1ADD
  • Download 1add
  • View 1add
Molmil generated image of 1add
A PRE-TRANSITION STATE MIMIC OF AN ENZYME: X-RAY STRUCTURE OF ADENOSINE DEAMINASE WITH BOUND 1-DEAZA-ADENOSINE AND ZINC-ACTIVATED WATER
Descriptor:ADENOSINE DEAMINASE, ZINC ION, 1-DEAZA-ADENOSINE
Authors:Wilson, D.K., Quiocho, F.A.
Deposit date:1992-12-22
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water.
Biochemistry, 32, 1993
2ADA
  • Download 2ada
  • View 2ada
Molmil generated image of 2ada
ATOMIC STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH A TRANSITION-STATE ANALOG: UNDERSTANDING CATALYSIS AND IMMUNODEFICIENCY MUTATIONS
Descriptor:ADENOSINE DEAMINASE, ZINC ION, 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE
Authors:Wilson, D.K., Quiocho, F.A.
Deposit date:1994-12-02
Release date:1995-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations.
Science, 252, 1991
1FKW
  • Download 1fkw
  • View 1fkw
Molmil generated image of 1fkw
MURINE ADENOSINE DEAMINASE (D295E)
Descriptor:ADENOSINE DEAMINASE, ZINC ION, PURINE RIBOSIDE
Authors:Wilson, D.K., Quiocho, F.A.
Deposit date:1996-02-29
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
Biochemistry, 35, 1996
1FKX
  • Download 1fkx
  • View 1fkx
Molmil generated image of 1fkx
MURINE ADENOSINE DEAMINASE (D296A)
Descriptor:ADENOSINE DEAMINASE, ZINC ION, 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE
Authors:Wilson, D.K., Quiocho, F.A.
Deposit date:1996-02-29
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase.
Biochemistry, 35, 1996
1UIO
  • Download 1uio
  • View 1uio
Molmil generated image of 1uio
ADENOSINE DEAMINASE (HIS 238 ALA MUTANT)
Descriptor:ADENOSINE DEAMINASE, ZINC ION, 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE
Authors:Wilson, D.K., Quiocho, F.A.
Deposit date:1996-08-30
Release date:1997-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation.
Biochemistry, 35, 1996
1UIP
  • Download 1uip
  • View 1uip
Molmil generated image of 1uip
ADENOSINE DEAMINASE (HIS 238 GLU MUTANT)
Descriptor:ADENOSINE DEAMINASE, ZINC ION, PURINE RIBOSIDE
Authors:Wilson, D.K., Quiocho, F.A.
Deposit date:1996-08-30
Release date:1997-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Site-directed mutagenesis of histidine 238 in mouse adenosine deaminase: substitution of histidine 238 does not impede hydroxylate formation.
Biochemistry, 35, 1996
1A4L
  • Download 1a4l
  • View 1a4l
Molmil generated image of 1a4l
ADA STRUCTURE COMPLEXED WITH DEOXYCOFORMYCIN AT PH 7.0
Descriptor:ADENOSINE DEAMINASE, ZINC ION, 2'-DEOXYCOFORMYCIN
Authors:Wang, Z., Quiocho, F.A.
Deposit date:1998-01-31
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Biochemistry, 37, 1998
1A4M
  • Download 1a4m
  • View 1a4m
Molmil generated image of 1a4m
ADA STRUCTURE COMPLEXED WITH PURINE RIBOSIDE AT PH 7.0
Descriptor:ADENOSINE DEAMINASE, ZINC ION, 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE
Authors:Wang, Z., Quiocho, F.A.
Deposit date:1998-01-31
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Biochemistry, 37, 1998
1KRM
  • Download 1krm
  • View 1krm
Molmil generated image of 1krm
CRYSTAL STRUCTURE OF BOVINE ADENOSINE DEAMINASE COMPLEXED WITH 6-HYDROXYL-1,6-DIHYDROPURINE RIBOSIDE
Descriptor:adenosine deaminase, ZINC ION, 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE
Authors:Kinoshita, T.
