1N1M
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH AN INHIBITOR
Descriptor:Dipeptidyl peptidase IV SOLUBLE FORM, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Rasmussen, H.B., Branner, S., Wiberg, F.C., Wagtmann, N.R.
Deposit date:2002-10-18
Release date:2002-12-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analogue
Nat.Struct.Biol., 10, 2003
1J2E
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE
Authors:Hiramatsu, H., Kyono, K., Higashiyama, Y., Fukushima, C., Shima, H., Sugiyama, S., Inaka, K., Yamamoto, A., Shimizu, R.
Deposit date:2002-12-30
Release date:2003-12-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold.
Biochem.Biophys.Res.Commun., 302, 2003
1NU6
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (DPP-IV)
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, MERCURY (II) ION, ...
Authors:Hennig, M., Stihle, M., Thoma, R., Ruf, A.
Deposit date:2003-01-31
Release date:2003-08-26
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis of Proline-Specific Exopeptidase Activity as Observed in Human Dipeptidyl Peptidase-IV.
Structure, 11, 2003
1NU8
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (DPP-IV) IN COMPLEX WITH DIPROTIN A (IPI)
Descriptor:Dipeptidyl peptidase IV, 3-mer peptide, N-ACETYL-D-GLUCOSAMINE
Authors:Thoma, R., Loeffler, B., Stihle, M., Huber, W., Ruf, A., Hennig, M.
Deposit date:2003-01-31
Release date:2003-08-26
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of Proline-Specific Exopeptidase Activity as Observed in Human Dipeptidyl Peptidase-IV.
Structure, 11, 2003
1ORV
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CRYSTAL STRUCTURE OF PORCINE DIPEPTIDYL PEPTIDASE IV (CD26)
Descriptor:dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ...
Authors:Engel, M., Hoffmann, T., Wagner, L., Wermann, M., Heiser, U., Kiefersauer, R., Huber, R., Bode, W., Demuth, H.U., Brandstetter, H.
Deposit date:2003-03-16
Release date:2003-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism
Proc.Natl.Acad.Sci.USA, 100, 2003
1ORW
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CRYSTAL STRUCTURE OF PORCINE DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR
Descriptor:dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ...
Authors:Engel, M., Hoffmann, T., Wagner, L., Wermann, M., Heiser, U., Kiefersauer, R., Huber, R., Bode, W., Demuth, H.U., Brandstetter, H.
Deposit date:2003-03-16
Release date:2003-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism
Proc.Natl.Acad.Sci.USA, 100, 2003
1PFQ
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CRYSTAL STRUCTURE OF HUMAN APO DIPEPTIDYL PEPTIDASE IV / CD26
Descriptor:Dipeptidyl peptidase IV soluble form, N-ACETYL-D-GLUCOSAMINE
Authors:Oefner, C., D'Arcy, A., Mac Sweeney, A., Pierau, S., Gardiner, R., Dale, G.E.
Deposit date:2003-05-27
Release date:2003-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.
Acta Crystallogr.,Sect.D, 59, 2003
1R9M
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV AT 2.1 ANG. RESOLUTION.
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Aertgeerts, K., Ye, S., Tennant, M.G., Collins, B., Rogers, J., Sang, B.C., Skene, R.J., Webb, D.R., Prasad, G.S.
Deposit date:2003-10-30
Release date:2004-06-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation.
Protein Sci., 13, 2004
1R9N
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A DECAPEPTIDE (TNPY) AT 2.3 ANG. RESOLUTION
Descriptor:Dipeptidyl peptidase IV, Neuropeptide Y, N-ACETYL-D-GLUCOSAMINE
Authors:Aertgeerts, K., Ye, S., Tennant, M.G., Collins, B., Rogers, J., Sang, B.-C., Skene, R., Webb, D.R., Prasad, G.S.
Deposit date:2003-10-30
Release date:2005-03-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation.
Protein Sci., 13, 2004
1RWQ
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH 5-AMINOMETHYL-6-(2,4-DICHLORO-PHENYL)-2-(3,5-DIMETHOXY-PHENYL)-PYRIMIDIN-4-YLAMINE
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, 5-(AMINOMETHYL)-6-(2,4-DICHLOROPHENYL)-2-(3,5-DIMETHOXYPHENYL)PYRIMIDIN-4-AMINE
Authors:Hennig, M., Thoma, R., Stihle, M.
