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8I5M
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BU of 8i5m by Molmil
Rat Kir4.1 in complex with PIP2
Descriptor: ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Zhao, C, Guo, J.
Deposit date:2023-01-26
Release date:2024-02-28
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Pharmacological inhibition of astrocytic Kir4.1 channel evokes rapid-onset antidepressant responses
To Be Published
8I5N
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BU of 8i5n by Molmil
Rat Kir4.1 in complex with PIP2 and Lys05
Descriptor: ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
Authors:Zhao, C, Guo, J.
Deposit date:2023-01-26
Release date:2024-02-28
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Pharmacological inhibition of astrocytic Kir4.1 channel evokes rapid-onset antidepressant responses
To Be Published
7UQR
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BU of 7uqr by Molmil
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the apo form with Kir6.2-CTD in the down conformation
Descriptor: ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-04-20
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (4.55 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7ZDZ
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BU of 7zdz by Molmil
Cryo-EM structure of the human inward-rectifier potassium 2.1 channel (Kir2.1)
Descriptor: Inward rectifier potassium channel 2, POTASSIUM ION, STRONTIUM ION
Authors:Fernandes, C.A.H, Venien-Bryan, C, Fagnen, C, Zuniga, D.
Deposit date:2022-03-30
Release date:2022-09-28
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel.
Sci Adv, 8, 2022
7UAA
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BU of 7uaa by Molmil
CryoEM structure of the pancreatic ATP-sensitive potassium channel in the ATP-bound state with Kir6.2-CTD in the up conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-03-11
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7U7M
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BU of 7u7m by Molmil
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with Kir6.2-CTD in the up conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-03-07
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7U6Y
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BU of 7u6y by Molmil
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of glibenclamide and ATP with Kir6.2-CTD in the down conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-03-06
Release date:2022-08-31
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7U2X
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BU of 7u2x by Molmil
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with Kir6.2-CTD in the down conformation
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-02-25
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7U24
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BU of 7u24 by Molmil
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and glibenclamide with Kir6.2-CTD in the up conformation
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ...
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-02-23
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7U1S
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BU of 7u1s by Molmil
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with SUR1-out conformation
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-02-22
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7U1E
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BU of 7u1e by Molmil
CryoEM structure of the pancreatic ATP-sensitive potassium channel bound to ATP with Kir6.2-CTD in the down conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-02-21
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (4.52 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7U1Q
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BU of 7u1q by Molmil
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with SUR1-in conformation
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-02-21
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7TYS
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BU of 7tys by Molmil
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with Kir6.2-CTD in the up conformation
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-02-14
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7TYT
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BU of 7tyt by Molmil
Cryo-EM structure of the pancreatic ATP-sensitive potassium channel bound to ATP and repaglinide with Kir6.2-CTD in the down conformation
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Shyng, S.L, Sung, M.W, Driggers, C.M.
Deposit date:2022-02-14
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel.
J.Mol.Biol., 434, 2022
7W4P
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BU of 7w4p by Molmil
The structure of KATP H175K mutant in closed state
Descriptor: 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Chen, L, Wang, M.
Deposit date:2021-11-28
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.19 Å)
Cite:Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
7W4O
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BU of 7w4o by Molmil
The structure of KATP H175K mutant in pre-open state
Descriptor: 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Chen, L, Wang, M.
Deposit date:2021-11-28
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
7S5Z
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BU of 7s5z by Molmil
Human KATP channel in open conformation, focused on Kir and one SUR, position 3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
Authors:Zhao, C, MacKinnon, R.
Deposit date:2021-09-12
Release date:2021-12-01
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S5T
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BU of 7s5t by Molmil
Human KATP channel in open conformation, focused on Kir (C166S G334D double mutant) and SUR TMD0
Descriptor: ATP-sensitive inward rectifier potassium channel 11, POTASSIUM ION
Authors:Zhao, C, MacKinnon, R.
Deposit date:2021-09-12
Release date:2021-12-01
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S61
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BU of 7s61 by Molmil
Human KATP channel in open conformation, focused on Kir and one SUR, position 5
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
Authors:Zhao, C, MacKinnon, R.
Deposit date:2021-09-12
Release date:2021-12-01
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S60
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BU of 7s60 by Molmil
Human KATP channel in open conformation, focused on Kir and one SUR, position 4
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
Authors:Zhao, C, MacKinnon, R.
Deposit date:2021-09-12
Release date:2021-12-01
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S5Y
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BU of 7s5y by Molmil
Human KATP channel in open conformation, focused on Kir and one SUR, position 2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
Authors:Zhao, C, MacKinnon, R.
Deposit date:2021-09-12
Release date:2021-12-01
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7S5X
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BU of 7s5x by Molmil
Human KATP channel in open conformation, focused on Kir and one SUR, position 1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ...
Authors:Zhao, C, MacKinnon, R.
Deposit date:2021-09-12
Release date:2021-12-01
Last modified:2021-12-08
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular structure of an open human K ATP channel.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MJP
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BU of 7mjp by Molmil
Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Sung, M.W, Shyng, S.L.
Deposit date:2021-04-20
Release date:2021-10-13
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MJQ
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BU of 7mjq by Molmil
Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 8, ...
Authors:Sung, M.W, Shyng, S.L.
Deposit date:2021-04-20
Release date:2021-10-13
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MJO
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BU of 7mjo by Molmil
Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 1
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ...
Authors:Sung, M.W, Shyng, S.L.
Deposit date:2021-04-20
Release date:2021-10-13
Last modified:2022-10-26
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.
Proc.Natl.Acad.Sci.USA, 118, 2021

 

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