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2QTS
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BU of 2qts by Molmil
Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel, CHLORIDE ION, ...
Authors:Jasti, J, Furukawa, H, Gonzales, E.B, Gouaux, E.
Deposit date:2007-08-02
Release date:2007-09-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
Nature, 449, 2007
3IJ4
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BU of 3ij4 by Molmil
Cesium sites in the crystal structure of a functional acid sensing ion channel in the desensitized state
Descriptor: Amiloride-sensitive cation channel 2, neuronal, CESIUM ION, ...
Authors:Gonzales, E.B, Gouaux, E.
Deposit date:2009-08-03
Release date:2009-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.
Nature, 460, 2009
3S3X
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BU of 3s3x by Molmil
Structure of chicken acid-sensing ion channel 1 AT 3.0 A resolution in complex with psalmotoxin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Amiloride-sensitive cation channel 2, neuronal, ...
Authors:Dawson, R.J.P, Benz, J, Stohler, P, Tetaz, T, Joseph, C, Huber, S, Schmid, G, Huegin, D, Pflimlin, P, Trube, G, Rudolph, M.G, Hennig, M, Ruf, A.
Deposit date:2011-05-18
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1.
Nat Commun, 3, 2012
3S3W
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BU of 3s3w by Molmil
Structure of chicken acid-sensing ion channel 1 at 2.6 a resolution and ph 7.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Amiloride-sensitive cation channel 2, ...
Authors:Dawson, R.J.P, Benz, J, Stohler, P, Tetaz, T, Joseph, C, Huber, S, Schmid, G, Huegin, D, Pflimlin, P, Trube, G, Rudolph, M.G, Hennig, M, Ruf, A.
Deposit date:2011-05-18
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1.
Nat Commun, 3, 2012
4FZ1
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BU of 4fz1 by Molmil
Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at high pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Pi-theraphotoxin-Pc1a
Authors:Baconguis, I, Gouaux, E.
Deposit date:2012-07-05
Release date:2012-08-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.359 Å)
Cite:Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes.
Nature, 489, 2012
4FZ0
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BU of 4fz0 by Molmil
Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at low pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, CHLORIDE ION, ...
Authors:Baconguis, I, Gouaux, E.
Deposit date:2012-07-05
Release date:2012-08-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes.
Nature, 489, 2012
4NTW
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BU of 4ntw by Molmil
Structure of acid-sensing ion channel in complex with snake toxin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ...
Authors:Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E.
Deposit date:2013-12-02
Release date:2014-02-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
4NTY
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BU of 4nty by Molmil
Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ...
Authors:Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E.
Deposit date:2013-12-02
Release date:2014-02-19
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
4NTX
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BU of 4ntx by Molmil
Structure of acid-sensing ion channel in complex with snake toxin and amiloride
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-DIAMINO-N-(AMINOIMINOMETHYL)-6-CHLOROPYRAZINECARBOXAMIDE, Acid-sensing ion channel 1, ...
Authors:Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E.
Deposit date:2013-12-02
Release date:2014-02-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
4NYK
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BU of 4nyk by Molmil
Structure of a membrane protein
Descriptor: Acid-sensing ion channel 1, CHLORIDE ION
Authors:Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E.
Deposit date:2013-12-10
Release date:2014-02-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.
Nature, 460, 2009
5WKU
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BU of 5wku by Molmil
Structure of an acid sensing ion channel in a resting state with barium
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, ...
Authors:Yoder, N, Gouaux, E.
Deposit date:2017-07-25
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Gating mechanisms of acid-sensing ion channels.
Nature, 555, 2018
5WKX
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BU of 5wkx by Molmil
Barium sites in the structure of a resting acid sensing ion channel
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, ...
Authors:Yoder, N, Gouaux, E.
Deposit date:2017-07-25
Release date:2018-08-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.034 Å)
Cite:Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography.
PLoS ONE, 13, 2018
5WKV
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BU of 5wkv by Molmil
Structure of an acid sensing ion channel in a resting state with calcium
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, ...
Authors:Yoder, N, Gouaux, E.
Deposit date:2017-07-25
Release date:2018-03-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Gating mechanisms of acid-sensing ion channels.
Nature, 555, 2018
5WKY
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BU of 5wky by Molmil
Bromide sites in the structure of an acid sensing ion channel in a resting state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, ...
Authors:Yoder, N, Gouaux, E.
Deposit date:2017-07-25
Release date:2018-08-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4 Å)
Cite:Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography.
PLoS ONE, 13, 2018
6AVE
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BU of 6ave by Molmil
Structure of an acid sensing ion channel in a resting state at high pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1
Authors:Yoder, N, Yoshioka, C, Gouaux, E.
Deposit date:2017-09-02
Release date:2018-03-21
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Gating mechanisms of acid-sensing ion channels.
Nature, 555, 2018
6BQN
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BU of 6bqn by Molmil
Cryo-EM structure of ENaC
Descriptor: 10D4 fab, 7B1 fab, EGFP-SCNN1G chimera, ...
Authors:Noreng, S, Bharadwaj, A, Posert, R, Yoshioka, C, Baconguis, I.
Deposit date:2017-11-28
Release date:2018-10-10
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the human epithelial sodium channel by cryo-electron microscopy.
Elife, 7, 2018
6CMC
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BU of 6cmc by Molmil
Barium sites in the structure of a desensitized acid sensing ion channel
Descriptor: Acid-sensing ion channel 1, CHLORIDE ION
Authors:Yoder, N, Gouaux, E.
Deposit date:2018-03-03
Release date:2018-08-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.671 Å)
Cite:Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography.
PLoS ONE, 13, 2018
6L6I
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BU of 6l6i by Molmil
hASIC1a co-crystallized with Mamb-1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1
Authors:Lei, F, Jian, S.
Deposit date:2019-10-29
Release date:2020-11-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:hASIC1a co-crystallized with Mamb-1
To Be Published
6L6N
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BU of 6l6n by Molmil
hASIC1a co-crystallized with Nafamostat
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lei, F, Jian, S.
Deposit date:2019-10-29
Release date:2021-01-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:hASIC1a co-crystallized with Mamb-1
To Be Published
6L6P
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BU of 6l6p by Molmil
hASIC2a co-crystallized with Mamb-1
Descriptor: Acid-sensing ion channel 2
Authors:Lei, F, Jian, S.
Deposit date:2019-10-29
Release date:2020-11-04
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:hASIC2a co-crystallized with Mamb-1
To Be Published
6VTK
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BU of 6vtk by Molmil
Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a desensitized state at low pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1
Authors:Yoder, N, Gouaux, E.
Deposit date:2020-02-12
Release date:2020-03-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity.
Elife, 9, 2020
6VTL
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BU of 6vtl by Molmil
Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a resting state at high pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1
Authors:Yoder, N, Gouaux, E.
Deposit date:2020-02-12
Release date:2020-03-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity.
Elife, 9, 2020
6WTH
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BU of 6wth by Molmil
Full-length human ENaC ECD
Descriptor: 10D4 Fab, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Posert, R, Baconguis, I, Noreng, S, Bharadwaj, A, Houser, A.
Deposit date:2020-05-02
Release date:2020-08-12
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Molecular principles of assembly, activation, and inhibition in epithelial sodium channel.
Elife, 9, 2020
6X9H
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BU of 6x9h by Molmil
Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion channel 1 (ASIC1)
Descriptor: 2-[4-(3,4-dimethoxyphenoxy)phenyl]-1H-benzimidazole-6-carboximidamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, ...
Authors:Liu, Y, Ma, J, DesJarlais, R.L, Hagan, R, Rech, J, Lin, D, Liu, C, Miller, R, Schoellerman, J, Luo, J, Letavic, M, Grasberger, B, Maher, M.
Deposit date:2020-06-02
Release date:2020-12-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1.
Commun Biol, 4, 2021
7CFS
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BU of 7cfs by Molmil
Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, CHOLESTEROL HEMISUCCINATE, ...
Authors:Sun, D.M, Liu, S.L, Li, S.Y, Yang, F, Tian, C.L.
Deposit date:2020-06-28
Release date:2020-10-21
Method:ELECTRON MICROSCOPY (3.56 Å)
Cite:Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
Elife, 9, 2020

 

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