1PMD
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PENICILLIN-BINDING PROTEIN 2X (PBP-2X)
Descriptor:PEPTIDOGLYCAN SYNTHESIS MULTIFUNCTIONAL ENZYME
Authors:Pares, S., Mouz, N., Dideberg, O.
Deposit date:1996-02-05
Release date:1997-02-05
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme.
Nat.Struct.Biol., 3, 1996
1QME
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PENICILLIN-BINDING PROTEIN 2X (PBP-2X)
Descriptor:PENICILLIN-BINDING PROTEIN 2X
Authors:Gordon, E.J., Mouz, N., Duee, E., Dideberg, O.
Deposit date:1999-09-28
Release date:2000-05-25
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Crystal Structure of the Penicillin-Binding Protein 2X from Streptococcus Pneumoniae and its Acyl-Enzyme Form: Implication in Drug Resistance.
J.Mol.Biol., 299, 2000
1QMF
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PENICILLIN-BINDING PROTEIN 2X (PBP-2X) ACYL-ENZYME COMPLEX
Descriptor:PENICILLIN-BINDING PROTEIN 2X
Authors:Gordon, E.J., Mouz, N., Duee, E., Dideberg, O.
Deposit date:1999-09-28
Release date:2000-05-25
Last modified:2013-04-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Crystal Structure of the Penicillin Binding Protein 2X from Streptococcus Pneumoniae and its Acyl-Enzyme Form: Implication in Drug Resistance
J.Mol.Biol., 299, 2000
1EWZ
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CRYSTAL STRUCTURE OF THE OXA-10 BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:BETA-LACTAMASE OXA-10
Authors:Golemi, D., Maveyraud, L., Vakulenko, S., Tranier, S., Ishiwata, A., Kotra, L.P., Samama, J.P., Mobashery, S.
Deposit date:2000-04-28
Release date:2000-11-01
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The First Structural and Mechanistic Insights for Class D beta-Lactamases: Evidence for a Novel Catalytic Process for Turnover of beta-Lactam Antibiotics
J.Am.Chem.Soc., 122, 2000
1E3U
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MAD STRUCTURE OF OXA10 CLASS D BETA-LACTAMASE
Descriptor:BETA-LACTAMASE OXA-10 (E.C.3.5.2.6)
Authors:Maveyraud, L., Golemi, D., Kotra, L.P., Tranier, S., Vakulenko, S., Mobashery, S., Samama, J.P.
Deposit date:2000-06-23
Release date:2001-01-12
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Insights Into Class D Beta-Lactamases are Revealed by the Crystal Structure of the Oxa10 Enzyme from Pseudomonas Aeruginosa
Structure, 8, 2000
1E4D
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STRUCTURE OF OXA10 BETA-LACTAMASE AT PH 8.3
Descriptor:BETA-LACTAMASE OXA-10 (E.C.3.5.2.6)
Authors:Maveyraud, L., Golemi, D., Kotra, L.P., Tranier, S., Vakulenko, S., Mobashery, S., Samama, J.P.
Deposit date:2000-07-03
Release date:2001-01-12
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights Into Class D Beta-Lactamases are Revealed by the Crystal Structure of the Oxa10 Enzyme from Pseudomonas Aeruginosa
Structure, 8, 2000
1FOF
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CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10
Descriptor:BETA-LACTAMASE OXA-10 (E.C.3.5.2.6)
Authors:Paetzel, M., Danel, F., de Castro, L., Mosimann, S.C., Page, M.G.P., Strynadka, N.C.J.
Deposit date:2000-08-28
Release date:2000-10-09
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the class D beta-lactamase OXA-10.
Nat.Struct.Biol., 7, 2000
1K25
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PBP2X FROM A HIGHLY PENICILLIN-RESISTANT STREPTOCOCCUS PNEUMONIAE CLINICAL ISOLATE
Descriptor:low-affinity Penicillin-binding protein 2X
Authors:Dessen, A., Mouz, N., Hopkins, J., Dideberg, O.
Deposit date:2001-09-26
Release date:2001-10-31
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of PBP2x from a highly penicillin-resistant Streptococcus pneumoniae clinical isolate: a mosaic framework containing 83 mutations.
J.Biol.Chem., 276, 2001
1K38
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CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-2
Descriptor:Beta-lactamase OXA-2 (E.C.3.5.2.6)
Authors:Kerff, F., Fonze, E., Bouillenne, F., Frere, J.M., Charlier, P.
Deposit date:2001-10-02
Release date:2003-06-24
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-2
To be Published
1K4E
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CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASES OXA-10 DETERMINED BY MAD PHASING WITH SELENOMETHIONINE
Descriptor:Beta-lactamase PSE-2 (E.C.3.5.2.6)
Authors:Kerff, F., Fonze, E., Bouillene, F., Frere, J.M., Charlier, P.
Deposit date:2001-10-08
Release date:2001-10-31
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:STRUCTURE OF CLASS D BETA-LACTAMASE OXA-2
To be Published
1K4F
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CRYSTAL STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 AT 1.6 A RESOLUTION
Descriptor:Beta-lactamase PSE-2 (E.C.3.5.2.6)
Authors:Kerff, F., Fonze, E., Bouillene, F., Frere, J.M., Charlier, P.
