1DZR
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RMLC FROM SALMONELLA TYPHIMURIUM
Descriptor:DTDP-4-DEHYDRORHAMNOSE 3\,5-EPIMERASE, GLYCEROL, SULFATE ION
Authors:Naismith, J.H., Giraud, M.F.
Deposit date:2000-03-07
Release date:2000-04-18
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Rmlc, the Third Enzyme of Dtdp-L-Rhamnose Pathway, is a New Class of Epimerase.
Nat.Struct.Biol., 7, 2000
1DZT
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RMLC FROM SALMONELLA TYPHIMURIUM
Descriptor:DTDP-4-DEHYDRORHAMNOSE 3\,5-EPIMERASE, GLYCEROL, SULFATE ION, ...
Authors:Naismith, J.H., Giraud, M.F.
Deposit date:2000-03-07
Release date:2000-04-18
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rmlc, the Third Enzyme of Dtdp-L-Rhamnose Pathway, is a New Class of Epimerase.
Nat.Struct.Biol., 7, 2000
1EP0
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HIGH RESOLUTION CRYSTAL STRUCTURE OF DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM
Descriptor:DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE
Authors:Christendat, D., Saridakis, V., Bochkarev, A., Pai, E.F., Arrowsmith, C.H., Edwards, A.M., Northeast Structural Genomics Consortium (NESG)
Deposit date:2000-03-24
Release date:2000-12-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.
J.Biol.Chem., 275, 2000
1EPZ
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CRYSTAL STRUCTURE OF DTDP-6-DEOXY-D-XYLO-4-HEXULOASE 3,5-EPIMERASE FROM METHANOBACTERIUM THERMOAUTOTROPHICUM WITH BOUND LIGAND.
Descriptor:DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE, THYMIDINE-5'-DIPHOSPHATE
Authors:Christendat, D., Saridakis, V., Bochkarev, A., Pai, E.F., Arrowsmith, C., Edwards, A.M.
Deposit date:2000-03-30
Release date:2000-12-13
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of dTDP-4-keto-6-deoxy-D-hexulose 3,5-epimerase from Methanobacterium thermoautotrophicum complexed with dTDP.
J.Biol.Chem., 275, 2000
1NXM
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THE HIGH RESOLUTION STRUCTURES OF RMLC FROM STREPTOCOCCUS SUIS
Descriptor:dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
Authors:Dong, C., Major, L.L., Allen, A., Blankenfeldt, W., Maskell, D., Naismith, J.H.
Deposit date:2003-02-11
Release date:2003-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High-Resolution Structures of RmlC from Streptococcus suis in Complex with Substrate Analogs Locate the Active Site of This Class of Enzyme
Structure, 11, 2003
1NYW
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THE HIGH RESOLUTION STRUCTURES OF RMLC FROM STREPTOCCUS SUIS IN COMPLEX WITH DTDP-D-GLUCOSE
Descriptor:dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase, 2'DEOXY-THYMIDINE-5'-DIPHOSPHO-ALPHA-D-GLUCOSE
Authors:Dong, C., Major, L.L., Allen, A., Blankenfeldt, W., Maskell, D., Naismith, J.H.
Deposit date:2003-02-14
Release date:2003-06-24
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-Resolution Structures of RmlC from Streptococcus suis in Complex with Substrate Analogs Locate the Active Site of This Class of Enzyme
Structure, 11, 2003
1NZC
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THE HIGH RESOLUTION STRUCTURES OF RMLC FROM STREPTOCOCCUS SUIS IN COMPLEX WITH DTDP-D-XYLOSE
Descriptor:dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase, THYMIDINE-5'-DIPHOSPHO-BETA-D-XYLOSE, NICKEL (II) ION
Authors:Dong, C., Major, L.L., Allen, A., Blankenfeldt, W., Maskell, D., Naismith, J.H.
Deposit date:2003-02-17
Release date:2003-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-Resolution Structures of RmlC from Streptococcus suis in Complex with Substrate Analogs Locate the Active Site of This Class of Enzyme
Structure, 11, 2003
1OFN
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PURIFICATION, CRYSTALLISATION AND PRELIMINARY STRUCTURAL STUDIES OF DTDP-4-KETO-6-DEOXY-GLUCOSE-5-EPIMERASE (EVAD) FROM AMYCOLATOPSIS ORIENTALIS; THE FOURTH ENZYME IN THE DTDP-L-EPIVANCOSAMINE BIOSYNTHETIC PATHWAY.
Descriptor:PCZA361.16, GLYCEROL
Authors:Merkel, A.B., Naismith, J.H.
