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1U0D	Y33H Mutant of Homing endonuclease I-CreI Descriptor: 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*CP*GP*C)-3', 5'-D(*GP*CP*GP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', DNA endonuclease I-CreI Authors: Sussman, D, Chadsey, M, Fauce, S, Engel, A, Bruett, A, Monnat, R, Stoddard, B.L, Seligman, L.M. Deposit date: 2004-07-13 Release date: 2004-11-02 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Isolation and characterization of new homing endonuclease specificities at individual target site positions. J.Mol.Biol., 342, 2004
3KO2	I-MsoI re-designed for altered DNA cleavage specificity (-7C) Descriptor: 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*GP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*CP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... Authors: Taylor, G.K, Stoddard, B.L. Deposit date: 2009-11-13 Release date: 2010-05-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res., 38, 2010
1AF5	GROUP I MOBILE INTRON ENDONUCLEASE Descriptor: I-CREI Authors: Heath, P.J, Stephens, K.M, Monnat Junior, R.J, Stoddard, B.L. Deposit date: 1997-03-21 Release date: 1997-07-23 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3 Å) Cite: The structure of I-Crel, a group I intron-encoded homing endonuclease. Nat.Struct.Biol., 4, 1997
4LQ0	Crystal structure of the I-LtrWI LAGLIDADG homing endonuclease bound to target DNA. Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: Chik, J, Shen, B, Stoddard, B. Deposit date: 2013-07-16 Release date: 2014-07-16 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Structural Comparisons of LAGLIDADG Homing Endonucleases. To be Published
4LOX	Crystal structure of the I-SmaMI LAGLIDADG homing endonuclease bound to cleaved DNA Descriptor: DNA (5'-D(*CP*GP*TP*AP*CP*AP*CP*CP*TP*GP*AP*TP*AP*A)-3'), DNA (5'-D(*GP*GP*TP*AP*TP*CP*CP*TP*CP*CP*AP*TP*TP*AP*T)-3'), DNA (5'-D(P*CP*AP*GP*GP*TP*GP*TP*AP*CP*G)-3'), ... Authors: Chik, J, Shen, B, Stoddard, B. Deposit date: 2013-07-14 Release date: 2014-09-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Crystal structure of a LAGLIDADG endonuclease from the Sordaria Macrospore. To be Published
2I3P	K28R mutant of Homing Endonuclease I-CreI Descriptor: 5'-D(*CP*GP*AP*AP*AP*TP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*AP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*TP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*AP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... Authors: Sussman, D, Rosen, L. Deposit date: 2006-08-20 Release date: 2006-09-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res., 34, 2006
2I3Q	Q44V mutant of Homing Endonuclease I-CreI Descriptor: 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*AP*CP*TP*CP*AP*CP*GP*TP*CP*GP*TP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*AP*CP*GP*TP*GP*AP*GP*TP*CP*AP*GP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... Authors: Rosen, L, Sussman, D. Deposit date: 2006-08-20 Release date: 2006-09-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res., 34, 2006
1BP7	GROUP I MOBILE INTRON ENDONUCLEASE I-CREI COMPLEXED WITH HOMING SITE DNA Descriptor: CALCIUM ION, DNA (5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP* GP*C)-3'), DNA (5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP* CP*G)-3'), ... Authors: Jurica, M.S, Monnat Junior, R.J, Stoddard, B.L. Deposit date: 1998-08-13 Release date: 1999-01-06 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3 Å) Cite: DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI. Mol.Cell, 2, 1998
1G9Y	HOMING ENDONUCLEASE I-CREI / DNA SUBSTRATE COMPLEX WITH CALCIUM Descriptor: 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... Authors: Chevalier, B, Monnat, R.J, Stoddard, B.L. Deposit date: 2000-11-28 Release date: 2001-04-02 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites. Nat.Struct.Biol., 8, 2001