Deposit date:2002-01-10
Release date:2003-01-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of bovine adenosine deaminase complexed with 6-hydroxy-1,6-dihydropurine riboside.
Acta Crystallogr.,Sect.D, 59, 2003
1NDV
  • Download 1ndv
  • View 1ndv
Molmil generated image of 1ndv
CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH FR117016
Descriptor:Adenosine deaminase, ZINC ION, N''-(4-(5-((1H-BENZIMIDAZOL-2-YLAMINO)METHYL)-2-THIENYL)-1,3-THIAZOL-2-YL)GUANIDINE
Authors:Kinoshita, T.
Deposit date:2002-12-09
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
1NDW
  • Download 1ndw
  • View 1ndw
Molmil generated image of 1ndw
CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH FR221647
Descriptor:Adenosine Deaminase, ZINC ION, 1-((1R)-1-(HYDROXYMETHYL)-3-PHENYLPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Authors:Kinoshita, T.
Deposit date:2002-12-09
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
1NDY
  • Download 1ndy
  • View 1ndy
Molmil generated image of 1ndy
CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH FR230513
Descriptor:Adenosine Deaminase, ZINC ION, 1-((1R)-1-(HYDROXYMETHYL)-3-(1-NAPHTHYL)PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Authors:Kinoshita, T.
Deposit date:2002-12-09
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
1NDZ
  • Download 1ndz
  • View 1ndz
Molmil generated image of 1ndz
CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH FR235999
Descriptor:Adenosine Deaminase, ZINC ION, 1-((1R)-1-(HYDROXYMETHYL)-3-(6-((3-(1-METHYL-1H-BENZIMIDAZOL-2-YL)PROPANOYL)AMINO)-1H-INDOL-1-YL)PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Authors:Kinoshita, T.
Deposit date:2002-12-09
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
1W1I
  • Download 1w1i
  • View 1w1i
Molmil generated image of 1w1i
CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPPIV OR CD26) IN COMPLEX WITH ADENOSINE DEAMINASE
Descriptor:DIPEPTIDYL PEPTIDASE IV, ADENOSINE DEAMINASE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Weihofen, W.A., Liu, J., Reutter, W., Saenger, W., Fan, H.
Deposit date:2004-06-22
Release date:2004-09-02
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface.
J. Biol. Chem., 279, 2004
1O5R
  • Download 1o5r
  • View 1o5r
Molmil generated image of 1o5r
CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH A POTENT INHIBITOR
Descriptor:Adenosine deaminase, ZINC ION, 1-[(1R)-3-(6-{[(BENZYLAMINO)CARBONYL]AMINO}-1H-INDOL-1-YL)-1-(HYDROXYMETHYL)PROPYL]-1H-IMIDAZOLE-4-CARBOXAMIDE
Authors:Kinoshita, T.
Deposit date:2003-10-05
Release date:2004-09-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
1QXL
  • Download 1qxl
  • View 1qxl
Molmil generated image of 1qxl
CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH FR235380
Descriptor:Adenosine deaminase, ZINC ION, 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(5-PHENYLPENTANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Authors:Kinoshita, T.
Deposit date:2003-09-08
Release date:2004-09-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
1UML
  • Download 1uml
  • View 1uml
Molmil generated image of 1uml
CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH A POTENT INHIBITOR FR233624
Descriptor:Adenosine deaminase, ZINC ION, 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(3-PHENYLPROPANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Authors:Kinoshita, T.
Deposit date:2003-10-03
Release date:2004-09-21
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
1V79
  • Download 1v79
  • View 1v79
Molmil generated image of 1v79
CRYSTAL STRUCTURES OF ADENOSINE DEAMINASE COMPLEXED WITH POTENT INHIBITORS
Descriptor:Adenosine deaminase, ZINC ION, 1-{(1R,2S)-1-[2-(2,3,-DICHLOROPHENYL)ETHYL]-2-HYDROXYPROPYL}-1H-IMIDAZOLE-4-CARBOXAMIDE
Authors:Kinoshita, T.