Deposit date:2003-04-17
Release date:2004-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Purification, Crystallization and Preliminary Structural Studies of Dtdp-4-Keto-6-Deoxy-Glucose-5-Epimerase (Evad) from Amycolatopsis Orientalis, the Fourth Enzyme in the Dtdp-L-Epivancosamine Biosynthetic Pathway.
Acta Crystallogr.,Sect.D, 58, 2002
1OI6
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STRUCTURE DETERMINATION OF THE TMP-COMPLEX OF EVAD
Descriptor:PCZA361.16, GLYCEROL, THYMIDINE-5'-PHOSPHATE
Authors:Merkel, A.B., Naismith, J.H.
Deposit date:2003-06-09
Release date:2004-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Position of a Key Tyrosine in Dtdp-4-Keto-6-Deoxy-D-Glucose-5-Epimerase (Evad) Alters the Substrate Profile for This Rmlc-Like Enzyme
J.Biol.Chem., 279, 2004
1PM7
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RMLC (DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE)STRUCTURE FROM MYCOBACTERIUM TUBERCULOSIS AND INHIBITOR DESIGN. THE APO STRUCTURE.
Descriptor:RFBC, ACETATE ION, GLYCEROL
Authors:Dong, C., Naismith, J.H., TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-06-10
Release date:2003-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis.
Bioorg.Med.Chem.Lett., 13, 2003
1RTV
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RMLC (DTDP-6-DEOXY-D-XYLO-4-HEXULOSE 3,5-EPIMERASE) CRYSTAL STRUCTURE FROM PSEUDOMONAS AERUGINOSA, APO STRUCTURE
Descriptor:dTDP-4-dehydrorhamnose 3,5-epimerase, S,R MESO-TARTARIC ACID
Authors:Dong, C.J., Naismith, J.H.
Deposit date:2003-12-10
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:RmlC (dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase) crystal structure from Pseudomonas aeruginosa, apo structure
TO BE PUBLISHED
1UPI
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MYCOBACTERIUM TUBERCULOSIS RMLC EPIMERASE (RV3465)
Descriptor:DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE
Authors:Kim, C.-Y., Naranjo, C., Waldo, G.S., Lekin, T., Segelke, B.W., Kantardjieff, K.A., Zemla, A., Terwilliger, T., Rupp, B., TB Structural Genomics Consortium (TBSGC)
Deposit date:2003-10-05
Release date:2003-10-07
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mycobacterium Tuberculosis Rmlc Epimerase (Rv3465): A Promising Drug-Target Structure in the Rhamnose Pathway
Acta Crystallogr.,Sect.D, 60, 2004
1WA4
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CRYSTAL STRUCTURE OF THE M131F L135A EVAD DOUBLE MUTANT
Descriptor:PCZA361.16, GLYCEROL
Authors:Merkel, A.B., Naismith, J.H.
Deposit date:2004-10-22
Release date:2007-01-30
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the M131F L135A Evad Double Mutant
To be Published
1WLT
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CRYSTAL STRUCTURE OF DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE HOMOLOGUE FROM SULFOLOBUS TOKODAII
Descriptor:176aa long hypothetical dTDP-4-dehydrorhamnose 3,5-epimerase
Authors:Watanabe, N., Sakai, N., Zilian, Z., Kawarabayasi, Y., Tanaka, I.
Deposit date:2004-06-29
Release date:2005-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of dTDP-4-dehydrorhamnose 3,5-epimerase homologue
to be published
2B9U
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CRYSTAL STRUCTURE OF DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE FROM SULFOLOBUS TOKODAII
Descriptor:hypothetical dTDP-4-dehydrorhamnose 3,5-epimerase
Authors:Rajakannan, V., Kondo, K., Mizushima, T., Suzuki, A., Yamane, T.
Deposit date:2005-10-13
Release date:2006-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal structure of dTDP-4-dehydrorhamnose 3,5-epimerase from sulfolobus tokodaii
TO BE PUBLISHED
2C0Z
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THE 1.6 A RESOLUTION CRYSTAL STRUCTURE OF NOVW: A 4-KETO-6-DEOXY SUGAR EPIMERASE FROM THE NOVOBIOCIN BIOSYNTHETIC GENE CLUSTER OF STREPTOMYCES SPHEROIDES
Descriptor:NOVW, SULFATE ION, 1,2-ETHANEDIOL
Authors:Jakimowicz, P., Tello, M., Freel-Meyers, C.L., Walsh, C.T., Buttner, M.J., Field, R.A., Lawson, D.M.
