authors:Hunkeler, M., Stuttfeld, E., Hagmann, A., Imseng, S., Maier, T.
Deposit date:2016-02-16
Release date:2016-04-20
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:The dynamic organization of fungal acetyl-CoA carboxylase.
Nat Commun, 7, 2016
5I6F
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CRYSTAL STRUCTURE OF C-TERMINAL VARIANT 1 OF CHAETOMIUM THERMOPHILUM ACETYL-COA CARBOXYLASE
Descriptor:Acetyl-CoA carboxylase-like protein
Authors:Hunkeler, M., Stuttfeld, E., Hagmann, A., Imseng, S., Maier, T.
Deposit date:2016-02-16
Release date:2016-04-20
Last modified:2016-04-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The dynamic organization of fungal acetyl-CoA carboxylase.
Nat Commun, 7, 2016
5FIF
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CARBOXYLTRANSFERASE DOMAIN OF A SINGLE-CHAIN BACTERIAL CARBOXYLASE
Descriptor:Carboxylase, 1,2-ETHANEDIOL
Authors:Hagmann, A., Hunkeler, M., Stuttfeld, E., Maier, T.
Deposit date:2015-12-23
Release date:2016-07-20
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (2.494 Å)
Cite:Hybrid Structure of a Dynamic Single-Chain Carboxylase from Deinococcus radiodurans.
Structure, 24, 2016
5CTE
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HUMANIZED YEAST ACC CARBOXYLTRANSFERASE DOMAIN BOUND TO 2,2-DIMETHYLPROPYL (1S)-1-METHYL-8-[(7-METHYL-1H-INDAZOL-5-YL)CARBONYL]-2,8-DIAZASPIRO[4.5]DECANE-2-CARBOXYLATE
Descriptor:Acetyl-CoA carboxylase, 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate, SULFATE ION
Authors:Vajdos, F.F.
Deposit date:2015-07-23
Release date:2015-10-14
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg.Med.Chem.Lett., 25, 2015
5CTC
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HUMANIZED YEAST ACC CARBOXYLTRANSFERASE DOMAIN BOUND TO TERT-BUTYL 7-[(7-METHYL-1H-INDAZOL-5-YL)CARBONYL]-2,7-DIAZASPIRO[3.5]NONANE-2-CARBOXYLATE
Descriptor:Acetyl-CoA carboxylase, tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate, SULFATE ION
Authors:Vajdos, F.F.
Deposit date:2015-07-23
Release date:2015-10-14
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg.Med.Chem.Lett., 25, 2015
5CTB
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HUMANIZED YEAST ACC CARBOXYLTRANSFERASE DOMAIN BOUND TO 6,7-DIMETHYL-1'-[(7-METHYL-1H-INDAZOL-5-YL)CARBONYL]SPIRO[CHROMENE-2,4'-PIPERIDIN]-4(3H)-ONE
Descriptor:Acetyl-CoA carboxylase, 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one, SULFATE ION
Authors:Vajdos, F.F.
Deposit date:2015-07-23
Release date:2015-10-14
Last modified:2015-11-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg.Med.Chem.Lett., 25, 2015
5CSL
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CRYSTAL STRUCTURE OF THE 500 KD YEAST ACETYL-COA CARBOXYLASE HOLOENZYME DIMER
Descriptor:Acetyl-CoA carboxylase, 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A
Authors:Wei, J., Tong, L.
Deposit date:2015-07-23
Release date:2015-10-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
Nature, 526, 2015
5CSK
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CRYSTAL STRUCTURE OF YEAST ACETYL-COA CARBOXYLASE, UNBIOTINYLATED
Descriptor:Acetyl-CoA carboxylase
Authors:Wei, J., Tong, L.
Deposit date:2015-07-23
Release date:2015-10-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
Nature, 526, 2015
4WZ8
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CRYSTAL STRUCTURE OF HUMAN-YEAST CHIMERA ACETYL COA CARBOXYLASE CT DOMAIN BOUND TO COMPOUND 6
Descriptor:Acetyl-CoA carboxylase, 1'-(2H-indazol-5-ylcarbonyl)-1-(propan-2-yl)-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-one
Authors:Vajdos, F.F.
Deposit date:2014-11-18
Release date:2014-12-10
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes.
J.Med.Chem., 57, 2014
4WYO
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CRYSTAL STRUCTURE OF HUMAN-YEAST CHIMERA ACETYL COA CARBOXYLASE CT DOMAIN BOUND TO COMPOUND 1
Descriptor:Acetyl-CoA carboxylase, 2'-tert-butyl-1-(2H-indazol-5-ylcarbonyl)-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazol]-7'(6'H)-one
Authors:Vajdos, F.F.
Deposit date:2014-11-17
Release date:2015-01-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes.
J.Med.Chem., 57, 2014
4RCN
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STRUCTURE AND FUNCTION OF A SINGLE-CHAIN, MULTI-DOMAIN LONG-CHAIN ACYL-COA CARBOXYLASE
Descriptor:long-chain acyl-CoA carboxylase
Authors:Tran, T.H., Tong, L.
Deposit date:2014-09-16
Release date:2014-11-05
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.
Nature, 518, 2015
4Q0G
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CRYSTAL STRUCTURE OF BETA SUBUNIT OF ACYL-COA CARBOXYLASE ACCD1 FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Probable acetyl-/propionyl-CoA carboxylase (Beta subunit) AccD1, GLYCEROL
Authors:Bie, H.Y., Yin, J., James, M.N.G., TB Structural Genomics Consortium (TBSGC)
Deposit date:2014-04-02
Release date:2016-04-20
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystal structure of Beta subunit of acyl-CoA carboxylase AccD1 from Mycobacterium tuberculosis
To be Published
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