Deposit date:2003-12-17
Release date:2004-12-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents
Bioorg.Med.Chem.Lett., 14, 2004
1WCY
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (DPPIV) COMPLEX WITH DIPROTIN A
Descriptor:Dipeptidyl peptidase IV, Diprotin A, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hiramatsu, H., Yamamoto, A., Kyono, K., Higashiyama, Y., Fukushima, C., Shima, H., Sugiyama, S., Inaka, K., Shimizu, R.
Deposit date:2004-05-07
Release date:2005-05-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A
Biol.Chem., 385, 2004
1TK3
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CRYSTAL STRUCTURE OF HUMAN APO DIPEPTIDYL PEPTIDASE IV/CD26
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Bjelke, J.R., Christensen, J., Branner, S., Wagtmann, N., Olsen, C., Kanstrup, A.B., Rasmussen, H.B.
Deposit date:2004-06-08
Release date:2004-07-06
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Tyrosine 547 Constitutes an Essential Part of the Catalytic Mechanism of Dipeptidyl Peptidase IV
J.Biol.Chem., 279, 2004
1TKR
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 INHIBITED WITH DIISOPROPYL FLUOROPHOSPHATE
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Bjelke, J.R., Christensen, J., Branner, S., Wagtmann, N., Olsen, C., Kanstrup, A.B., Rasmussen, H.B.
Deposit date:2004-06-09
Release date:2004-07-06
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Tyrosine 547 Constitutes an Essential Part of the Catalytic Mechanism of Dipeptidyl Peptidase IV
J.Biol.Chem., 279, 2004
1W1I
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CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPPIV OR CD26) IN COMPLEX WITH ADENOSINE DEAMINASE
Descriptor:DIPEPTIDYL PEPTIDASE IV, ADENOSINE DEAMINASE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Weihofen, W.A., Liu, J., Reutter, W., Saenger, W., Fan, H.
Deposit date:2004-06-22
Release date:2004-09-02
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface.
J. Biol. Chem., 279, 2004
1U8E
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 MUTANT Y547F
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Bjelke, J.R., Christensen, J., Branner, S., Wagtmann, N., Olsen, C., Kanstrup, A.B., Rasmussen, H.B.
Deposit date:2004-08-05
Release date:2004-08-17
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV
J.Biol.Chem., 279, 2004
1X70
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Kim, D., Wang, L., Beconi, M., Eiermann, G.J., Fisher, M.H., He, H., Hickey, G.J., Leiting, B., Lyons, K.
Deposit date:2004-08-12
Release date:2005-01-18
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
J.Med.Chem., 48, 2005
1XFD
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STRUCTURE OF A HUMAN A-TYPE POTASSIUM CHANNEL ACCELERATING FACTOR DPPX, A MEMBER OF THE DIPEPTIDYL AMINOPEPTIDASE FAMILY
Descriptor:Dipeptidyl aminopeptidase-like protein 6, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Strop, P., Bankovich, A.J., Hansen, K.C., Garcia, K.C., Brunger, A.T.
Deposit date:2004-09-14
Release date:2004-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family
J.Mol.Biol., 343, 2004
2BGN
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HIV-1 TAT PROTEIN DERIVED N-TERMINAL NONAPEPTIDE TRP2-TAT(1-9) BOUND TO THE ACTIVE SITE OF DIPEPTIDYL PEPTIDASE IV (CD26)
Descriptor:DIPEPTIDYL PEPTIDASE IV, ADENOSINE DEAMINASE, TAT PROTEIN, ...
Authors:Weihofen, W.A., Liu, J., Reutter, W., Saenger, W., Fan, H.