1G9Z	LAGLIDADG HOMING ENDONUCLEASE I-CREI / DNA PRODUCT COMPLEX WITH MAGNESIUM Descriptor: 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*A)-3', 5'-D(P*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', ... Authors: Chevalier, B, Monnat, R.J, Stoddard, B.L. Deposit date: 2000-11-28 Release date: 2001-04-02 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites. Nat.Struct.Biol., 8, 2001
3QQY	Crystal structure of a novel LAGLIDADG homing endonuclease, I-OnuI (from Ophiostoma novo-ulmi subsp. americana) Descriptor: DNA (26-MER), MAGNESIUM ION, Ribosomal protein 3/homing endonuclease-like protein fusion Authors: Takeuchi, R, Stoddard, B.L. Deposit date: 2011-02-16 Release date: 2011-07-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.401 Å) Cite: Tapping natural reservoirs of homing endonucleases for targeted gene modification. Proc.Natl.Acad.Sci.USA, 108, 2011
3R7P	The crystal structure of I-LtrI Descriptor: DNA (5'-D(*CP*AP*AP*AP*TP*GP*CP*TP*CP*CP*TP*AP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*TP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*GP*CP*AP*TP*TP*TP*G)-3'), ... Authors: Mak, A.N.S, Takeuchi, R, Edgell, D.R, Stoddard, B.L. Deposit date: 2011-03-22 Release date: 2011-07-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.704 Å) Cite: Tapping natural reservoirs of homing endonucleases for targeted gene modification. Proc.Natl.Acad.Sci.USA, 108, 2011
4AAF	Crystal structure of the mutant D75N I-CreI in complex with an altered target (The four central bases, 2NN region, are composed by TGCA from 5' to 3') Descriptor: 1,2-ETHANEDIOL, 24MER DNA, DNA ENDONUCLEASE I-CREI Authors: Molina, R, Redondo, P, Stella, S, Marenchino, M, D'Abramo, M, Gervasio, F.L, Epinat, J.C, Valton, J, Grizot, S, Duchateau, P, Prieto, J, Montoya, G. Deposit date: 2011-12-01 Release date: 2012-05-02 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Non-Specific Protein-DNA Interactions Control I-Crei Target Binding and Cleavage. Nucleic Acids Res., 40, 2012
4AQU	Crystal structure of I-CreI complexed with its target methylated at position plus 2 (in the b strand) in the presence of calcium Descriptor: 5'-D(*DCP*CP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*5CMP *GP*AP*CP*GP*TP*TP*TP*TP*GP*A)-3', 5'-D(*DTP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*DAP *GP*AP*CP*AP*GP*TP*TP*TP*GP*G)-3', CALCIUM ION, ... Authors: Valton, J, Daboussi, F, Leduc, S, Redondo, P, Macmaster, R, Molina, R, Montoya, G, Duchateau, P. Deposit date: 2012-04-19 Release date: 2012-07-04 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: 5'-Cytosine-Phosphoguanine (Cpg) Methylation Impacts the Activity of Natural and Engineered Meganucleases. J.Biol.Chem., 287, 2012
2AB5	bI3 LAGLIDADG Maturase Descriptor: SULFATE ION, mRNA maturase Authors: Longo, A, Leonard, C.W, Bassi, G.S, Berndt, D, Krahn, J.M, Hall, T.M, Weeks, K.M. Deposit date: 2005-07-14 Release date: 2005-08-30 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Evolution from DNA to RNA recognition by the bI3 LAGLIDADG maturase Nat.Struct.Mol.Biol., 12, 2005
3EH8	Crystal structure of Y2 I-AniI variant (F13Y/S111Y)/DNA complex with calcium Descriptor: 31-MER, CALCIUM ION, Intron-encoded DNA endonuclease I-AniI Authors: Takeuchi, R, Stoddard, B.L. Deposit date: 2008-09-11 Release date: 2009-01-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation. Nucleic Acids Res., 37, 2009
3E54	Archaeal Intron-encoded Homing Endonuclease I-Vdi141I Complexed With DNA Descriptor: DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DTP*DCP*DTP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(*DTP*DTP*DGP*DGP*DCP*DTP*DAP*DCP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(P*DGP*DAP*DGP*DAP*DGP*DTP*DCP*DAP*DG)-3'), ... Authors: Nomura, N, Nomura, Y, Sussman, D, Stoddard, B.L. Deposit date: 2008-08-13 Release date: 2008-12-30 Last modified: 2021-11-10 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases Nucleic Acids Res., 36, 2008