Deposit date:2005-09-09
Release date:2006-01-25
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The 1.6 A Resolution Crystal Structure of Novw: A 4-Keto-6-Deoxy Sugar Epimerase from the Novobiocin Biosynthetic Gene Cluster of Streptomyces Spheroides
Proteins, 63, 2006
2IXC
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RMLC M. TUBERCULOSIS WITH DTDP-RHAMNOSE
Descriptor:DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC, 2'-DEOXY-THYMIDINE-BETA-L-RHAMNOSE
Authors:Dong, C., Naismith, J.H.
Deposit date:2006-07-07
Release date:2006-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Rmlc, a C3' and C5' Carbohydrate Epimerase, Appears to Operate Via an Intermediate with an Unusual Twist Boat Conformation.
J.Mol.Biol., 365, 2007
2IXH
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RMLC P AERUGINOSA WITH DTDP-RHAMNOSE
Descriptor:DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE, 2'-DEOXY-THYMIDINE-BETA-L-RHAMNOSE
Authors:Dong, C., Naismith, J.H.
Deposit date:2006-07-08
Release date:2006-10-26
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation.
J. Mol. Biol., 365, 2007
2IXI
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RMLC P AERUGINOSA WITH DTDP-XYLOSE
Descriptor:DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE, THYMIDINE-5'-DIPHOSPHATE, S,R MESO-TARTARIC ACID
Authors:Dong, C., Naismith, J.H.
Deposit date:2006-07-08
Release date:2006-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Rmlc, a C3' and C5' Carbohydrate Epimerase, Appears to Operate Via an Intermediate with an Unusual Twist Boat Conformation.
J.Mol.Biol., 365, 2007
2IXJ
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RMLC P AERUGINOSA NATIVE
Descriptor:DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE, S,R MESO-TARTARIC ACID
Authors:Dong, C., Naismith, J.H.
Deposit date:2006-07-08
Release date:2006-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Rmlc, a C3' and C5' Carbohydrate Epimerase, Appears to Operate Via an Intermediate with an Unusual Twist Boat Conformation.
J.Mol.Biol., 365, 2007
2IXK
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RMLC P AERUGINOSA WITH DTDP-4-KETO RHAMNNOSE (THE PRODUCT OF THE REACTION)
Descriptor:DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE, DTDP-4-KETO-L-RHAMNOSE
Authors:Dong, C., Naismith, J.H.
Deposit date:2006-07-08
Release date:2006-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Rmlc, a C3' and C5' Carbohydrate Epimerase, Appears to Operate Via an Intermediate with an Unusual Twist Boat Conformation.
J.Mol.Biol., 365, 2007
2IXL
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RMLC S. SUIS WITH DTDP-RHAMNOSE
Descriptor:DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE, 2'-DEOXY-THYMIDINE-BETA-L-RHAMNOSE, NICKEL (II) ION
Authors:Dong, C., Naismith, J.H.
Deposit date:2006-07-08
Release date:2006-10-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Rmlc, a C3' and C5' Carbohydrate Epimerase, Appears to Operate Via an Intermediate with an Unusual Twist Boat Conformation.
J.Mol.Biol., 365, 2007
3EJK
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CRYSTAL STRUCTURE OF DTDP SUGAR ISOMERASE (YP_390184.1) FROM DESULFOVIBRIO DESULFURICANS G20 AT 1.95 A RESOLUTION
Descriptor:dTDP Sugar Isomerase, UNKNOWN LIGAND, CITRIC ACID, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2008-09-18
Release date:2008-09-30
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of dTDP Sugar Isomerase (YP_390184.1) from DESULFOVIBRIO DESULFURICANS G20 at 1.95 A resolution
To be published
3RYK
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1.63 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE (RFBC) FROM BACILLUS ANTHRACIS STR. AMES WITH TDP AND PPI BOUND
Descriptor:dTDP-4-dehydrorhamnose 3,5-epimerase, PYROPHOSPHATE 2-, THYMIDINE-5'-DIPHOSPHATE
Authors:Halavaty, A.S., Kuhn, M., Minasov, G., Shuvalova, L., Kwon, K., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-05-11
Release date:2011-05-25
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.631 Å)
Cite:Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RfbC).
Acta Crystallogr F Struct Biol Commun, 73, 2017
4HMZ
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CRYSTAL STRUCTURE OF CHMJ, A 3'-MONOEPIMERASE FROM STREPTOMYCES BIKINIENSIS IN COMPLEX WITH DTDP-QUINOVOSE
Descriptor:Putative 3-epimerase in D-allose pathway, 1,2-ETHANEDIOL, [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl (2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate
Authors:Holden, H.M., Kubiak, R.L.
Deposit date:2012-10-18
Release date:2012-11-21
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Functional Studies on a 3'-Epimerase Involved in the Biosynthesis of dTDP-6-deoxy-d-allose.
Biochemistry, 51, 2012
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