8IET
 
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8UUK
 | | Pendrin in apo | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, Lauryl Maltose Neopentyl Glycol, ... | | Authors: | Wang, L, Hoang, A, Zhou, M. | | Deposit date: | 2023-11-01 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024
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8SHC
 | | Pendrin in complex with Niflumic acid | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID, CHLORIDE ION, ... | | Authors: | Wang, L, Hoang, A, Zhou, M. | | Deposit date: | 2023-04-13 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024
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8SH3
 | | Pendrin in complex with iodide | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, IODIDE ION, ... | | Authors: | Wang, L, Hoang, A, Zhou, M. | | Deposit date: | 2023-04-13 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024
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8SIE
 | | Pendrin in complex with bicarbonate | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, BICARBONATE ION, CHOLESTEROL, ... | | Authors: | Wang, L, Hoang, A, Zhou, M. | | Deposit date: | 2023-04-16 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024
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8SGW
 | | Pendrin in complex with chloride | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHLORIDE ION, CHOLESTEROL, ... | | Authors: | Wang, L, Hoang, A, Zhou, M. | | Deposit date: | 2023-04-13 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Mechanism of anion exchange and small-molecule inhibition of pendrin.
Nat Commun, 15, 2024
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8HZN
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8UC1
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7WLB
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7WL8
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7XUH
 | | Down-regulated in adenoma in complex with TQR1122 | | Descriptor: | 2-[4,8-dimethyl-2-oxidanylidene-7-[[3-(trifluoromethyl)phenyl]methoxy]chromen-3-yl]ethanoic acid, CHOLESTEROL HEMISUCCINATE, Chloride anion exchanger | | Authors: | Li, X.R, Chi, X.M, Zhang, Y.Y, Zhou, Q. | | Deposit date: | 2022-05-18 | | Release date: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | structure of human SLC26A3 in complex with TQR1122
To Be Published
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7XUJ
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7XUL
 | | Human SLC26A3 in complex with Tenidap | | Descriptor: | 5-chloranyl-2-oxidanyl-3-thiophen-2-ylcarbonyl-indole-1-carboxamide, CHOLESTEROL HEMISUCCINATE, Chloride anion exchanger | | Authors: | Li, X.R, Chi, X.M, Zhang, Y.Y, Zhou, Q. | | Deposit date: | 2022-05-18 | | Release date: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Structure of human SLC26A3 in complex with Tenidap
To Be Published
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7WK7
 | | Mouse Pendrin bound bicarbonate in inward state | | Descriptor: | BICARBONATE ION, Pendrin | | Authors: | Liu, Q.Y, Zhang, X, Sun, L, Chen, Z.G. | | Deposit date: | 2022-01-08 | | Release date: | 2023-05-17 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger.
Nat Commun, 14, 2023
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8OPQ
 | | Structure of Human Solute Carrier 26 family member A6 (SLC26A6) anion transporter in an inward-facing state | | Descriptor: | CHLORIDE ION, Solute carrier family 26 member 6 | | Authors: | Tippett, D.N, Breen, C, Butler, S.J, Sawicka, M, Dutzler, R. | | Deposit date: | 2023-04-07 | | Release date: | 2023-05-17 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange.
Elife, 12, 2023
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7WL7
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7WK1
 | | Mouse Pendrin bound chloride in inward state | | Descriptor: | CHLORIDE ION, Pendrin | | Authors: | Liu, Q.Y, Zhang, X, Sun, L, Chen, Z.G. | | Deposit date: | 2022-01-08 | | Release date: | 2023-04-12 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger.
Nat Commun, 14, 2023
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7WL9
 | | Mouse Pendrin in chloride and bicarbonate in asymmetric state | | Descriptor: | CHLORIDE ION, Pendrin | | Authors: | Liu, Q.Y, Zhang, X, Sun, L, Chen, Z.G. | | Deposit date: | 2022-01-12 | | Release date: | 2023-04-12 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger.
Nat Commun, 14, 2023
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7WLA
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7WL2
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7WLE
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7XLM
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7SUN
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7S9B
 | | Cryo-EM Structure of dolphin Prestin: Sensor Down I (Expanded) state | | Descriptor: | Prestin | | Authors: | Bavi, N, Clark, M.D, Contreras, G.F, Shen, R, Reddy, B.G, Milewski, W, Perozo, E. | | Deposit date: | 2021-09-20 | | Release date: | 2021-11-03 | | Last modified: | 2021-12-29 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | The conformational cycle of prestin underlies outer-hair cell electromotility.
Nature, 600, 2021
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7S9C
 | | Cryo-EM Structure of dolphin Prestin: Sensor Down II (Expanded II) state | | Descriptor: | Prestin | | Authors: | Bavi, N, Clark, M.D, Contreras, G.F, Shen, R, Reddy, B.G, Milewski, W, Perozo, E. | | Deposit date: | 2021-09-20 | | Release date: | 2021-11-03 | | Last modified: | 2021-12-29 | | Method: | ELECTRON MICROSCOPY (6.7 Å) | | Cite: | The conformational cycle of prestin underlies outer-hair cell electromotility.
Nature, 600, 2021
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