3FD2	Crystal structure of mMsoI/DNA complex with calcium Descriptor: 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... Authors: Li, H, Monnat, R.J. Deposit date: 2008-11-24 Release date: 2009-06-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins. Nucleic Acids Res., 37, 2009
2EX5	Group I Intron-encoded Homing Endonuclease I-CeuI Complexed With DNA Descriptor: CALCIUM ION, DNA endonuclease I-CeuI, I-CeuI DNA target site, ... Authors: Spiegel, P.C, Stoddard, B.L. Deposit date: 2005-11-07 Release date: 2006-05-23 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The structure of I-CeuI homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold. Structure, 14, 2006
2FLD	I-MsoI Re-Designed for Altered DNA Cleavage Specificity Descriptor: 5'-D(*CP*GP*GP*AP*AP*CP*GP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*CP*TP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*AP*GP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*CP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... Authors: Ashworth, J, Duarte, C.M, Havranek, J.J, Sussman, D, Monnat, R.J, Stoddard, B.L, Baker, D. Deposit date: 2006-01-05 Release date: 2006-06-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Computational redesign of endonuclease DNA binding and cleavage specificity. Nature, 441, 2006
1P8K	The structure and DNA recognition of a bifunctional homing endonuclease and group I intron splicing factor Descriptor: 5'-D(P*CP*CP*TP*CP*CP*TP*CP*AP*GP*CP*GP*CP*GP*CP*T)-3', 5'-D(P*GP*CP*GP*CP*GP*CP*TP*GP*AP*GP*GP*AP*GP*GP*TP*TP*TP*C)-3', 5'-D(P*GP*CP*GP*CP*TP*TP*TP*AP*CP*AP*GP*AP*GP*AP*AP*A)-3', ... Authors: Stoddard, B.L, Bolduc, J.M. Deposit date: 2003-05-07 Release date: 2004-01-20 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. Genes Dev., 17, 2003
1M5X	Crystal structure of the homing endonuclease I-MsoI bound to its DNA substrate Descriptor: 5'-D(*CP*GP*GP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*CP*TP*GP*C)-3', 5'-D(*GP*CP*AP*GP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*CP*CP*G)-3', CALCIUM ION, ... Authors: Chevalier, B, Turmel, M, Lemieux, C, Monnat, R.J, Stoddard, B.L. Deposit date: 2002-07-10 Release date: 2003-06-03 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI J.Mol.Biol., 329, 2003
1N3F	Crystal structure of I-CreI bound to a palindromic DNA sequence II (palindrome of right side of wildtype DNA target sequence) Descriptor: 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*GP*A)-3', 5'-D(P*GP*AP*CP*AP*GP*TP*TP*TP*CP*G-3'), CALCIUM ION, ... Authors: Chevalier, B, Turmel, M, Lemieux, C, Monnat, R.J, Stoddard, B.L. Deposit date: 2002-10-28 Release date: 2003-06-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI J.Mol.Biol., 329, 2003
1N3E	Crystal structure of I-CreI bound to a palindromic DNA sequence I (palindrome of left side of wildtype DNA target sequence) Descriptor: 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3', 5'-D(P*GP*AP*CP*GP*TP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... Authors: Chevalier, B, Turmel, M, Lemieux, C, Monnat, R.J, Stoddard, B.L. Deposit date: 2002-10-28 Release date: 2003-06-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI J.Mol.Biol., 329, 2003
1T9I	I-CreI(D20N)/DNA complex Descriptor: 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*CP*G)-3', CALCIUM ION, ... Authors: Chevalier, B, Sussman, D, Otis, C, Boudreau, D, Turmel, M, Lemieux, C, Stephens, K, Monnat Jr, R.J, Stoddard, B.L. Deposit date: 2004-05-17 Release date: 2004-11-16 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Metal-Dependent DNA Cleavage Mechanism of the I-CreI LAGLIDADG Homing Endonuclease. Biochemistry, 43, 2004

 

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