Deposit date:2003-12-14
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
1V7A
  • Download 1v7a
  • View 1v7a
Molmil generated image of 1v7a
CRYSTAL STRUCTURES OF ADENOSINE DEAMINASE COMPLEXED WITH POTENT INHIBITORS
Descriptor:adenosine deaminase, ZINC ION, 1-{(1R,2S)-2-HYDROXY-1-[2-(2-NAPHTHYLOXY)ETHYL]PROPYL}-1H-IMIDAZONE-4-CARBOXAMIDE
Authors:Kinoshita, T.
Deposit date:2003-12-14
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
2BGN
  • Download 2bgn
  • View 2bgn
Molmil generated image of 2bgn
HIV-1 TAT PROTEIN DERIVED N-TERMINAL NONAPEPTIDE TRP2-TAT(1-9) BOUND TO THE ACTIVE SITE OF DIPEPTIDYL PEPTIDASE IV (CD26)
Descriptor:DIPEPTIDYL PEPTIDASE IV, ADENOSINE DEAMINASE, TAT PROTEIN, ...
Authors:Weihofen, W.A., Liu, J., Reutter, W., Saenger, W., Fan, H.
Deposit date:2005-01-03
Release date:2005-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal Structures of HIV-1 Tat-Derived Nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) Bound to the Active Site of Dipeptidyl-Peptidase Iv (Cd26)
J.Biol.Chem., 280, 2005
2A3L
  • Download 2a3l
  • View 2a3l
Molmil generated image of 2a3l
X-RAY STRUCTURE OF ADENOSINE 5'-MONOPHOSPHATE DEAMINASE FROM ARABIDOPSIS THALIANA IN COMPLEX WITH COFORMYCIN 5'-PHOSPHATE
Descriptor:AMP deaminase, ZINC ION, PHOSPHATE ION, ...
Authors:Han, B.W., Wesenberg, G.E., Phillips Jr., G.N., Bitto, E., Bingman, C.A., Allard, S.T.M., Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2005-06-25
Release date:2005-07-19
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Membrane association, mechanism of action, and structure of Arabidopsis embryonic factor 1 (FAC1).
J.Biol.Chem., 281, 2006
1VFL
  • Download 1vfl
  • View 1vfl
Molmil generated image of 1vfl
ADENOSINE DEAMINASE
Descriptor:Adenosine deaminase, ZINC ION
Authors:Kinoshita, T.
Deposit date:2004-04-16
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Compound Recognition by Adenosine Deaminase
Biochemistry, 44, 2005
1WXY
  • Download 1wxy
  • View 1wxy
Molmil generated image of 1wxy
CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE LIGATED WITH A POTENT INHIBITOR
Descriptor:Adenosine deaminase, ZINC ION, N-[4,5-BIS(4-HYDROXYPHENYL)-1,3-THIAZOL-2-YL]HEXANAMIDE
Authors:Kinoshita, T.
Deposit date:2005-02-02
Release date:2005-08-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of Compound Recognition by Adenosine Deaminase
Biochemistry, 44, 2005
1WXZ
  • Download 1wxz
  • View 1wxz
Molmil generated image of 1wxz
CRYSTAL STRUCTURE OF ADENOSINE DEAMINASE LIGATED WITH A POTENT INHIBITOR
Descriptor:Adenosine deaminase, ZINC ION, 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE
Authors:Kinoshita, T.
Deposit date:2005-02-02
Release date:2005-08-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism
J.Med.Chem., 48, 2005
2AMX
  • Download 2amx
  • View 2amx
Molmil generated image of 2amx
CRYSTAL STRUCTURE OF PLASMODIUM YOELII ADENOSINE DEAMINASE (PY02076)
Descriptor:adenosine deaminase, COBALT (II) ION, UNKNOWN ATOM OR ION
Authors:Dong, A., Vedadi, M., Wasney, G., Zhao, Y., Lew, J., Alam, Z., Melone, M., Koeieradzki, I., Edwards, A.M., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Bochkarev, A., Hui, R., Amani, M., Structural Genomics Consortium (SGC)
Deposit date:2005-08-10
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
<12>
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan