1A76
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FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
Descriptor:FLAP ENDONUCLEASE-1 PROTEIN, MANGANESE (II) ION
Authors:Hwang, K.Y., Baek, K., Kim, H., Cho, Y.
Deposit date:1998-03-20
Release date:1999-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
1A77
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FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII
Descriptor:FLAP ENDONUCLEASE-1 PROTEIN, MAGNESIUM ION
Authors:Hwang, K.Y., Baek, K., Kim, H., Cho, Y.
Deposit date:1998-03-20
Release date:1999-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
1B43
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FEN-1 FROM P. FURIOSUS
Descriptor:PROTEIN (FEN-1)
Authors:Hosfield, D.J., Mol, C.D., Shen, B., Tainer, J.A.
Deposit date:1999-01-05
Release date:2000-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Cell(Cambridge,Mass.), 95, 1998
1MC8
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CRYSTAL STRUCTURE OF FLAP ENDONUCLEASE-1 R42E MUTANT FROM PYROCOCCUS HORIKOSHII
Descriptor:Flap Endonuclease-1
Authors:Matsui, E., Musti, K.V., Abe, J., Yamazaki, K., Matsui, I., Harata, K.
Deposit date:2002-08-06
Release date:2002-10-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular Structure and Novel DNA Binding Sites Located in Loops of Flap Endonuclease-1 from Pyrococcus horikoshii
J.BIOL.CHEM., 277, 2002
1RXV
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CRYSTAL STRUCTURE OF A. FULGIDUS FEN-1 BOUND TO DNA
Descriptor:5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG), Flap structure-specific endonuclease
Authors:Chapados, B.R., Hosfield, D.J., Han, S., Qiu, J., Yelent, B., Shen, B., Tainer, J.A.
Deposit date:2003-12-18
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1RXW
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CRYSTAL STRUCTURE OF A. FULGIDUS FEN-1 BOUND TO DNA
Descriptor:5'-d(*C*pG*pA*pT*pG*pC*pT*pA)-3', 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG)-3', Flap structure-specific endonuclease
Authors:Chapados, B.R., Hosfield, D.J., Han, S., Qiu, J., Yelent, B., Shen, B., Tainer, J.A.
Deposit date:2003-12-18
Release date:2004-01-27
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1UL1
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CRYSTAL STRUCTURE OF THE HUMAN FEN1-PCNA COMPLEX
Descriptor:Flap endonuclease-1, Proliferating cell nuclear antigen, MAGNESIUM ION
Authors:Sakurai, S., Kitano, K., Yamaguchi, H., Hamada, K., Okada, K., Fukuda, K., Uchida, M., Ohtsuka, E., Morioka, H., Hakoshima, T.
Deposit date:2003-09-05
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for recruitment of human flap endonuclease 1 to PCNA
EMBO J., 24, 2005
2IZO
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STRUCTURE OF AN ARCHAEAL PCNA1-PCNA2-FEN1 COMPLEX
Descriptor:FLAP STRUCTURE-SPECIFIC ENDONUCLEASE, DNA POLYMERASE SLIDING CLAMP C, DNA POLYMERASE SLIDING CLAMP B, ...
Authors:Dore, A.S., Kilkenny, M.L., Roe, S.M., Pearl, L.H.
Deposit date:2006-07-25
Release date:2006-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of an Archaeal PCNA1-PCNA2-Fen1 Complex: Elucidating PCNA Subunit and Client Enzyme Specificity.
Nucleic Acids Res., 34, 2006
3ORY
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CRYSTAL STRUCTURE OF FLAP ENDONUCLEASE 1 FROM HYPERTHERMOPHILIC ARCHAEON DESULFUROCOCCUS AMYLOLYTICUS
Descriptor:flap endonuclease 1, PHOSPHATE ION
Authors:Mase, T., Kubota, K., Miyazono, K., Kawarabayashii, Y., Tanokura, M.
Deposit date:2010-09-08
Release date:2011-02-09
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of flap endonuclease 1 from the hyperthermophilic archaeon Desulfurococcus amylolyticus
Acta Crystallogr.,Sect.F, 67, 2011
3Q8K
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CRYSTAL STRUCTURE OF HUMAN FLAP ENDONUCLEASE FEN1 (WT) IN COMPLEX WITH PRODUCT 5'-FLAP DNA, SM3+, AND K+
Descriptor:Flap endonuclease 1, DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E., Classen, S., Chapados, B.R., Arvai, A., Finger, D.L., Guenther, G., Tomlinson, C.G., Thompson, P., Sarker, A.H., Shen, B., Cooper, P.K., Grasby, J.A., Tainer, J.A.
Deposit date:2011-01-06
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2001 Å)
Cite:Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
3Q8L
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CRYSTAL STRUCTURE OF HUMAN FLAP ENDONUCLEASE FEN1 (WT) IN COMPLEX WITH SUBSTRATE 5'-FLAP DNA, SM3+, AND K+
Descriptor:Flap endonuclease 1, DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E., Classen, S., Chapados, B.R., Arvai, A., Finger, D.L., Guenther, G., Tomlinson, C.G., Thompson, P., Sarker, A.H., Shen, B., Cooper, P.K., Grasby, J.A., Tainer, J.A.
Deposit date:2011-01-06
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.319 Å)
Cite:Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
3Q8M
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CRYSTAL STRUCTURE OF HUMAN FLAP ENDONUCLEASE FEN1 (D181A) IN COMPLEX WITH SUBSTRATE 5'-FLAP DNA AND K+
Descriptor:Flap endonuclease 1, DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E., Classen, S., Chapados, B.R., Arvai, A., Finger, D.L., Guenther, G., Tomlinson, C.G., Thompson, P., Sarker, A.H., Shen, B., Cooper, P.K., Grasby, J.A., Tainer, J.A.
Deposit date:2011-01-06
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Cell(Cambridge,Mass.), 145, 2011
3QE9
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (D173A) IN COMPLEX WITH DNA (COMPLEX I)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Orans, J., McSweeney, E.A., Iyer, R.R., Hast, M.A., Hellinga, H.W., Modrich, P., Beese, L.S.
Deposit date:2011-01-20
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
3QEA
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH DNA (COMPLEX II)
Descriptor:Exonuclease 1, DNA (5'-D(P*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Orans, J., McSweeney, E.A., Iyer, R.R., Hast, M.A., Hellinga, H.W., Modrich, P., Beese, L.S.
Deposit date:2011-01-20
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
3QEB
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CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH DNA AND MN2+ (COMPLEX III)
Descriptor:Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*CP*GP*AP*CP*AP*T)-3'), DNA (5'-D(P*TP*CP*GP*AP*CP*TP*AP*GP*CP*G)-3'), ...
Authors:Orans, J., McSweeney, E.A., Iyer, R.R., Hast, M.A., Hellinga, H.W., Modrich, P., Beese, L.S.
Deposit date:2011-01-20
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family.
Cell(Cambridge,Mass.), 145, 2011
4Q0R
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THE CATALYTIC CORE OF RAD2 (COMPLEX I)
Descriptor:DNA repair protein RAD2, DNA (5'-D(*CP*TP*GP*AP*GP*TP*CP*AP*GP*AP*GP*CP*AP*AP*A)-3')
Authors:Mietus, M., Nowak, E., Jaciuk, M., Kustosz, P., Nowotny, M.
Deposit date:2014-04-02
Release date:2014-08-27
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4Q0W
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HE CATALYTIC CORE OF RAD2 IN COMPLEX WITH DNA SUBSTRATE (COMPLEX II)
Descriptor:DNA repair protein RAD2, DNA (5'-D(*TP*TP*TP*GP*AP*TP*CP*CP*GP*TP*CP*CP*AP*CP*CP*TP*TP*T)-3'), DNA (5'-D(*TP*TP*AP*GP*GP*TP*GP*GP*AP*CP*GP*GP*AP*TP*CP*AP*TP*T)-3'), ...
Authors:Mietus, M., Nowak, E., Jaciuk, M., Kustosz, P., Nowotny, M.
Deposit date:2014-04-02
Release date:2014-08-27
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4Q0Z
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THE CATALYTIC CORE OF RAD2 IN COMPLEX WITH DNA SUBSTRATE (COMPLEX III)
Descriptor:Rad2p, DNA (5'-D(*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*T)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*T)-3'), ...
Authors:Mietus, M., Nowak, E., Jaciuk, M., Kustosz, P., Nowotny, M.
Deposit date:2014-04-02
Release date:2014-08-27
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4Q10
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THE CATALYTIC CORE OF RAD2 IN COMPLEX WITH DNA SUBSTRATE (COMPLEX IV)
Descriptor:DNA repair protein RAD2, DNA (5'-D(*TP*TP*TP*TP*GP*CP*TP*CP*CP*CP*TP*TP*GP*TP*CP*TP*CP*AP*GP*TP*TP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*TP*CP*TP*GP*AP*GP*AP*CP*AP*AP*GP*GP*GP*AP*GP*CP*TP*TP*TP*T)-3'), ...
Authors:Mietus, M., Nowak, E., Jaciuk, M., Kustosz, P., Nowotny, M.
Deposit date:2014-04-02
Release date:2014-08-27
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding.
Nucleic Acids Res., 42, 2014
4WA8
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METHANOPYRUS KANDLERI FEN-1 NUCLEASE
Descriptor:Flap endonuclease 1, CHLORIDE ION
Authors:Shah, S., Dunten, P., Horton, N.C.
Deposit date:2014-08-28
Release date:2014-11-12
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and specificity of FEN-1 from Methanopyrus kandleri.
Proteins, 83, 2015
5CNQ
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CRYSTAL STRUCTURE OF THE HOLLIDAY JUNCTION-RESOLVING ENZYME GEN1 (WT) IN COMPLEX WITH PRODUCT DNA, MG2+ AND MN2+ IONS
Descriptor:Nuclease-like protein, R, DNA (5'-D(*TP*GP*AP*GP*CP*GP*GP*TP*GP*GP*TP*TP*GP*GP*T)-3'), ...
Authors:Liu, Y.J., Freeman, A.D.J., Declais, A.C., Wilson, T.J., Gartner, A., Lilley, D.M.J.
Deposit date:2015-07-17
Release date:2015-12-30
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.
Cell Rep, 13, 2015
5CO8
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CRYSTAL STRUCTURE OF THE HOLLIDAY JUNCTION-RESOLVING ENZYME GEN1 (WT) IN COMPLEX WITH PRODUCT DNA AND MG2+ ION
Descriptor:DNA (31-MER), Nuclease-like protein, DNA (5'-D(*AP*GP*AP*CP*TP*GP*CP*AP*GP*TP*TP*GP*AP*GP*TP*C)-3'), ...
Authors:Liu, Y.J., Freeman, A.D.J., Declais, A.C., Wilson, T.J., Gartner, A., Lilley, D.M.J.
Deposit date:2015-07-20
Release date:2016-01-13
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA.
Cell Rep, 13, 2015
5FV7
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HUMAN FEN1 IN COMPLEX WITH AN N-HYDROXYUREA COMPOUND
Descriptor:FLAP ENDONUCLEASE 1, MAGNESIUM ION, 1-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Authors:Exell, J.C., Thompson, M.J., Finger, L.D., Shaw, S.K., Abbott, W.M., McWhirter, C., Debreczeni, J.E., Jones, C.D., Nissink, J.W.M., Ward, T.A., Sioberg, C.W.L., Molina, D.M., Durant, S.T., Grasby, J.A.
Deposit date:2016-02-03
Release date:2016-08-17
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Cellular Active N-Hydroxyurea Fen1 Inhibitors Block Substrate Entry to the Active Site
Nat.Chem.Biol., 12, 2016
5K97
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FLAP ENDONUCLEASE 1 (FEN1) D233N WITH CLEAVED PRODUCT FRAGMENT AND SM3+
Descriptor:Flap endonuclease 1, DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E., Arvai, A.S., Tainer, J.A.
Deposit date:2016-05-31
Release date:2017-06-28
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
5KSE
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FLAP ENDONUCLEASE 1 (FEN1) R100A WITH 5'-FLAP SUBSTRATE DNA AND SM3+
Descriptor:Flap endonuclease 1, DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3'), DNA (5'-D(P*TP*AP*AP*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3'), ...
Authors:Tsutakawa, S.E., Arvai, A.S., Tainer, J.A.
Deposit date:2016-07-08
Release date:2017-06-28
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Nat Commun, 8, 2017
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