Deposit date:2001-10-08
Release date:2001-10-31
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the class D beta-lactamase OXA-2
To be Published
1K54
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OXA-10 CLASS D BETA-LACTAMASE PARTIALLY ACYLATED WITH REACTED 6BETA-(1-HYDROXY-1-METHYLETHYL) PENICILLANIC ACID
Descriptor:Beta lactamase OXA-10 (E.C.3.5.2.6)
Authors:Golemi, D., Maveyraud, L., Vakulenko, S., Samama, J.P., Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
1K55
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OXA 10 CLASS D BETA-LACTAMASE AT PH 7.5
Descriptor:Beta lactamase OXA-10 (E.C.3.5.2.6)
Authors:Golemi, D., Maveyraud, L., Vakulenko, S., Samama, J.P., Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
1K56
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OXA 10 CLASS D BETA-LACTAMASE AT PH 6.5
Descriptor:OXA10 beta-lactamase (E.C.3.5.2.6)
Authors:Golemi, D., Maveyraud, L., Vakulenko, S., Samama, J.P., Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
1K57
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OXA 10 CLASS D BETA-LACTAMASE AT PH 6.0
Descriptor:BETA LACTAMASE OXA-10 (E.C.3.5.2.6))
Authors:Golemi, D., Maveyraud, L., Vakulenko, S., Samama, J.P., Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
1K6R
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STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH MOXALACTAM
Descriptor:Beta-lactamase PSE-2 (E.C.3.5.2.6)
Authors:Kerff, F., Fonze, E., Sauvage, E., Frere, J.M., Charlier, P.
Deposit date:2001-10-17
Release date:2003-06-24
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:CRYSTAL STRUCTURE OF CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH DIFFERENT SUBSTRATES AND ONE INHIBITOR.
To be Published
1K6S
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STRUCTURE OF THE CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH A PHENYLBORONIC ACID
Descriptor:Beta-lactamase PSE-2 (E.C.3.5.2.6)
Authors:Kerff, F., Fonze, E., Sauvage, E., Frere, J.M., Charlier, P.
Deposit date:2001-10-17
Release date:2003-06-24
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:CRYSTAL STRUCTURE OF CLASS D BETA-LACTAMASE OXA-10 IN COMPLEX WITH DIFFERENT SUBSTRATES AND ONE INHIBITOR.
To be Published
1M6K
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STRUCTURE OF THE OXA-1 CLASS D BETA-LACTAMASE
Descriptor:beta-lactamase OXA-1 (E.C.3.5.2.6)
Authors:Sun, T., Nukaga, M., Mayama, K., Braswell, E.H., Knox, J.R.
Deposit date:2002-07-16
Release date:2003-01-14
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Comparison of beta-lactamases of classes A and D: 1.5A crystallographic structure of the class D OXA-1 oxacillinase
PROTEIN SCI., 12, 2003
1MWR
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STRUCTURE OF SEMET PENICILLIN BINDING PROTEIN 2A FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS STRAIN 27R (TRIGONAL FORM) AT 2.45 A RESOLUTION.
Descriptor:penicillin-binding protein 2a
Authors:Lim, D.C., Strynadka, N.C.J.
Deposit date:2002-10-01
Release date:2002-11-06
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Nat.Struct.Biol., 9, 2002
1MWS
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STRUCTURE OF NITROCEFIN ACYL-PENICILLIN BINDING PROTEIN 2A FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS STRAIN 27R AT 2.00 A RESOLUTION.
Descriptor:penicillin-binding protein 2a
Authors:Lim, D.C., Strynadka, N.C.J.
Deposit date:2002-10-01
Release date:2002-11-06
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Nat.Struct.Biol., 9, 2002
1MWT
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STRUCTURE OF PENICILLIN G ACYL-PENICILLIN BINDING PROTEIN 2A FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS STRAIN 27R AT 2.45 A RESOLUTION.
Descriptor:Structure of penicillin G acyl-Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r at 2.45 A resolution.
Authors:Lim, D.C., Strynadka, N.C.J.
Deposit date:2002-10-01
Release date:2002-11-06
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Nat.Struct.Biol., 9, 2002
1MWU
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STRUCTURE OF METHICILLIN ACYL-PENICILLIN BINDING PROTEIN 2A FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS STRAIN 27R AT 2.60 A RESOLUTION.
Descriptor:penicillin-binding protein 2a
Authors:Lim, D.C., Strynadka, N.C.J.
Deposit date:2002-10-01
Release date:2002-11-06
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.
Nat.Struct.Biol., 9, 2002
1PYY
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DOUBLE MUTANT PBP2X T338A/M339F FROM STREPTOCOCCUS PNEUMONIAE STRAIN R6 AT 2.4 A RESOLUTION
Descriptor:Penicillin-binding protein 2X
Authors:Chesnel, L., Pernot, L., Lemaire, D., Champelovier, D., Croize, J., Dideberg, O., Vernet, T., Zapun, A.
Deposit date:2003-07-09
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:The Structural Modifications Induced by the M339F Substitution in PBP2x from Streptococcus pneumoniae Further Decreases the Susceptibility to beta-Lactams of Resistant Strains
J.Biol.Chem., 278, 2003
1RP5
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PBP2X FROM STREPTOCOCCUS PNEUMONIAE STRAIN 5259 WITH REDUCED SUSCEPTIBILITY TO BETA-LACTAM ANTIBIOTICS
Descriptor:penicillin-binding protein 2x (E.C.3.4.-.-.)
Authors:Pernot, L., Chesnel, L., Legouellec, A., Croize, J., Vernet, T., Dideberg, O., Dessen, A.
Deposit date:2003-12-03
Release date:2004-02-03
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:A PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibiotics.
J.Biol.Chem., 279, 2004
1XA1
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CRYSTAL STRUCTURE OF THE SENSOR DOMAIN OF BLAR1 FROM STAPHYLOCOCCUS AUREUS IN ITS APO FORM
Descriptor:Regulatory protein blaR1
Authors:Wilke, M.S., Hills, T.L., Zhang, H.Z., Chambers, H.F., Strynadka, N.C.
Deposit date:2004-08-24
Release date:2004-09-07
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus.
J.Biol.Chem., 279, 2004
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