Deposit date:2005-01-03
Release date:2005-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal Structures of HIV-1 Tat-Derived Nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) Bound to the Active Site of Dipeptidyl-Peptidase Iv (Cd26)
J.Biol.Chem., 280, 2005
2BGR
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CRYSTAL STRUCTURE OF HIV-1 TAT DERIVED NONAPEPTIDES TAT(1-9) BOUND TO THE ACTIVE SITE OF DIPEPTIDYL PEPTIDASE IV (CD26)
Descriptor:DIPEPTIDYL PEPTIDASE IV, HIV-1 TAT PROTEIN DERIVED N-TERMINAL NONAPEPTIDE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Weihofen, W.A., Liu, J., Reutter, W., Saenger, W., Fan, H.
Deposit date:2005-01-04
Release date:2005-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of HIV-1 Tat-Derived Nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) Bound to the Active Site of Dipeptidyl-Peptidase Iv (Cd26)
J.Biol.Chem., 280, 2005
1Z68
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CRYSTAL STRUCTURE OF HUMAN FIBROBLAST ACTIVATION PROTEIN ALPHA
Descriptor:fibroblast activation protein, alpha subunit, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Aertgeerts, K., Levin, I., Shi, L., Prasad, G.S., Zhang, Y., Kraus, M.L., Salakian, S., Snell, G.P., Sridhar, V., Wijnands, R., Tennant, M.G.
Deposit date:2005-03-21
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha.
J.Biol.Chem., 280, 2005
2BUA
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CRYSTAL STRUCTURE OF PORCINE DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A LOW MOLECULAR WEIGHT INHIBITOR.
Descriptor:DIPEPTIDYL PEPTIDASE IV, N-ACETYL-D-GLUCOSAMINE, 1-METHYLAMINE-1-BENZYL-CYCLOPENTANE, ...
Authors:Nordhoff, S., Cerezo-Galvez, S., Feurer, A., Hill, O., Matassa, V.G., Metz, G., Rummey, C., Thiemann, M., Edwards, P.J.
Deposit date:2005-06-09
Release date:2006-01-23
Last modified:2018-08-22
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors.
Bioorg. Med. Chem. Lett., 16, 2006
2BUB
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A REVERSED AMIDE INHIBITOR
Descriptor:DIPEPTIDYL PEPTIDASE 4, N-ACETYL-D-GLUCOSAMINE, N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE
Authors:Nordhoff, S., Cerezo-Galvez, S., Feurer, A., Hill, O., Matassa, V.G., Metz, G., Rummey, C., Thiemann, M., Edwards, P.J.
Deposit date:2005-06-09
Release date:2006-01-23
Last modified:2018-08-22
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors.
Bioorg. Med. Chem. Lett., 16, 2006
2BUC
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CRYSTAL STRUCTURE OF PORCINE DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH A TETRAHYDROISOQUINOLINE INHIBITOR
Descriptor:DIPEPTIDYL PEPTIDASE IV, N-ACETYL-D-GLUCOSAMINE, (S)-2-[(R)-3-AMINO-4-(2-FLUORO-PHENYL)-BUTYRYL]-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID AMIDE, ...
Authors:Nordhoff, S., Cerezo-Galvez, S., Feurer, A., Hill, O., Matassa, V.G., Metz, G., Rummey, C., Thiemann, M., Edwards, P.J.
Deposit date:2005-06-09
Release date:2006-01-23
Last modified:2018-08-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors.
Bioorg. Med. Chem. Lett., 16, 2006
2AJ8
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PORCINE DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH 7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONE (BDPX)
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ...
Authors:Engel, M., Hoffmann, T., Manhart, S., Heiser, U., Chambre, S., Huber, R., Demuth, H.U., Bode, W.
Deposit date:2005-08-01
Release date:2006-02-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.
J.Mol.Biol., 355, 2006
2AJB
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PORCINE DIPEPTIDYL PEPTIDASE IV (CD26) IN COMPLEX WITH THE TRIPEPTIDE TERT-BUTYL-GLY-L-PRO-L-ILE (TBU-GPI)
Descriptor:Dipeptidyl peptidase 4, 3-methyl-L-valyl-L-prolyl-L-isoleucine, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Engel, M., Hoffmann, T., Manhart, S., Heiser, U., Chambre, S., Huber, R., Demuth, H.U., Bode, W.
Deposit date:2005-08-01
Release date:2006-02-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.
J.Mol.Biol., 355, 2006
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